|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ERK signaling pathway may induce gemcitabine chemoresistance in pancreatic cancer cell line SW1990 by regulating the expression of mdr-1 and RRM1 gene显示文摘调查在细胞外的调整信号的激酶(英皇家空军之阶级最低之兵) 之间的关系的目的小径,多在 gemcitabine (宝石) 的药抵抗基因(mdr-1 ) ,核糖核甙酸还原酶 M1 (RRM1 ) 基因和他们的角色在胰腺的癌症房间的化学抵抗力衬里 SW1990。宝石抵抗房间建模的方法被一个逐步的方法构造。Immunohistochemistry 被用来在半在确定的房间紧张测量英皇家空军之阶级最低之兵蛋白质(ERK1/2 ) 的表示量的方法。mdr-1 和 RRM1 的 mRNA 表示被 RT-PCR 检测。MTT 试金被执行决定 IC50 价值。确定的宝石抵抗的房间拉紧的结果能在宝石(0, 30, 60, 100, 150 和 200 nmol/L ) 的中等包含的不同集中层次获得稳定的生长和经过能力。英皇家空军之阶级最低之兵蛋白质, mdr-1 和 RRM1 基因的表示被提高由宝石集中的增加伴随了。在 mdr-1, RRM1 表示和宝石抵抗水平之间有高度积极的关联(r = 0.960, P = 0.002 并且 r = 0.966, P = 0.002 ) 。英皇家空军之阶级最低之兵蛋白质的表示也与 mdr-1 和 RRM1 水平相关(r =−0.943, P = 0.005 并且 r =−0.883, P = 0.02 ) 。在 200 nmol/L 的宝石抵抗水平, ERK1/2 的灰规模价值是 164.22 ± 13.17, mdr-1/β-actin 和 RRM1/β-actin 是 1.41 ± 0.04 和 1.45 ± 0.18 分别地;在与英皇家空军之阶级最低之兵小径禁止者 U0126 对待以后,这些价值同时地减少了到 186.85 ± 13.14, 0.2 3 ± 0.02 和 0.21 ± 0.03 分别地;相反地, ERK1/2 灰规模价值是 106.55 ± 16.45, mdr-1/β-actin 和 RRM1/β-actin 是 1.50 ± 0.07 和 1.52 ± 0.12,分别地它介绍了一个趋势在与英皇家空军之阶级最低之兵小径使活跃之物 EGF 对待以后,同时地增加。在 0 nmol/L 和 200 个 nmol/L 层次的宝石抵抗的房间的 IC50 价值分别地是 4.104 和 10.20。在与 U0126 对待以后,这些价值分别地减少了到 3.26 和 4.50;当与 EGF 对待时, IC50 价值分别地增加了到 8.89 和 17.17。英皇家空军之阶级最低之兵小径可以在 mdr-1 和 RRM1 基因表示的规定通过参予在胰腺的房间线 SW1990 导致 GEM-chemoresistance 的结论。 | Denglin Chen Derong Xie Shuangshuang Guo Qiong Yang Zhimin Jiang Zhuofei Bi Wen Ma | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 3 |
| 2 | Unsymmetrical photochromic bithienylethene-bridge tetraphenylethene molecular switches:Synthesis,aggregation-induced emission and information storage显示文摘Aggregation-induced emission(AIE) active photochromic molecules have attracted growing attention for their versatile applications.Here we designed and synthesized five newly unsymmetrical photochromic diarylethene(DAE) dyads(BTE1-5) by connecting tetraphenylethene(TPE) and aromatic substituent via bithienylethene(BTE) bridge.The chemical structures of those compounds were identified by ^1H NMR,^(13)C NMR and HRMS.The absorption and emission of these dyads were investigated by UV-vis and fluore scence spectroscopy,respectively.The results showed that all those compounds exhibited typically AIE or aggregation-induced emission enhancement(AIEE) characteristic.Particularly,when an aggregationcaused quenching(ACQ) fluorophore(triphenylamine) was grafted to the molecule,connecting with TPE via BTE-bridge,the ACQ phenomenon was dissipated and converted to an AIE luminophore,and those compounds exhibited photochromism upon irradiation with alternative UV and visible light.The solution or solid of those compounds showed distinctly fluorescence switching 'ON' or 'OFF' observation upon irradiation with alternative UV and visible light.It is interesting that BTE1 could be applied in recording and rewritable information storage,and the cyclization quantum yields could be affected by substituent significantly. | Liangwei Ma Chengpeng Li Qing Yan Sheng Wang Wangen Miao Derong Cao | 2020 | Chinese Chemical Letters2020，31，2： | 1 |
| 3 | Photo-induced morphology transition of a multifunctional photochromic bisthienylethene molecule with switchable aggregation-induced emission显示文摘A novel multifunctional molecule BTE-CNPH was designed and synthesized by connecting 2-(3′,5′-bis(trifluoromethyl)-biphenyl-4-yl)-2-cyanovinyl group to both side of the bisthienylethene(BTE), which exhibited excellent aggregation-induced emission(AIE) and bistable photochromism. High-contrast(>60) reversible fluorescence switching was achieved in the 1 D nanowires, solid of BTE-CNPH and also in a polymethyl methacrylate(PMMA) film loaded with 1% BTE-CNPH under the alternative irradiation by 365 nm and visible light. Interestingly, the nanowire-like assembly morphology of BTE-CNPH in aqueous tetrahydrofuran(THF) solution of specific concentration was observed to translate into amorphous pieces gradually upon prolonged irradiation by the 365 nm, accompanying with photo-tunable AIE emission. | Sheng Wang Fang Wang Chengpeng Li Teng Li Derong Cao Xiang Ma | 2018 | Science China Chemistry2018，61，10： | 1 |
| 4 | Migration of bisphenol A and its related compounds in canned seafood and dietary exposure estimation显示文摘The present study sought to investigate the migration of target bisphenols,such as bisphenol-A(BPA),bisphenol-F(BPA),bisphenol-A diglycidyI ether(BADGE),bisphenol-A(2,3-dihydroxypropyl)glycidyl ether(BADGE.H_(2)O),bisphenol-A bis(2,3-dihydroxypropyl)ether(BADGE.2H_(2)O),and bisphenol F diglycidyl ether(BFDGE)in 102 samples of several canned seafood,namely canned Antarctic krill,scallop,oysters,mussel,clam,and mantis shrimp stored for months at different temperatures through a high-performance liquid chromatographic-fluorescence detector com-bined with a microwave-assisted extraction method.Except for BFDGE,the other five bisphenols were observed in most of the analyzed sam-ples.The canned shrimp showed the highest migration of BPA(0.089 mg/kg),exceeding the specific migration limit(SML)of BPA(0.05 mg/kg)specified by the European Union,while the migration levels of BADGE and its derivatives were within their SMLs.The migration behavior of bisphenols in the canned seafood was majorly affected by the analytes,storage conditions,and food types.BPA,BADGE.H_(2)O,and BADGE 2H_(2)O were characterized by a rapid migration during the first half of the shelf life,which increased with the increase of temperature,followed by a stabilization or decline of their concentrations for prolonged durations.Besides,the migration of target bisphenols was significantly influenced by the storage temperature in some seafood species.Notably,higher migration level of BPA was found in samples with higher fat content.The average dietary exposure of Chinese adults to BPA,BPF,BADGE.2H_(2)O,BADGE.H_(2)O,and BADGE of canned seafood was estimated at 11.69,1.21,6.47,8.74,and 4.71 ng/(kg d),respectively.The target hazard quotient values of all the analyzed bisphenols were below 1 for the Chinese adults,suggesting an insignificant exposure to these bisphenols through canned seafood consumption. | Na Lin Derong Ma Zhidong Liu Xichang Wang Liyan Ma | 2022 | Food Quality and Safety2022，6，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员