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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 3 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 4 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 5 | Expression analysis of a-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture显示文摘α-smooth muscle actin(α-SMA) and tenascin-C are stress-induced phenotypic features of myofibroblasts. The expression levels of these two proteins closely correlate with the extracellular mechanical microenvironment. We investigated how the expression of α-SMA and tenascin-C was altered in the periodontal ligament(PDL) under orthodontic loading to indirectly reveal the intrinsic mechanical microenvironment in the PDL. In this study, we demonstrated the synergistic effects of transforming growth factor-β1(TGF-β1) and mechanical tensile or compressive stress on myofibroblast differentiation from human periodontal ligament cells(h PDLCs). The h PDLCs under higher tensile or compressive stress significantly increased their levels of α-SMA and tenascin-C compared with those under lower tensile or compressive stress. A similar trend was observed in the tension and compression areas of the PDL under continuous light or heavy orthodontic load in rats. During the time-course analysis of expression, we observed that an increase in α-SMA levels was matched by an increase in tenascin-C levels in the PDL under orthodontic load in vivo. The time-dependent variation of α-SMA and tenascin-C expression in the PDL may indicate the time-dependent variation of intrinsic stress under constant extrinsic loading. | Hui Xu Ding Bai L-Bruno Ruest Jian Q Feng Yong-Wen Guo Ye Tian Yan Jing Yao He Xiang-Long Han | 2015 | International Journal of Oral Science2015，7，4： | 5 |
| 6 | A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment(摘要)显示文摘 | Wang, J Xia, TS Liu, XA Ding, Q Du, Q Yin, H Wang, S | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 7 | SELECTIVE DIMERIZATION OF BUTANAL TO BUTYL BUTYRATE CATALYZED BY LANTHANOCENE/n-BuLi SYSTEMS显示文摘SELECTIVEDIMERIZATIONOFBUTANALTOBUTYLBUTYRATECATALYZEDBYLANTHANOCENE/n-BuLiSYSTEMS￥FanXU,LiLuZHANG,MingYAO,YuanChenDING,ZhiMi... | Xu, F Zhang, LL Yao, YM Ding, YC Bai, ZM Shen, Q | 1995 | Chinese Chemical Letters1995，6，7： | 2 |
| 8 | Single machine scheduling with deadlines and increasing rates of processing times显示文摘 | Cheng T C E Ding Q | 2000 | Acta Informatica2000，36，910： | 2 |
| 9 | Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin显示文摘 | Y Ding J Li X Luan Y.H Ding Q Lai J.A Rafols J.W Phillis J.C Clark F.G Diaz | 2004 | Neuroscience2004，，3： | 2 |
| 10 | Inheritance of Ear Tip-Barrenness Trait in Maize显示文摘这篇论文的目的是在玉米(Zea mays L.) 学习耳朵尖端不孕特点的继承模式。在玉米的耳朵尖端不孕特点能被分类进二种类型,尖端贫瘠并且 tip-barrenless。二个近交系, 1x01-3 (tip-barrenless 类型) , wx04-1 (尖端贫瘠的类型) ,和他们的 F1, F2, BC1, BC2 代在他们的耳朵尖端不孕类型上被分析。结果证明 F1 是尖端贫瘠的类型;尖端贫瘠的类型对 tip-barrenless 类型的比率跟随了 12.78:在 F1 分离群体的 1 比率和在 BC1 的 2.75:l 比率。χ 2 测试显示耳朵尖端不孕类型的特点跟随了 2 副本显性基因的一个继承模式。社会科学统计套装软体分析显示耳朵尖端不孕长度的特点具有反常分发。上面的结果意味着那:(1 ) 玉米耳朵尖端不孕类型的特点被 2 副本显性基因控制;尖端贫瘠的类型在 tip-barrenless 类型上是主导的;(2 ) 尖端不孕长度的特点是多基因控制,主要基因期望的量标识; 数量性状。 | MENG Zhao-dong ZHANG Fa-jun DING Zhao-hua SUN Q i WANG Li-ming GUO Qing-fa WANG Hong-gang | 2007 | Agricultural Sciences in China2007，6，5： | 2 |
| 11 | On Marcinkiewicz integral with homogeneous kernels显示文摘 | DING Y LU S Z XUE Q Y | 2000 | J of Mathematical Analysis and Application2000，245，： | 1 |
| 12 | Role of the crystallite phase of TiO2 in heterogeneous photocatalysis for phenol oxidation in water显示文摘 | Ding Z Lu G Q Greenfield P F | 2000 | J Phys Chem B2000，104，19： | 1 |
| 13 | B7H1-Ig fusion protein activates the CD4^+ IFN-gamma receptor^+ type 1 T regulatory subset through IFN gamma-secreting Th1 cells显示文摘 | Ding Q Lu L Wang B etal | 2006 | J Immunol2006，177，： | 1 |
| 14 | A concise survey of scheduling with time-dependent processing times显示文摘 | Cheng T C E Ding Q Lin B M T | 2004 | European Journal of Operational Research2004，152，： | 1 |
| 15 | TRPC6 Up-regulation in Ang Ⅱ-induced podocyte apoptosis might result from ERK activation and NF-kB translocation显示文摘 | Zhang H Ding J Fan Q | 2009 | Exp Biol Med2009，234，9： | 1 |
| 16 | Risks of CHD identified by different criteria of metabolic syndrome and related changes of adipocytokines in elderly postmenopausal women显示文摘 | Ding Q F Hayashi T Zhang X J | 2007 | J Diabetes Complications2007，21，5： | 1 |
| 17 | Atmospheric hexachloroeyclohexartes in the North Pacific Ocean and the adjacent arctic region: spatial patterns, chiral signatures, and sea - air exchanges 显示文摘 | DING X WANG X M XIE Z Q | 2007 | Environ Sci Technol2007，41，： | 1 |
| 18 | FP-projective dimensions显示文摘 | MAO L X DING N Q | 2005 | Communications in Algebra2005，33，： | 1 |
| 19 | Time domain buffeting analysis of suspension bridge subjected to turbulent wind with effective action angle显示文摘 | Ding Q Lee P K K Lo S H | 2000 | Journal of Sound and Vibration2000，233，2： | 1 |
| 20 | Re verse signaling using an inducible costimulator to enhance im munogenic function of dendritic cells显示文摘 | Tang G Qin Q Zhang P Wang G Liu M Ding Q | 2009 | Ceil Mol Life Sci2009，66，： | 1 |
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