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| 1 | Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice显示文摘Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col1 a1-Cre transgene minimally impacts bone mass in mice, but deleting Kindlin-2 using the 10-kb mouse Dmp1-Cre transgene, which targets osteocytes and mature osteoblasts, results in striking osteopenia in mice. Kindlin-2 loss reduces the osteoblastic population but increases the osteoclastic and adipocytic populations in the bone microenvironment. Kindlin-2 loss upregulates sclerostin in osteocytes,downregulates β-catenin in osteoblasts, and inhibits osteoblast formation and differentiation in vitro and in vivo. Upregulation ofβ-catenin in the mutant cells reverses the osteopenia induced by Kindlin-2 deficiency. Kindlin-2 loss additionally increases the expression of RANKL in osteocytes and increases osteoclast formation and bone resorption. Kindlin-2 deletion in osteocytes promotes osteoclast formation in osteocyte/bone marrow monocyte cocultures, which is significantly blocked by an anti-RANKLneutralizing antibody. Finally, Kindlin-2 loss increases osteocyte apoptosis and impairs osteocyte spreading and dendrite formation.Thus, we demonstrate an important role of Kindlin-2 in the regulation of bone homeostasis and provide a potential target for the treatment of metabolic bone diseases. | Huiling Cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu Cao Guozhi Xiao | 2020 | Bone Research2020，8，1： | 8 |
| 2 | Label-free Detection of Biotin Using Nanoporous TiO2/DNA Thin-film Coated Wavelength Interrogated Surface Plasmon Resonance Sensors显示文摘 | LI Qiushun HE Hao WANG Junnan ZHENG Hui SHI Jianguo LI Mingyu DONG Wenfei QI Zhimei | 2014 | Chemical Research in Chinese Universities2014，30，1： | 4 |
| 3 | Charge-controlled permeability of polyelectrolyte microcapsules显示文摘 | TONG Weijun DONG Wenfei GAO Changyou | 2005 | The Journal of Physical Chemistry B2005，，13： | 1 |
| 4 | Polymorph switching of calcium carbonate crystals by polymer-controlled crystallization 显示文摘 | Xu Anwu Dong Wenfei Antonietti M C?lfen H | 2008 | Advanced Functional Materials2008，18，8： | 1 |
| 5 | Radiation effects on the immiscible polymer blend of nylon1010 and high-impact strength polystyrene (11):mechanical properties and morphology显示文摘 | Wenfei Dong Guangxin Chen Wanxi Zhang | 2001 | Radiation Physics and Chemistry2001，60，6： | 1 |
| 6 | One-step synthesis of carbon-coated monocrystal molybdenum oxides nanocomposite as high-capacity anode materials for lithiumion batteries显示文摘Benefitting from higher specific capacities,acceptable cost,nontoxicity and unique crystal structures,the molybdenum oxides have been studied as the anode materials for lithium ion batteries(LIBs).Herein,a direct current(DC)arc-discharge plasma technique has been developed to in-situ synthesize carboncoated monocrystal molybdenum oxides((MoO3NRs/MoO2NPs)@C)nanocomposites,using coarse MoO_(3) bulk as the raw material and methane(CH4)gas as the carbon source.It is indicated that crystallographic traits of MoO_(3) and MoO2 nuclei give rise to an anisotropic growth of monocrystal MoO3 nanorods(NRs)along<100>direction and an isotropic growth of monocrystal MoO_(2) nanoparticles(NPs).The carbon shells on MoO3/MoO2 nanostructures are generated from the absorption of carbon atoms in surrounding atmosphere or the release of supersaturated carbon atoms in MoeOeC solid solution.Unique constitution and pseudo-capacitive behavior of(MoO3NRs/MoO2NPs)@C bring merits to excellent cycling performance and rate capability,i.e.a remarkable specific capacity of 840 mAh·g^(-1) after 100 cycles at a current density of 0.1 Ag^(-1) and a retained capacity of 210 mAh·g^(-1) at 6.4 A g^(-1).This work has offered a simple and efficient approach to fabricate the carbon-coated molybdenum oxides nanostructures for promising anode materials of LIBs。 | Zhiguo Rong Canfeng Fang Zhongyuan Zhang Wenfang Miao Xiyang Li Jingshuang Liang Wenfei Yang Yinong Wang Xiane Guo Youngguan Jung Xinglong Dong | 2021 | Journal of Materiomics2021，7，3： | 1 |
| 7 | A Two-Layer Fuzzy Control Strategy for the Participation of Energy Storage Battery Systems in Grid Frequency Regulation显示文摘To address the frequency fluctuation problem caused by the power dynamic imbalance between the power system and the loadwhen a large number of newenergy sources are connected to the grid,a two-layer fuzzy control strategy is proposed for the participation of the energy storage battery system in FM.Firstly,considering the coordination of FM units responding to automatic power generation control commands,a comprehensive allocation strategy of two signals under automatic power generation control commands is proposed to give full play to the advantages of two FM signals while enabling better coordination of two FM units responding to FM commands;secondly,based on the grid FM demand and battery FM capability,a double-layer fuzzy control strategy is proposed for FM units responding to automatic power generation control commands in a coordinated manner under dual-signal allocation mode to precisely allocate the power output depth of FM units,which can control the fluctuation of frequency deviation within a smaller range at a faster speed while maintaining the battery charge state;finally,the proposed Finally,the proposed control strategy is simulated and verified inMatlab/Simulink.The results show that the proposed control strategy can control the frequency deviation within a smaller range in a shorter time,better stabilize the fluctuation of the battery charge level,and improve the utilization of the FM unit. | Wei Chen Na Sun Zhicheng Ma Wenfei Liu Haiying Dong | 2023 | Energy Engineering2023，120，6： | 1 |
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