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| 1 | Measurement of liver volume and its clinical significance in cirrhotic portal hypertensive patients显示文摘 | Zhu JY Leng XS Dong N Qi GY Du RY | 1999 | World Journal of Gastroenterology1999，5，6： | 10 |
| 2 | Neuroprotective effects of INT-777 against Aβ1-42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice显示文摘OBJECTIVE To investigate the neuroprotective effects of TGR5 agonist INT-777 in the Aβ_(1-42)-treated mouse model of acute neurotoxicity.METHODS Cognitive impairment was induced by single intracerebroventricular injection of aggregated Aβ_(1-42)(410 pmol per mouse;5 μL)into the mouse brain in normal ICR mice.After3 d,INT-777(0.75,1.5 or 3.0 μg per mouse) was infused into the same site.Another 3 d later,the cognition function was evaluated by Morris water maze(MWM),novel objective recognition(NOR),and Y maze tests.Furthermore,the levels of TGR5,TNF-α,IL-1β,IL-6,NF-κB p65,Iba1,caspase 3,Bcl-2,Bax,PSD95,and synaptophysin in the hippocampus and frontal cortex were detected using Western blotting.Microglia activation in the hippocampal CA1,CA3 and DG regions and frontal cortex were detected by immunohistochemistry.TUNEL staining was used to detect the apoptotic cells.The number of spines in the hippocampal CA1,CA3 and DG regions and frontal cortex was detected by GolgiCox staining.RESULTS INT-777(1.5 or 3.0 μg per mouse) significantly ameliorated memory impairment in the Aβ_(1-42)-treated mice,evidenced by increased the time spent in the target quadrant(P<0.05),and the number of target crossings(P<0.05) in the MWM test,increased the discrimination index in the NOR test(P<0.05),and increased the number of correct choices(P<0.05,P<0.01) and decreased the latency(P<0.05) to enter the shock-free compartment in the Y-maze test.Importantly,this treatment reversed Aβ_(1-42)-induced TGR5 down-regulation(P<0.05,P<0.01),suppressed the increase of nuclear NF-κB p65(P<0.05,P<0.01) and mitigated neuroinflammation,evidenced by lower proinflammatory cytokines such as TNF-α(P<0.05),IL-1β(P<0.05),IL-6(P<0.05,P<0.01),and less Iba1-positive cells in the hippocampal CA1,CA3 and DG regions and frontal cortex(P<0.05,P<0.01) as well as the protein level of Iba1.INT-777(1.5 or3.0 μg per mouse) also pronouncedly suppressed apoptosis through the reduction of TUNEL-positive cells(P<0.05,P<0.01),decreased activation of caspase 3(P<0.05),increased ratio of Bcl-2/Bax(P<0.05,P<0.01),and ameliorated synaptic dysfunction via promoting dendritic spines generation(P<0.05,P<0.01) with the upregulation of PSD95(P<0.05) and synaptophysin proteins(P<0.05).CONCLUSION INT-777 has potent neuroprotective effects against Aβ_(1-42)-induced neurotoxicity,which suggests that the activation of TGR5 could be a novel and promising strategy for the treatment of AD. | WU Xian LYU Yang-ge DU Yi-feng CHEN Fang Miranda N REED HU Mei Vishnu SUPPIRAMANIAM TANG Su-su HONG Hao | 2018 | 中国药理学与毒理学杂志2018，32，9： | 6 |
| 3 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 4 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 5 | Sufficient Conditions of Robust Schur Stability for Uncertain 2-D Polynomials | XIAO Yang\+1\ \ DU Xi\|yu\+1\ \ Rolf Unbehauen\+2 1.Institute of Information Science, Northern Jiaotong University Beijing 100044, P.R.China 2. Institute of General and Theoretic Electronic\|Technique University of Erlangen\|Nürnberg Cauerstr.7, 910 | 1999 | Systems Science and Systems Engineering1999，9，3： | 4 |
| 6 | Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts 显示文摘 | Mookerjee I Unemofi E N DU X J | 2005 | Ann N Y Acad Sci2005，1041，： | 1 |
| 7 | The accumulation of P53 abnormalities is associated with progression of mucosa-associated lymphoid tissue lymphoma显示文摘 | Du M Peng H Singh N | 1995 | Blood1995，86，： | 1 |
| 8 | Simultaneous production and recovery of fumaric acid from immobilized Rhizopus oryzae with a rotary biofilm contactor and an adsorption column 显示文摘 | Cao N J Du J X Gong C S | 1996 | Applied and Environmental Microbiology1996，62，8： | 1 |
| 9 | Different patterns of N-acetylaspartate loss in subeortical ischemic vascular dementia and AD显示文摘 | Schuff N Capizzano AA Du AT | 2003 | Neurology2003，61，3： | 1 |
| 10 | Accurate error- rate performance analysis of OFDM on frequency-se- lective Nakagami-m fading channels显示文摘 | DU Z CHENG J L BEAULIEU N C | 2006 | IEEE Trans Commun2006，54，2： | 1 |
| 11 | The natural history of in- tracranial cavernous malformations显示文摘 | Gross BA Lin N Du R | 2011 | Neurosurg Focus2011，30，6： | 1 |
| 12 | Cu-Si1-xGex core shell nanowire arrays as three-dimensional electrodes for high-rate capability lithium-ion batteries 显示文摘 | WANG J Z DU N ZHANG H | 2012 | Jour- nal of Power Sources2012，208，： | 1 |
| 13 | Land cover changes and their biogeophysical effects on climate显示文摘 | Rezaul Mahmood Roger A. Pielke Kenneth G. Hubbard Dev Niyogi Paul A. Dirmeyer Clive McAlpine Andrew M. Carleton Robert Hale Samuel Gameda Adriana Beltrán‐Przekurat Bruce Baker Richard McNider David R. Legates Marshall Shepherd Jinyang Du Peter D. Blanken | 2014 | Int J Climatol2014，，4： | 1 |
| 14 | The protective effect of peony extract on a- cute myocardial infarction in rats显示文摘 | Mo X Zhao N Du X | 2011 | Phytomedicine2011，18，6： | 1 |
| 15 | Conditioning with purine analogs leads to good engraftment rates of immunodepleted grafts for aplastic anemia显示文摘 | Novitzky N Thomas V du Toit C | 2013 | Biol Blood Marrow Transplant2013，19，4： | 1 |
| 16 | Application of evo-lving Takagi-Sugeno fuzzy model to nonlinear system identification 显示文摘 | Du H P Zhang N | 2008 | Applied Soft Computing2008，8，1： | 1 |
| 17 | Lipase-eatalyzed biodiesel production from soybean oil deodorizer distillate with absorbent present in tert-butanol system显示文摘 | WANG L DU W LIU D LI L DAI N | 2006 | J Mol Catal B2006，43，14： | 1 |
| 18 | Molecular evidence for spread of two major methicillin-resistant staphylococcus aureus clones with a unique geographic distribution in Chinese hospitals 显示文摘 | Liu YD Wang H Du N | 2009 | Antinmicrob Agents Chemother2009，53，2： | 1 |
| 19 | 显示文摘 | Du D Wang J Smith J N | 2009 | Anal Chem2009，81，22： | 1 |
| 20 | The what, where, how and why of gene ontology-a primer for bioinformaticians 显示文摘 | DU PLEASSIS L SKUNCA N DESSIMOZ C | 2011 | Briefings in Bioinformatics2011，12，6： | 1 |
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