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| 1 | Anti-cd TCR antibody-expanded cd T cells:a better choice for the adoptive immunotherapy of lymphoid malignancies显示文摘Cell-based immunotherapy for lymphoid malignancies has gained increasing attention as patients develop resistance to conventional treatments.cd T cells,which have major histocompatibility complex(MHC)-unrestricted lytic activity,have become a promising candidate population for adoptive cell transfer therapy.We previously established a stable condition for expanding cd T cells by using anti-cd T-cell receptor(TCR)antibody.In this study,we found that adoptive transfer of the expanded cd T cells to Daudi lymphoma-bearing nude mice significantly prolonged the survival time of the mice and improved their living status.We further investigated the characteristics of these antibody-expanded cd T cells compared to the more commonly used phosphoantigen-expanded cd T cells and evaluated the feasibility of employing them in the treatment of lymphoid malignancies.Slow but sustained proliferation of human peripheral blood cd T cells was observed upon stimulation with anti-cd TCR antibody.Compared to phosphoantigen-stimulated cd T cells,the antibody-expanded cells manifested similar functional phenotypes and cytotoxic activity towards lymphoma cell lines.It is noteworthy that the anti-cd TCR antibody could expand both the Vd1 and Vd2 subsets of cd T cells.The in vitro-expanded Vd1 T cells displayed comparable tumour cell-killing activity to Vd2 T cells.Importantly,owing to higher C–C chemokine receptor 4(CCR4)and CCR8 expression,the Vd1 T cells were more prone to infiltrate CCL17-or CCL22-expressing lymphomas than the Vd2 T cells.Characterizing the peripheral blood cd T cells from lymphoma patients further confirmed that the anti-cd TCR antibody-expanded cd T cells could be a more efficacious choice for the treatment of lymphoid malignancies than phosphoantigen-expanded cd T cells. | Jianhua Zhou Ning Kang Lianxian Cui Denian Ba Wei He | 2012 | Cellular & Molecular Immunology2012，9，1： | 17 |
| 2 | Progress of Study on Application of Rare Earth Metals in Steels显示文摘With the improvement of the clean steel by degrees, the functions of rare earth metals in steel are more focused on modification of inclusions and micro alloying.The new study concerning the application of RE metals in clean steels were investigated by ICP, metallographic examination, SEM, EDS, EPMA, TEM and IMMA.The mechanism of corrosion resistance in the weather resistance steel was clarified.The mechanism of abrasion resistance and the life of fatigue enhanced in the RE - heavy rails steel were discussed.Progress in study of application of rare earth metals in steels (including weather resistance steel, low alloy steel, and heavy rails steel) was covered in this paper. | Wang Longmei Lin Qin Ji Jingwen Lan Denian | 2004 | Journal of Rare Earths2004，22，z1： | 5 |
| 3 | Generation of human neutralizing monoclonal antibodies against the 2009 pandemic H 1N 1 virus from peripheral blood memory B lymphocytes显示文摘2009 H1N1 流行性感冒流行表明了对人的全球健康威胁的意义。尽管流行 H1N1 疫苗很快被开发了,被动 serotherapy 可以在孩子对感染提供优异立即的保护,老、妥协免疫者的病人在流行性感冒期间流行。这里,我们基于使不朽的 Epstein-Barr 病毒(EBV ) 使用了新奇策略从个人屏蔽高病毒的抵销 monoclonal 抗体(MAbs ) 的外部血记忆 B 房间与 2009 流行 H1N1 疫苗的 PANFLU.1 种牛痘。通过 13 090 使不朽的记忆 B 房间的一幅巨大的屏幕,从三的克隆选择了 vaccinees,七 MAbs 与两个高病毒的抵销能力和红血球凝聚抑制(HAI ) 被识别对 2009 个流行 H1N1 病毒的活动。这些 MAbs 可以与严重呼吸症候群为感染的病人的被动 serotherapy 治疗有重要临床的含意,特别孩子,老并且 immunodeficient 个人。我们为从使 EBV 不朽的外部血记忆 B 房间产生高亲密关系的 MAbs 的成功的策略可能也对另外的传染或自体免疫的疾病适用。 | Hao Wang Chi Ma Yanlai Lu Xu Ji Yongsheng Pang Fang Hua Lianxian Cui Denian Ba Wei He | 2013 | Cellular & Molecular Immunology2013，10，5： | 3 |
| 4 | New study concerning development of application of rare earth metals in steels 显示文摘 | Wang Longmei Lin Qin Wen Jing Lan Denian | 2006 | Journal of Alloys and Compounds2006，408，412： | 1 |
| 5 | γδ T cells recognize tumor cells via CDR3δ region显示文摘 | Chunping Xu Huiyuan Zhang Hongbo Hu Hongbin He Zhun Wang Yong Xu Hui Chen Wei Cao Sumei Zhang Lianxian Cui Denian Ba Wei He | 2006 | Molecular Immunology2006，，4： | 1 |
| 6 | Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an antivascular endothelial growth factor/vascular permeability factor antibody 显示文摘 | Yuan F Chen Y Denian M | 1996 | Proc Nad Acad Sci USA1996，93，14： | 1 |
| 7 | Reducing redundancy in subspace clustering显示文摘 | CHU Yihong CHEN Yiju YANG Denian | | 0，，10： | 1 |
| 8 | Activity of Recombinant Human Interleukin-15 against Tumor Recurrence and Metastasis in Mice显示文摘Transplantable experimental tumor models were constructed to study the activities of recombinant human interleukin-15 (rhIL-15) against tumor recurrence and metastasis. The results showed that tumor nodule formation was retarded and tumor growth was inhibited in the subcutaneous tumor model of LA795 lung adenocarcinoma after treatment with rhIL-15, and the survival rate of T739 tumor-bearing mice treated with rhIL-15 was much higher than that of mice treated with either saline or with the same dose of rhIL-2. This indicats that rhIL-15 had better antitumor effect than rhIL-2 at the same dose level. In some rhIL-15 treated mice, the tumor cells inoculated subcutaneously were eradicated and there was no tumor formation even 138 days after tumor cell inoculation. The tumor-free mice were rechallenged with live tumor cells and no tumor reoccurred in the following two months in all of these mice, indicating that long-lasting antitumor systemic immunity developed. It was also shown that tumor recurrence and metastasis were inhibited markedly after treatment with rhIL-15, but not with the same dose of rhIL-2, in both subcutaneously and intravenously disseminated tumor models of LA795 lung adenocarcinoma. Simultaneously, the CTL and NK cell activities of the splenocytes obtained from tumor-bearing mice that had been treated with either rhIL-15 or rhIL-2 were both markedly enhanced. However, the enhancement of CTL and NK cell activities was more significant in rhIL-15 treated mice than that in rhIL-2 treated mice. This suggests that the anti-tumor effect of rhIL-15 in vivo was achieved by enhancing the CTL and NK cell activities in tumor immune response. | Feng Tang Luting Zhao Yan Jiang Denian Ba Lianxian Cui Wei He | 2008 | Cellular & Molecular Immunology2008，5，3： | 1 |
| 9 | Technology innovations on high quality special steel products显示文摘Because special steels are the basic materials for industrialization,a national R&D program on special steel technology for high quality products have been granted to promote the special steel production and applications since 2008.Since then,great progresses have been achieved on ferritic stainless steel sheets,heat resistance steel pipes and tubes,microalloyed forging steel bars,and mould steel forgings for hot working. The ratio of ferritic stainless steel sheets produced by TISCO and Baosteel has been promoted through technology innovations and increased 42%and 48 in 2009 respectively.439M steel sheets have been used to exhaust system,and 444 steel sheets have been applied to kitchen and architecture.The production technologies for heat resistance steel pipes and tubes(T/P92,S3043,S31042 steels) have been developed in Baosteel and Pansteel to meet the market requirements.Meanwhile,the round bloom technology has been initiated in Xingcheng Steel.The new technologies for microalloyed forging steels,low cost steel bar,and tailored steel and components,were proposed by CISRI based on the understanding of precise chemical composition and segregation control.And the applications of microalloyed forging steel bars have been promoted remarkably.The researchers have developed high quality mould steel technologies,heavy section forgings of 718 steel,high premium H13 steel blocks and large diameter mandrels used for seamless pipe rolling.The technology innovations of the program could lead to the progress of production technology in special steel sheets,pipes,bars and forgings,and meet the demands from market.For the moment,it is actually believed that there still strong requirements for the technology innovations on special steels. | DONG Han~(1)),CHEN Silian~(1)),LAN Denian~(2)) and LIU Zhongdong~(1)) 1) Central Iron & Steel Research Institute,Beijing 100081,China 2) Chinese Iron & Steel Association,Beijing 100711,China | 2010 | Baosteel Technical Research2010，4，S1： | 1 |
| 10 | On multicast routing using rectilinear Steiner trees for LEO satellite networks显示文摘 | YANG Denian LIAO Wanjiun | 2004 | Proc IEEE Globecom2004，5，： | 1 |
| 11 | In vitro and in vivo resistance of Leishmania infantum to meglumine antimoni- ate: A study of 37 strains collected from patients with visceral leishmaniasis显示文摘 | Faraut-Gamharelli F Piarroux R Denian M | 1997 | Antimicrob Agents Chemother1997，41，： | 1 |
| 12 | On Multicast Routing Using Rectilinear Steiner Trees for LEO Satellite Networks显示文摘 | Yang Denian Liao Wanjiun | 2008 | IEEE Trans on Vehicular Technology2008，57，4： | 1 |
| 13 | A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease显示文摘 | Jianmin Zhang Xiaobing Wu Chuan Qin Jin Qi Shibin Ma Huiyuan Zhang Qingli Kong Dongqing Chen Denian Ba Wei He | 2006 | 中国生物学文摘2006，20，3： | 0 |
| 14 | Solvent-free Synthesis of Flowable Carbon Clusters with Customizable Size and Tunable Optical Performance显示文摘我们建议一条快速、没有溶剂的线路因为综合的发光的碳由控制聚乙烯乙二醇(木钉) 的碳化聚类。这条途径还不包含溶剂自己把先锋用作推迟媒介,因此展示温和、绿的化学,并且也启用制服大小的碳簇,直径能容易从经由反应时间的控制的 0.7 ~ 3.5 nm 被调节的形成。以尺寸, resultants 分别地作为 sub-nano 碳簇(SNC ) 和碳点(CD ) 被表示。得益于抛锚的木钉分割的表面,二在水、器官的溶剂在房间温度和优秀溶解度显示出有利 flowability。他们的光表演和结构的比较表明他们分享一样的色基。特别地, SNC 证明柔韧的相片马厩和 pH 稳定的光致发光和罐头直接被用于考虑到它的突出的 biocompatibility 的房间成像。而且,它的量收益(5.5%) 比 CD (1.5%) 的高约 3 倍,能被灵巧的化学减小戏剧性地提高到 18.8% 。我们预计这些木钉衍生物与容易的合成,可控制的光表演和优秀物理性质标记愿望高度在未来应用正在呼吁。 | Denian Li Qi Li Xuan Hu Jing Huang Hairong Li Lijie Dong HaJan Xie Chuanxi Xiong | 2013 | Chinese Journal of Chemistry2013，31，12： | 0 |
| 15 | CHINA: MEDICAL SCIENCE AND TECHNOLOGY DEVELOPMENT显示文摘Ⅰ. ORGANIZATION AND PERSONNEL At present there are 795 research institutes in China (in 1987 there were 351 independent ones and 441 affiliated ones) under the Chinese Academy of Medical Science,the Chinese Academy of Preventive Medicine,the Academy of Traditional Chinese Medicine and the Chinese Academy of Military Medicine.They are playing the role of research centers for basic and clinical medicine,preventive medicine,traditional Chinese medicine,and mili- | Ba Denian(Chinese Academy of Medical Science, Beijing) President of Chincse Academy of Medical Science. | 1996 | Bulletin of the Chinese Academy of Sciences1996，10，4： | 0 |
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