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| 1 | Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis显示文摘AIM: To investigate the intestinal anti-inflammatory effect and mechanism of a probiotic Lactobacillus sakuvarius ssp.salivariusCECT5713 in the TNBS model of rat colitis.METHODS: Female Wistar rats (180-200 g) were used in this study. A group of rats were administered orally the probiotic L. salivarius ssp. salivarius (5×108 CFU suspended in 0.5 mL of skimmed milk) daily for 3 wk. Two additional groups were used for reference, a non-colitic and a control colitic without probiotic treatment, which received orally the vehicle used to administer the probiotic. Two weeks after starting the experiment, the rats were rendered colitic by intracolonic administration of 10 mg of TNBS dissolved in 0.25 mL of 500 mL/L ethanol. One week after colitis induction, all animals were killed and colonic damage was evaluated both histologically and biochemically. The biochemical studies performed in colonic homogenates include determination of myeloperoxidase (MPO) activity,glutathione (GSH) content, leukotriene B4 (LTB4) and tumor necrosis factor α (TNF-α) levels, as well as inducible nitric oxide synthase (iNOS) expression. In addition, the luminal contents obtained from colonic samples were used for microbiological studies, in order to determine Lactobacilli and Bifidobacteria counts.RESULTS: Treatment of colitic rats with L. salivarius ssp.salivarius resulted in amelioration of the inflammatory response in colitic rats, when compared with the corresponding control group without probiotic treatment. This antiinflammatory effect was evidenced macroscopically by a significant reduction in the extent of colonic necrosis and/or inflammation induced by the administration of TNBS/ethanol (2.3+0.4 cm vs3.4+0.3 cm in control group,P<0.01) and histologically by improvement of the colonic architecture associated with a reduction in the neutrophil infiltrate in comparison with non-treated colitic rats. The latter was confirmed biochemically by a significant reduction of colonic MPO activity (105.3+26.0 U/g vs180.6±21.9 U/g, P<0.05), a marker of neutrophil infiltration. The beneficial effect was associated with an increase of the colonic GSH content (1 252±42 nmol/g vs 1 087+51 nmol/g, P<0.05),which is depleted in colitic rats, as a consequence of the oxidative stress induced by the inflammatory process. In addition, the treatment of colitic rats with L. salivarius resulted in a significant reduction of colonic TNF-α levels (509.4±68.2 pg/g vs782.9±60.1 pglg, P<0.01) and in a lower colonic iNOS expression, when compared to TNBS control animals without probiotic administration. Finally,treated colitic rats showed higher counts of Lactobacilli species in colonic contents than control colitic rats, whereas no differences were observed in Bifidobacteria counts.CONCLUSION: Administration of the probiotic L. salivarius ssp. salivarius CECT5713 facilitates the recovery of the inflamed tissue in the TNBS model of rat colitis, an effect associated with amelioration of the production of some of the mediators involved in the inflammatory response in the intestine, such as cytokines, including TNF-α and NO. This beneficial effect could be ascribed to its effect on the altered immune response that occurs in this inflammatory condition. | Laura Peran Desiree Camuesco Monica Comalada Ana Nieto Angel Concha Maria Paz Diaz-Ropero Monica Olivares Jordi Xaus Antonio Zarzuelo Julio Galvez | 2005 | World Journal of Gastroenterology2005，11，33： | 17 |
| 2 | Asthma and gastroesophageal reflux disease: Effect of long-term pantoprazole therapy显示文摘AIM: To define the prevalence of gastroesophageal reflux disease (GERD) in mild persistent asthma and to value the effect of pantoprazole therapy on asthmatic symptoms.METHODS: Seven of thirty-four asthmatic patients without GERD served as the non-GERD control group.Twenty-seven of thirty-four asthmatic patients had GERD (7/27 also had erosive esophagitis, sixteen of them presented GERD symptoms. An upper gastrointestinal endoscopy was performed in all the subjects to obtain five biopsy specimens from the lower 5 cm of the esophagus. Patients were considered to have GERD when they had a dilation of intercellular space (DIS)>0.74 μm at transmission electron microscopy.Patients with GERD were treated with pantoprazole,80 mg/day. Forced expiratory volume in one second (FEV1) was performed at entry and after 6 mo of treatment. Asthmatic symptoms were recorded. The required frequency of inhaling rapid acting 32-agonists was self-recorded in the patients' diaries.RESULTS: Seven symptomatic patients presented erosive esophagitis. Among the 18 asymptomatic patients, 11 presented DIS, while all symptomatic patients showed ultrastructural esophageal damage.Seven asymptomatic patients did not present DIS. At entry the mean of FEV1 was 1.91 L in symptomatic GERD patients and 1.88 L in asymptomatic GERD patients.After the treatment, 25 patients had a complete recovery of DIS and reflux symptoms. Twenty-three patients presented a regression of asthmatic symptoms with normalization of FEV1. Four patients reported a significant improvement of symptoms and their FEV1 was over 80%.CONCLUSION: GERD is a highly prevalent condition in asthma patients. Treatment with pantoprazole (80 mg/day)determines their improvement and complete regression. | Calabrese Carlo Fabbri Anna Areni Alessandra Scialpi Carlo Zahlane Desiree Di Febo Giulio | 2005 | World Journal of Gastroenterology2005，11，48： | 10 |
| 3 | Pharmacological effects of lipid-lowering drugs on circulating adipokines显示文摘The cardioprotective effects of lipid-lowering drugs have been primarily attributed to their effects on blood lipid metabolism.However,emerging evidence indicates that lipid-lowering drugs also modulate the synthesis and secretion of adipose tissue-secreted proteins referred to as adipokines.Adipokines influence energy homeostasis and metabolism and have also been shown to modulate the vascular inflammatory cascade.The purpose of this review will be to examine the reported effects of commonly used lipid-lowering drugs(statins,fibrates,niacin and omega-3-fatty acids) on the circulating concentrations of leptin,adiponectin,tumor necrosisfactor-α(TNF-α),Retinol binding protein 4(RBP4) and resistin.Overall,the lipid-lowering drugs reviewed have minimal effects on leptin and resistin concentrations.Conversely,circulating adiponectin concentrations are consistently increased by each lipid-lowering drug reviewed with the greatest effects produced by niacin.Studies that have examined the effects of statins,niacin and omega-3-fatty acids on TNF-α demonstrate that these agents have little effect on circulating TNF-α concentrations.Niacin and fibrates appear to lower RBP4 but not resistin concentrations.The results of the available studies suggest that a strong relationship exists between pharmacological reductions in blood lipids and adiponectin that is not obvious for other adipokines reviewed. | Desiree Wanders Eric P Plaisance Robert L Judd | 2010 | World Journal of Diabetes2010，1，4： | 5 |
| 4 | Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats显示文摘目的: Adiponectin 被报导了在在体积的病理学的室的改变,而是 adiponectin 的角色期间施加保护的效果导致超载的心失败遗体不清楚。在这研究,我们在心脏的 myocyte 上调查了 adiponectin 的效果在 rats.Methods 的可收缩的机能障碍追随者体积超载: 体积超载被 infrarenal 主动脉静脉 cava 通过手术在老鼠导致管。老鼠是在 2- 的静脉内地管理的 adenoviral adiponectin, 6 星期、 9 星期的后面的管。adiponectin, adiponectin 受体(AdipoR1/R2 和 T-cadherin ) 和 AMPK 活动的蛋白质表示用西方的污点分析被测量。孤立的室的 myocytes 在管以后的 12 个星期被准备检验 myocytes 和细胞内部的 Ca 2+ transient.Results 的可收缩的表演: A-V 管在浆液和心肌的 adiponectin 层次导致了重要减小,心肌的 adiponectin 受体(AdipoR1/R2 和 T-cadherin ) 层次,以及心肌的 AMPK 活动。与这些变化一致,孤立的 myocytes 在房间弄短和细胞内部的 Ca 2+ 展出了重要消沉短暂。adenoviral adiponectin 的管理显著地增加了浆液 adiponectin 层次并且阻止了 myocyte 在管老鼠的可收缩的机能障碍。而且,有 recombinant adiponectin 的孤立的 myocytes 的预告的处理(2.5 μ g/mL ) 显著地在管老鼠改进了他们的可收缩的性能,但是没在控制或 adenoviral 有效果管理 adiponectin 的 rats.Conclusion : 这些结果表明在 adiponectin downregulation 和体积之间的积极关联导致超载的室的改变。Adiponectin 在体积起一个保护的作用导致超载的心失败。 | Li-li WANG Dori MILLER Desiree WANDERS Gayani NANAYAKKARA Rajesh AMIN Robert JUDD Edward E MORRI-SON Ju-ming ZHONG | 2016 | Acta Pharmacologica Sinica2016，37，2： | 4 |
| 5 | A mini review on two-dimensional nanomaterial assembly显示文摘Two-dimensional(2D)nanomaterials have attracted a great deal of attention since the discovery of graphene in 2004,due to their intriguing physicochemical properties and wide-ranging applications in catalysis,energy-related devices,electronics and optoelectronics.To maximize the potential of 2D nanomaterials for their technological applications,controlled assembly of 2D nanobulding blocks into integrated systems is critically needed.This mini review summarizes the reported strategies of 2D materials-based assembly into integrated functional nanostructures,from in-situ assembly method to post-synthesis assembly.The applications of 2D assembled integrated structures are also covered,especially in the areas of energy,electronics and sensing,and we conclude with discussion on the remaining challenges and potential directions in this emerging field. | Zhiwei Fang Qiyu Xing Desiree Fernandez Xiao Zhang Guihua Yu | 2020 | Nano Research2020，13，5： | 4 |
| 6 | Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux显示文摘AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER.METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry.Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM).Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed.RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagus,5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis.After 3 mo of therapy, 13/15 patients (86.7%, P<0.01)showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months,complete recovery of DIS and heartburn were achieved in one.CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases. | Carlo Calabrese Anna Fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio Di Febo | 2005 | World Journal of Gastroenterology2005，11，12： | 3 |
| 7 | Simulating bed evolution following the Barlin Dam(Taiwan,China)failure with implications for sediment dynamics modeling of dam removal显示文摘The failure of the Barlin Dam in Taiwan,China offers an important case study for evaluating concepts in modeling the rapid erosion and channel recovery following intentional and unplanned dam removals.We present a modeling effort that applied a 1D and quasi-2D uncoupled hydraulics and sediment model(NETSTARS) to evaluate how discretization and parameterization influence thefitofbed elevationpredictions to observations following dam failure.Our analysis evaluated the model sensitivity to sediment transport function,active layer thickness,and number of stream tubes used to define the cross-section.Results indicate that a) the model is more sensitive to active layer thickness and sediment transport function than to the number of stream tubes,b) development of dam removal models are likely to benefit from varying the active layer thickness in time,and c) increased lateral discretization does not appear to improve model fit in the steep and rapidly changing river environment at our site.We conclude with discussion on differences between,identifying the need for,and general use of 1D,quasi-2D,and fully 2D models in dam removal and failure analysis. | Hsiao-Wen Wang Desiree Tullos Wei-Cheng Kuo | 2016 | International Journal of Sediment Research2016，31，4： | 3 |
| 8 | Targeted treatment of cancer with radiofrequency electromagnetic fields amplitude-modulated at tumor-specific frequencies显示文摘In the past century, there have been many attempts to treat cancer with low levels of electric and magnetic fields. We have developed noninvasive biofeedback examination devices and techniques and discovered that patients with the same tumor type exhibit biofeedback responses to the same, precise frequencies. Intrabuccal administration of 27.12 MHz radiofrequency(RF) electromagnetic fields(EMF), which are amplitude-modulated at tumor-specific frequencies, results in long-term objective responses in patients with cancer and is not associated with any significant adverse effects. Intrabuccal administration allows for therapeutic delivery of very low and safe levels of EMF throughout the body as exemplified by responses observed in the femur, liver, adrenal glands, and lungs. In vitro studies have demonstrated that tumor-specific frequencies identified in patients with various forms of cancer are capable of blocking the growth of tumor cells in a tissue- and tumor-specific fashion. Current experimental evidence suggests that tumor-specific modulation frequencies regulate the expression of genes involved in migration and invasion and disrupt the mitotic spindle. This novel targeted treatment approach is emerging as an appealing therapeutic option for patients with advanced cancer given its excellent tolerability. Dissection of the molecular mechanisms accounting for the anti-cancer effects of tumor-specific modulation frequencies is likely to lead to the discovery of novel pathways in cancer. | Jacquelyn W.Zimmerman Hugo Jimenez Michael J.Pennison Ivan Brezovich Desiree Morgan Albert Mudry Frederico P.Costa Alexandre Barbault Boris Pasche | 2013 | Chinese Journal of Cancer2013，32，11： | 3 |
| 9 | Recombination mechanisms and thermal droop in AlGaN-based UV-B LEDs显示文摘This paper reports a comprehensive analysis of the origin of the electroluminescence(EL)peaks and of the thermal droop in UV-B AlGaN-based LEDs.By carrying out spectral measurements at several temperatures and currents,(i)we extract information on the physical origin of the various spectral bands,and(ii) we develop a novel closed-form model based on the Shockley–Read–Hall theory and on the ABC rate equation that is able to reproduce the experimental data on thermal droop caused by non-radiative recombination through deep levels.In the samples under test,the three EL bands are ascribed to the following processes:band-to-band recombination in the quantum wells(main EL peak),a parasitic intra-bandgap radiative transition in the quantum well barriers,and a second defect-related radiative process in the p-AlGaN superlattice. | CARLO DE SANTI MATTEO MENEGHINI DESIREE MONTI JOHANNES GLAAB MARTIN GUTTMANN JENS RASS SVEN EINFELDT FRANK MEHNKE JOHANNES ENSLIN TIM WERNICKE MICHAEL KNEISSL GAUDENZIO MENEGHESSO ENRICO ZANONI | 2017 | Photonics Research2017，5，2： | 2 |
| 10 | 胰腺偶发囊肿的管理--美国放射学院(ACR)偶发病变委员会白皮书显示文摘美国放射学院(American College of Radiology,ACR)偶发病变委员会(Incidental Findings Committee,IFC)发布了CT或MR偶发胰腺囊肿的管理建议。该建议是对美国放射学院杂志(JACR)2010年发布的肾上腺、肾脏、肝脏以及胰腺偶发病变管理白皮书中胰腺部分的更新。该管理方案由多位腹部影像医师、1位胃肠道学医师以及1位胰腺外科医师所组成的胰腺亚组委员会制定。该方案参考已发表的文献和专家意见,经反复协商,最终达成共识。该方案的分支成功地根据患者的临床特点及影像特征将胰腺囊肿进行分类,评估终点为良性和/或进展缓慢病变的诊断(足以结束随访)或具体的管理建议。该方案适用于大多数但非全部的病理及临床情况。该方案旨在通过提供胰腺偶发囊肿的管理指导,来提高患者的管理质量。 | Alec J.Megibow Mark E.Baker Desiree E.Morgan Ihab R.Kamel Dushyant V.Sahani Elliot Newman William R.Brugge Lincoln L.Berland Pari V.Pandharipande 赵心明 曾蒙苏 薛华丹 刘再毅 石喻 | 2018 | 放射学实践2018，33，2： | 2 |
| 11 | Functional states of resident vascular stem cells and vascular remodeling显示文摘最近的证据显示脉管的干细胞(VSC ) 的不同类型住在动脉和静脉的墙壁的层以内。这些居民 VSC 的精确身份仍然是不清楚的;通常,出生后的 vasculature 包含 multilineage 干细胞和脉管的房间可以参予脉管的修理和损害形成的系特定的祖先 / 茎房间。然而,内在的机制遗体糟糕理解。在这评论,我们总结潜在的分子的机制,它可以控制居民 VSC 的静止和激活并且加亮居民 VSC 的微分状态直接被连接到脉管的修理或损害形成的一个观点。 | Desiree F. Leach Mitzi Nagarkatti Prakash Nagarkatti Taixing Cui | 2015 | Frontiers in Biology2015，10，5： | 2 |
| 12 | Deregulation of microRNA-503 Contributes to Diabetes Mellitus–Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia显示文摘 | Andrea Caporali Marco Meloni Christine V?llenkle Desiree Bonci Graciela B. Sala-Newby Roberta Addis Gaia Spinetti Sergio Losa Rachel Masson Andrew H. Baker Reuven Agami Carlos le Sage Gianluigi Condorelli Paolo Madeddu Fabio Martelli Costanza Emanueli | 2011 | Circulation2011，，3： | 2 |
| 13 | Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts显示文摘 | Todd H. Baron Gavin C. Harewood Desiree E. Morgan Munford Radford Yates | 2002 | Gastrointestinal Endoscopy2002，，1： | 1 |
| 14 | 猪链球菌与猪流感病毒混合感染促进溶血素基因缺失型链球菌侵入呼吸道分子机制的研究显示文摘猪链球菌在世界范围内广泛存在,是危害养猪业发展的重要传染源之一,能够引起猪脑膜炎、关节炎、肺炎、心内膜炎、流产以及仔猪的突然死亡。溶血素(SLY)是猪链球菌分泌的唯一能够引起细胞毒性的可溶性蛋白,它能在宿主细胞膜上打孔引起细胞崩解。然而,不是所有的猪链球菌致病株均分泌SLY蛋白。 | Meng Fan-dan Tong Jie Votsch Desiree | 2019 | 中国预防兽医学报2019，41，6： | 1 |
| 15 | Blocking the effects of interleukin-6 in rheumatoid Arthritis and other infammatory rheumatic diseases:systematic literature review and meta-analysis Informing a consensus statement显示文摘 | Monika MSchoels Desiree vander Heijde Ferdinand C Breedveld | 2013 | Ann Rheum Dis2013，72，： | 1 |
| 16 | Gendered expectations and gendered experiences:immigrant students'''' adaptation in schools显示文摘 | Desiree Baolian Qin-Hilliard | | 0，，100： | 1 |
| 17 | Effectiveness of monovalent rotavirus vaccine in Bolivia: case-control study 显示文摘 | Manish M Patel Maritza Patzi Desiree Pastor | 2013 | BMJ2013，346，： | 1 |
| 18 | Acute necrotizing pancreatitis显示文摘 | Todd H Baron M D Desiree E | 1999 | N Engl J Med1999，340，18： | 1 |
| 19 | To split or not to split:colostomy complications for anorectal malformations or hirschsprung disease:a single center experience and a systematic review of the literature显示文摘 | Desiree van den Hondel D Sloots C Meeussen C | 2014 | Eur J Pediatr Surg2014，24，1： | 1 |
| 20 | In search of offshoring:Evidence from US imports of services显示文摘 | Desiree van Welsum | 2004 | Birkbeck Working Papers in Economics & Finance(BWPEF0402) Birkbeck College London2004，2004，： | 1 |
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