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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 3 | Adhering to a t'ai chiprogram to improve glucose control and quality of life forindividuals with type 2 diabetes显示文摘 | Song R Ahn S Roberts BL | 2009 | J Altern ComplementMed2009，15，6： | 1 |
| 4 | Intranasal dexmedetomidine following failed chloral hydrate sedation in children 显示文摘 | Li BL Yuan VM Song XR | 2014 | An- aesthesia2014，69，： | 1 |
| 5 | Organization of Human ACAT-2 gene and its cell type-specific Promoter Activity显示文摘 | Song BL Qi W Yang XY | 2001 | Biochem Biophys Res Commun2001，282，2： | 1 |
| 6 | Retroperitoneal liposarcoma: MR characteristics and pathological correlative analysis 显示文摘 | Song T Shen J Liang BL | 2007 | Abdom Imaging2007，32，5： | 1 |
| 7 | Human acyl-CoA: cholesterol acyltransferase 2 gene expression in intestinal caco-2 cells and in hepatocellular carcinoma 显示文摘 | Song BL Wang CH Yao XM | 2006 | Biochem J2006，394，3： | 1 |
| 8 | Antiviral effect of catechins green tea on influenza virus显示文摘 | SONG JM LEE KH SEONG BL | 2005 | Antivir Res2005，68，2： | 1 |
| 9 | Caspase-3 antisense oligodeoxynucleotides inhibit apoptosis in gammairradiated human leukemia HL-60 cells 显示文摘 | Zhang XT Song TB Du BL Li DM Li XM | 2007 | Apoptosis2007，12，4： | 1 |
| 10 | Two human ACAT2 mRNAs varients produced by alternative splicing and coding for novel isoenzymes显示文摘 | Yao XM Wang CH Song BL | 2005 | Acts Biochimicaet Biophysica Sinica2005，37，12： | 1 |
| 11 | The effects of an integrated healtheducation and exercise program in community-dwelling older adultswith hypertension:a randomized controlled trial显示文摘 | Park YH Song M Cho BL | 2011 | Patient EducCouns2011，82，1： | 1 |
| 12 | Delayed protection against ischemia-induced ventricular arrhythmias and infarct size limitation by the prior administration of escherichia coli endotoxin显示文摘 | Song W Furman BL Parratt JR | 1996 | Br J Pharmacol1996，118，8： | 1 |
| 13 | Engineered recombinant enteropeptidase catalytic subunit:effect of N-terminal modifieaction显示文摘 | Song HW Choi SI Seong BL | | 0，，01： | 1 |
| 14 | A randomized study of the effects of t'ai chi on muscle strength, bone mineral density, and fear of falling in women with osteoarthritis显示文摘 | Song R Roberts BL Lee EO | 2010 | Journal of Alternative and Complementary Medicine2010，16，3： | 1 |
| 15 | Niemann-Pick Cl-Like 1 and choles-terol uptake显示文摘 | Wang U Song BL | 2012 | Biochim Biophys Acta2012，1821，7： | 1 |
| 16 | Cognitive and lin- guistic correlates of children's discourse after closed head inju- ry: a three-year follow-up 显示文摘 | Brookshire BL Chapman SB Song J | 2000 | J Int Neuropsychol Soc2000，6，7： | 1 |
| 17 | Intranasal dexmedetomidine following failed chloral hydrate sedation in children 显示文摘 | Li BL Yuen VM Song XR | 2014 | Anaesthesia2014，69，3： | 1 |
| 18 | Intranasal dexmedetomidine following failed chloral hydrate sedation in children 显示文摘 | Li BL Yuan VM Song XR | 2014 | Anaesthesia2014，69，： | 1 |
| 19 | Single nueleotide polymor- phisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma显示文摘 | Song CM Kwon TK Park BL | 2015 | Environ Mol Mutagen2015，56，1： | 1 |
| 20 | Delayed protection against ischemia-induced ventricular arrhythmias and infarct size limitation by the prior administration of escherichia coli endotoxin显示文摘 | Song W Furman BL Parratt JR | 1996 | Br J Pharmacol1996，118，8： | 1 |
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