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639篇 您的检索式：作者名="Dillon J"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Hydrogen storage using carbon adsorbents: past, present and future显示文摘	Dillon A C Heben M J	2001	Appl Phys A2001，72，2：	1
3	The relationship of the number of Meissner's corpuscles to dermatoglyphic characters and finger size显示文摘	Dillon YK Haynes J Henneberg M	2001	Journal of Anatomy2001，199，5：	1
4	Use of Raman scattering to investigate disorder and crystallite formation in as-deposited and annealed carbon films显示文摘	DILLON R O WOOLLAM J A KATKANANT V	1984	Phys Rev B1984，29，6：	1
5	Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function 显示文摘	Parrish-Novak J Dillon SR Nelson A	2000	Nature2000，408，6808：	1
6	Alentivirus-based system to functionally silence genes in primarymammalian cells, stem cells and transgenic mice by RNAinterference 显示文摘	Rubinson D A Dillon C P Kwiatkowski A J	2003	Nat Genet2003，33，3：	1
7	Realized heritability of growth rate in the hard clam Mercenaria mercenaria 显示文摘	Hadley N H Dillon Jr R T Manzi J J	1991	Aquacul ture1991，93，：	1
8	Hard clam,Mercenaria mercenaria,broodstocks:growth of selected hatchery stocks and their reciprocal crosses显示文摘	Manzi J J Hadley N H Dillon R T	1991	Aquaculture1991，94，1：	1
9	An APN permutation in dimension six显示文摘	Browning K A Dillon J Mcquistan M T	2010	Contemporary Mathemat ics Journal of American Mathematical Society2010，518，1：	1
10	Separation and charac- terization of Nom by high - performance liquid chromatography and on - line three - dimensional excitation emission matrix fluo- rescence detection 显示文摘	Wu F C Evans R D Dillon P J	2003	Environmental Science & Technology2003，37，16：	1
11	The health and psycho - social consequence of ketamine use显示文摘	Copeland J Dillon P	2005	Int J Drug Policy2005，16，：	1
12	The role of the nucleus ae- cumbens and rostral anterior eingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques 显示文摘	Wacker J Dillon DG Pizzagalli DA	2009	Neuro- Image2009，46，：	1
13	Storage ofhydrogen in single - walled carbon nanotubes显示文摘	A C Dillon K M Jones T A Bekkedahl C H Kiang D S Bethune M J Heben	1997	Nature1997，386，：	1
14	Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function显示文摘	PARRISH-NOVAK J DILLON S R NELSON A	2000	Nature2000，408，6808：	1
15	The health and psycho-social consequences of ketamine use显示文摘	Copeland J Dillon P	2005	Int J Drug Policy2005，16，2：	1
16	EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides 显示文摘	Ozen S Ruperto N Dillon M J	2006	Ann Rheum Dis2006，65，7：	1
17	Decentralized multi-objective bilevel decision making with fuzzy de-mands显示文摘	Zhang G Lu J Dillon T	2007	Knowledge-Based Systems2007，20，5：	1
18	Active facets on titani- um(Ⅲ) -doped TiO2: an effective strategy to improve the visible- light photocatalytic activity 显示文摘	Zuo F Bozhilov K Dillon R J	2012	Angew Chem Int Ed2012，124，25：	1
19	lnterleukin 21 and its receptor are involved in NK expansion and regulation of lymphocyte function显示文摘	Parrish-Novak J Dillon SR Nelson A	2000	Nature2000，408，6808：	1
20	Thermodynamics of elastic-plastic materia ls as a theory with internal state variables 显示文摘	Kratochvil J Dillon O W	1969	Journal of Applied Physics1969，40，8：	1

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