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| 1 | Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta显示文摘The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids(compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-amine(1), 4-(2-(2, 5-dioxopyrrolidin-1-yl)ethyl)phenyl acetate(2), and N-(9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-yl)acetamide(3). These compounds were evaluated for their cytotoxicity against human cervical cancer He La cells. Compounds 1 and 3 significantly inhibited the proliferation of He La cells with IC_(50) values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L^(-1), respectively. | DU Jing DING Jie MU Zhen-Qiang GUAN Shu-Hong CHENG Chun-Ru LIU Xuan GUO De-An | 2018 | Chinese Journal of Natural Medicines2018，16，2： | 10 |
| 2 | Characteristic gene expression profiles in the progression from normal gastric epithelial cells to moderate gastric epithelial dysplasia and to gastric cancer显示文摘 | LI Mao-lan ZHANG Jing-cheng LI Song-gang WU Wen-guang RAO Long-hua DONG Ping GU Jun LU Jian-hua ZHANG Lin DING Qi-chen WU Xiang-song MU Jia-sheng YANG Jia-hua ZHANG Wen-jie CHEN Lei LIU Ying-bin | 2012 | Chinese Medical Journal2012，，10： | 8 |
| 3 | Analysis of In-hospital Neonatal Death in the Tertiary Neonatal Intensive Care Unit in China: A Multicenter Retrospective Study显示文摘 | Chen-Hong Wang Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Xiao-Mei Tong Hong Liu Guo-Fang Ding Bin Yi Xin-Nian Pan Dan-Ni Zhong Ling Liu Mei Li Cui-Qing Li Shi-Wen Xia Hong-Yun Wang Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Ruo-Bing Shan De-Zhi Mu Xiao-Hong Liu Si-Qi Zhuang Jing Guo Li Liu Jia-Jun Zhu Hong Xiong | 2016 | Chinese Medical Journal2016，，22： | 8 |
| 4 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 5 | High-Temperature Metamorphism, Anataxis and Tectonic Evolution of a Mafic Granulite from the Eastern Himalayan Orogen显示文摘The Himalayan Orogen, resulting from the Tertiary collision of Indian and Asian continents, is a natural laboratory for studying metamorphism, partial melting and granite formation of collisional orogens. However, metamorphic and anatectic conditions and timescales of meta-mafic rocks in the Greater Himalayan Sequences(GHS) in the east-central Himalaya remain controversial. In this paper, we conduct a study of petrology and geochronology of mafic granulite from the Eastern Himalayan Syntaxis(EHS). The mafic granulite with abundant leucosome bands occurs as layers within felsic granulites and is well deformed. The granulite consists of garnet, plagioclase, amphibole and quartz with minor clinopyroxene, orthopyroxene, biotite, rutile, titanite and ilmenite. The garnet has growth compositional zoning and contains abundant mineral inclusions in its core. Peak metamorphic mineral assemblage of the granulite is garnet, amphibole, plagioclase, quartz, clinopyroxene and rutile, recording a high-pressure(HP) and high-temperature(HT) peak-metamorphism under conditions of 14–15.5 kbar and 780–790℃ in the presence of melt. The reconstructed clockwise P-T path is characterized by an early heating and burial prograde metamorphism, and late isothermal and cooling decompression retrogression. The granulite witnessed a long lasting HT metamorphism, partial melting and melt crystallization process which began at ca. 39 Ma and lasted to ca. 11 Ma. The present study shows that various high-grade rocks of the GHS in the EHS core experienced similar metamorphic conditions and P-T-t paths, indicating that they occurred as a coherent slab during the subduction and exhumation of Indian lithosphere. The significant melts generated during the prograde metamorphism of the GHS rocks not only contributed to the formation of the Himalayan leucogranite, but also resulted in the rheological weakening and ductile flow of the thickened lower crust of the Himalayan Orogen. | Zeming Zhang Huixia Ding Xin Dong Zuolin Tian Dongyan Kang Hongchen Mu Shengkai Qin Yuanyuan Jiang Mengmei Li | 2018 | Journal of Earth Science2018，29，5： | 7 |
| 6 | Automatic Test Method Research on the Word Part of Document Format Translator显示文摘 | MU Yongmin WANG Rui ZHANG Zhihua DING Yuan WU Miao | 2013 | Chinese Journal of Electronics2013，22，1： | 7 |
| 7 | Cobalt phthalocyanine-graphene complex for electro-catalytic oxidation of dopamine显示文摘Cobalt phthalocyanine-graphene(CoPc-Gr) complex are fabricated through π-π interaction of each components,with CoPc adsorbed/inserted on/in the graphene sheets.The obtained complex could be used in the electro-chemical detection of various medicines.CoPc-Gr modified glassy electrode shows excellent response to the electro-oxidation of dopamine(DA) and ascorbic acid(AA),much better than those of CoPc,graphene oxide(GrO) or graphene(Gr) modified electrode.Significantly,the detection of dopamine is a diffusion-controlled process,highly selective,and has a low detection limit and broad linear range. | Jinghe Yang Di Mu Yongjun Gao Juan Tan Anhui Lu Ding Ma | 2012 | Journal of Natural Gas Chemistry2012，21，3： | 6 |
| 8 | The Lifespan-Promoting Effect of Otophylloside B in Caenorhabditis elegans显示文摘Aging is the major risk factor for many human diseases and degeneration.Thus,clinically effective medicine could delay the process of aging and aging-related diseases are desperately wanted.In traditional Chinese medicine(TCM),some were claimed to slow down aging.Qingyangshen(Cynanchum otophyllum schneid)is such a TCM.Here,we assayed the longevity effect of compound Otophylloside B(Ot B),a C-21 steroidal glycoside isolated from Qingyangshen,in Caenorhabditis elegans,which is a popular model for aging research.Our results showed that Ot B could modestly extend the lifespan of C.elegans,delay the age-related decline of body movement and improve the stress resistance.Further investigating the molecular mechanism of lifespan extension effect revealed that Ot B could activate the FOXO transcription factor DAF-16.Ot B could not further extend the lifespan of long-lived mutant of insulin/IGF-1-like receptor(daf-2).In addition,Ot B also requires SIR-2.1 and CLK-1 which is an enzyme in ubiquinone synthesis,for lifespan extension. | Jie Yang Qin-Li Wan Quan-Zhang Mu Chun-Feng Wu Ai-Jun Ding Zhong-Lin Yang Ming-Hua Qiu Huai-Rong Luo | 2015 | Natural Products and Bioprospecting2015，5，4： | 6 |
| 9 | Effect of tin addition on corrosion behavior of a low-alloy steel in simulated costal-industrial atmosphere显示文摘The effect of tin addition on the atmospheric corrosion behavior of a low-alloy steel in sim ulated coastalindustrial atm osphere has been investigated by indoor wet/dry cyclic corrosion test (CCT). The results indicate that tin addition can obviously make the steel substrate more resistant to atmospheric corrosion by suppressing the cathodic H^+ reduction reaction, and but tin addition is not of obvious beneficial effect when the steel is covered with a thicker rust layer during long-term corrosion process. The reason lies in the fact that the presence of un-reduced H^+ can lower the electrolyte pH value and lead to a loose and porous rust layer on tin-containing steel sample than that on tin-free steel sample. In addition, the 120 CCT cycles corrosion process of the two steels can be divided into three stages. Both the tin-free and tin-containing steels show an increasing corrosion rate during the initial corrosion stage and then exhibit a decreasing corrosion rate during the second and third corrosion stages. Moreover, tin addition makes the tin-containing steel rust layer have a higher amount of α-FeOOH and lower am ount of γ-FeOOH and Fe3O4 than the tin-free steel rust layer. | Bo Liu Xin Mu Ying Yang Long Hao Xueyong Ding Junhua Dong Zhe Zhang Huaxing Hou Wei Ke | 2019 | Journal of Materials Science & Technology2019，35，7： | 6 |
| 10 | Epidemiology of urticaria in China:a population-based study显示文摘Background:Urticaria is a common skin disease characterized by episodes of wheals,and it has a negative effect on patients’quality of life.Large-scale population-based epidemiological studies of urticaria are scarce in China.The aim of this survey was to determine the prevalence,clinical forms,and risk factors of urticaria in the Chinese population.Methods:This survey was conducted in 35 cities from 31 provinces,autonomous regions,and municipalities of China.Two to three communities in each city were selected in this investigation.Participants completed questionnaires and received dermatological examinations.We analyzed the prevalence,clinical forms,and risk factors of urticaria.Results:In total,44,875 questionnaires were distributed and 41,041 valid questionnaires were collected(17,563 male and 23,478 female participants).The lifetime prevalence of urticaria was 7.30%,with 8.26%in female and 6.34%in male individuals(P<0.05).The point prevalence of urticaria was 0.75%,with 0.79%in female and 0.71%in male individuals(P<0.05).Concomitant angioedema was found in 6.16%of patients.Adults had a higher prevalence of urticaria than adolescents and children.Living in urban areas,exposure to pollutants,an anxious or depressed psychological status,a personal and family history of allergy,thyroid diseases,and Helicobacter pylori infection were associated with a higher prevalence of urticaria.Smoking was correlated with a reduced risk of urticaria.Conclusion:This study demonstrated that the lifetime prevalence of urticaria was 7.30%and the point prevalence was 0.75%in the Chinese population;women had a higher prevalence of urticaria than men.Various factors were correlated with urticaria. | Jiaqing Li Dandan Mao Shuoshuo Liu Ping Liu Jing Tian Chenhong Xue Xiaojing Liu Ruiqun Qi Bingxue Bai Jianjun Nie Siqi Ye Yu Wang Yuye Li Qing Sun Juan Tao Shuping Guo Hong Fang Jianqin Wang Qiri Mu Quanzhong Liu Yan Ding Jianzhong Zhang | 2022 | Chinese Medical Journal2022，，11： | 6 |
| 11 | Space Flight Validation of Design and Engineering of the ZDPS-1A Pico-satellite显示文摘The ZDPS-1A pico-satellites are the first satellites in China within the 1-10 kg mass range that are successfully operated on orbit. Unlike common pico-satellites, they are designed to be 'larger but stronger' with more powerful platforms and unique payloads so as to bear a better promise for real applications. Through their space flight mission, the functionality and performance of the two flight models are tested on orbit and validated to be mostly normal and in consistency with design and ground tests with only several inconforming occasions. Moreover, they have worked properly on orbit for one year so far, well exceeding their life expectancy of three months. Therefore, the space flight mission has reached all its goals, and verified that the design concept and the engineering process of the picosatellites are sufficient in allowing them the desired functionality and performance in, and the adaption to the launch procedure and the low-Earth orbit space environment. In the foreseeable future, the platform together with the design concept and the engineering process of the pico-satellites are expected to be applied to more complicated real space applications. | YANG Mu WANG Hao WU Changju WANG Chunhui DING Licong ZHENG Yangming JIN Zhonghe | 2012 | Chinese Journal of Aeronautics2012，25，5： | 5 |
| 12 | Primary closure versus T-tube drainage in laparoscopic common bile duct exploration: a meta-analysis of randomized clinical trials显示文摘 | Xiangsong Wu Yong Yang Ping Dong Jun Gu Jianhua Lu Maolan Li Jiasheng Mu Wenguang Wu Jiahua Yang Lin Zhang Qichen Ding Yingbin Liu | 2012 | Langenbeck’s Archives of Surgery2012，，6： | 4 |
| 13 | Developing nonlinear adaptive optimal regulators through an improved neural learning mechanism显示文摘Optimal feedback design of dynamical systems is a significant topic in automatic control community and information science.As for nonlinear systems,optimal control design always leads to coping with the nonlinear Hamilton-Jacobi-Bellman equation.Nevertheless,it is intractable to acquire the analytic solution of the nonlinear Hamilton-JacobiBellman equation for general nonlinear systems. | Ding WANG Chaoxu MU | 2017 | Science China(Information Sciences)2017，60，5： | 4 |
| 14 | Tetrandrine inhibits proliferation of colon cancer cells by BMP9/PTEN/PI3K/AKT signaling显示文摘Despite advances in screening and treatment,colon cancer remains one of the leading causes of cancer-related death.Finding novel and useful drug treatment targets is also an urgent need for clinical applications.Tetrandrine(Tet)is extracted from the Chinese medicinal herbal medicine,which is a well-known calcium blocker with a variety of pharmacological activities,including anti-cancer.In this study,we recruited cell viability assay,flow cytometry analysis,cloning formation to confirm that Tet can inhibit the proliferation of SW620 cells,and induce apoptosis.Mechanically,we confirmed that Tet up-regulates the mRNA and protein level of BMP9 in SW620 cells.Over-expression BMP9 enhances the anticancer effects of Tet in SW620 cells,but these effects can be partly reversed by silencing BMP9.Also,Tet reduces phosphorylation of Aktl/2/3 in SW620 cells,which could be elevated by overexpressed BMP9 and impaired by silencing BMP9.Furthermore,we demonstrated that Tet reduces phosphorylated PTEN,which can be promoted by overexpressed BMP9,analogously also be attenuated through silencing BMP9.Finally,we introduced a xenograft tumor model to investigate the anti-proliferative effect of Tet,further to explore the effects of BMP9 and PTEN in SW620 cells.Our findings suggested that the anti-cancer activity of Tet in SW620 cells may be mediated partly by up-regulating BMP9,followed by inactivation PI3K/Akt through up-regulating PTEN at least. | Ya Zhou Li Mu Xiao-Lu Liu Qin Li Li-Xuan Ding Hong-Chuan Chen Ying Hu Fu-Shu Li Wen-Juan Sun Bai-Cheng He Ke Wu | 2021 | Genes & Diseases2021，8，3： | 4 |
| 15 | How the Internet Promotes China’s Exports:A Firm-level Perspective显示文摘The development of information and communications technologyv(ICT),particularly the Internet,has reduced trade costs.However,it remains unclear whether these reduced costs are reflected in the “extensive margins”of firms'exports(which refer to the probability of firms exporting)or the “intensive margins”(which refer to the value of firms'export).To test this,we used the concepts of information cost and binary margins,an augmented trade model of firm heterogeneity,a two-stage Heckman estimation,and data from the World Bank Enterprise Survey of Chinese firms in 2012.The results revealed that reduced trade costs from the use of ICT were positively related to extensive margins but that the connection with intensive margins was not significant.The results lead to the conclusion that reduced information costs related to a firm's exporting behavior were primarily reflcted in variable trade cosis.This study offers theoretical and empirical evidence for China 3 policies towards the Internet,which are relevant for the export of manufactured goods.The government should encourage the use of ICT to enhance firms export opporunities while facing current trade policy uncerainty. | Yifei Mu Zhen Chen Yibing Ding Yuqing Wang Bo Pang | 2020 | China & World Economy2020，28，5： | 4 |
| 16 | Drift analysis of MH370 debris in the southern Indian Ocean显示文摘 | Jia GAO Lin MU Xianwen BAO Jun SONG Yang DING | 2018 | Frontiers of Earth Science2018，12，3： | 3 |
| 17 | Square-Preserving and Symplectic Structure and Scheme for Quantum Sysyem显示文摘The time-dependent Schrodinger equation is a square-preserving and symplectic(SPS)transformation.The canonical'equations of quantum systems are deduced by using eigenfanction expansion.The normal-square of wavefunction of the quantum systems is an invariant integral of the canonical equations and then the symplectic schemes that based on both Cayley transformation and diagonal Fade approximation to exp(x)are also sq uare-preserving.The evaluated example show that the SPS approach is reasonable and effective for solving time-evolution of quantum system. | DING Pei-zhu WU Cheng-xun MU Ying-kui LI Yan-xin JIN Ming-xing | 1996 | Chinese Physics Letters1996，13，4： | 3 |
| 18 | Impact of being overweight on the surgical outcomes of patients with gastric cancer: A meta-analysis显示文摘AIM: To investigate the effect of being overweight on the surgical results of patients with gastric cancer. METHODS: Comprehensive electronic searches of the PubMed, Web of Science, and Cochrane Library databases were conducted. Studies were identified that included patients with surgical complications from gastric cancer who were classified as normal weight [body mass index (BMI) < 25 kg/m 2 ] or overweight (BMI ≥ 25 kg/m 2 ). The operative time, retrieved lymph nodes, blood loss, and long-term survival were analyzed. A subgroup analysis was conducted based on whether patients received laparoscopic or open gastrectomy procedures. All statistical tests were performed using ReviewerManager 5.1.2 software. RESULTS: This meta-analysis included 23 studies with 20678 patients (15781 with BMI < 25 kg/m 2 ; 4897 with BMI ≥ 25 kg/m 2 ). Overweight patients had significantly increased operation times [MD: -29.14; 95%CI: -38.14-(-20.21); P < 0.00001], blood loss [MD: -194.58; 95%CI: -314.21-(-74.95); P = 0.001], complications (RR: 0.75; 95%CI: 0.66-0.85; P < 0.00001), anastomosis leakages (RR: 0.59; 95%CI: 0.42-0.82; P = 0.002), and pancreatic fistulas (RR: 0.486; 95%CI: 0.34-0.63; P < 0.00001), whereas lymph node retrieval was decreased significantly in the overweight group (MD: 1.69; 95%CI: 0.75-2.62; P < 0.0001). In addition, overweight patients had poorer long-term survival (RR: 1.14; 95%CI: 1.07-1.20; P < 0.0001). No significant difference was detected for the mortality and length of hospital stay. CONCLUSION: This meta-analysis demonstrates that a high BMI not only increases the surgical difficulty and complications but also impairs the long-term survival of patients with gastric cancer. | Xiang-Song Wu Wen-Guang Wu Mao-Lan Li Jia-Hua Yang Qi-Chen Ding Lin Zhang Jia-Sheng Mu Jun Gu Ping Dong Jian-Hua Lu Ying-Bin Liu | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 19 | An Economic Benefit Evaluation Model and its Application for Optimizing Transmission Capacity of Multinational Interconnections显示文摘Multinational power grid interconnections play a critical part in supporting the vision of global energy internet.During the early stages of the Global Energy Internet,the value proposition of multinational interconnections should be carefully investigated in order to stimulate the activities for associated countries in such potential interconnections.This paper proposes a new e conomic benefit evaluation model which is quantified by using a chronological production cost simulation approach.The economic benefit model comprehensively considered investment costs and the benefits of the decrease of load payments and the increase of net generation revenue due to a transmission project interconnected with different countries.This economic benefit model can assist to quantitatively determine the optimal transmission capacity for multinational interconnections to achieve maximum economic benefits as a whole.In the case study,the economic benefit of an interconnected system of western China and the Gulf States is assessed by using the method proposed in this paper.And the optimal interconnection capacity with maximum benefit is achieved.The case study shows that the proposed method can be used for economic benefit assessment and is of great significance to the multinational and intercontinental transmission interconnections. | Xiaojun Wang Ruimin Jiang Pei Zhang Yunfei Mu Maosheng Ding | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 2 |
| 20 | Anthraquinone derivative as high-performance anode material for sodium-ion batteries using ether-based electrolytes显示文摘Organic materials, especially the carbonyl compounds, are promising anode materials for room temperature sodium-ion batteries owing to their high reversible capacity, structural diversity as well as eco-friendly synthesis from bio-mass. Herein, we report a novel anthraquinone derivative, C_(14)H_6 O_4 Na_2 composited with carbon nanotube(C_(14)H_6 O_4 Na_2-CNT), used as an anode material for sodium-ion batteries in etherbased electrolyte. The C_(14)H_6 O_4 Na_2-CNT electrode delivers a reversible capacity of 173 mAh g^(-1) and an ultra-high initial Coulombic efficiency of 98% at the rate of 0.1 C. The capacity retention is 82% after 50 cycles at 0.2 C and a good rate capability is displayed at 2 C.Furthermore, the average Na insertion voltage of 1.27 V vs. Na^+/Na makes it a unique and safety battery material, which would avoid Na plating and formation of solid electrolyte interface. Our contribution provides new insights for designing developed organic anode materials with high initial Coulombic efficiency and improved safety capability for sodium-ion batteries. | Linqin Mu Yaxiang Lu Xiaoyan Wu Yuejun Ding Yong-Sheng Hu Hong Li Liquan Chen Xuejie Huang | 2018 | Green Energy & Environment2018，3，1： | 2 |
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