|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Salivary microbiota may predict the presence of esophageal squamous cell carcinoma显示文摘The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P < 0.05). The areas under the ROC curves for Streptococcus salivarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC. | Junmin Wei Ruifeng Li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi Lin Yu Deng Dongyang Yang Huabin Zhang Liangfang Li Xiaosong Ben Guibin Qiao Wanwei Liu Zijun Li | 2022 | Genes & Diseases2022，9，4： | 2 |
| 2 | A new modified canine model of portal vein thrombosis显示文摘Portal vein thrombosis (PVT) is a common complication of liver cirrhosis. Gao et al. [1] reported that the prevalence of PVT in patients with cirrhosis is 8.82%. With the rapid developments in image-based diagnostic technology, the diagnosis rate of PVT is gradually increasing [2]. A follow-up study of 1243 patients with cirrhosis revealed that the cumulative incidences of PVT at 1, 3, and 5 years are 4.6%, 8.2%, and 10.7%, respectively [3]. PVT is a life-threatening factor for patients with cirrhosis, leading to portal hypertension and aggravating gastrointestinal hemorrhage [4]. The prevention of PVT has become a focus of clinical concern nowadays. It is well known that the establishment of animal models is the basis of scientific research. However, it is currently difficult to establish PVT models in large animals. Thereby, the establishment of a stable PVT animal model to study PVT is urgent and significant. We successfully established a new canine model of PVT involving the injection of an autologous thrombus through an indwelling catheter in the portal vein. This model is reliable for further studies of surgical treatment and drug therapy for PVT. | Liming Deng Tuo Deng Dongyang Luo Zhihe Deng Changtie Peng Gang Chen Guozuo Xiong | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 1 |
| 3 | Development prospects of metal-based two-dimensional nanomaterials in lithium-sulfur batteries显示文摘A lithium-sulfur(Li-S)system is an important candidate for future lithium-ion system due to its low cost and high specific theoretical capacity(1675 m Ah/g,2600 Wh/kg),which is greatly hindered by the poor conductivity of sulfur,large volume change and dissolution of lithium polysulfides.Two-dimensional(2D)materials with monolayers or few-layers usually have peculiar structures and physical/chemical properties,which can resolve the critical issues in Li-S batteries.Especially,the metal-based 2D nanomaterials,including ferrum,cobalt or other metal-based composites with various anions,can provide high conductivity,large surface area and abundant reaction sites for restraining the diffusion for lithium polysulfides.In this mini-review,we will present an overview of recent developments on metal-based 2D nanomaterials with various anions as the electrode materials for Li-S batteries.Since the main bottleneck for the Li-S system is the shuttle of polysulfides,emphasis is placed on the structure and components,physical/chemical interaction and interaction mechanisms of the 2D materials.Finally,the challenges and prospects of metal-based 2D nanomaterials for Li-S batteries are discussed and proposed. | Yuxue Mo Liling Liao Dongyang Li Rongwu Pan Yanhong Deng Yanliang Tan Haiqing Zhou | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 4 | How to Comprehensively Utilize the Discarded Fresh Tobacco Leaf ?显示文摘This paper aims to explore comprehensive utilization way of discarded fresh tobacco leaf. Based on modern tobacco demands on green,environmental protection and sustainable development,as well as actual situation of biogas production facility in some villages of local tobacco area,this paper selects Longwan Village of Fengshiyan Town as the experimental site and explores the rational way of discarded fresh tobacco leaf biogas fermentation. Results show that cutting and fermentation of discarded fresh tobacco leaf before adding into biogas digester is conductive to improving p H in fermentation process,reducing crust amount,and effectively improving biogas production amount and rate. The study can provide reference for effective processing and rational utilization of discarded fresh tobacco leaf. | Xiqing LIU Weiping FENG Zhifu XU Dongyang HU Zairan DENG Wenyu LI | 2015 | Asian Agricultural Research2015，7，12： | 0 |
| 5 | A color-based FHGC approach facilities DNA-based clinical molecular diagnostics显示文摘The flow-through hybridization and gene chip(FHGC)was developed to used in clinical molecular diagnostics for thalassemia,human papillomavirus(HPV),and other dis-eases.FHGC could improve hybridization efficiency and reduce hands-on time,thus improving precision,repro-ducibility,and traceability.Multiple genotypes can be detected simultaneously without incurring high costs.^(1)During the experiment,the polymerase chain reaction(PCR)product or buffer forced through the membrane matrix,PCR products are apprehended by a probe attached to the membrane. | Ruyi Zhang Dongyang Deng Min Ren Jiangyan He Fang Chen Shujuan Yan | 2023 | Genes & Diseases2023，10，4： | 0 |
| 6 | Crystallization Regulation and Morphological Evolution for HTM-free Tin-Lead (1.28eV) Alloyed Perovskite Solar Cells显示文摘There have been huge achievements of all-perovskite tandem solar cells,which recently realized the highest power conversion efficiency of 24.8%.However,the complex device structure and complicated manufacture processes severely restrict the further development of all-perovskite tandem solar cells.In this work,we successfully fabricated high-efficiency hole transport material-free(HTM-free)Sn−Pb alloyed narrow bandgap perovskite solar cells(PSCs)by introducing guanidinium thiocyanate(GASCN)and hydroiodic acid(HI)into the perovskite precursor solution.GASCN and HI play a positive synergy effect during perovskite crystallization process resulting in larger grain size,fewer surface defects,and lower trap density to suppress the Sn^(2+)oxidation degradation.Furthermore,they could effectively adjust the energy level of perovskite materials,reduce the energy level difference between perovskite and ITO resulting in more efficiently transport of free hole charge carriers.As a result,with adding GASCN and HI,the achieved highest power conversion efficiency of HTM-free devices increased from 12.58%to 17.85%,which is one of the highest PCEs among all values reported to date for the HTM-free narrow-bandgap(1.2-1.4 eV)Sn−Pb binary PSCs.Moreover,the optimized device shows improved environmental stability.Our additive strategy manifests a remarkable step towards the facile,cost-efficient fabrication of HTM-free perovskite-based tandem solar cells with both high efficiency and simple fabrication process. | Hang Hu Xianyong Zhou Jiabang Chen Deng Wang Dongyang Li Yulan Huang Luozheng Zhang Yuanjun Peng Feng Wang Jingxia Huang Naichao Chen Liang Sun Xuesong Liu Xingzhu Wang Jianyong Ouyang Baomin Xu | 2023 | Energy & Environmental Materials2023，6，2： | 0 |
| 7 | Tetrathiafulvalene esters with high redox potentials and improved solubilities for non-aqueous redox flow battery applications显示文摘The exploitation of high performance redox-active substances is critically important for the development of non-aqueous redoxflow batteries.Herein,three tetrathiofulvalene(TTF)derivatives with different substitution groups,namely TTF diethyl ester(TTFDE),TTF tetramethyl ester(TTFTM),and TTF tetraethyl ester(TTFTE),are prepared and their energy storage properties are evaluated.It has been found that the redox potential and solubility of these TTF derivatives in conventional carbonate electrolytes increases with the number of ester groups.The battery with a catholyte of 0.2 mol L^(-1) of TTFTE delivers a specific capacity of more than 10 Ah L^(-1) at the current density of 0.5 C with two discharge voltage platforms locating at as high as 3.85 and 3.60 V vs.Li/Liþ.Its capacity retention can be improved from 2.34 Ah L^(-1) to 3.60 Ah L^(-1) after 100 cycles by the use of an anion exchange membrane to block the crossover of TTF species.The excellent cycling stability of the TIF esters is supported by their well-delocalized electrons,as revealed by the density function theory calculations.Therefore,the introduction of more and larger electron-withdrawing groups is a promising strategy to simultaneously increase the redox-potential and solubility of redox-active ma-terials for non-aqueous redoxflow batteries. | Weikang Hu Jiaqi Xu Nanjie Chen Zongcai Deng Yuekun Lai Dongyang Chen | 2024 | Green Energy & Environment2024，9，5： | 0 |
| 8 | Stream Monitoring and Preliminary Co-Treatment of Acid Mine Drainage and Municipal Wastewater along Dunkard Creek Area显示文摘This study investigated coal-mine drainage(AMD)and municipal wastewater(MWW)contaminant concentrations and conducted the combined treatment in phases I and II:phase I,evaluating the effects of mixing the two based on the extent of acid neutralization and metals removal;phase II:conducting anaerobic batch reactor treatment of AMD and MWW under varying COD/sulfate ratios(0.04-5.0).In phase I,acid mine drainage water quality conditions are as follows:pH 4.5,acidity 467.5 mg/L as CaCO3,alkalinity 96.0 mg/L as CaCO3,Cl-11.8 mg/L,SO42-1722 mg/L,TDS 2757.5 mg/L,TSS 9.8 mg/L,BOD 14.7 mg/L,Fe 138.1 mg/L,Mg 110.8 mg/L.Mn 7.5 mg/L,Al 8.1 mg/L,Na 114.2 mg/L,and Ca 233.5 mg/L.Results of the mixing experiments indicated significant removal of selected metals(Fe 85~98%,Mg 0~65%,Mn 63~89%,Al 98~99%,Na 0~30%),acidity(77~95%)from the mine water and pH was raised to above 6.3.The Phase II results suggested under the wide range of COD/sulfate ratios,COD and sulfate removal varied from 37.4%-100%and 0%-93.5%respectively.During biological treatment,alkalinity was generated which leads to pH increase to around 7.6-8.5.The results suggested feasibility of the proposed technology for co-treatment of AMD and MWW.A conceptual design of co-treatment system which is expected to remove a matrix of pollutants has been provided to utilize all the locally available water resources to achieve the optimum treatment efficiency.The technology also offers an opportunity to significantly reduce capital and operating costs compared to the existing treatment methodologies used.Featured Application:In this study,we have measured the concentrations of contaminants in acid mine drainage(AMD)and municipal wastewater(MWW)and conducted the combined treatment in phases I and II.This is significant because in previous years there was a massive fish kill that is linked to the high total dissolved solids(TDS)and salinity content in the water.With the current proposed combined treatment technology,it shows high potential in reducing TDS and salinity content in the combined wastewater which will prevent similar accident(Dunkard creek fish kill in 2019)happening again. | Dongyang Deng Lian-shin Lin Andrea Nana Ofori-Boadu | 2020 | Hydro Science & Marine Engineering2020，2，2： | 0 |
| 9 | Advances in Transition-Metal-Catalyzed Hydrogermylation of Alkenes and Alkynes显示文摘Hydrogermylation of alkenes and alkynes provides a straightforward synthetic route to organogermanium compounds that have been found applications in organic synthesis,medicinal chemistry,and material science.This paper reviews the advances in transition-metal-catalyzed hydrogermylation of unsaturated carbon-carbon bonds,including alkenes,alkynes,dienes,and allenes,with the objective of providing readers with the status of the field.Progress,problems,and perspectives in this field are discussed. | Zungui Zhao Furen Zhang Dongyang Wang Liang Deng | 2023 | Chinese Journal of Chemistry2023，41，22： | 0 |
| 10 | Four-coordinate disilyl cobalt(Ⅱ)complexes with NHC ligation:Synthesis,characterization,and reactivity显示文摘Silyl cobalt species are putative intermediates in cobalt-catalyzed transformations of hydrosilanes.However,their reactivity has remained poorly understood.Reported here is the investigation on four-coordinate disilyl Co(Ⅱ)complexes with N-hetereocyclic carbene ligation.The reactions of[(ICy)_(2)Co(vtms)](ICy=1,3-dicyclohexylimidazol-2-ylidene,vtms=vinyltrimethylsilane)with primary and secondary hydrosilanes(3 equiv.)furnish the four-coordinate disilyl complexes[trans-(ICy)_(2)Co(SiHRR')_(2)](SiHRR'=SiH_(2)Mes,1;SiH_(2)Ph,2;SiH_(2)Cy,3;SiHPh_(2),4;SiHEt_(2),5)in moderate to good yields.The structures of 1,2 and 4 were established by single-crystal X-ray diffraction.Solution magnetic susceptibility measurement and EPR spectroscopy indicate their low-spin nature(S=1/2).Reactivity studies on 4 led to the establishment of the conversions of 4 to the disilyl dihydride Co(Ⅲ)complex[K(THF)][(ICy)_(2)Co(H)_(2)(SiHPh_(2))_(2)]_n(6)and the fluorosilyl Co(Ⅱ)complex[(ICy)_(2)Co(THF)(SiFPh_(2))][BF_(4)](7)when 4 was treated with excess amount of K and AgBF_(4),respectively,in THF.These conversions hint at the high activity of low-valent and high-valent disilyl cobalt species[trans-(ICy)_(2)Co(SiHPh_(2))_(2)]^(1-)and[trans-(ICy)_(2)Co(SiHPh_(2))_(2)]^(2+).Complex 4 is reactive toward terminal alkynes,but inert toward alkenes and internal alkynes.The reactions of 4 with terminal alkynes CyC≡CH and Me_(3)SiC≡CH(3 equiv.)yield the Co(Ⅱ)complexes[(ICy)_(2)Co(C≡CCy)_(2)](8)and[(ICy)_(2)Co(C≡CSiMe_(3))((SiMe_(3))C=CH_(2))](9),respectively,along with H_(2)SiPh_(2)and alkynylsilanes RC≡CSiHPh_(2)(R=Cy,SiMe_(3)),whereas the reaction with 4-CF_(3)C_(6)H_(4)C≡CH(3 equiv.)produce[(ICy)_(2)Co(C≡CAr)((Ar)C=CH(SiHPh_(2))C=CHAr)](Ar=4-CF_(3)C_(6)H_(4))(10)and H_(2)SiPh_(2).These reactions are proposed to involveσ-bond metathesis reactions between alkyne C(sp)-H bonds and Co-Si bonds in 4.Complexes 6–10 have been characterized by NMR spectroscopy,X-ray diffraction study,and elemental analysis. | Lan Zhou Dongyang Wang Chengbo Yang Liang Deng | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 11 | Isolable Anion Radicals of Nitrosoarenes显示文摘Summary of main observation and conclusion The rich redox chemistry of nitrosoarenes has rendered these reactive molecules very useful in modern synthetic and material chemistry.Electrochemical studies have revealed the capability of nitrosoarenes to undergo one-electron oxidation or reduction reaction for a long time.However,the isolation and structural characterization of nitrosoarene radical compounds deviating the stabilization of transition-metal have not been achieved.Investigation on the reduction reaction of nitrosoarenes bearing steric demanding substituents has now revealed that the interaction of 2,6-dimesityl-1-nitroso-benzene(DmpNO)or 2,4,6-tri(tert-butyl)-1-nitroso-benzene(TtpNO)with KC8 and crypt-2,2,2 can produce the corresponding anion radical compound[K(crypt-2,2,2)][DmpNO](1)or[K(crypt-2,2,2)][TtpNO](2)in good isolated yield.Compounds 1 and 2 represent the first examples of isolable nitrosoarene radical compounds deviating the stabilization of transition-metal,and have been characterized by single-crystal X-ray diffraction study,electron paramagnetic resonance(EPR)spectroscopy,and elemental analysis.Theoretical study in collaboration with the characterization data revealed that the unpaired spin in[DmpNO]·-and[TtpNO]·-delocalizes on the nitroso and the central phenyl groups. | Dongyang Wang Masilamani Tamizmani Xuebing Leng Liang Deng | 2020 | Chinese Journal of Chemistry2020，38，2： | 0 |
| 12 | Study on Chemical Constituents of Ethanol Extract from Yao Medicine Cissampelopsis spelaeicola显示文摘[Objectives]The research aimed to study the chemical constituents of ethanol extract from Yao medicine Cissampelopsis spelaeicola.[Methods]The petroleum ether,ethyl acetate and n-butanol fractions from 75%ethanol extract of C.spelaeicola were isolated and purified by silica gel,SephadexLH-20 gel column and AB-8 macroporous resin column,etc.The structures of the compounds were analyzed and identified by physicochemical properties and spectral data(mass spectrometry,hydrogen spectrum and carbon spectrum).[Results]Twelve compounds were isolated and identified from 75%ethanol extract of C.spelaeicola.β-sitostero(I)and stigmasterol(II)were isolated from petroleum ether fraction;p-hydroxybenzoic acid(III),β-daucossterol(IV),protocatechuic acid(V),6β-hydroxyeremophi-7(11)-en-12,8β-olide(VI),10β-hydroxyeremophil-7(11)-en-8,12-olide(VII),10β-hydroxyeremophi-7(11),8(9)-dien-8,12-olide(VIII),quercetin(IX),hyperin(X)and 4α-hydroxy-eudesman-11-ene(XI)were isolated from ethyl acetate fraction;quercetin-3-O-robinobioside(XII)was isolated from n-butanol fraction.Compounds I-XII were isolated from C.spelaeicola for the first time.[Conclusions]The study can lay material foundation for activity study of C.spelaeicola. | Shuang LIANG Wenfang MA Kewen LIANG Lichun ZHAO Gang DENG Dongyang XIE | 2020 | Medicinal Plant2020，11，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员