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您的检索式：作者名="Deyong Gan"
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| 1 | Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma显示文摘Gastric carcinoma (GC) progression is mainly caused by local aggression and lymph node metastasis. However, some patients with early T-stage disease have lymph node metastasis, whereas some patients with late T-stage disease do not have lymph node metastasis, which indicates that invasion and metastasis are not always sequential in some GC patients. In the present study, the data of 101 GC cases were acquired from TCGA and divided into T-late-N-negative and T-early-N-positive groups according to pathological stages. A total of 338 genes were identified as differential genes between the T-late-N-negative and T-early-N-positive groups. GSEA showed that epithelial cell signaling in the Helicobacter pylori (HP ) infection pathway was enriched in the T-early-N-positive group. MB staining indicated that the HP infection rate was 63% (39/62) in N-positive patients compared to 42% (16/38) in N-negative patients. To investigate the potential mechanism, we focused on the gene chemokine (C-X-C motif) receptor 2 (CXCR2), which was not only clustered in the gene set of epithelial cells signaling in the HP infection pathway but also significantly upregulated in T-early-N-positive GC by the analysis of the different genes based on the TCGA dataset. A meta-analysis showed that CXCR2 expression was positively correlated with N-stage but not with T-stage in GC. This study indicated that invasion and metastasis could be independent processes driven by different molecular mechanisms in some GC patients. HP infection was a potential factor that promoted lymph node metastasis by upregulating CXCR2 expression. | Lang Zha Xiong Guo Xiaolong Liang Yuedong Chen Deyong Gan Wenwen Li Ziwei Wang Hongyu Zhang | 2023 | Genes & Diseases2023，10，6： | 0 |
| 2 | Photoacoustic method for the measurement of the nonlinearity parameter of liquids显示文摘A new method for measurement of the nonlinearity parameter B / A of liq uids by means of photoacoustic pulses is dcscribed. The photoacoustic pulsc is gener ated by a focused laser pulse via the laser-induced breakdown mechanism in liquids.Inthe range pf the propagation distance, in which the photoacoustic pulses were meas ured, the variation of the amplitude of photoacoustic pulse with the distance is very close to the spherical attenuation law. From the variation of the rise time of photoacoustic pulse wavefront propagating through a certain distance, the parameter B / A of liquid is determined. Comparing with the plane pulsed wave with bounded beam, the effect of diffraction may e avoided by using the spherical pulsed wave. The nonlinearity parameter B / A of water is obtained by the present method. the results are rcasonably good. | QI Yirang XU Longjiang ZHANG Deyong and ZHOU Ruchehg (Ocean University of Qingdao, Qingdao 266003) ZHANG Xiaorong, GAN Changming and LIN Jingbo (The Laboratory of Modern Acoustics, Najing University. Nanjing 210008) | 1994 | Chinese Journal of Acoustics1994，13，3： | 0 |
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