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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Toward a Theory of Stakeholder Identification And Salience:Defining The Principle of Who and What Really Counts显示文摘 | RONALD K MITCHELL BRADLEY R AGLE DONNA J WOOD | 1997 | Academy of Management Review1997，22，4： | 1 |
| 4 | To- ward a Theory of Stakeholder Identification and Salience: Defining the Principle of Who and What Really Counts 显示文摘 | Ronald K Mitchell Bradley R Agle Donna J Wood | 1997 | Academy of Management Review1997，，： | 1 |
| 5 | Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 显示文摘 | TERESA T F ERIC B R DONNA S | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 6 | Responses of three grass species to creosote during phytoremediation显示文摘 | Xiao-Dong Huang Yousef El-Alawi Donna M Penrose Bernard R Glick Bruce M Greenberg | 2004 | Environmental Pollution2004，，3： | 1 |
| 7 | Effects of nutrition education progranms on anthropometric measurements and pregnancy outconme of adolescents显示文摘 | Donna Jean arbara J Janice R | 2002 | Am Diet Assoc2002，102，3： | 1 |
| 8 | Effectiveness of state pollution prevention programs and policies显示文摘 | Donna R H | 2013 | Contemporary Economic Policy2013，31，2： | 1 |
| 9 | Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia显示文摘 | Jeremy W Fox Edward D Lamperti Yaman Z Ek?io?lu Susan E Hong Yuanyi Feng Donna A Graham Ingrid E Scheffer William B Dobyns Betsy A Hirsch Rodney A Radtke Samuel F Berkovic Peter R Huttenlocher Christopher A Walsh | 1998 | Neuron1998，，6： | 1 |
| 10 | Secondary metabolites from entomopathogenic hypocrealean fungi显示文摘 | Moln~r I Donna M G Krasnoff S B | 2010 | Nat ProdRep2010，27，9： | 1 |
| 11 | Toward a theory of stakeholder identification and salience:defining the principle of who and what really counts显示文摘 | Ronald K Mitchell Bradley R Agle Donna J Wood | | 0，，04： | 1 |
| 12 | CpG Island Methylator Phenotype is Associated With Response to Adjuvant Irinotecan-Based Therapy for Stage 3 Colon Cancer显示文摘 | Stacey Shiovitz Monica M. Bertagnolli Lindsay A. Renfro Eunmi Nam Nathan R. Foster Slavomir Dzieciatkowski Yanxin Luo Victoria Valinluck Lao Raymond J. Monnat Mary J. Emond Nancy Maizels Donna Niedzwiecki Richard M. Goldberg Leonard B. Saltz Alan Venook R | 2014 | Gastroenterology2014，，： | 1 |
| 13 | Mechanism and regulation of selenoprotein synthesis显示文摘 | Driscoll Paul R | 2003 | Annu Rev Nutr2003，23，： | 1 |
| 14 | Crease:another Ca deficiency-related fruit disorder?显示文摘 | Storey R Treeby MT Donna JM 2002 | 2002 | J Hort Sci Biotechnol2002，77，5： | 1 |
| 15 | Toward a theory of stakeholder identification and salience: defining the principle of who and what really counts 显示文摘 | Ronald K M Bradleg R A Donna J W | 1997 | The Academy of Management Review1997，，4： | 1 |
| 16 | International Trade Commission Votes to Continue Cases on Honey from Argentina and China 显示文摘 | Donna R Koehnke | 2001 | American Bee Journal2001，，1： | 1 |
| 17 | Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to fischer 344 rats and B6C3F1 mice显示文摘 | Culp Sandra J Blankenship Lonnie R Kusewitt Donna F | 1999 | Chemico-Biol Interactions1999，122，3： | 1 |
| 18 | Reference and PDF-manager software: complexities, support and workflow 显示文摘 | THOMAS L M DONNA R B | 2010 | Medical Reference Services Quarterly2010，29，4： | 1 |
| 19 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 20 | Electrochemical study of self-assembled monolayers of a β-cyclodextrin methyl sulfide covalently linked to anthraquinone 显示文摘 | Keith J Stine Donna M Andrauska Abdul R Khan | 1999 | Journal of Electroanalytical Chemistry1999，465，： | 1 |
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