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| 1 | A PP2C-1 Allele Underlying a Quantitative Trait Locus Enhances Soybean l O0-Seed Weight显示文摘栽培大豆可以在驯服期间失去某有用基因 loci。从野大豆的基因的基因渗入能拓宽基因背景并且改进大豆农学的特点。在这研究,通过 recombinant 的整个染色体的定序,生来的线人口源于在野大豆 ZYD7 和栽培大豆 HN44 之间的一个十字,并且为种子重量量的特点 loci 印射,我们发现从野大豆 ZYD7 的磷酸酶 2C-1 ( PP2C-1 )等位基因在种子重量/尺寸贡献增加。PP2C-1 可以由提高覆盖物的房间尺寸并且激活一个子集完成这功能播种特点相关的基因。我们发现 PP2C-1 与 GmBZR1 被联系, Arabidopsis BZR1 的大豆 ortholog,之一在发信号的 brassinosteroid (BR ) 给抄写因素调音,并且便于 dephosphorylated GmBZR1 的累积。相反,有在 N 终点的一些氨基酸的变化的 PP2C-2 等位基因没展出这功能。而且,我们证明 GmBZR1 能在转基因的植物支持种子重量 / 尺寸。通过栽培大豆就职的分析,我们发现 40% 检验就职没有 PP2C-1 等位基因,建议这些就职能被这等位基因的介绍改进。一起拿,我们的学习识别精英等位基因 PP2C-1,它能在由分子帮助繁殖的这等位基因的那操作可以增加的大豆,和针尖提高种子重量或尺寸在大豆的生产和另外的荚 / 庄稼。 | Xiang Lu Qing Xiong Tong Cheng Qing-Tian Li Xin-Lei Liu Ying-Dong Bi Wei Li Wan-Ke Zhang Biao Ma Yong-Cai Lai Wei-Guang Du Wei-Qun Man Shou-Yi Chen Jin-Song Zhang | 2017 | Molecular Plant2017，10，5： | 17 |
| 2 | An R2R3-type transcription factor gene AtMYB59 regulates root growth and cell cycle progression in Arabidopsis显示文摘MYB 蛋白质在真核细胞的有机体起重要作用。在植物, R1R2R3 类型 MYB 蛋白质在房间周期控制工作。然而, R2R3 类型 MYB 蛋白质是否也涉及房间部门过程,仍然保持未知。这里,我们报导那 R2R3 类型抄写因素基因, AtMYB59,涉及房间周期前进和根生长的规定。AtMYB59 蛋白质在洋葱的原子核是局部性的表皮的房间并且 transactivation 活动。在酵母房间的 AtMYB59 的表示压制房间增长,和 transformants 与更长的房间有更多的原子核和更高的 aneuploid DNA 内容。在 AtMYB59 的保存领域的变化在酵母细胞生长上废除它的效果。在同步 Arabidopsis 房间暂停, AtMYB59 基因明确地在房间周期前进期间在 S 阶段被表示。表示和 promoter-GUS 分析表明 AtMYB59 基因富有地在根被表示。转基因的植物 overexpressing AtMYB59 更短的根与野类型的植物(Arabidopsis 就职 Col-0 ) 相比,并且在在根尖端的有丝分裂的房间的一半附近在中期。相反地,空变异的 myb59-1 比关口在中期让更长的根和更少有丝分裂的房间,建议那 AtMYB59 可以由扩大有丝分裂的房间的中期禁止根生长。AtMYB59 调整许多下游的基因,包括 CYCB1; 1 基因,可能通过到 MYB 应答的元素的绑定。这些结果在细胞周期规定和植物根生长为 AtMYB59 支持一个角色。 | Rui-Ling Mu Yang-Rong Cao Yun-Feng Liu Gang Lei Hong-Feng Zou Yong Liao Hui-Wen Wang Wan-Ke Zhang Biao Ma Ji-Zhou Du Ming Yuan Jin-Song Zhang Shou-Yi Chen | 2009 | Cell Research2009，19，11： | 16 |
| 3 | Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease显示文摘Genistein is effective against amyloid-β toxicity,but the underlying mechanisms are unclear.We hypothesized that genistein may protect neurons by inhibiting the mitochondrial apoptotic pathway,and thereby play a role in the prevention of Alzheimer's disease.A rat model of Alzheimer's disease was established by intraperitoneal injection of D-galactose and intracerebral injection of amyloid-β peptide(25–35).In the genistein treatment groups,a 7-day pretreatment with genistein(10,30,90 mg/kg) was given prior to establishing Alzheimer's disease model,for 49 consecutive days.Terminal deoxyribonucleotidyl transferase-mediated d UTP nick end labeling assay demonstrated a reduction in apoptosis in the hippocampus of rats treated with genistein.Western blot analysis showed that expression levels of capase-3,Bax and cytochrome c were decreased compared with the model group.Furthermore,immunohistochemical staining revealed reductions in cytochrome c and Bax immunoreactivity in these rats.Morris water maze revealed a substantial shortening of escape latency by genistein in Alzheimer's disease rats.These findings suggest that genistein decreases neuronal loss in the hippocampus,and improves learning and memory ability.The neuroprotective effects of genistein are associated with the inhibition of the mitochondrial apoptotic pathway,as shown by its ability to reduce levels of caspase-3,Bax and cytochrome c. | Yan Wang Biao Cai Jing Sha Ting-ting Wang Run-ze Cai Chang-ju Ma Tao Han Jun Du | 2016 | Neural Regeneration Research2016，11，7： | 12 |
| 4 | Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the trace显示文摘二十年后来过去了第一细菌的整个染色体的定序,它为微生物引起的染色体提供新机会。因而,可观的基因差异由细菌的染色体编码了,在在一样的种类之中,种类被揭示了。在最近的年里,染色体定序技术和生物信息学很快发展了,它导致了转变并且为在传染疾病流行病的解剖使用的细菌的染色体比较帮助了策略和方法论的应用程序。细菌的整个染色体的定序并且生物信息的计算允许 genotyping 在疾病控制满足流行病学的学习的要求。在这评论,我们构画出意义并且总结细菌的染色体在细菌的疾病控制和预防的上下文定序的角色。我们讨论细菌的染色体在爆发察觉,跟踪的来源,传播模式发现,和新流行克隆定序的应用程序鉴定。染色体在传染疾病监视网络定序并且数据分享的宽应用程序将更加支持爆发察觉和早警告阻止细菌的疾病的传播。 | Biao Kan Haijian Zhou Pengcheng Du Wen Zhang Xin Lu Tian Qin Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 11 |
| 5 | Methodology development and application of X-ray imaging beamline at SSRF显示文摘This paper introduces some latest developments regarding the X-ray imaging methodology and applications of the X-ray imaging and biomedical application beamline(BL13W1)at Shanghai Synchrotron Radiation Facility in the past 5 years.The photon energy range of the beamline is 8–72.5 keV.Several sets of X-ray imaging detectors with different pixel sizes(0.19–24 lm)are used to realize X-ray microcomputed tomography(X-ray micro-CT)and X-ray in-line phase-contrast imaging.To satisfy the requirements of user experiments,new X-ray imaging methods and image processing techniques are developed.In vivo dynamic micro-CT experiments with living insects are performed in 0.5 s(sampling rate of 2 Hz,2 tomograms/s)with a monochromatic beam from a wiggler source and in 40 ms(sampling rate of 25 Hz,25 tomograms/s)with a white beam from a bending magnet source.A new X-ray imaging method known as move contrast X-ray imaging is proposed,with which blood flow and moving tissues in raw images can be distinguished according to their moving frequencies in the time domain.Furthermore,X-ray speckle-tracking imaging with twice exposures to eliminate the edge enhancement effect is developed.A high-precision quantification method is realized to measure complex three-dimensional blood vessels obtained via X-ray micro-CT.X-ray imaging methods such as three-dimensional X-ray diffraction microscopy,small-angle X-ray scattering CT,and X-ray fluorescence CT are developed,in which the X-ray micro-CT imaging method is combined with other contrast mechanisms such as diffraction,scattering,and fluorescence contrasts respectively.Moreover,an X-ray nano-CT experiment is performed with a 100 nm spatial resolution.Typical user experimental results from the fields of material science,biomedicine,paleontology,physics,chemistry,and environmental science obtained on the beamline are provided. | Hong-Lan Xie Biao Deng Guo-Hao Du Ya-Nan Fu Han Guo Yan-Ling Xue Guan-Yun Peng Fen Tao Ling Zhang Ti-Qiao Xiao | 2020 | Nuclear Science and Techniques2020，31，10： | 7 |
| 6 | Research Status and Progress on Modification of Dietary Fiber at Home and Abroad显示文摘Studies have shown that modified dietary fiber has better physical and chemical properties and functions,and can better play its physiological effects.This paper systematically and comprehensively expounded the application progress of chemical separation method,microbial fermentation method,physical method,enzyme method and steam explosion method in dietary fiber modification,and expounded the development prospect of modified dietary fiber,so as to provide reference for further study on development and application of dietary fiber. | Xiaoran DUAN Suyan GAO Shoumin JIA Litian ZHANG Ruihuan DU Aili XIANG Biao QI Lei WANG | 2019 | Agricultural Biotechnology2019，8，4： | 5 |
| 7 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 8 | Comparison of Space Glucose Control and Routine Glucose Management Protocol for Glycemic Control in Critically Ⅲ Patients: A Prospective, Randomized Clinical Study显示文摘 | Biao Xu Wei Jiang Chun-Yao Wang Li Weng Xiao-Yun Hu Jin-Min Peng Bin Du | 2017 | Chinese Medical Journal2017，，17： | 4 |
| 9 | Novel hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites for dramatically enhanced electromagnetic absorbing properties显示文摘In order to prevent the microwave leakage and mutual interference,more and more microwave absorbing devices are added into the design of electronic products to ensure its routine operation.In this work,we have successfully prepared MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) hierarchical composites by one-pot hydrothermal method and focused on the relationship between structures and electromagnetic absorbing properties.Supported by comprehensive characterizations,M0S_(2) nanosheets were proved to be anchored on the surface and interlayer of Ti_(3)C_(2)T_(x) through a hydrothermal process.Additionally,TiO_(2) nanoparticles were obtained in situ.Due to these hierarchical structures,the MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites showed greatly enhanced microwave absorbing performance.The MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites exhibit a maximum reflection loss value of -33.5 dB at 10.24 GHz and the effective absorption bandwidth covers 3.1GHz(13.9-17 GHz)at the thickness of 1.0 mm,implying the features of wide frequency and light weight.This work in the hierarchical structure of MoS_(2)/TiO_(2)/Ti_(3)C_(2)T_(x) composites opens a promising door to the exploration of constructing extraordinary electromagnetic wave absorbents. | Heng DU Qipeng ZHANG Biao ZHAO Frank MARKEN Qiancheng GAO Hongxia LU Li GUAN Hailong WANG Gang SHAO Hongliang XU Rui ZHANG Bingbing FAN | 2021 | Journal of Advanced Ceramics2021，10，5： | 4 |
| 10 | Facile synthesis of zinc-based organic framework for aqueous Hg (Ⅱ) removal: Adsorption performance and mechanism显示文摘Mercury(Hg)ions can lead to a serious impact on the environment;therefore,it was necessary to find an effective method for absorbing these toxic Hg ions.Here,the adsorbent(Zn-AHMT)was synthesized from zinc nitrate and 4-amino 3-hydrazine-5 mercapto-1,2,4-triazole(AHMT)by one-step method and,characterized the microstruc-ture and absorption performance by fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Brunauer-Emmett Teller(BET),Thermal Gravimetric Analyzer(TGA)and X-ray photoelectron spectroscopy(XPS).Through a plethora of measurements,we found that the maximum adsorption capacity was 802.8 mg/g when the optimal pH of Zn-AHMT was 3.0.The isothermal and kinetic experiments confirm that the reaction process of Zn-AHMT was chemisorption,while the adsorption process conforms to the Hill model and pseudo second order kinetic model.Thermodynamic experiments showed that the adsorption process was spontaneous and exothermic.Selective experiments were performed in the simulated wastewater containing Mn,Mg,Cr,Al,Co,Ni,Hg ions.Our results showed that the Zn-AHMT has a stronger affinity for Hg ions.The removal rate of Zn-AHMT remained above 98%,indicating that the Zn-AHMT had a good stability validated by three adsorption-desorption repeatable tests.According to the XPS results,the adsorption reaction of Zn-AHMT was mainly attributed to the chelation and ion exchange.This was further explained by both density functional theory(DFT)calculation and frontier molecular orbital theory.We therefore propose the adsorption mechanism of Zn-AHMT.The adsorption reaction facilitates via the synergistic action of S and N atoms.Moreover,the bonding between the adsorbent and the N atom has been proved to be more stable.Our study demonstrated that Zn-AHMT had a promising application prospect in mercury removal. | Biao Zeng Wei Wang Sijin He Guo Lin Wenjia Du Jun Chang Zhao Ding | 2021 | Nano Materials Science2021，3，4： | 3 |
| 11 | Self-Healing Liquid Metal Magnetic Hydrogels for Smart Feedback Sensors and High-Performance Electromagnetic Shielding显示文摘Hydrogels exhibit potential applications in smart wearable devices because of their exceptional sensitivity to various external stimuli.However,their applications are limited by challenges in terms of issues in biocompatibility,custom shape,and self-healing.Herein,a conductive,stretchable,adaptable,self-healing,and biocompatible liquid metal GaInSn/Ni-based composite hydrogel is developed by incorporating a magnetic liquid metal into the hydrogel framework through crosslinking polyvinyl alcohol(PVA)with sodium tetraborate.The excellent stretchability and fast self-healing capability of the PVA/liquid metal hydrogel are derived from its abundant hydrogen binding sites and liquid metal fusion.Significantly,owing to the magnetic constituent,the PVA/liquid metal hydrogel can be guided remotely using an external magnetic field to a specific position to repair the broken wires with no need for manual operation.The composite hydrogel also exhibits sensitive deformation responses and can be used as a strain sensor to monitor various body motions.Additionally,the multifunctional hydrogel displays absorption-dominated electromagnetic interference(EMI)shielding properties.The total shielding performance of the composite hydrogel increases to~62.5 dB from~31.8 dB of the pure PVA hydrogel at the thickness of 3.0 mm.The proposed bioinspired multifunctional magnetic hydrogel demonstrates substantial application potential in the field of intelligent wearable devices. | Biao Zhao Zhongyi Bai Hualiang Lv Zhikai Yan Yiqian Du Xiaoqin Guo Jincang Zhang Limin Wu Jiushuai Deng David Wei Zhang Renchao Che | 2023 | Nano-Micro Letters2023，15，6： | 3 |
| 12 | Cholera Caused by a New Clone of Serogroup O1 Vibrio cholerae-Beijing Municipality,China,June 2021显示文摘Several lineages have been identified in the population of serogroup O1 Vibrio cholerae(V.cholerae)(1-3).The strains,which were responsible for the ongoing seventh cholera pandemic,were in Lineage 2.Nearly all the V.cholerae strains in this lineage carried genes coding cholera toxin(ctxAB)(1-2).Lineage 3b consists of strains isolated from different continents and the vast majority of strains in this lineage lack the ctxAB genes. | Hanqiu Yan Bo Pang Xin Lu Zhiyong Gao Pan Lu Xin Zhang Mengyu Wang Lingyu Shen Wenxuan Zhao Jianhong Zhao Weili Liang Lei Jia Haijian Zhou Zhigang Cui Xiaoli Du Biao Kan Quanyi Wang | 2022 | China CDC weekly2022，4，2： | 3 |
| 13 | Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP显示文摘 | Juyi Gao Jianli Tao Weili Liang Meng Zhao Xiaoxia Du Shan Cui Haifeng Duan Biao Kan Xiaodong Su Zhengfan Jiang | 2015 | Cell Research2015，25，5： | 2 |
| 14 | Structure-dependent electromagnetic wave absorbing properties of bowl-like and honeycomb TiO_(2)/CNT composites显示文摘Materials that can efficiently absorb electromagnetic waves(EMWs)are required to deal with electromagnetic pollution.Structure design appears to be an efficient way to improve the EMW-absorption performance of such materials,particularly when adjustment of the constitution or mixing ratio is limited.In this study,bowl-like and honeycomb titanium dioxide/carbon nanotube(TiO_(2)/CNT)composites with different CNT contents were fabricated using the methods of hierarchical and mixing vacuum-assisted filtration,respectively.Compared to the honeycomb structure,the bowl-like structure simultaneously facilitated greater interfacial polarization and conduction loss in favor of dielectric polarization,and augmented multiple reflections.The high porosity of the honeycomb structure was conducive to optimizing the impedance matching characteristics.The bowl-like TiO_(2)/CNT composite exhibited a minimum reflection loss(RL_(min))of-38.6 dB(1.5 mm)with a wide effective absorption band(EAB;<-10 dB)of4.2 GHz,while the honeycomb TiO_(2)/CNT composite showed an RLminof-34.8 dB(2.1 mm)with an EAB of 4.3 GHz.The required mixing ratio in the matrix was only 15 wt%,outperforming that of the most closely related composites.Thus,both the bowl-like and honeycomb TiO_(2)/CNT composites are ideal candidates for light-weight and highly efficient EMW-absorbing materials. | Hua Jian Qinrui Du Qiaoqiao Men Li Guan Ruosong Li Bingbing Fan Xin Zhang Xiaoqin Guo Biao Zhao Rui Zhang | 2022 | Journal of Materials Science & Technology2022，，14： | 2 |
| 15 | X-ray fluorescence microtomography based on polycapillary- focused X-rays from laboratory source显示文摘X-ray fluorescence microtomography(μXFCT)is a nondestructive analytical technique and has been widely used to nondestructively detect and quantify the elemental composition and distributions in samples. Usually, synchrotron radiation X-rays are used for μXFCT, due to its high flux density. In this paper, a laboratory-sourcebased μXFCT system was developed, in which a polycapillary lens is employed to focus the X-ray beam and improve the flux density. The maximum likelihood expectation maximization algorithm was used to reconstruct the computed tomography slices at a limited number of projections. The experimental results demonstrated that the developed system could reveal the elemental distribution inside the test sample, with an elemental sensitivity of 1000 ppm. | Bing-Gang Feng Fen Tao Yi-Ming Yang Tao Hu Fei-Xiang Wang Guo-Hao Du Yan-Ling Xue Ya-Jun Tong Tian-Xi Sun Biao Deng Ti-Qiao Xiao | 2018 | Nuclear Science and Techniques2018，29，6： | 2 |
| 16 | CircTUBD1 Regulates Radiation-induced Liver Fibrosis Response via a circTUBD1/micro-203a-3p/Smad3 Positive Feedback Loop显示文摘Background and Aims: Radiation-induced liver fibrosis (RILF), delayed damage to the liver (post-irradiation) re-mains a major challenge for the radiotherapy of liver ma-lignancies. This study investigated the potential function and mechanism of circTUBD1 in the development of RILF. Methods: By using a dual luciferase assay, RNA pull- down assays, RNA sequencing, chromatin immunoprecipi-tation (known as ChIP) assays, and a series of gain- or loss-of-function experiments, it was found that circTUBD1 regulated the activation and fibrosis response of LX-2 cells induced by irradiation via a circTUBD1/micro-203a-3p/ Smad3 positive feedback loop in a 3D system. Results: Knockdown of circTUBD1 not only reduced the expression of α-SMA, as a marker of LX-2 cell activation, but also significantly decreased the levels of hepatic fibrosis mol-ecules, collagen type I alpha 1 (COL1A1), collagen type III alpha 1 (COL3A1), and connective tissue growth factor (CTGF) in a three-dimensional (3D) culture system and RILF model in vivo. Notably, knockdown of circTUBD1 al-leviated early liver fibrosis induced by irradiation in mice models. Conclusions: This study is the first to reveal the mechanism and role of circTUBD1 in RILF via a circTUBD1/ micro-203a-3p/Smad3 feedback loop, which provides a novel therapeutic strategy for relieving the progression of RILF. | Hao Niu Li Zhang Biao Wang Guang-Cong Zhang Juan Liu Zhi-Feng Wu Shi-Suo Du Zhao-Chong Zeng | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 2 |
| 17 | Chinese Pathogen Identification Net:A Laboratory Network for Surveillance and Response of Bacterial Infectious Diseases显示文摘Infectious diseases are a sustained threat to social development and public health.Bacterial infectious diseases,including plague,cholera,anthrax,brucellosis,typhoid fever,meningitis,and even those caused by antimicrobial-resistant bacteria,have been prevalent around the world for a long time,and still trigger outbreaks and long-term epidemics in different countries or regions nowadays(1),and trans-regional spread of diseases has frequently exhibited epidemic patterns. | Zhigang Cui Haijian Zhou Shuang Meng Xiaoli Du Jianguo Xu Biao Kan | 2022 | China CDC weekly2022，4，12： | 2 |
| 18 | Compare the epidemiological and clinical features of imported and local COVID-19 cases in Hainan, China显示文摘Background:Effective management of imported cases is an important part of epidemic prevention and control.Hainan Province,China reported 168 coronavirus disease 2019(COVID-19),including 112 imported cases on February 19,2020,but successfully contained the epidemic within 1 month.We described the epidemiological and clinical characteristics of COVID-19 in Hainan and compared these features between imported and local cases to provide information for other international epidemic areas.Methods:We included 91 patients(56 imported and 35 local cases)from two designated hospitals for COVID-19 in Haikou,China,from January 20 to February 19,2020.Data on the demographic,epidemiological,clinical and laboratory characteristics were extracted from medical records.Patients were followed until April 21,2020,and the levels of antibodies at the follow-ups were also analysed by the Wilcoxon matched-pairs signed ranks test.Results:Of the 91 patients,78(85.7%)patients were diagnosed within the first three weeks after the first case was identified(Day 1:Jan 22,2020),while the number of local cases started to increase during the third week No new cases occurred after Day 29.Fever and cough were two main clinical manifestations.In total,15(16.5%)patients were severe,14(15.4%)had complicated infections,nine(9.9%)were admitted to the intensive care unit,and three died.The median duration of viral shedding in feces was longer than that in nasopharyngeal swabs(19 days vs 16 days,P=0.007).Compared with local cases,imported cases were older and had a higher incidence of fever and concurrent infections.There was no difference in outcomes between the two groups.IgG was positive in 92.8%patients(77/83)in the follow-up at week 2 after discharge,while 88.4%patients(38/43)had a reduction in IgG levels in the follow-up at week 4 after discharge,and the median level was lower than that in the follow-up at week 2(10.95 S/Cut Off(S/CO)vs 15.02 S/CO,P<0.001).Conclusion:Imported cases were more severe than local cases but had similar prognoses.The level of IgG antibodies declined from week 6 to week 8 after onset.The short epidemic period in Hainan suggests that the epidemic could be quickly brought under control if proper timely measures were taken. | Biao Wu Zi-Ying Lei Kun-Liang Wu Jian-Rong He Hui-Juan Cao Juan Fu Feng Chen Yuan Chen Bao Chen Xiao-Li Zhou Tao Huang Tao Wu Yong-Guo Du Suo-Xian Chen Fu-Rong Xiao Zhi-Liang Gao Jing He Feng Lin Bing-Liang Lin | 2020 | Infectious Diseases of Poverty2020，9，5： | 2 |
| 19 | Calibrating the linearity between grayscale and element content for X-ray KES imaging of alloys显示文摘Doped elements in alloys significantly impact their performance.Conventional methods usually sputter the surface material of the sample,or their performance is limited to the surface of alloys owing to their poor penetration ability.The X-ray K-edge subtraction(KES)method exhibits great potential for the nondestructive in situ detection of element contents in alloys.However,the signal of doped elements usually deteriorates because of the strong absorption of the principal component and scattering of crystal grains.This in turn prevents the extensive application of X-ray KES imaging to alloys.In this study,methods were developed to calibrate the linearity between the grayscale of the KES image and element content.The methods were aimed at the sensitive analysis of elements in alloys.Furthermore,experiments with phantoms and alloys demonstrated that,after elaborate calibration,X-ray KES imaging is capable of nondestructive and sensitive analysis of doped elements in alloys. | Xiao-Lu Ju Biao Deng Ke Li Fu-Cheng Yu Hai-Peng Zhang Ming-Wei Xu Guo-Hao Du Hong-Lan Xie Bin Li Ti-Qiao Xiao | 2022 | Nuclear Science and Techniques2022，33，1： | 2 |
| 20 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
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