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| 1 | Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats显示文摘AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.METHODS: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis. | Tae Young Oh Chang Yell Shin Yong Sung Sohn Dong Hwan Kim Byoung Ok Ahn Eun Bang Lee Cho Hyun Park | 2005 | World Journal of Gastroenterology2005，11，47： | 5 |
| 2 | Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in pharmaceutical industry?显示文摘3 D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3 D printing was developed in the 1980 s and the technology has found widespread industrial applications for production from automotive parts to machine tools,its application in pharmaceutical area is still limited. However,the potential of 3 D printing in the pharmaceutical industry is now being recognized. The ability of 3 D printing to produce medications to exact specifications tailored to the needs of individual patients has indicated the possibility of developing personalized medicines. The technology allows dosage forms to be precisely printed in various shapes,sizes and textures that are difficult to produce using traditional techniques. However,there are various challenges associated with the proper application of3 D printing in the pharmaceutical sector which should be overcome to exploit the scope of this technology. In this review,an overview is provided on the various 3 D printing technologies used in fabrication of complex dosage forms along with their feasibility and limitations. | Shrawani Lamichhane Santosh Bashyal Taekwang Keum Gyubin Noh Jo Eun Seo Rakesh Bastola Jaewoong Choi Dong Hwan Sohn Sangkil Lee | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 5 |
| 3 | Effects and regulation of osteopontin in rat hepatic stellate cells显示文摘 | Sung Hee Lee Geom Seog Seo Young Nyun Park Tae Moo Yoo Dong Hwan Sohn | 2004 | Biochemical Pharmacology2004，，12： | 1 |
| 4 | Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH 2 -terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts显示文摘 | Eun-Jeon Park Yu-Zhe Zhao Youn-Chul Kim Dong Hwan Sohn | 2007 | European Journal of Pharmacology2007，，2： | 1 |
| 5 | Effects of Noscarna? on hypertrophic scarring in the rabbit ear model: Histopathological aspects显示文摘 | Dong Won Lee Sae Kwang Ku Hyuk Jun Cho Jeong Hwan Kim Tran Tuan Hiep Sang Duk Han Bo Gyun Kim Min Kyung Kang Eui Seon Do Joon Ho Jun Sun Woo Jang Mi-Won Son Young Taek Sohn Han-Gon Choi Chul Soon Yong Jong Oh Kim | 2012 | Archives of Pharmacal Research2012，，11： | 1 |
| 6 | Purification of wastewater from paper fac- tory by superconducting magnetic separation 显示文摘 | Dong - Woo Ha Tae - Hyung Kim Myung - Hwan Sohn | 2010 | IEEE Transactions on Applied Superconductivity2010，20，3： | 1 |
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