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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 3 | Land subsidence monitoring by D-InSAR technique显示文摘Nowadays, the researches of using Differential Interferometric Synthetic Aperture Radar (D-InSAR) tech- nique to monitor the land subsidence are mainly on how to qualitatively analyze the subsidence areas and values, but the analysis of subsidence process and mechanism are insufficient. In order to resolve these problems, 6 scenes of ERS1/2 images captured during 1995 and 2000 in a certain place of Jiangsu province were selected to obtain the subsidence and velocities in three time segments by ''two-pass'' D- InSAR method. Then the relationships among distributions of pumping wells, exploitation quantity of groundwater, and confined water levels were studied and the subsidence mechanism was systematically analyzed. The results show that using D-InSAR technique to monitor the deformation of large area can obtain high accuracies, the disadvantages of classical observation methods can be remedied and there is a linear relationship among the velocities of land subsidence, the water level and the exploitation quantity. | Fan Hongdong Deng Kazhong Ju Chengyu Zhu Chuanguang Xue Jiqun China | 2011 | Mining Science and Technology2011，21，6： | 15 |
| 4 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 5 | Tauroursodeoxycholic acid(TUDCA) inhibits influenza A viral infection by disrupting viral proton channel M2显示文摘Influenza is a persistent threat to human health and there is a continuing requirement for updating antiinfluenza strategies. Initiated by observations of different endoplasmic reticulum(ER) responses of host to seasonal H1N1 and highly pathogenic avian influenza(HPAI) A H5N1 infections, we identified an alternative antiviral role of tauroursodeoxycholic acid(TUDCA), a clinically available ER stress inhibitor, both in vitro and in vivo. Rather than modulating ER stress in host cells, TUDCA abolished the proton conductivity of viral M2 by disrupting its oligomeric states, which induces inefficient viral infection. We also showed that M2 penetrated cells, whose intracellular uptake depended on its proton channel activity,an effect observed in both TUDCA and M2 inhibitor amantadine. The identification and application of TUDCA as an inhibitor of M2 proton channel will expand our understanding of IAV biology and complement current anti-IAV arsenals. | Ning Li Yanxu Zhang Shuangxiu Wu Ruodan Xu Zhiqing Li Jindong Zhu Hongliang Wang Xiao Li Mingyao Tian Huijun Lu Ningyi Jin Chengyu Jiang | 2019 | Science Bulletin2019，64，3： | 6 |
| 6 | Paleozoic convergence processes in the southwestern Central Asian Orogenic Belt:Insights from U–Pb dating of detrital zircons from West Junggar,northwestern China显示文摘The West Junggar orogen,located in the southwestern Central Asian Orogenic Belt(CAOB),preserves an abundant record of tectonic processes associated with the evolution of the Junggar Ocean.In this study,we use detrital zircon U–Pb age data from Ordovician to Carboniferous sandstones in the southern and central West Junggar domains,complemented by literature data,to better constrain the tectonic evolution of the southwestern CAOB.The Kekeshayi,Qiargaye,and Laba formations in the southern West Junggar domain were deposited during the Darriwilian-Sandbian,Katian-Aeronian,and Homerian-Emsian,respectively.Detrital zircon provenances of these formations display a marked shift from the southern West Junggar domain to the Paleo-Kazakhstan Continent(PKC).This suggests that the southern West Junggar intra-oceanic arc might have gradually accreted to the northern margin of the PKC prior to the Emsian,which has significantly contributed to the lateral growth of the PKC.The Carboniferous strata,Xibeikulasi,Baogutu,and Tailegula formations,in the central West Junggar domain represent a coherent sequence of volcaniclastic turbidites and were deposited in a progressively shrinking remnant oceanic basin during the Visean to Moscovian.They contain unimodal detrital zircon distributions and are derived from the local and coeval magmatic rocks in the central West Junggar domain.We propose that the final closure of the Junggar Ocean likely occurred in the end of the Late Carboniferous in response to regional amalgamation events in the southwestern CAOB,which marks the final assembly of the Kazakhstan Orocline.The central and southern West Junggar domains underwent individual evolution in the Paleozoic,and were recombined by the significant intra-continental reworking along the large-scale strike-slip faults. | Pan Zhang Guocan Wang Tianyi Shen Ali Polat Chengyu Zhu | 2021 | Geoscience Frontiers2021，12，2： | 3 |
| 7 | The Zα domain of fish PKZ facilitates the B-Z conformational transition of oligonucleotide DNAs with d(GC), inserts显示文摘PKZ (象 PKR 一样) 在鱼作为 elF2 kinase 家庭的一个成员被发现,它在 C 终端并且也拥有 eIF2 kinase 的一个保存催化领域在 N 终端的二个 Z-DNA-binding 领域(Z1 和 Z2 ) 。PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能仍然保持不清楚。调查 PKZ Z 怎么与 Z-DNA 交往的分子的机制,我们在 Escherichia coli 罗塞达碑紧张表示了 Z 多肽 Z12 并且在 Ni-NTA 上由亲密关系层析净化了树脂。oligonucleotide DNA 与的不同长度各种各样插入,也就是 d (GC ) n (n = 6, 8, 10, 13 ) , d (TA ) n (n = 6, 10 ) , non-d (GC ) ,和 non-d (TA ) ,被设计并且综合。圆形的二色性光谱和胶化活动性移动试金被用来在不同 oligonucleotide DNA 的 conformational 转变上调查 Z12 的效果。结果证明 oligonucleotide DNA 当 Z12 不在时保留了常规 B-DNA 符合构造。与 Z12 滴定的增加的数量, d (GC ) n 被认出并且在某种程度上把符合构造变换成 Z-DNA。与增加重复数字(从 n = 6 到 n = 13 ) , conformational 转变的趋势变得更明显。然而,有 n 插入的 d (TA ) 的 oligonucleotides 的符合构造面对 Z12 有点变化了,并且 Z12 没在有 non-d (GC ) 或 non-d (TA ) 的 oligonucleotides 的转变插入的 conformational 上有效果。胶化活动性移动试金进一步证明 Z12 能与 d (GC ) 绑在 oligonucleotide 10。换句话说, Z12 能与 n 插入到 Z-DNA 符合构造的 d (GC ) 转 oligonucleotides 并且与高亲密关系绑在它。 | Puzhong Lu Shoulong Deng Youlin Zhu Yongbin Yan Yong Liu Chengyu Hu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 3 |
| 8 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 9 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 10 | The Zα domain of fish PKZ converts DNA hairpin with d(GC)n inserts to Z-conformation显示文摘PKZ,蛋白质 kinase 包含 Z-DNA 领域,是脊椎动物 eIF2 kinase 家庭的一个新奇成员。在 N 终点在 C 终点和二个 Z-DNA 有约束力的领域(Z1 和 Z2 ) 包含一个催化领域, PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能尚待被证实。这里,蛋白质被表示在 DNA conformational 转变,野类型的 Z1Z2 和 11 异种上理解 PKZ Z 的影响并且净化。同时, DNA hairpinsd (GC ) 的几不同长度 nT4 (GC ) n (n = 26 ) 并且 RNA hairpinr (GC ) 6T4 (GC ) 6 被综合。这些合成 DNA 或 RNA 发卡的符合构造上的 Z1Z2 和变异的蛋白质的效果被使用圆形的二色性光谱和胶化活动性移动试金调查。结果证明 DNA 发卡当 Z1Z2 不在时保留了常规 B-DNA 符合构造,当一些 DNA 发卡(n3 ) 在 Z1Z2 正式就职下面被变换成 Z 符合构造时。趋势按比例与 GC 重复的增加的数量被联系。与 Z1Z2 比较, Z1Z1 而非 Z2Z2 在变换 d (GC ) 显示了一个更高的能力 6T4 (GC ) 6 从 B- 到 Z-DNA。这些结果证明那 Z1 子域比 Z2 子域在 BZ conformational 转变的过程起了一个更必要的作用。变异的蛋白质(K34A, N38A, R39A, Y42A, P57A, P58A,和 W60A ) 不能变换 d (GC ) 6T4 (GC ) 6 进 Z-DNA,而 S35A 或 K56A 保留了一些部分活动。有趣地, Z1Z2 也能导致 r (GC ) 6T4 (GC ) 从 A 符合构造的 6 RNA 到在适当条件下面的 Z 符合构造。 | Puzhong Lu Shoulong Deng Chuxin Wu Youlin Zhu Yong Liu Gang Lin Yongbin Yan Chengyu Hu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 2 |
| 11 | New Small Shelly Fossils(Acanthocassis and Xinlispina Gen.Nov.) from the Fortunian Stage(Early Cambrian) in Southern China显示文摘We describe new material of three-dimensionally phosphatized small shelly fossils Acanthocassis and Xinlispina gen.nov.from the Fortunian Stage(early Cambrian) of southern Shaanxi and northern Sichuan Provinces.The new materials allow description of the delicate morphology of these skeletons, and also their skeletogenesis.Acanthocassis and Xinlispina have comparable morphological features: a main branch and radially arranged sub-branches.They differ from each other in many details, e.g., the presence of a single central branch only in Xinlispina, and the presence of small nodes only in Acanthocassis.Acanthocassis cannot be a naked anthopolyp or hydropolyp because of the more-or-less stiffened cuticle and the absence of a mouth.Acanthocassisand Xinlispina differ from coeval sponge spicules and chancelloriid sclerites and rosettes of crossed pedicellariae of echinoderms, and might be cuticular ornaments of animals of unclear affinities.They occur in the first small shelly fossil assemblage zone, and could be adopted as auxiliary fossils for biostratigraphic correlation in southern China. | SHAO Tiequan LIU Yunhuan WANG Qi ZHANG Huaqiao TANG Hanhua CAO Xi HE Huahua ZHANG Yanan LI Yuan ZHENG Panlin ZHU Chengyu HU Jiaxi | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 12 | XPC gene intron 11 C/A polymorphism is a predictive biomarker for the sensitivity to NP chemotherapy in patients with non--small cell lung cancer 显示文摘 | LiBo Zhu Qian Xu ChengYu Hong | 2010 | Anti-Cancer Drugs2010，21，7： | 1 |
| 13 | Technical feasibility study of an onshore ballast water treatment system显示文摘To fulfill the requirements of Guidelines forapproval of ballast water management system(G8),a setof onshore ballast water treatment equipment utilizingmicro-pore ceramic filtration(MPCF)and UV radiation(MPCF&UV)system was designed and set up with amaximum flow rate of 80 m^(3)·h^(-1).Technical feasibilities ofMPCF&UV system were evaluated in three areas:removalefficiencies of indicator organism and oceanic bacteria,perdurability of a ceramic filter,and application on nativeseawater.The results showed that no indicator organism(Dunaliella)or oceanic bacteria was detected aftertreatment of 20 L MPCF and UV radiation at 1.3×10^(4)μW·s·cm^(-2).A 20 L ceramic filter can run continuouslyfor 5.3 h at the flow rate of 15 m3·h-1 before itspressure drop up to 0.195 MPa.The removal percentage oftotal plankton amounts were 91.9%at a flow rate of70 m^(3)·h^(-1)by 80 L MPCF and UV radiation at 1.3×10^(4)μW·s·cm^(-2). | Shengjie LIU Manxia ZHANG Xiang LI Xiaojia TANG Lingling ZHANG Yimin ZHU Chengyu YUAN | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 1 |
| 14 | Performance Monitoring of a Glass Fiber-Reinforced Polymer Bar Soil Nail during Laboratory Pullout Test Using FBG Sensing Technology显示文摘 | Huafu Pei Jianhua Yin Honghu Zhu Chengyu Hong | 2013 | International Journal of Geomechanics2013，，4： | 1 |
| 15 | A tunable optical delayer based on SBS slow light of ring configuration显示文摘 | Lu Zhiwei Ba Dexin Zhu Chengyu | 2012 | Applied Physics B:Lasers and Optics2012，109，1： | 1 |
| 16 | Nuclear RIPK1 promotes chromatin remodeling to mediate inflammatory response显示文摘RIPK1 is a master regulator of multiple cell death pathways,including apoptosis and necroptosis,and inflammation.Importantly,activation of RIPK1 has also been shown to promote the transcriptional induction of proinflammatory cytokines in cells undergoing necroptosis,in animal models of amyotrophic lateral sclerosis(ALS)and Alzheimer's disease(AD),and in human ALS and AD.Rare human genetic carriers of non-cleavable RIPK1 variants(D324V and D324H)exhibit distinct symptoms of recurrent fevers and increased transcription of proinflammatory cytokines.Multiple RIPK1 inhibitors have been advanced into human clinical trials as new therapeutics for human inflammatory and neurodegenerative diseases,such as ALS and AD.However,it is unclear whether and how RIPK1 kinase activity directly mediates inflammation independent of cell death as the nuclear function of RIPK1 has not yet been explored.Here we show that nuclear RIPK1 is physically associated with the BAF complex.Upon RIPK1 activation,the RIPK1/BAF complex is recruited by specific transcription factors to active enhancers and promoters marked by H3K4me1 and H3K27ac.Activated nuclear RIPK1 mediates the phosphorylation of SMARCC2,a key component of the BAF complex,to promote chromatin remodeling and the transcription of specific proinflammatory genes.Increased nuclear RIPK1 activation and RIPK1/BAF-mediated chromati n-remodeling activity were found in cells expressi ng non-cleavable RIPK1,and in creased enrichment of activated RIPK1 on active enhancers and promoters was found in an animal model and human pathological samples of ALS.Our results suggest that RIPK1 kinase serves as a transcriptional coregulator in nucleus that can transmit extracellular stimuli to the BAF complex to modulate chromatin accessibility and directly regulate the transcription of specific genes involved in mediating inflammatory resp onses. | Wanjin Li Bing Shan Chengyu Zou Huibing Wang Meng-Meng Zhang Hong Zhu Masanori Gomi Naito Daichao Xu Vica Jean Manuel Lauren Mifflin Zhaodong Hou John Ravits Junying Yuan | 2022 | Cell Research2022，32，7： | 1 |
| 17 | Ctenopharyngodon idella IKKβ interacts with PKR and IκBα显示文摘原子因素 kappa-B kinase (IKK ) 的禁止者是 IKK 建筑群的一个子单元。它能响应大量刺激通过 phosphorylating IB 激活 NF-B 小径。在现在的学习,从草鲤鱼的 IKK 基因(Ctenopharyngodon idella;KT282114 ) 被相应克隆克隆并且识别并且 cDNA 结束(种族) 快速扩大技术。完全的 CiIKK cDNA 是在长度的 3428 bp,与编码 778 氨基酸的多肽的 2337 bp 的最长开的读物框架(ORF ) 。CiIKK 的推出的氨基酸顺序有类似的领域分发到那些哺乳动物。例如, CiIKK 在 N 终端由一个 serine/threonine kinase 领域组成,在中间的一个基本区域 leucin 拉链(BRLZ ) 领域, homeobox 联系了 leucin 拉链(HALZ ) 领域和 IKK NEMO (NF-B 必要调节的人) 在 C 终端的有约束力的领域。种系发生的树分析也证明 CiIKK 对 zebrafish IKK (DrIKK ) 并且清楚地高度相应从不同哺乳动物并且两栖动物对应物。CiIKK 的表示无所不在地在草鲤鱼并且显著地的肝,肠,肾,鳃,怒气,心,和大脑纸巾被发现在在刺激与下面的 CIK 房间起来调整 Poly 我: C 和使紫外失去活性草鲤鱼出血性的病毒。在小径在鱼和 CiIKK 的角色调查 NF-B 小径的激活机制,我们在试金下面由 co-immunoprecipitation 和 GST 拉与 IB 与 IKK 和 IKK 探索了蛋白质 kinase R (PKR ) 的蛋白质相互作用。在每对之间的相互作用被证实。结果建议 CiIKK 可以是在在鱼的 NF-B 小径的激活的一个主要成员。 | Haizhou Wang Qun Xu Xiaowen Xu Yousheng Hu Qunhao Hou Youlin Zhu Chengyu Hu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 1 |
| 18 | Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury显示文摘Spinal cord injury(SCI)is a severe disease of the nervous system that causes irreparable damage and loss of function,for which no effective treatments are available to date.Engineered extracellular vesicles(EVs)carrying therapeutic molecules hold promise as an alternative SCI therapy depending on the specific functionalized EVs and the appropriate engineering strategy.In this study,we demonstrated the design of a drug delivery system of peptide CAQK-modified,siRNA-loaded EVs(C-EVs-siRNA)for SCI-targeted therapy.The peptide CAQK was anchored through a chemical modification to the membranes of EVs isolated from induced neural stem cells(iNSCs).CCL2-siRNA was then loaded into the EVs through electroporation.The modified EVs still maintained the basic properties of EVs and showed favorable targeting and therapeutic effects in vitro and in vivo.C-EVs-siRNA specifically delivered siRNA to the SCI region and was taken up by target cells.C-EVs-siRNA used the inherent anti-inflammatory and neuroreparative functions of iNSCs-derived EVs in synergy with the loaded siRNA,thus enhancing the therapeutic effect against SCI.The combination of targeted modified EVs and siRNA effectively regulated the microenvironmental disturbance after SCI,promoted the transformation of microglia/macrophages from M1 to M2 and limited the negative effects of the inflammatory response and neuronal injury on functional recovery in mice after SCI.Thus,engineered EVs are a potentially feasible and efficacious treatment for SCI,and may also be used to develop targeted treatments for other diseases. | Yuluo Rong Zhuanghui Wang Pengyu Tang Jiaxing Wang Chengyue Ji Jie Chang Yufeng Zhu Wu Ye Jianling Bai Wei Liu Guoyong Yin Lipeng Yu Xuhui Zhou Weihua Cai | 2023 | Bioactive Materials2023，，5： | 1 |
| 19 | Enantiomeric characterization and structure elucidation of Otamixaban显示文摘Otamixaban is a potent(Ki=0.5 nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibrational circular dichroism(VCD) spectroscopy. Selected by a spectrum similarity index, the calculated spectra of several higher energy conformers were found to match well with the observed spectra. The characteristic IR bands of these conformers were also identified and attributed to the solvation effect.Combined with both the single crystal x-ray diffraction results for an intermediate and the proton NMR study, the absolute configuration of Otamixaban is unambiguously determined to be(R,R). | Jian Shen Jiping Yang Winfried Heyse Harald Schweitzer Norbert Nagel Doris Andert Chengyue Zhu Vincent Morrison Gregory A.Nemeth Teng-Man Chen Zhicheng Zhao Timothy A.Ayers Yong-Mi Choi | 2014 | Journal of Pharmaceutical Analysis2014，4，3： | 1 |
| 20 | Spatial beam shaping for high-power frequency tripling lasers based on a liquid crystal spatial light modulator显示文摘 | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Can Cui Yi Chen Du Pengyuan Dexin Ba Zhenxing Zheng Hang Yuan Lei Shi Zhenxu Bai Zhaohong Liu Chengyu Zhu Yongkang Dong Luoxian Zhou | 2016 | Optics Communications2016，，： | 1 |
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