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| 1 | Composition and solution properties of fluorinated block copolymers and their surface structures in the solid state显示文摘A series of diblock copolymers composed of methyl methacrylate and 2-perfluorooctylethyl methacry-late(PMMA144-b-PFMAn) with various PFMA block lengths were prepared by atom transfer radical po-lymerization(ATRP).The surface structures and properties of these polymers in the solid state and in solution were investigated using contact angle measurement,X-ray photoelectron spectroscopy(XPS),sum frequency generation(SFG) vibrational spectroscopy,surface tension and dynamic laser light scattering(DLS).It was found that with increasing PFMA block length,water and oil repellency de-creased,the ratio of F/C increased with increasing film depth,and the degree of ordered packing of the perfluoroalkyl side chains at the surface decreased.When the number of PFMA block units reached 10,PMMA segments were detected at the copolymer surface,which was attributed to the PFMA block length affecting molecular aggregation structure of the copolymer in the solution and the interfacial structure at the air/liquid interface,which in turn affects surface structure formation during solution solidification.The results suggest that copolymer solution properties play an important role in struc-ture formation on the solid surface. | NI HuaGang XUE DongWu WANG XiaoFang ZHANG Wei WANG XinPing SHEN ZhiQuan | 2009 | Science China Chemistry2009，52，2： | 6 |
| 2 | Molecular basis for ligand activation of the human KCNQ2 channel显示文摘The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy,pain and several other diseases related to neuronal hyper-excitability.A list of synthetic compounds have been developed to directly activate KCNQ2,yet our knowledge of their activation mechanism is limited,due to lack of high-resolution structures.Here,we report cryo-electron microscopy(cryo-EM)structures of the human KCNQ2 determined in apo state and in complex with two activators,ztz240 or retigabine,which activate KCNQ2 through different mechanisms.The activator-bound structures,along with electrophysiology analysis,reveal that ztz240 binds at the voltage-sensing domain and directly stabilizes it at the activated state,whereas retigabine binds at the pore domain and activates the channel by an allosteric modulation.By accurately defining ligand-binding sites,these KCNQ2 structures not only reveal different ligand recognition and activation mechanisms,but also provide a structural basis for drug optimization and design. | Xiaoxiao Li Qiansen Zhangc Peipei Guo Jie Fu Lianghe Mei Dashuai Lv Jiangqin Wang Dongwu Lai Sheng Ye Huaiyu Yang Jiangtao Guo | 2021 | Cell Research2021，31，1： | 3 |
| 3 | Macro–meso two-scale model for predicting the VOC diffusion coefficients and emission characteristics of porous building materials显示文摘 | Jianyin Xiong Yinping Zhang Xinke Wang Dongwu Chang | 2008 | Atmospheric Environment2008，，21： | 1 |
| 4 | Macro meso two-scale model for predicting the VOC diffusion coefficients and emission characteristics of porous building materials 显示文摘 | Jianyin Xiong Yinping Zhang Xinke Wang Dongwu Chang | 2008 | Atmospheric Environment2008，42，21： | 1 |
| 5 | Isolation and Identification of Bacterial Pathogens of Proteus vulgaris and Chryseobacterium meningosepticum from Peodiscus sinensis and Observation on the Histopathology显示文摘Two dominant strains of bacteria Lb18-01 and Lb18-02 were isolated and purified from scabies,liver and intestine of diseased Peodiscus sinensis.By artificial infection test,the two strains were verified as pathogenic strains with similar characters to that of natural infectious cases.The strains Lb18-01 and Lb18-02 showed strong pathogenicity to healthy P.sinensis in the artificial infection experiment,so they were the pathogenic strain of the disease.According to the morphology,physicochemical characteristics,16 S rDNA sequence analysis and phylogenetic tree clustering,the pathogenic strains Lb18-01 and Lb18-02 were identified as Proteus vulgaris and Chryseobacterium meningosepticum which were tolerant to 20 drugs such as penicillin,tetracycline and ampicillin.Histopathological observation on diseased P.sinensis showed the pathological symptoms of sepsis such as hemorrhage and congestion of liver,spleen and intestine,and glomerular disintegration. | Guomin JIANG Li LIU Wuying CHU Zhigang HE Li ZOU Dongwu WANG Shiming DENG | 2021 | Agricultural Biotechnology2021，10，2： | 0 |
| 6 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits显示文摘Dear Editor,Kv4.3 is an A-type voltage-gated potassium channel that is characterized by fast activation at subthreshold membrane potentials,rapid inactivation,and quick recovery from inactiva-tionJ In neurons,Kv4.3 conducts the transient subthreshold somatodendritic A-type potassium current(Isa),knock down of which results in neuropathic pain and epilepsy.2 In cardiomyocytes,Kv4.3 generates the transient outward potassium current(lto)and its dysfunction is related to a variety of heart diseases,such as hypertrophy,heart failure,myocardial infarction,heart valvular disease,atrial fibrillation,and diabetic cardiomyopathy. | Demin Ma Cheng Zhao Xiaochen Wang Xiaoxiao Yi Zha Yan Zhang Guosheng Fu Ping Liang Jiangtao Guo Dongwu Lai | 2022 | Cell Research2022，32，4： | 0 |
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