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| 1 | XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks显示文摘 | Julie K Horton Mary Watson Donna F Stefanick Daniel T Shaughnessy Jack A Taylor Samuel H Wilson | 2008 | Cell Research2008，18，1： | 17 |
| 2 | Caveolae/caveolin-1/ERK_(1/2)信号通路在降钙素基因相关肽抑制血管平滑肌细胞增殖中的作用(英文)显示文摘业已证明,Caveolae及其蛋白caveolin-1参与了细胞膜的胆固醇转运和细胞膜的信号转导.我们前期工作发现降钙素基因相关肽(CGRP)抑制血管平滑肌细胞(VSMC)增殖的信号通路与抑制ERK1/2活性和上调caveolin-1表达有关.本文研究Caveolae及caveolin-1在CGRP抑制VSMC增殖中的作用,进一步研究caveolin-1表达增加是否有直接抑制ERK1/2信号激酶活性的作用.采用大鼠主动脉贴块法培养VSMC,取3~10代VSMC用于实验,10%小牛血清(FBS)用于刺激VSMC增殖,用β-环糊精(cyclodextrin)或菲律宾菌素(filipin)剥夺胆固醇破坏Caveolae结构;MTT法和流式细胞仪用于检测细胞增殖;蛋白质印迹和免疫共沉淀法分别用于检测目的蛋白的表达或蛋白质间相互作用.结果显示,CGRP呈时间和浓度依赖性显著抑制10%FBS诱导的VSMC增殖.细胞Caveolae结构的破坏能降低CGRP抑制VSMC增殖作用,同时也增加了ERK1/2的磷酸化;β-环糊精孵育细胞能降低caveolin-1的表达.免疫共沉淀发现10%FBS和/或CGRP共同孵育细胞对非磷酸化ERK1/2与caveolin-1的结合无差别,但10%FBS能降低磷酸化ERK1/2与caveolin-1的结合,CGRP预孵育细胞能增加这两者的相互作用.结果揭示,Caveolae及caveolin-1可以正调控CGRP抑制VSMC增殖作用,其机制可能与CGRP增加caveolin-1与p-ERK1/2在Caveolae的结合,并抑制p-ERK1/2核转位作用有关. | 谌赟 戴忠 刘彦梅 田海红 邓水秀 陈临溪 Wang H Donna 秦旭平 | 2013 | 生物化学与生物物理进展2013，40，5： | 9 |
| 3 | The vanilloid receptor and hypertension显示文摘Mammalian transient receptor potential (TRP) channels consist of six related protein sub-families that are involved in a variety of pathophysiological function, and disease development. The TRPV1 channel, a member of the TRPV sub-family, is identified by expression cloning using the “hot” pepper-derived vanilloid compound capsaicin as a ligand. Therefore, TRPV1 is also referred as the vanilloid receptor (VR1) or the capsaicin receptor. VR1 is mainly expressed in a subpopulation of primary afferent neurons that project to cardiovascular and renal tissues. These capsaicin-sensitive primary afferent neurons are not only involved in the perception of somatic and visceral pain, but also have a “sensory-effector” function. Regarding the latter, these neurons release stored neuropeptides through a calcium-dependent mechanism via the binding of capsaicin to VR1. The most studied sensory neuropeptides are calcitonin gene-related peptide (CGRP) and substance P (SP), which are potent vasodilators and natriuretic/diuretic factors. Recent evidence using the model of neonatal degeneration of capsaicin-sensitive sensory nerves revealed novel mechanisms that underlie increased salt sensitivity and several experimental models of hypertension. These mechanisms include insufficient suppression of plasma renin activity and plasma aldosterone levels subsequent to salt loading, enhancement of sympathoexcitatory response in the face of a salt challenge, activation of the endothelin-1 receptor, and impaired natriuretic response to salt loading in capsaicin-pretreated rats. These data indicate that sensory nerves counterbalance the prohypertensive effects of several neurohormonal systems to maintain normal blood pressure when challenged with salt loading. The therapeutic utilities of vanilloid compounds, endogenous agonists, and sensory neuropeptides are also discussed. | Donna H WANG | 2005 | Acta Pharmacologica Sinica2005，26，3： | 6 |
| 4 | Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord显示文摘瞄准: 调查效果选择在针的绳索,背面的根 ganglia (DRG ) 和高腌吸入的老鼠血压回答上的 mesenteric 动脉的更低的胸、上面的腰部的片断的 TRPV1 隧道击倒。 | Shuang-quan YU Donna H WANG | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 5 | Cholesteryl ester storage disease: Review of the findings in 135 reported patients with an underdiagnosed disease显示文摘 | Donna L. Bernstein Helena Hülkova Martin G. Bialer Robert J. Desnick | 2013 | Journal of Hepatology2013，，6： | 2 |
| 6 | Inter-organizational Business Process Redesign:Merging Technological and Process Innovation显示文摘 | Clark Theodore H Stoddard Donna B | 1996 | Journal of Management Information Systems1996，13，2： | 1 |
| 7 | Strategic Implementation as a Core Competency: The5P' s Model 显示文摘 | MILDRED G P DONNA A LESLIE A T JOHN H H | 2007 | Jour- nal of Management Research2007，，7： | 1 |
| 8 | Hyperuricemia and cardiovascular events in successfully treated hypertensive patients显示文摘 | Michael H Karen K Steinberg Donna F Stroup | 1999 | Hypertension1999，34，： | 1 |
| 9 | Effectiveness of state pollution prevention programs and policies显示文摘 | Donna R H | 2013 | Contemporary Economic Policy2013，31，2： | 1 |
| 10 | Hyperarousal and insomnia :State of the science 显示文摘 | Michael H Bonnet Donna L | 2010 | Sleep Medicine Reviews2010，14，1： | 1 |
| 11 | Effects of post harvest storage and dormancy status on ABA content,metabolism,and expression of genes involved in ABA biosynthesis and metabolism in potato tuber tissues显示文摘 | Luis D B Donna K Linda H | | 0，，45： | 1 |
| 12 | Variable Antigens of Ureaplasma Urealyticum Containing Both Serovar-Specific and Serovar-Cross-Reactive Epitopes显示文摘 | Harold L W Donna K B Gail H C | 1990 | Infect Immun1990，58，11： | 1 |
| 13 | Effects of vasoactivepeptides on cytosolic calcium in cultured mesangial cells 显示文摘 | Aviv H Nanni P Donna G | 1986 | Am J Physiol1986，251，： | 1 |
| 14 | Ganglioneuroma of the adrenal gland 显示文摘 | Daniela S A Donna E H | 2009 | J Urology2009，，182： | 1 |
| 15 | The Hazards of Moist Toilet Paper Allergy to the Preservative Methylchloroisothiazolinone/Methylisothiazolinone显示文摘 | Kevin H Gardner Mark D P Davis MD Donna M Richardson RN | 2010 | ARCH D ER-MATOL2010，8，： | 1 |
| 16 | Hyperarousal and insomnia: State of the science显示文摘 | Michael H Bonnet Donna L Arand | 2010 | Sleep Medicine Reviews2010，14，： | 1 |
| 17 | Social subordination produces distinct stress-related phenotypes in female rhesus monkeys 显示文摘 | Vasiliki M Melinda H Donna T | 2012 | Psychoneuroendocrinol2012，37，7： | 1 |
| 18 | Framework for Census Coverage Error Components显示文摘 | Mary H Mulry Donna K Kostanich | 2006 | ASA Section on Survey Research Methods2006，，8： | 1 |
| 19 | Behaviour of hybrid FRP-UHPC beams in flexure under fatigue loading 显示文摘 | DONNA C RAAFAT E H | 2011 | Composite Structures2011，94，1： | 1 |
| 20 | Prevention of endothelin-1-induced increases in blood pressure: role of endogenous CGRP 显示文摘 | Wang Youping Wang Donna H | 2004 | Am J Physiol Heart Circ Physiol2004，287，： | 1 |
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