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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population显示文摘 | Jin, G. F. Wang, L. N. Chen, W. S. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 7 |
| 3 | Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population显示文摘 | Jin, G. F. Miao, R. F. Deng, Y. M. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Wang, L. Chen, W. S. Shen, J. Wang, X. R. Xu, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 7 |
| 4 | Modeling effects of oxygen inhibition in mask-based stereolithography显示文摘 | Amit S. Jariwala Fei Ding Aparna Boddapati Victor Breedveld Martha A. Grover Clifford L. Henderson David W. Rosen | 2011 | Rapid Prototyping Journal2011，，3： | 2 |
| 5 | Relationships among Leymus species assessed by RAPD markers显示文摘 | R. W. Yang Y. H. Zhou C. B. Ding Y. L. Zheng L. Zhang | 2008 | Biologia Plantarum2008，，2： | 1 |
| 6 | Underground water Cherenkov muon detector array with the Tibet air shower array for gamma-ray astronomy in the 100 TeV region显示文摘 | M. Amenomori S. Ayabe X. J. Bi D. Chen S. W. Cui Danzengluobu L. K. Ding X. H. Ding C. F. Feng Zhaoyang Feng Z. Y. Feng X. Y. Gao Q. X. Geng H. W. Guo H. H. He M. He K. Hibino N. Hotta Haibing Hu H. B. Hu J. Huang Q. Huang H. Y. Jia F. Kajino K. Kasahara | 2007 | Astrophysics and Space Science (-)2007，，1： | 1 |
| 7 | The influence of Y-dopant on the properties of BST films derived from a sol-gel process显示文摘 | Hu-Yong Tian Wei-Gen Luo Ai-Li Ding Qing-Rui Yin H. L. W. Chan | 2001 | Ferroelectrics2001，，1： | 1 |
| 8 | Air quality during the 2008 Beijing Olympics: secondary pollutants and regional impact显示文摘 | Wang T. Nie W. Gao J. Xue L. K. Gao X. M. Wang X. F. Qiu J. Poon C. N. Meinardi S. Blake D. Wang S. L. Ding A. J. Chai F. H. Zhang Q. Z. Wang W. X | 2010 | 2010 (204)2010，，204： | 1 |
| 9 | Formation of a lamellar 14H-type long period stacking ordered structure in an as-cast Mg–Gd–Zn–Zr alloy显示文摘 | Y. J. Wu D. L. Lin X. Q. Zeng L. M. Peng W. J. Ding | 2009 | Journal of Materials Science2009，，6： | 1 |
| 10 | Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals显示文摘 | L. Liu H. Ding H. R. Wang Y. J. Xu G. L. Cui P. H. Wang G. Yuan X. F. Yu D. W. Wang | 2012 | Diabetologia2012，，6： | 1 |
| 11 | Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1α expression显示文摘 | Jamie Y. Ding Christian W. Kreipke Patrick Schafer Steven Schafer Susan L. Speirs José A. Rafols | 2009 | Brain Research2009，，： | 1 |
| 12 | Thyrotropin and Thyroid Cancer Diagnosis: A Systematic Review and Dose-Response Meta-Analysis显示文摘 | Donald S. A. McLeod Karen F. Watters Anthony D. Carpenter Paul W. Ladenson David S. Cooper Eric L. Ding | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，8： | 1 |
| 13 | Relationships among Leymus species assessed by RAPD markers显示文摘 | R. W. Yang Y. H. Zhou C. B. Ding Y. L. Zheng L. Zhang | 2008 | Biologia Plantarum2008，，2： | 1 |
| 14 | Ozone production and hydrocarbon reactivity in Hong Kong, Southern China显示文摘 | Zhang J. Wang T. Chameides W. L. Cardelino C. Kwok J. Blake D. R. Ding A. So K. L | 2007 | Atmospheric Chemistry and Physics2007，，73： | 1 |
| 15 | Nosocomial acute-onset postoperative endophthalmitis at a university teaching hospital in China显示文摘 | M. Lin W. Zhang Y. Liu L. Wang Y. Ding X. Wu Y. Shi L. Sun Y. Li | 2011 | Journal of Hospital Infection2011，，4： | 1 |
| 16 | Adsorption of uranium ions from aqueous solution by amine-group functionalized magnetic Fe 3 O 4 nanoparticle显示文摘 | G. W. Peng D. X. Ding F. Z. Xiao X. L. Wang N. Hun Y. D. Wang Y. M. Dai Z. Cao | 2014 | Journal of Radioanalytical and Nuclear Chemistry2014，，3： | 1 |
| 17 | Characteristics of trace gaseous pollutants at a regional background station in Northern China显示文摘 | Meng Z. Y. Xu X. B. Yan P. Ding G. A. Tang J. Lin W. L. Xu X. D. Wang S. F | 2009 | 2009 (156)2009，，156： | 1 |
| 18 | The composition of Hirsutella sinensis , anamorph of Cordyceps sinensis显示文摘 | C. Li Z. Li M. Fan W. Cheng Y. Long T. Ding L. Ming | 2006 | Journal of Food Composition and Analysis2006，，8： | 1 |
| 19 | Concordance of sustained virological response 4, 12, and 24 weeks post‐treatment with sofosbuvir‐containing regimens for hepatitis C virus显示文摘 | Eric M. Yoshida Mark S. Sulkowski Edward J. Gane Robert W. Herring Vlad Ratziu Xiao Ding Jing Wang Shu‐Min Chuang Julie Ma John McNally Luisa M. Stamm Diana M. Brainard William T. Symonds John G. McHutchison Kimberly L. Beavers Ira M. Jacobson K. Rajender | 2015 | Hepatology2015，，1： | 1 |
| 20 | Modulus, Fracture Strength, and Brittle vs. Plastic Response of the Outer Shell of Arc-grown Multi-walled Carbon Nanotubes显示文摘 | W. Ding L. Calabri K. M. Kohlhaas X. Chen D. A. Dikin R. S. Ruoff | 2007 | Experimental Mechanics2007，，1： | 1 |
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