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1篇 您的检索式：作者名="Doris Andert"

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		题名	作者	年代	出处	被引量
	1	Enantiomeric characterization and structure elucidation of Otamixaban显示文摘Otamixaban is a potent(Ki=0.5 nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibrational circular dichroism(VCD) spectroscopy. Selected by a spectrum similarity index, the calculated spectra of several higher energy conformers were found to match well with the observed spectra. The characteristic IR bands of these conformers were also identified and attributed to the solvation effect.Combined with both the single crystal x-ray diffraction results for an intermediate and the proton NMR study, the absolute configuration of Otamixaban is unambiguously determined to be(R,R).	Jian Shen Jiping Yang Winfried Heyse Harald Schweitzer Norbert Nagel Doris Andert Chengyue Zhu Vincent Morrison Gregory A.Nemeth Teng-Man Chen Zhicheng Zhao Timothy A.Ayers Yong-Mi Choi	2014	Journal of Pharmaceutical Analysis2014，4，3：	1

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