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| 1 | Comparative pharmacokinetics of six major compounds in normal and insomnia rats after oral administration of Ziziphi Spinosae Semen aqueous extract显示文摘Ziziphi Spinosae Semen(ZSS),a traditional Chinese medicine,is used in clinics for the treatment of insomnia in China and other Asian countries.Herein,we described for the first time a comparative pharmacokinetics study of the six major compounds of ZSS in normal control(NC)and para-chlorophenylalanine(PCPA)-induced insomnia model(IM)rats that were orally administered the aqueous extract of ZSS.An ultra-high-performance liquid chromatography coupled with quadrupole orbitrap mass(UHPLC-Q-Orbitrap-MS)method was developed and validated for the simultaneous determination of coclaurine,magnoflorine,spinosin,6000-feruloylspinosin,jujuboside A(JuA),and jujuboside B(JuB)in ZSS in rat plasma.The established approach was successfully applied to a comparative pharmacokinetic study.The systemic exposures of spinosin and 6000-feruloylspinosin were decreased in the IM group compared to the NC group,while plasma clearance(CL)was significantly increased.The Tmax values of JuA and JuB in IM rats were significantly lower than those in NC rats.The T1/2 of JuA in the IM group was significantly accelerated.The pharmacokinetic parameters of coclaurine and magnoflorine were not evidently affected between the two groups.These results indicate that the pathological state of insomnia altered the plasma pharmacokinetics of spinosin,6000-feruloylspinosin,JuA,and JuB in the ZSS aqueous extract,providing an experimental basis for the role of ZSS in insomnia treatment.The comparative pharmacokinetics-based UHPLC-Q-Orbitrap-MS using full-scan mode can therefore provide a reliable and suitable means for the screening of potentially effective substances applied as quality markers of ZSS. | Chenhui Du Yan Yan Chenxi Shen Xiaofang Cui Xiangping Pei Xuemei Qin | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 14 |
| 2 | Energy Aware Spectrum Access in Cognitive Radio Networks with Imperfect Channel Sensing显示文摘Due to the problem of spectrum underutilization and energy inefficiency in wireless communications,the research on energy efficient Cognitive Radio Networks (CRNs) has received significant attention in both industry and academia.In this paper,we consider the problem of optimal spectrum selection and transmission parameters design with the objective of minimizing energy consumption in CRNs.Since the system state cannot be directly observed due to miss detections and estimation errors,we formulate the optimal spectrum access problem as a Partially Observable Markov Decision Process (POMDP).In particular,the proposed scheme selects the optimal spectrum,modulation and coding scheme,transmission power,and link layer frame size in each time slot according to the belief state,which captures all the history information of past actions and observations.The optimal policy can be acquired by solving POMDP problem with linear programming based algorithm.Simulation results show that significant energy savings can be achieved by the proposed scheme. | Wei Yifei Du Chenhui Feng Ruijun F. Richard Yu | 2012 | China Communications2012，9，9： | 2 |
| 3 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 4 | Epstein-Barr virus infection:the leading cause of multiple sclerosis显示文摘In a recent study published in Science,Bjornevik and colleagues demonstrated Epstein-Barr virus(EBV)infection is a trigger for multiple sclerosis(MS)in a longitudinal analysis of more than 10 million US military individuals who were on active duty.1 MS is an autoimmune disease that originates in the central nervous system characterized by inflammatory demyelinating lesions.There is no consensus on the etiology of MS.However,we all know that MS is a multifactorial disease which can be influenced by genetic and environmental factors.Genetic factors associated with MS risk are mainly major histocompatibility class Ⅱ(MHC Ⅱ)alleles(e.g.,HLA-DRB1^(*)15:01,the earliest identified and most dominant risk factor in MS)and MHC I alleles(e.g.,HLA-A^(*)02 and HLA B^(*)44,decreasing MS susceptibility). | Ruirui He Yanyun Du Chenhui Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 5 | Overcoming power efficiency limitation of white fluorescence light-emitting diodes via multilevel-hydrogen-bond matrix显示文摘High power efficiency and low efficiency roll-off at practical luminance are two requirements for new-generation energy-saving lighting technologies,which are still bottlenecks of thermally activated delayed fluorescence(TADF)white organic light-emitting diodes(WOLED),despite the advantages of TADF materials and devices in low cost and high sustainability.Herein,we developed a spiro phosphine oxide host named SSOXSPO,which can form multiple and multidirectional intermolecular hydrogen bonds(IHB).The resulted multilevel IHB network integrates long-range ordered and short-range disordered alignments for suppressing triplet-polaron quenching(TPQ)and triplet-triplet annihilation(TTA).Electronic characteristics of SSOXSPO matrix are further regulated,leading to the optimal exciton allocation through balancing energy and charge transfer.As consequence,using SSOXSPO as host,the single-emissive-layer TADF WOLEDs realized the record performance,including ultralow operation voltage as∼4.0 V,power efficiency beyond fluorescent tube(70.1 lm W−1)and negligible external quantum efficiency roll-off(3%)at 1000 nits for indoor lighting.This work demonstrates that multiple interplays supported by host matrixes in TADF WOLEDs can facilitate the synergistic effects of TADF emitters on 100%exciton utilization. | Ruiming Du Peng Ma Yi Man Yudong Pang Chunbo Duan Chunmiao Han Jing Zhang Chenhui Cao Ying Wei Xinfeng Shui Hui Xu | 2023 | Aggregate2023，4，6： | 0 |
| 6 | Tuning coordination environment of iron ions to ensure ultra-high pseudocapacitive capability in iron oxide显示文摘The mechanism governing the pseudocapacitive lithium storage behavior is one of the most critical unsolved issues in conversion-type anodes for lithium-ion batteries.In this work,we,for the first time,demonstrate that the pseudocapacitive capability of iron oxide-based anodes is closely associated with the electronic structures of iron ions.As proof of concept,the introduction of amorphization,nitrogen doping,oxygen vacancies reduces the coordination of iron ions and contributes significantly to the pseudocapacitive lithium storage capability of iron oxide,reaching up to 96%of the specific capacity at 1 mV·s^(−1).Due to the significantly modulated coordination environment,the 3d electrons of Fe(II)are delocalized with increased spin state and the energy band gap is narrowed,accompanied by an upshift of Fermi energy.The redox activity and carrier mobility of iron oxides are substantially increased,which substantially enhance the exchange current density and thereby improve the pseudocapacitive capability of iron oxide. | Wubin Du Chenhui Yan Mingxi Gao Jian Chen Panyu Gao Xuebin Yu Yinzhu Jiang Wenping Sun Yongfeng Liu Mingxia Gao Shibo Xi Hongge Pan | 2023 | Nano Research2023，16，5： | 0 |
| 7 | A ɑ-KA fluorescent probe for discrimination of blood cancer serum显示文摘a-Ketoglutaric acid(a-KA) is an important metabolic intermediate in tricarboxylic acid circle in our body.The mutations of isocitrate dehydrogenase-1(IDH1) and isocitrate dehydrogenase-2(IDH2), however,will lead to the transformation of a-KA into 2-hydroxyglutarate(2-HG), which is confirmed to closely related to actue myeloid leukemia(AML). Therefore it is of great significance to detect a-KA level changes in serum. In this paper, a fluorescent 'off-on' probe CH for a-KA was designed based on naphthalimide fluorophore by introducing a hydrazine group for a-KA recognition and a long alkyl amino chain to enhance PET efficiency and water solubility. Cetyltrimethyl ammonium bromide(CTAB) was added toform self-assembly micelles for accelerating the recognition process. CH shows a 28-fold fluorescence enhancement((I - I_0)/I_0 at 550 nm) over other biological species by optimizing the chemical recognition process of CH with a-KA. Significantly, CH was successfully applied for thefluorescence discrimination of all kinds of blood cancer serum samples. This work would provide a potential method that is quick and convenient for sensing a-KA and may promote fluorescence detection in clinical diagnosis. | Yao Kang Jiangli Fan Qiang Jin Chenhui Shi Jianjun Du Xiaojun Peng | 2017 | Chinese Chemical Letters2017，28，10： | 0 |
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