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| 1 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 2 | Personalized Recommendation Algorithm Based on Preference Features显示文摘A hybrid collaborative filtering algorithm based on the user preferences and item features is proposed. A thorough investigation of Collaborative Filtering(CF) techniques preceded the development of this algorithm. The proposed algorithm improved the user-item similarity approach by extracting the item feature and applying various item features' weight to the item to confirm different item features. User preferences for different item features were obtained by employing user evaluations of the items. It is expected that providing better recommendations according to preferences and features would improve the accuracy and efficiency of recommendations and also make it easier to deal with the data sparsity. In addition, it is expected that the potential semantics of the user evaluation model would be revealed. This would explain the recommendation results and increase accuracy. A portion of the MovieLens database was used to conduct a comparative experiment among the proposed algorithms,i.e., the collaborative filtering algorithm based on the item and the collaborative filtering algorithm based on the item feature. The Mean Absolute Error(MAE) was utilized to conduct performance testing. The experimental results show that employing the proposed personalized recommendation algorithm based on the preference-feature would significantly improve the accuracy of evaluation predictions compared to two previous approaches. | Liang Hu Guohang Song Zhenzhen Xie Kuo Zhao | 2014 | Tsinghua Science and Technology2014，19，3： | 8 |
| 3 | Photoluminescence and defect evolution of nano-ZnO thin films at low temperature annealing显示文摘Nano-ZnO thin films composed of nanoparticles with sizes of 10-16 nm on silicon substrates at low temperature were prepared by sol-gel method.By placing the nano-ZnO thin films at room temperature or annealing at 100°C in air for 10 h intermittently,within a total 70 h annealing time,the evolution of PL spectra of the nano-ZnO thin films were studied in detail.As the annealing time increases,the PL peaks shift from violet to blue and green bands.The PL peaks at violet and blue bands decrease with the annealing time,but the PL peaks at green band are opposite.The PL spectra are related to the defects in the nano-ZnO thin films.The PL peaks positioned at 430 nm are mainly related to defects of zinc interstatials(Zni),oxygen vacancies and(Vo);the ones at 420 nm to oxygen interstitials(Oi),Zinc vacancies(Vzn),Zni ;and the ones at 468 nm to Vzn,Zni,and charged oxygen interstatials(Vo+).The green luminescence is related to Oi,Vo and Zni.The evolutions of PL spectra and the defects are also related to the concentrations of Zn in the thin films,the thicknesses of the films and the annealing time.For the films with 0.5 M and 1.0 M Zn concentrations,after 20 h and 30 h annealing in air at 100°C,respectively,either placing them in air at room temperature or continuing anneal in air at 100°C,the PL spectra are stable.Under the low temperature annealing,Zni decreases with the annealing time,and Oi increases.Sufficient Oi favors to keep the nano-ZnO thin films stable.This result is important to nano-ZnO thin films as electron transport layers in inverted or tandem organic solar cells. | YANG AiLing YANG Yun ZHANG ZhenZhen BAO XiChang YANG RenQiang LI ShunPin SUN Liang | 2013 | Science China(Technological Sciences)2013，56，1： | 5 |
| 4 | A core-shell structured COYID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity显示文摘Although inoculation of COVID-19 vaccines has rolled out globally,there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries.Here,we report on the development of a highly efficacious mRNA vaccine,SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex(LPP)nanoparticles.SWOT 23 is easy to produce using a large-scale microfluidics-based apparatus.The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability,and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration.Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123,represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2,but also a panel of variants including D614G and N501Y variants.In addition,SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge.Taken together,SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. | Ren Yang Yao Deng Baoying Huang Lei Huang Ang Lin Yuhua Li Wenling Wang Jingjing Liu Shuaiyao Lu Zhenzhen Zhan Yufei Wang Ruhan A Wen Wang Peihua Niu Li Zhao Shiqiang Li Xiaopin Ma Luyao Zhang Yujian Zhang Weiguo Yao Xingjie Liang Jincun Zhao Zhongmin Liu Xiaozhong Peng Hangwen Li Wenjie Tan | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 3 |
| 5 | Effects of silver nanoparticles with different dosing regimens and exposure media on artificial ecosystem显示文摘Due to the wide use of silver nanoparticles(AgNPs) in various fields, it is crucial to explore the potential negative impacts on the aquatic environment of AgNPs entering into the environment in different ways. In this study, comparative experiments were conducted to investigate the toxicological impacts of polyvinylpyrrolidone-coated silver nanoparticles(PVP-AgNPs) with two kinds of dosing regimens, continuous and one-time pulsed dosing, in different exposure media(deionized water and XiangJiang River water). There were a number of quite different experimental results(including 100% mortality of zebrafish,decline in the activity of enzymes, and lowest number and length of adventitious roots) in the one-time pulsed dosing regimen at high PVP-AgNP concentration exposure(HOE)compared to the three other treatments. Meanwhile, we determined that the concentration of leached silver ions from PVP-AgNPs was too low to play a role in zebrafish death. Those results showed that HOE led to a range of dramatic ecosystem impacts which were more destructive than those of other treatments. Moreover, compared with the continuous dosing regimen, despite the fact that higher toxicity was observed for HOE, there was little difference in the removal of total silver from the aquatic environment for the different dosing regimens. No obvious differences in ecological impacts were observed between different water columns under low concentration exposure. Overall, this work highlighted the fact that the toxicity of Ag NPs was impacted by different dosing regimens in different exposure media, which may be helpful for assessments of ecological impacts on aquatic environments. | Jingwen Zeng Piao Xu Guiqiu Chen Guangming Zeng Anwei Chen Liang Hu Zhenzhen Huang Kai He Zhi Guo Weiwei Liu Jing Wu Jiangbo Shi | 2019 | Journal of Environmental Sciences2019，31，1： | 2 |
| 6 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 7 | Mannose selection system used for cucumber transformation显示文摘 | Zhengquan He Zhenzhen Duan Wei Liang | | 0，，： | 1 |
| 8 | Genome sequence of Gossypium anomalum facilitates interspecific introgression breeding显示文摘Crop wild relatives are an important reservoir of natural biodiversity. However, incorporating wild geneticdiversity into breeding programs is often hampered by reproductive barriers and a lack of accurate genomicinformation. We assembled a high-quality, accurately centromere-anchored genome of Gossypium anomalum, a stress-tolerant wild cotton species. We provided a strategy to discover and transfer agronomicallyvaluable genes from wild diploid species to tetraploid cotton cultivars. With a (Gossypium hirsutum 3 G.anomalum)2 hexaploid as a bridge parent, we developed a set of 74 diploid chromosome segment substitution lines (CSSLs) of the wild cotton species G. anomalum in the G. hirsutum background. This set of CSSLsincluded 70 homozygous substitutions and four heterozygous substitutions, and it collectively containedabout 72.22% of the G. anomalum genome. Twenty-four quantitative trait loci associated with plant height,yield, and fiber qualities were detected on 15 substitution segments. Integrating the reference genome withagronomic trait evaluation of the CSSLs enabled location and cloning of two G. anomalum genes thatencode peroxiredoxin and putative callose synthase 8, respectively, conferring drought tolerance andimproving fiber strength. We have demonstrated the power of a high-quality wild-species reference genomefor identifying agronomically valuable alleles to facilitate interspecific introgression breeding in crops. | Zhenzhen Xu Jiedan Chen Shan Meng Peng Xu Caijiao Zhai Fang Huang Qi Guo Liang Zhao Yonggang Quan Yixin Shangguan Zhuang Meng Tian Wen Ya Zhang Xianggui Zhang Jun Zhao Jianwen Xu Jianguang Liu Jin Gao Wanchao Ni Xianglong Chen Wei Ji Nanyi Wang Xiaoxi Lu Shihong Wang Kai Wang Tianzhen Zhang Xinlian Shen | 2022 | Plant Communications2022，3，5： | 1 |
| 9 | A Novel Metastable Ti-25Nb-2Mo-4Sn Alloy with High Strength and Low Young’s Modulus显示文摘 | Shun Guo Zhenzhen Bao Qingkun Meng Liang Hu Xinqing Zhao | 2012 | Metallurgical and Materials Transactions A2012，，10： | 1 |
| 10 | Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis显示文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention. | Fubing Li Huichun Liang Hua You Ji Xiao Houjun Xia Xi Chen Maobo Huang Zhuo Cheng Chuanyu Yang Wenjing Liu Hailin Zhang Li Zeng Yingying Wu Fei Ge Zhen Li Wenhui Zhou Yi Wen Zhongmei Zhou Rong Liu Dewei Jiang Ni Xie Bin Liang Zhenzhen Liu Yanjie Kong Ceshi Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 11 | Mannose selection system used for cucumber transformation显示文摘 | Zhengquan He ZhenZhen Duan Wei Liang Faju Chen Wei Yao Hongwei Liang Chaoyin Yue Zongxiu Sun Fan Chen Jianwu Dai | 2006 | Plant Cell Reports2006，，9： | 1 |
| 12 | The challenges of precision radiotherapy technology to the traditional theory of radiobiology显示文摘With the development of modern computing technology and medical physics,radiotherapy has made great progress.The theoretical basis of radiobiology seems to lag behind the clinical application of radiotherapy,which hampers the further improvement of treatment efficacy and the optimization of treatment modality.In this paper,some emerging challenges of precision radiotherapy technology to the traditional theory of radiobiology,such as radiosensitivity,dose-response curve and survival curve,linear-quadratic model,4Rs theory,as well as the interaction between cancer and microenvironment,radiation-induced second primary cancers(RISPC),will be discussed.The interplay between precision radiotherapy and traditional radiobiology theories will be addressed with the aim to potentially solve some of the challenging problems. | Ma Shumei Liang Zhenzhen Chen Qiao Liu Rui Guo Yutian Liu Xiaodong | 2019 | 中华放射医学与防护杂志2019，39，8： | 0 |
| 13 | Spectral Characteristics and Quantitative Analysis of Troxerutin-Cu^2+ Complex显示文摘[Objectives]This study aims to establish a simple,convenient,fast,low-cost,low-consumption and efficient method for quality control of troxerutin.[Methods]In NaAc-phosphate buffer at pH=8,troxerutin could react with Cu^2+to form complex,which had a characteristic absorption peak at 408 nm in the ultraviolet spectrum.The content of troxerutin could be determined indirectly by measuring the absorbance of the complex.[Results]Within the linear range of 27.82-74.19μg/mL,the absorbance of the complex has a good linear relationship with the concentration of troxerutin.The regression equation is A=0.0119C-0.1384(r=0.9991),and the detection limit is 1.59μg/mL.This method used to determine the content of troxerutin in samples from different manufacturers,and the recovery is 100.9%-102.7%.[Conclusions]The ultraviolet spectrophotometry is used in this experiment to indirectly determine the content of troxerutin by measuring the absorbance of troxerutin-Cu^2+complex,and the results are accurate,reproducible and highly precise.This method can be used for quantitative analysis of troxerutin. | Yu LIN Liujun LIANG Wen LIU Zhenzhen PAN Fengfeng XIE | 2020 | Asian Agricultural Research2020，12，3： | 0 |
| 14 | GPGPU Cloud: A Paradigm for General Purpose Computing显示文摘The Kepler General Purpose GPU (GPGPU) architecture was developed to directly support GPU virtualization and make GPGPU cloud computing more broadly applicable by providing general purpose computing capability in the form of on-demand virtual resources. This paper describes a baseline GPGPU cloud system built on Kepler GPUs, for the purpose of exploring hardware potential while improving task performance. This paper elaborates a general scheme which defines the whole cloud system into a cloud layer, a server layer, and a GPGPU layer. This paper also illustrates the hardware features, task features, scheduling mechanism, and execution mechanism of each layer. Thus, this paper provides a better understanding of general-purpose computing on a GPGPU cloud. | Liang Hu Xilong Che Zhenzhen Xie | 2013 | Tsinghua Science and Technology2013，18，1： | 0 |
| 15 | Single-cell landscape analysis reveals distinct regression trajectories and novel prognostic biomarkers in primary neuroblastoma显示文摘Neuroblastoma(NB),which is the most common pediatric extracranial solid tumor,varies widely in its clinical presentation and outcome.NB has a unique ability to spontaneously differentiate and regress,suggesting a potential direction for therapeutic intervention.However,the underlying mechanisms of regression remain largely unknown,and more reliable prognostic biomarkers are needed for predicting trajectories for NB.We performed scRNAseq analysis on 17 NB clinical samples and three peritumoral adrenal tissues.Primary NB displayed varied cell constitution,even among tumors of the same pathological subtype.Copy number variation patterns suggested that neuroendocrine cells represent the malignant cell type.Based on the differential expression of sets of related marker genes,a subgroup of neuroendocrine cells was identified and projected to differentiate into a subcluster of benign fibroblasts with highly expressed CCL2 and ZFP36,supporting a progressive pathway of spontaneous NB regression.We also identified prognostic markers(STMN2,TUBA1A,PAGE5,and ETV1)by evaluating intra-tumoral heterogeneity.Lastly,we determined that ITGB1 in M2-like macrophages was associated with favorable prognosis and may serve as a potential diagnostic marker and therapeutic target.In conclusion,our findings reveal novel mechanisms underlying regression and potential prognostic markers and therapeutic targets of NB. | Qingqing Liu Zhenni Wang Yan Jiang Fengling Shao Yue Ma Mingzhao Zhu Qing Luo Yang Bi Lijian Cao Liang Peng Jianwu Zhou Zhenzhen Zhao Xiaobin Deng Tong-Chuan He Shan Wang | 2022 | Genes & Diseases2022，9，6： | 0 |
| 16 | Amyloidβneurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor显示文摘Dear Editor,Alzheimer’s disease(AD),the most common neurodegenerative disorder and a leading cause of dementia is characterized by progressive memory deficits,cognitive impairment and personality changes.The accumulation of extracellular amyloid beta(Aβ)plaques consisted by Aβpeptide and intracellular neurofibrillary tangles(NFTs)composed by misfolded hyperphosphorylated tau are main pathological hallmarks of AD,which ultimately lead to the dysfunction and loss of synapses and the eventual death of neuron.Neuroinflammation plays a causal role in AD pathogenesis.While the mechanism underlying neuroinflammationinduced AD pathology has not been fully elucidated,increasing evidence proposed that the kynurenine pathway(KP),a major route for L-tryptophan(L-Trp)catabolism,plays an important role. | Zhenzhen Duan Shengnan Zhang Heng Liang Zikang Xing Leilei Guo Lei Shi Lisha Du Chunxiang Kuang Osamu Takikawa Qing Yang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 17 | Exploration of Experimental Teaching of Analysis of Traditional Chinese Medicine Based on'Five-in-One'Practice Teaching System显示文摘Analysis of Traditional Chinese Medicine is a compulsory comprehensive professional course for Chinese pharmacy major,and it is the necessary knowledge for modern Chinese pharmacy talents.In this paper,the experimental teaching of Analysis of Traditional Chinese Medicine under the'five-in-one'practice teaching mode of Guangxi University of Chinese Medicine was explored to provide reference for the experimental teaching of the course Analysis of Traditional Chinese Medicine. | Zhiying WEI Shenggao YIN Jie LIANG Chengsheng LU Fangchan LI Zhenzhen PAN Kuikui CHEN Xiaojiao PAN | 2021 | Medicinal Plant2021，12，4： | 0 |
| 18 | Degradation kinetics of larotaxel and identification of its degradation products in alkaline condition显示文摘Larotaxel, a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors. In this research, a selective LC–MS method was developed and validated for the study of degradation kinetics of larotaxel, which was carried out in aqueous solutions with different pH(1.5, 3.0, 5.0, 6.5, 7.4, 9.0, 10 and 11.0) and temperature(0, 25, 37 and 45 °C). The linear range was 0.5–25 μg/mL, the intra-and inter-day precisions were less than 7.0%, and accuracy ranged from 97.4–104.5% for each analyte. The observed rate obtained by measuring the remaining intact larotaxel was shown to follow first-order kinetics. The activation energies for degradation were 126.7 and 87.01 k J/mol at pH 1.5 and 11, respectively. Although larotaxel was stable in pH 5, 6.5 and 7.4 buffers at 37 °C for 24 h during our study, increasing or decreasing the pH of the solutions would decrease its stabilities. Moreover, three main degradation products in alkaline condition were separated by HPLC and identified by Q–TOF–MS. The three degradation products were confirmed as 10-deacetyl larotaxel, 7, 8-cyclopropyl baccatin Ⅲ and 10-deacetyl-7, 8-cyclopropyl baccatin Ⅲ. | Xiaoming Liang Zhenzhen Liu Huiyan Shi Yuanyuan Zhang Shixiao Wang Kaishun Bi Xiaohui Chen | 2017 | Journal of Pharmaceutical Analysis2017，7，2： | 0 |
| 19 | A nanocomposite competent to overcome cascade drug resistance in ovarian cancer via mitochondria dysfunction and NO gas synergistic therapy显示文摘Ovarian cancer(OC)is one of the most common and recurring malignancies in gynecology.Patients with relapsed OC always develop'cascade drug resistance'(CDR)under repeated chemotherapy,leading to subsequent failure of chemotherapy.To overcome this challenge,amphiphiles(P1)carrying a nitric oxide(NO)donor(Isosorbide 5-mononitrate,ISMN)and high-density disulfide are synthesized for encapsulatingmitochondria-targeted tetravalent platinum prodrug(TPt)to construct a nanocomposite(INP@TPt).Mechanism studies indicated that INP@TPt significantly inhibited drug-resistant cells by increasing cellular uptake and mitochondrial accumulation of platinum,depleting glutathione,and preventing apoptosis escape through generating highly toxic peroxynitrite anion(ONOO−).To better replicate the microenvironmental and histological characteristics of the drug resistant primary tumor,an OC patient-derived tumor xenograft(PDXOC)model in BALB/c nude mice was established.INP@TPt showed the best therapeutic effects in the PDXOC model.The corresponding tumor tissues contained high ONOO−levels,which were attributed to the simultaneous release of O_(2)^(·−)and NO in tumor tissues.Taken together,INP@TPtbased systematic strategy showed considerable potential and satisfactory biocompatibility in overcoming platinum CDR,providing practical applications for ovarian therapy. | Min Zhong Peiqin Liang Zhenzhen Feng Xin Yang Guang Li Rui Sun Lijuan He Jinxiu Tan Yangpengcheng Xiao Zhiqiang Yu Muhua Yi Xuefeng Wang | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，6： | 0 |
| 20 | The proatherosclerotic function of indoleamine 2, 3- dioxygenase 1 in the developmental stage of atherosclerosis显示文摘The discrepancy of indoleamine 2,3-dioxygenase 1(IDO1)function in atherosclerosis has been noted.Compared to the protective effect of IDO1 against established atherogenesis,the role of IDO1 in the developmental process of atherosclerosis is still unclear.Here,the expression patterns and activities of IDO1 and its isoenzyme tryptophan 2,3-dioxygenase(TDO)in aortas and blood samples of patients with atherosclerosis were investigated.IDO1 and TDO were colocalized with CD3-positive lymphocytes and CD68-positive macrophages in atherosclerotic lesions.The expression and activity of IDO1 and TDO increased with the grade of the histological classification in early atherosclerosis(grade I,II),but the increase did not continue in advanced atherosclerosis(grade III).Treatment of THP-1 macrophages(THP-M)with oxidized low-density lipoprotein(oxLDL)induced the expression of IDO1 via the PI3K/Akt/NF-κB pathway,indicating the potential function of IDO1 in foam cells.Before and after treatment with oxLDL on THP-M,IFN-γ-induced IDO1 exhibited different degrees of promotion on foaming,inflammatory factor production and cell apoptosis.Finally,we found that the IDO1 inhibitor 1-methyl-tryptophan could elevate the high-density lipoprotein cholesterol level in serum and reduce the area of the aortic atherosclerotic lesions in high-fat diet-fed ApoE−/−mice.Our study indicated that IDO1 played a complicated and unfixed role in the entire process of atherogenesis,despite the atheroprotective role in established atherosclerosis.IDO1 also had proatherosclerotic functions in the developmental stages of atherosclerosis.Modulation of IDO1 could be a good method for alleviating atherosclerosis. | Heng Liang Mantian Chen Fangfei Qi Lei Shi Zhenzhen Duan Ruoyu Yang Jinchao He Bin Lou Yigang Li Qing Yang | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
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