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| 1 | Hepatitis E virus in patients with acute severe liver injury显示文摘AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant unit.METHODS: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain reaction.RESULTS: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient died from sepsis and liver failure precipitated as a result of hepatitis E infection and previously undiagnosed cirrhosis. Histopathology data to date is limited to mainly that seen for endemic HepE. All patients, with the exception of patient 1, demonstrated characteristics of HepE infection, as seen in previously described locally acquired cases.CONCLUSION: In patients with acute severe liver injury, HEV testing should be part of the initial diagnostic investigation algorithm irrespective of suspected initial diagnosis, age or travel history. | Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy Janice Davidson Harry R Dalton Linda Scobie | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 2 | Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials显示文摘 | Gilles R Dagenais Janice Pogue Kim Fox Marteen L Simoons Salim Yusuf | 2006 | The Lancet2006，，9535： | 2 |
| 3 | Using professional specialty competencies to guide course development显示文摘 | Gwendolyn F Janice K David R | | 0，，8： | 1 |
| 4 | Effects of nutrition education progranms on anthropometric measurements and pregnancy outconme of adolescents显示文摘 | Donna Jean arbara J Janice R | 2002 | Am Diet Assoc2002，102，3： | 1 |
| 5 | A taxonomy of DDoS attacks and DDoS defense mechanisms 显示文摘 | JELENA M JANICE M PETER R | 2004 | Computer Communication Re- view2004，34，2： | 1 |
| 6 | Angiotensin-converting-enzyme inhibitors in stable vascular disease without left ventricular systolic dysfunction or heart failure: a combined analysis of three trials显示文摘 | Gilles R Dagenais Janice Pogue Kim Fox Marteen L Simoons Salim Yusuf | 2006 | The Lancet . 2006 (9535)2006，，9535： | 1 |
| 7 | DUROS technology delivers peptides and proteins at consistent rate continuously for 3 to 12 months 显示文摘 | Catherine M R Thomas R A Bing Y Janice D John P C Scott D L | 2008 | Journal of Diabetes Science and Technology2008，2，3： | 1 |
| 8 | Not so naive bayes: Aggregating one-dependence estimators 显示文摘 | Geoffrey I Webb Janice R Boughton WANG Zhihai | 2005 | Journal of Marching Learning2005，58，1： | 1 |
| 9 | Patient-centered care and adherence:definitions and applications to improve outcomes显示文摘 | Janice H R Lynn C C Judith A B | 2008 | J AANP2008，20，1： | 1 |
| 10 | Extended culture of mouse embryo cells without senescence: inhibition by serum显示文摘 | Deryk T L Janice I F Cathleen L R | 1987 | Science1987，236，： | 1 |
| 11 | Parathyroid hormone stimulatess endothelial expression of atheroscler,otic parameters through protein hinase pathways 显示文摘 | GLORIA R JACQUES B JANICE G | 2007 | Am J Physiol Renal Physiol2007，292，4： | 1 |
| 12 | EuroOOPS: An international, multicentre study to implement nutritional risk screening and evaluate clinical outcome显示文摘 | Janice Sorensen Jens Kondrup Jacek Prokopowicz Marc Schiesser Lukas Kr?henbühl Rémy Meier Martin Liberda | 2008 | Clinical Nutrition2008，，3： | 1 |
| 13 | Biochar effects on soil biota-A reviewe显示文摘 | JOHANNES L MATTHIAS C R JANICE T | 2011 | Soil Biology & Biochemis- try2011，，43： | 1 |
| 14 | Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia显示文摘 | Jon B K David G William M P Visith T Janice A S Leroy R S Shang Z G Jian C Evelyne G | 2003 | Respir Physiol Neurobiol2003，136，： | 1 |
| 15 | Influence Strategy Efficacy in Supplier-Distributor Relationship显示文摘 | Nevin John R | 2006 | Journal of Business Research2006，59，5： | 1 |
| 16 | Efficacy of reco mbinant methionyl human leptin therapy for the extreme insulin resistance of the rabson-mendenhallsy ndrome显示文摘 | Elaine C Janice R Y Nancy S | 2004 | J Clin Endocrinol Metab2004，89，4： | 1 |
| 17 | Caring as an Imperative for Nursing Education显示文摘 | Patricia R Cook Janice A | 2003 | Nurs Educ Perspect2003，24，4： | 1 |
| 18 | H1N1 2009 influenza virus infection during pregnancy in the USA显示文摘 | Denise J Jamieson Margaret A Honein Sonja A Rasmussen Jennifer L Williams David L Swerdlow Matthew S Biggerstaff Stephen Lindstrom Janice K Louie Cara M Christ Susan R Bohm Vincent P Fonseca Kathleen A Ritger Daniel J Kuhles Paula Eggers Hollianne Bruce H | 2009 | The Lancet2009，，9688： | 1 |
| 19 | Health promoting health services: areview of the evidence 显示文摘 | Clare M Anske R Janice C | 2010 | Health Promoting Health Services2010，25，2： | 1 |
| 20 | Phylogenetic relationships among virulent Newcastle disease virus isolates from the 2002-2003 outbreak in California and other recent outbreaks in North America显示文摘 | Janice C P Dennis A S Peter R W | 2004 | J Clin Microbiol2004，42，5： | 1 |
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