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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Preparation of megabase-size DNA from plant nuclei 显示文摘 | Zhang H B Zhao X Ding X | 1995 | Plant J1995，7，： | 1 |
| 4 | Syntheses and structures of 1D and 2D coordination polymers derived from pyridine-2,4,6-tricarboxylic acid显示文摘 | Gao H L Ding B Yi L | 2006 | Inorg Chem Commun2006，8，： | 1 |
| 5 | XPS studies on the electronic structure of bonding between solid and solutes:Adsorption of arsenate,chromate,phosphate,Pb2+,and Zn2+ ions on amorphous black ferric oxyhydroxide显示文摘 | DING M JONG B H W S DE ROOSENDAAL S J | 2000 | Geochimica et Cosmochimica Acta2000，64，6： | 1 |
| 6 | 显示文摘 | Yin J H Ding J Liu B H | 2006 | Appl Phys Lett2006，88，16： | 1 |
| 7 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 8 | 显示文摘 | Li X H Ding B Lin J Y Yu J Y | 2009 | Journal of Physi- cal Chemistry C2009，113，20： | 1 |
| 9 | Extreme Learn- ing Machine for Regression and Multiclass Classification 显示文摘 | Huang G B Zhnu H M Ding X J | 2012 | IEEE Trans on Systems Matt and Cybernetics- part B: Cybernetics2012，42，2： | 1 |
| 10 | Novel transfer alignment of shipbornegimbaled inertial navigation systems显示文摘 | Ding Z J Cai H Yang H B | 2014 | Transacations of the Japan Society for Aeronautical and Space Sciences2014，57，2： | 1 |
| 11 | Comparison of cer- ebral blood volume and permeability in preoperative grading of intraeranial glioma using CT perfusion imaging 显示文摘 | DING B LING H W CHEN K M | 2006 | Neurora- diology2006，48，10： | 1 |
| 12 | Risk factors for cervical canaer in China: a case-control study显示文摘 | Cai H B Ding X H Zhou Y F | 2008 | Eur J Gynaecol Oncol2008，29，1： | 1 |
| 13 | New overlapping gene encoded by Cucumber mosaic virus genome显示文摘 | Ding S W Anderson B J Symons R H | 1994 | Virology1994，198，： | 1 |
| 14 | First 3D Pr(Ⅲ)-Ni(Ⅱ)-Na(I) polymer and a 3D Pr(Ⅲ) open network based on pyridine-2,4,6-tricarboxylic acid显示文摘 | Gao H L Yi L Ding B | 2006 | Inorg Chem2006，45，2： | 1 |
| 15 | Large-scale preparation of carbon-encapsulated cobalt nanoparticles by the catalytic method显示文摘 | B H Liu J Ding Z Y Zhong | 2002 | ChemicalPhysics Letters2002，358，： | 1 |
| 16 | Application of Chemometric Methods to Analyze the Distribution and Chemical Fraction Patterns of Metals in Sediment from a Metropolitan river显示文摘 | Ding H J Ji H B | 2010 | Envb''onmental Earth Science2010，，3： | 1 |
| 17 | Civil Aero-engine Fault Diagnosis Based on Fuzzy Least Square Support Vector Machine 显示文摘 | Qu H C Ding X B | 2012 | Applied Mechan- ics and Materials2012，130，： | 1 |
| 18 | Multi-innovation least squares identification methods based on the auxiliary model for MISO systems显示文摘 | DING F CHEN H B LI M | 2007 | Applied Mathematics and Computation2007，187，2： | 1 |
| 19 | XPS studies on the electronic structure of bonding between solid and solutes: Adsorption of arsenate, chromate, phosphate, Pb^2+, and Zn^2+ ions on amorphous black ferric oxyhydroxide显示文摘 | Ding M de Jong B H W S Roosendaal S J Vredenberg A | 2000 | Geochim Cosmochim Acta2000，64，7： | 1 |
| 20 | Thermodynamic Model for Electrical Tree Propagation Kinetics in Combined Electrical and Mechanical Stresses显示文摘 | Ding H Z Varlow B R | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，1： | 1 |
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