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| 1 | Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and Hep G2 hepatoma cells显示文摘AIM To investigate whether Dihydromyricetin(DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 expression.METHODS The correlation between Notch1 and Hes1(a Notch1 target molecule) expression in hepatoma samples was confirmed by q RT-PCR. In addition, MTT assays, flow cytometry and TUNEL analysis showed that DHM possessed strong anti-tumor properties, evidenced not only by reduced cell proliferation but also by enhanced apoptosis in QGY7701 and Hep G2 hepatocellular carcinoma(HCC) cells. The expressions of Notch1, Hes1, Bcl-2 and Bax were determined by Western blot.RESULTS Among the tested samples(n = 64), the expression levels of Notch1(75% of patients) and Hes1(79.7% of patients) m RNA in tumor tissues were higher than in the normal liver tissues. There was a negative correlation between the expression of Notch1 and the degree of differentiation and positively correlated with the Alpha Fetal Protein concentration. The viability of HCC cells treated with DHM was significantly inhibited in a dose and time-dependent manner. Apoptosis was induced in Hep G2 and QGY7701 cell lines following 24 h of DHM treatment. After treatment with DHM, the protein expression of Notch1 was downregulated, the apoptosis-related protein Bax was upregulated and Bcl2 was downregulated. Notch1 si RNA further enhanced the anti-tumor properties of DHM. CONCLUSION Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1. | Cai-Jie Lu Yi-Feng He Wei-Zhuang Yuan Li-Jun Xiang Jian Zhang Yan-Rui Liang Juan Duan Yun-He He Ming-Yi Li | 2017 | World Journal of Gastroenterology2017，23，34： | 19 |
| 2 | Designing solid-state interfaces on lithium-metal anodes: a review显示文摘Li-metal anodes are one of the most promising energy storage systems that can considerably exceed the current technology to meet the ever-increasing demand of power applications. The apparent cycling performances and dendrite challenges of Li-metal anodes are highly influenced by the interface layer on the Li-metal anode because the intrinsic high reactivity of metallic Li results in an inevitable solid-state interface layer between the Li-metal and electrolytes. In this review, we summarize the recent progress on the interfacial chemistry regarding the interactions between electrolytes and ion migration through dynamic interfaces. The critical factors that affect the interface formation for constructing a stable interface with a low resistance are reviewed. Moreover, we review emerging strategies for rationally designing multiple-structured solid-state electrolytes and their interfaces, including the interfacial properties within hybrid electrolytes and the solid electrolyte/electrode interface. Finally, we present scientific issues and perspectives associated with Li-metal anode interfaces toward a practical Li-metal battery. | Chen-Zi Zhao Hui Duan Jia-Qi Huang Juan Zhang Qiang Zhang Yu-Guo Guo Li-Jun Wan | 2019 | Science China Chemistry2019，62，10： | 14 |
| 3 | Design of the Full-disk Magneto Graph (FMG) onboard the ASO-S显示文摘The Full-disk Magneto Graph(FMG),a payload onboard the Advanced Space Solar Observatory(ASO-S),will measure the vector magnetic field in the photosphere.The instrument consists of a frontwindow filter,a telescope,an LCVR polarimeter,an image-stabilization system,a seven-stage tunable Lyot filter,a CMOS camera with 4096×4096 pixels and a pair of calibration/focus wheels.In this paper,we describe the design of the FMG instrument and provide a summary of test observations carried out with the FMG prototype. | Yuan-Yong Deng Hai-Ying Zhang Jian-Feng Yang Fu Li Jia-Ben Lin Jun-Feng Hou Zhen Wu Qian Song Wei Duan Xian-Yong Bai Dong-Guang Wang Juan Lv Wei Ge Jia-Ning Wang Zhao-Ying Zheng Chen-Jie Wang Nan-Ge Wang Hou-Kun Ni Yi-Zhong Zeng Yang Zhang Xiao Yang Ying-Zi Sun Zhi-Yong Zhang Xiao-Fan Wang | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 14 |
| 4 | Effect of CO_2 Enrichment on the Growth and Nutrient Uptake of Tomato Seedlings显示文摘Exposing tomato seedlings to elevated CO2 concentrations may have potentially profound impacts on the tomato yield and quality. A growth chamber experiment was designed to estimate how different nutrient concentrations influenced the effect of elevated CO2 on the growth and nutrient uptake of tomato seedlings. Tomato (Hezuo 906) was grown in pots placed in controlled growth chambers and was subjected to ambient or elevated CO2 (360 or 720μL L-1) and four nutrient solutions of different strengths (1/2-, 1/4-, 1/8-, and 1/16-strength Japan Yamazaki nutrient solutions) in a completely randomized design. The results indicated that some agricultural characteristics of the tomato seedlings such as the plant height, stem thickness, total dry and fresh weights of the leaves, stems and roots, the G value (G value = total plant dry weight/seedling age), and the seedling vigor index (seedling vigor index = stem thickness/(plant height×total plant dry weight) increased with the elevated CO2, and the increases were strongly dependent on the nutrient solution concentrations, being greater with higher nutrient solution concentrations. The elevated CO2 did not alter the ratio of root to shoot. The total N, P, K, and C absorbed from all the solutions except P in the 1/8- and 1/16-strength nutrient solutions increased in the elevated CO2 treatment. These results demonstrate that the nutrient demands of the tomato seedlings increased at elevated CO2 concentrations. | LI Juan ZHOU Jian-Min DUAN Zeng-Qiang DU Chang-Wen WANG Huo-Yan | 2007 | Pedosphere2007，17，3： | 13 |
| 5 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 6 | Genome-wide Association Analysis of Ten Chilling Tolerance Indices at the Germination and Seedling Stages in Maize显示文摘玉米幼苗对很敏感寒心,特别在转变阶段从期间对自造营养物质的生长不是自养。寒心的忍耐的基因基础的基因解剖将为玉米 inbreds 的基因改进提供有用信息。在这研究,染色体宽的协会分析被进行探索在种子萌芽和幼苗的寒心的忍耐与 125 inbreds 的一块协会面板上演的玉米的基因体系结构。十个忍耐索引( 10 萌芽率和幼苗的表演的比率在寒心的应力和控制条件下面的生长相关的特点)被调查估计与寒心的忍耐联系的 43 单个核苷酸多型性的 inbreds ,和一个总数的寒心的忍耐的能力被检测,与没有,他们,与在萌芽和幼苗的寒心的忍耐有关同时上演。关联分析也表明在种子萌芽阶段的寒心的忍耐的基因基础在幼苗阶段与那通常不同。另外,包含 43 单个核苷酸多型性中的 31 个的 40 候选人基因的一个总数根据他们的功能被预言,并且被组织进五个范畴。在寒心的忍耐的这些候选人基因的可能的角色也被讨论。 | Juan Huang Jianhua Zhang Wenzhen Li Wei Hu Lichao Duan Yang Feng Fazhan Qiu Bing Yue | 2013 | Journal of Integrative Plant Biology2013，55，8： | 12 |
| 7 | Effects of 24-Epibrassinolide on Antioxidant System in Cucumber Seedling Roots Under Hypoxia Stress显示文摘This article aims to study the effects of exogenous 24-epibrassinolide (EBR) on the changes in ROS, activities of antioxidative enzymes and antioxidants in cucumber (Cucumis sativus L.) seedling roots under hypoxia stress. Seedlings of a hypoxia- resistant cultivar, Lübachun 4, and a hypoxia-sensitive cultivar, Zhongnong 8, were hydroponically grown for 8 d in normoxic or hypoxic nutrient solutions that were added or not added with 10-3 mg L-1 EBR. Under hypoxia stress, the ROS levels and the lipid peroxidation were significantly increased in the roots upon exposure to hypoxia stress, which were inhibited by EBR application. The EBR treatment significantly increased the seedlings growth and SOD, APX, GR activities, and contents of AsA and GSH under hypoxia stress. From the results obtained in this study, it can be concluded that oxidative damage on seedling roots by hypoxia stress can be considerably alleviated and the tolerance of plants was elevated. | KANG Yun-yan GUO Shi-rong LI Juan DUAN Jiu-ju | 2007 | Agricultural Sciences in China2007，6，3： | 11 |
| 8 | Glacier change in the Tanggula Mountains, Tibetan Plateau,in 1969-2015显示文摘To improve our knowledge of glacier change in the Tanggula Mountains located in the northeast of the Tibetan Plateau,we delineated outlines of the glaciers in 1991 and 2015 using Landsat TM/OLI images and compared them with the reported glacier data in the First Chinese Glacier Inventory in 1969 and the Second Chinese Glacier Inventory in 2007.These comparisons showed that the glacier area and ice volume decreased by 524.8 km2 and 37 km3,respectively.The majority of the glacier area loss was concentrated in the area class of 1-5 km2,between 5300 m and 5500 m in elevation,on north and east facing slopes and in the Dam Qu River basin.These glacier changes exhibited spatial and temporal differences.The glacier retreat rate gradually increased from 1969 to 2015,and the rate in the east was higher than that in the west.From 1969 to 2015,the warming rate in the Tanggula Mountains was 0.38°C/10a,while the annual precipitation only increased by 0.4%.The slight increase in the amount of precipitation made a limited contribution to glacier change,while the change in temperature led to noticeable shrinkage of the glaciers.Contrary to the retreat or stagnation of most glaciers in the study area,there were 10 glaciers that experienced clear advance in 1986-2015 with noticeable increases in both area and length.Whether or not these 10 glaciers are surge glaciers requires further study. | DUAN Hong-yu YAO Xiao-jun LIU Shi-yin GAO Yong-peng QI Miao-miao LIU Juan ZHANG Da-hong LI Xiao-feng | 2019 | Journal of Mountain Science2019，16，11： | 8 |
| 9 | Effects of elevated CO_2 concentration on growth and water usage of tomato seedlings under different ammonium/nitrate ratios显示文摘增加的大气的 CO2 集中通常被期望提高农业 C3 蔬菜罪的光合作用和生长,因此导致庄稼产量的增加。然而,很少在植物生长和开发上对提高的 CO2 和 N 种类的联合效果被知道。二个生长房间实验被进行决定 NH4 (+)/NO3 (?) 比率的效果并且在生理的发展和西红柿幼苗的水使用提高了 CO2 集中。西红柿与营养液在生长房间在 NH4 (+)/NO3 (?) 比率和 CO2 集中变化在集装箱为 45 d 被种。结果显示出那植物高度,茎厚度,全部的干燥重量,叶子的干燥重量,茎和根, G 价值(总数种干燥重量/幼苗天),叶绿素内容,光合的率,叶级、整个的植物级的水使用效率和西红柿幼苗的累积的水消费与在提高的 CO2 处理在营养液增加 NO3 (?)的比例被增加。植物生物资源,植物高度,茎厚度和光合的率比在周围的 CO2 集中在提高的 CO2 集中更高是 67% , 22% , 24% 和 55% ,取决于 NH4 (+)/NO3 (?) 比率的价值。这些结果显示那提高的 CO2 集中没减轻 100% NH4 (+)-N 的不利效果(在营养液) 在西红柿幼苗上。在两 CO2 水平,营养液的 NH4 (+)/NO3 (?) 比率强烈几乎影响了植物性能的每项措施,并且硝酸盐美联储植物达到了更大的生物资源生产,作为与铵美联储植物相比。这些现象似乎与光合的率和西红柿幼苗的累积的水消费的协调规定有关。 | LI Juan ZHOU Jian-min DUAN Zeng-qiang | 2007 | Journal of Environmental Sciences2007，19，9： | 7 |
| 10 | Comparative Genomic Analysis of Enterovirus 71 Revealed Six New Potential Neurovirulence-associated Sites显示文摘在现在的学习,完全的染色体四普通(4/EV71/Wenzhou/CHN/2014, 15/EV71/Wenzhou/CHN/2014, 116/EV71/Wenzhou/CHN/2014,和 120/EV71/Wenzhou/CHN/2014 ) 并且二剧毒(11/EV71/Wenzhou/CHN/2014 和 109/EV71/Wenzhou/CHN/2014 ) enterovirus (EV71 ) 71 孤立被定序并且描述。他们是在长度的 7405 bp 并且属于 EV71 亚遗传型 C4 (C4a 簇) 。核苷酸顺序排列揭示了六个核苷酸变化( G P151 T P151 , G P199 P199 , G P261 T P261 , A P328 C P328 , G P422 P422 ,和 G P437 T P437 )在二剧毒在 IRES 元素的 5UTR 以内孤立。怒火和 FCE 的 RNA 第二等的结构预言显示普通孤立分享的类似的结构,它与那些不同剧毒孤立。而且, G P114 C P114 和 G P151 T P151 变化在剧毒孤立在 SL II 贡献了唯一的 RNA 第二等的结构的形成。而且, EV71 孤立的 82 的 nucleotide/amino 酸顺序排列显示了那六个地点(T P488 和 C 在 5UTR 的 P577 ;Asn 在 2A 的 P57 ;Ile 在 3C 的 P56 ;C P10 和 A 在 3UTR 的 P47 ) 潜在地与 EV71 的 neurovirulence 被联系。最后, 2A 的 3D 结构是类似的,而 VP1 和 3C 的结构是可变的。 | JIA Qing Jun CHEN Xin Yu LI De Zhou XU Juan Juan XU Zhi Gang DUAN Zhi Liang WEN Jin Sheng | 2016 | Biomedical and Environmental Sciences2016，29，10： | 5 |
| 11 | Impacts of smoking status on the clinical outcomes of coronary non-target lesions in patients with coronary heart disease:a single-center angiographic study显示文摘Background:Coronary atherosclerotic plaque could go through rapid progression and induce adverse cardiac events.This study aimed to evaluate the impacts of smoking status on clinical outcomes of coronary non-target lesions.Methods:Consecutive patients with coronary heart disease who underwent two serial coronary angiographies were included.All coronary non-target lesions were recorded at first coronary angiography and analyzed using quantitative coronary angiography at both procedures.Patients were grouped into non-smokers,quitters,and smokers according to their smoking status.Clinical outcomes including rapid lesion progression,lesion re-vascularization,and myocardial infarction were recorded at second coronary angiography.Multivariable Cox regression analysis was used to investigate the association between smoking status and clinical outcomes.Results:A total of 1255 patients and 1670 lesions were included.Smokers were younger and more likely to be male compared with nonsmokers.Increase in percent diameter stenosis was significantly lower(2.7[0.6,7.1]%vs.3.5[0.9,8.9]%)and 3.4[1.1,7.7]%,P=0.020)in quitters than those in smokers and non-smokers.Quitters tended to have a decreased incidence of rapid lesions progression(15.8%[76/482]vs.21.6%[74/342]and 20.6%[89/431],P=0.062),lesion re-vascularization(13.1%[63/482]vs.15.5%[53/432]and 15.5%[67/431],P=0.448),lesion-related myocardial infarction(0.8%[4/482]vs.2.6%[9/342]and 1.4%[6/431],P=0.110)and all-cause myocardial infarction(1.9%[9/482]vs.4.1%[14/342]and 2.3%[10/431],P=0.128)compared with smokers and non-smokers.In multivariable analysis,smoking status was not an independent predictor for rapid lesion progression,lesion re-vascularization,and lesion-related myocardial infarction except that a higher risk of all-cause myocardial infarction was observed in smokers than non-smokers(hazards ratio:3.00,95%confidence interval:1.04-8.62,P=0.042).Conclusion:Smoking cessation mitigates the increase in percent diameter stenosis of coronary non-target lesions,meanwhile,smokers are associated with increased risk for all-cause myocardial infarction compared with non-smokers. | Hao-Bo Xu Juan Wang Ji-Lin Chen Chao Guo Jian-Song Yuan Xin Duan Feng-Huan Hu Wei-Xian Yang Xiao-Liang Luo Rong Liu Jin-Gang Cui Sheng-Wen Liu Xiao-Jin Gao Yu-Shi Chun Shu-Bin Qiao | 2020 | Chinese Medical Journal2020，，19： | 5 |
| 12 | Inhibition of Magnolol and Honokiol on Cytochrome P450 Enzymes in Rat and Human Liver Microsomes显示文摘Objective The purpose of this work is to evaluate the in vitro inhibitory effect of magnolol(MN) and honokiol(HN) on rat / human cytochrome P450(CYP) enzymes(1A2/1A2, 2D/2D6, 3A/3A4, 2E1/2E1, and 2C/2C9). Methods Rat liver microsomes(RLM) and human liver microsomes(HLM) were used as the enzyme sources. After the probe substrate of each CYP isoforms was co-incubated individually with MN or HN in RLM or HLM, the metabolite production of each probe substrate in RLM and HLM incubation medium was determined and used to evaluate the activity of corresponding CYP isoforms. Results MN inhibited rat CYP1A2 and human CYP3A4 with the IC50 values of 10.0 and 56.2 μmol/L, respectively. HN inhibited rat CYP1A2 and CYP2E1, human CYP1A2 and CYP3A4 with the IC50 values of 12.1, 12.6, 17.8, and 43.9 μmol/L, respectively. Conclusion HN is a moderate or weak inhibitor of human CYP1A2. Both MN and HN are weak or non inhibitors of the other tested human CYP isoforms. The results suggest that no significant metabolic interaction seems likely to occur when the substrate drugs of CYP isoforms tested in the present work are co-administered with MN and HN. | Jin Duan Juan Xiao Yong Chen Feng-mei Han | 2015 | Chinese Herbal Medicines2015，7，2： | 5 |
| 13 | A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants显示文摘Herbgenomics is an emerging field of traditional Chinese medicine(TCM)research and development.By combining TCM research with genomics,herbgenomics can help to establish the scientific validity of TCM and bring it into wider usage within the field of medicine.Salvia Linn.(S.Linn.)is a large genus of Labiatae that includes important medicinal plants.In this herbgenomics study,the complete chloroplast(cp)genomes of two Salvia spp.—namely,S.przewalskii and S.bulleyana,which are used as a surrogate for S.miltiorrhiza—were sequenced and compared with those of two other reported Salvia spp.—namely,S.miltiorrhiza and S.japonica.The genome organization,gene number,type,and repeat sequences were compared.The annotation results showed that both Salvia plants contain 114 unique genes,including 80 protein-coding,30 transfer RNA(tRNA),and four ribosomal RNA(rRNA)genes.Repeat sequence analysis revealed 21 forward and 22 palindromic sequences in both Salvia cp genomes,and 17 and 21 tandem repeats in S.przewalskii and S.bulleyana,respectively.A synteny comparison of the Salvia spp.cp genomes showed a high degree of sequence similarity in the coding regions and a relatively high divergence of the intergenic spacers.Pairwise alignment and single-nucleotide polymorphism(SNP)analyses found some candidate fragments to identify Salvia spp.,such as the intergenic region of the trnV–ndhC,trnQ–rps16,atpI–atpH,psbA–ycf3,ycf1,rpoC2,ndhF,matK,rpoB,rpoA,and accD genes.All of the results—including the repeat sequences and SNP sites,the inverted repeat(IR)region border,and the phylogenetic analysis—showed that S.przewalskii and S.bulleyana are extremely similar from a genetic standpoint.The cp genome sequences of the two Salvia spp.reported here will pave the way for breeding,species identification,phylogenetic evolution,and cp genetic engineering studies of Salvia medicinal plants. | Conglian Liang Lei Wang Juan Lei Baozhong Duan Weisi Ma Shuiming Xiao Haijun Qi Zhen Wang Yaoqi Liu Xiaofeng Shen Shuai Guo Haoyu Hu Jiang Xu Shilin Chen | 2019 | Engineering2019，5，5： | 5 |
| 14 | Trends in sunshine duration and atmospheric visibility in the Yunnan-Guizhou Plateau,1961-2005显示文摘Using the observed data from 184 stations over the Yunnan-Guizhou Plateau (YGP) from 1961 to 2005,the long-term trends in sunshine duration,cloud amount,dry visibility (Vd),dry extinction,and water vapor over the YGP are analyzed.The results show that 85% of the stations recorded shortening annual sunshine duration,with the decrease rates between -12.2 and -173.7 h/10yr.Results of Mann-Kendall tests indicate that,among the stations with decreasing sunshine duration,63.7% of them experienced an abrupt change that started in the 1970s and peaked in the 1980s.This decreasing trend has reversed in the early years of the 21st century.The cloud cover and water vapor content in the mid and lower levels over the YGP had no obvious changes during the study period.The annual averages of Vd declined from 34 km in the 1960s to 27 km at present.The annual mean dry extinction coefficient trended upward,from 0.176 to 0.190,on the YGP from 1980 to 2005.Analyses of cloud cover,water vapor,atmos-pheric visibility,and dry extinction coefficient revealed that emitted tropospheric aerosols (including air pollutants) resulting from increased energy consumption over the YGP could be a major factor influencing the reductions of sunshine duration and atmospheric visibility. | XiaoBo Zheng TianLiang Zhao YuXiang Luo ChangChun Duan Juan Chen | 2011 | Research in Cold and Arid Regions2011，3，2： | 4 |
| 15 | Mutation analysis in a Chinese family with multiple endocrine neoplasia type 1显示文摘(MEN1 ) 背景多重内分泌的瘤形成类型 1 是被肿瘤 suppressor 基因 MEN1 的 germline 变化引起的正染色体的主导的癌症症候群。这研究试图在中国家谱 withMEN1 识别变化。有 MEN1 的一个大中国家庭被收集的方法。所有编码区域和他们 MEN1 基因的邻近的序列被放大并且定序。在这个家庭,的结果在 exon 的异质接合的 cytosine 插入 10 (c.1546_1547insC ) 导致 MEN1 的一个框架移动变化在 proband 和他的家庭的另外的二个受苦的成员被发现。这个变化在 intron 被连接到新奇单个核苷酸多型性(SNP ) 3 (IVS3+18C > T ) 。结论在 exon 的变化 10 MEN1 基因力量与 MEN1 导致甲状旁腺的增生和垂体腺瘤和 cosegregate 的开发症候群。新发现 IVS3+18C 的意义 > MEN1 的 T 需要进一步的调查。 | ZHA Bing-bing LIANG Wang LIU Jun CHENG Juan HONG Xiao-wu LIU Jing LI Yi-ming MA Duan | 2010 | Chinese Medical Journal2010，，5： | 3 |
| 16 | In vitro Screening of Ginkgolic Acids for Antiparasitic Activity against Cryptosporidium andersoni显示文摘Cryptosporidium is a protozoan parasite belonging to the phylum Apicomplexa that causes self-limiting diarrhea in immunocompetent individuals, and it may also cause chronic and life-threatening diarrhea in those that are immunocompromised[1]. The two main routes of Cryptosporidium transmission are via water and food. At least 30 Cryptosporidium species have been confirmed, including C. andersoni, with more than 70 genotypes of undefined species. | Chidiebere E.UGWU JIANG Yan Yan WU Liang XU Yu Xin YIN Jian Hai DUAN Li Ping CHEN Sheng Xia LIU Hua PAN Wei QUAN Hong SHEN Yu Juan CAO Jian Ping | 2019 | Biomedical and Environmental Sciences2019，32，4： | 3 |
| 17 | Characteristics of the Spectra of Superior Vena Cava Flow Doppler Velocities in Primary Pulmonary Hypertension with Tricuspid Regurgitation显示文摘 | CHEN Hong-mao DUAN Yun -you LI Juan ZHOU Ning LIU Shan-shan | 2007 | Journal of US-China Medical Science2007，4，1： | 3 |
| 18 | Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish显示文摘 | Qian BA Juan DUAN Jia-qiang TIAN Zi-liang WANG Tao CHEN Xiao-guang LI Pei-zhan CHEN Song-jie WU Li XlANG Jing-quan LI Rui-ai CHU Hui WANG | 2013 | Acta Pharmacologica Sinica2013，34，8： | 3 |
| 19 | Cloud Classification and Distribution of Cloud Types in Beijing Using Ka-Band Radar Data显示文摘A cloud clustering and classification algorithm is developed for a ground-based Ka-band radar system in the vertically pointing mode. Cloud profiles are grouped based on the combination of a time–height clustering method and the k-means clustering method. The cloud classification algorithm, developed using a fuzzy logic method, uses nine physical parameters to classify clouds into nine types: cirrostratus, cirrocumulus, altocumulus, altostratus, stratus, stratocumulus, nimbostratus,cumulus or cumulonimbus. The performance of the clustering and classification algorithm is presented by comparison with all-sky images taken from January to June 2014. Overall, 92% of the cloud profiles are clustered successfully and the agreement in classification between the radar system and the all-sky imager is 87%. The distribution of cloud types in Beijing from January 2014 to December 2017 is studied based on the clustering and classification algorithm. The statistics show that cirrostratus clouds have the highest occurrence frequency(24%) among the nine cloud types. High-level clouds have the maximum occurrence frequency and low-level clouds the minimum occurrence frequency. | Juan HUO Yongheng BI Daren Lü Shu DUAN | 2019 | Advances in Atmospheric Sciences2019，36，8： | 2 |
| 20 | Surgery Upregulates High Mobility Group Box‐1 and Disrupts the Blood–Brain Barrier causing Cognitive Dysfunction in Aged Rats显示文摘 | Hui‐Juan He Yi Wang Yuan Le Kai‐Ming Duan Xue‐Bin Yan Qin Liao Yan Liao Jian‐Bin Tong Niccolò Terrando Wen Ouyang | 2012 | CNS Neurosci Ther2012，，： | 2 |
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