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| 1 | Microvessel density is a prognostic marker of human gastric cancer显示文摘AIM: To investigate whether microvessel density (MVD) is related with prognosis in gastric cancer patients, and the expression of cyclooxygenase-2 (COX-2) and vessel endothelial growth factor (VEGF) so as to determine the possible role of COX-2 and VEGF in gastric cancer angiogenesis.METHODS: Forty-seven formalin-fixed paraffin-embedded tissue samples of gastric cancer were evaluated for COX-2, VEGF by immunohitochemical staining. To assess tumor angiogenesis, MVD was determined by immunohitochemical staining of endothelial protein factor Ⅷ-related antigen. The relationship among COX-2 and VEGF expression, MVD, and clinicopathologic parameters was analyzed. RESULTS: Among the 67 samples, high MVD was significantly associated with lymph node metastasis and poor survival. Multivariate survival analysis showed that MVD value and lymph node metastasis were independent prognostic factors. The expression rate of COX-2 and VEGF was significantly higher than that of the adjacent tissues. COX-2 and VEGF expression in gastric cancer was significantly correlated with tumor differentiation and depth of invasion, but not with survival. The mean MVD value of COX-2 or VEGF positive tumors was higher than that of COX-2 or VEGF negative tumors. A significant correlation was found between the expressions of COX-2and VEGF. CONCLUSION: MVD may be one of the important prognostic factors for gastric cancer patients. COX-2 and VEGF may play an important role in tumor progression by stimulating angiogenesis. VEGF might play a main role in the COX-2 angiogenic pathway. The inhibition of angiogenesis or COX-2, VEGF activity may have an important therapeutic benefit in the control of gastric cancer. | Hong-Chuan Zhao Rong Qin Xiao-Xin Chen Xia Sheng Ji-Feng Wu Dao-Bin Wang Gui-Hua Chen | 2006 | World Journal of Gastroenterology2006，12，47： | 25 |
| 2 | BMI, WC, WHtR, VFI and BFI: Which Indictor is the Most Efficient Screening Index on Type 2 Diabetes in Chinese Community Population显示文摘Objective Obesity is a major risk factor for type 2 diabetes, many indexes can be used to describes obesity and predict diabetes. This research attempts to identify the best indicator of obesity to screening diabetes in Chinese population. Methods A cross-sectional data of 8121 subjects aged 35-60 years were included in this research belongs to the Diabetes Appropriate Technology Intervention Study. Anthropometric indicators including body weight, height, waist circumferences (WC), body fat index (BFI) and visceral fat index (VFI) and blood biochemical indicators after an overnight fast [fasting blood glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triacylglycerol] were measured. BMI (body mass index) and Weight to Height Ratio was calculated. Results Subjects with obesity had a higher risk of physician diagnosed diabetes (OR=2.50, 95% CI 1.83-3.43), new diagnosed diabetes (OR=4.23, 95% CI 2.91-6.15) and pre-diabetes (OR=1.75, 95% CI 1.31-2.34) compared to those with normal Body mass index (BMI). There was a significant trend of increased risk of all diabetes status with increased waist circumference (WC). The waist-to-height ratio (WHtR) yielded the most significant association with new diagnosed diabetes and physician diagnosed diabetes than other indices. Conclusion Central obesity is significantly correlated with diabetes. VFI was most correlated with pre-diabetes while WHtR is an efficient screening index than BMI and WC in Chinese community diabetes screening. | MI Sheng Quan YIN Peng HU Nan LI Jian Hong CHEN Xiao Rong CHEN Bo YAN Liu Xia ZHAO Wen Hua | 2013 | Biomedical and Environmental Sciences2013，26，6： | 20 |
| 3 | Formation mechanisms of megadunes and lakes in the Badain Jaran Desert,Inner Mongolia显示文摘Field observations demonstrate that calc-sinters occurred in the lakes of Badain Jaran Desert. 87Sr/86Sr ratios,14C,δ 13C and mineral com-positions of calc-sinters,and 3He/4He,4He/20Ne,δ 18O,δ D,pH and TDS of water from springs and lakes are analyzed in detail. The results indicate that the lake water is supplied through deep fault zone. The “ker-nel” of stabilized dunes in the Badain Jaran Desert perhaps consists of calc-sinters and calcareous ce-mentation layers. Deep-seated groundwater effuses from this “kernel” and recharges to lakes in desert. Precipitation and snowmelt water from the Qing-hai-Tibet Plateau is fed into the Badain Jaran Desert,Gurinai,Wentougaole and Ejinqi areas through the Xigaze-Langshan Fault zone. The isotopic composi-tions of groundwater in the Alax Plateau are abnor-mal due to the strong evaporation of the Gyaring and Ngoring lake water in the headstream of the Yellow River. Groundwater dissolves dissoluble fractions of rocks during its transportation through the fault zone and flows out of the mouth of spring in the Badan Jaran Desert. The dissoluble fractions are finally de-veloped into calc-sinters and calcareous cementation layers around the spring. Calci-sinters are gradually largened and eventually emerge on the surface of lake water. Eolian sands accumulate on the surfaces of calc-sinters and calcareous cementation layers,and eventually develop into dunes. Invasion of magma causes an increase in the temperature of groundwater within the faults. Groundwater evapora-tion provides water vapor for the formation of humid stabilized dunes during its upwelling. Rhizoconcre-tions found in Yihejigede indicate that the dune was formed and remained immovable 4700 years ago. The height of the megadunes is proportional to thermal quantity carried by the groundwater. | CHEN Jiansheng ZHAO Xia SHENG Xuefen DONG Haizhou RAO Wenbo SU Zhiguo | 2006 | Chinese Science Bulletin2006，51，24： | 19 |
| 4 | Transurethral seminal vesiculoscopy for recurrent hemospermia: experience from 419 cases显示文摘 | Rui Chen Lei Wang Xia Sheng Shu-Guang Piao Xin-Wen Nian Xin Cheng Tie Zhou Hui-Zhen Li Ya-Wei Liu Guang-Hua Chen Chun-Lei Zhang De-Pei Kong Guang-An Xiao Xin Lu Zhen-Yu Jia Zhi-Yong Liu Ying-Hao Sun | 2018 | Asian Journal of Andrology2018，20，5： | 18 |
| 5 | Water in the upper mantle and deep crust of eastern China: concentration, distribution and implications显示文摘Understanding the concentration and distribution of water in the Earth's mantle plays a substantial role in studying its chemical, physical and dynamic processes. After a decade of research, a comprehensive dataset of water content in upper-mantle samples has been built for eastern China, which is now the only place with water-content data from such diverse types of natural samples, and provides an integrated picture of the water content and its distribution in the upper mantle at a continental scale. The main findings include the following:(i) the temporal heterogeneity of the water content in the lithospheric mantle from early Cretaceous(~120 Ma) to Cenozoic(<40 Ma) was tightly connected with the stability of the North China Craton(from its destruction to its consolidation);(ii) the heterogeneous water content in the Cenozoic lithospheric mantle beneath different blocks of eastern China was not only inherited from tectonic settings from which they came, but was also affected later by geological processes they experienced;(iii) the distinct water content between the lowermost crust and lithospheric mantle of eastern China and its induced rheological contrast at the base of the crust indicate that the continental crust–mantle boundary could behave either in a coupled or decoupled manner beneath different areas and/or at different stages;(iv) the alkali basalts of eastern China demonstrate a heterogeneous distribution of water content in the mantle;local and regional comparisons of the water content between the lithospheric mantle and basalts' source indicate that the Cenozoic alkali basalts in eastern China were not sourced from the lithospheric mantle.Instead, the inferred high water contents in the mantle sources suggest that the Cenozoic eastern China basalts were likely sourced from the mantle transition zone(MTZ); and(v) both oceanic and continental crusts may carry a certain amount of water back into the deep mantle of eastern China by plate subduction.Such recycled crustal materials have not only created a local water-rich zone, but have also introduced crustal geochemical signatures into the mantle, both accounting for crustal geochemical imprints in the intra-plate magmatic rocks of eastern China. | Qun-Ke Xia Jia Liu István Kovács Yan-Tao Hao Pei Li Xiao-Zhi Yang Huan Chen Ying-Ming Sheng | 2019 | National Science Review2019，6，1： | 16 |
| 6 | Images for diagnosis Sarcomatoid carcinoma of the renal pelvis in duplex kidney显示文摘肾的骨盆的 Sarcomatoid 过渡房间癌是一个稀罕的瘤,仅仅 14 个插图丰富的例子以前报导了。双肾是尿道的最普通的先天的反常,与约 2% 的发生。在双肾的肾的骨盆的瘤形成是稀罕的。我们报导了癌其 sarcomatoid 与两个肾的单位的膀胱手铐切除外科与肾盂积水膨出,和全部的 nephroureterectomy 从复制肾的骨盆的上面的部分发源的一个案例被执行。因为肾的骨盆的 sarcomatoid 癌的稀罕性质和它对辅助治疗的反应的明显的缺乏,做早诊断和早激进的外科改进幸存是必要的。为经常、勤奋的监视或对待的建筑群强调需要是重要的有在有瘤形成的风险的情况下的任何一个一半的肾盂积水膨出的双肾。 | CHEN Ge-ming CHEN Shan-wen XIA Dan LI Jun YAN Sheng JIN Bai-ye | 2011 | Chinese Medical Journal2011，，13： | 8 |
| 7 | BRIF and CARIF progress显示文摘China Institute of Atomic Energy (CIAE) is currently constructing Beijing rare ion beam facility (BRIF) and is proposing China advanced rare ion beam facility (CARIF). This paper is aiming at introducing the progress of BRIF project and the con ceptual design CARIF. The ISOL type facility BRIF under construction is composed of a 100 MeV 300 ?A proton cyclotron, an ISOL with mass resolution of 20000, and a super-conducting LINAC of 2 MeV/q, and will be commissioned in 2013. CARIF facility proposed is planned to use both ISOL and PF techniques. It is based on a China advanced research reactor CARR that was critical, with ISOL separation of fission fragment, post acceleration to 150 MeV/u, and fragmentation of neu tron-rich fission fragment beam like 132Sn. Such unique combination will allow CARIF to deliver beam intensity better than the best world facilities by more than one order of magnitude. | LIU WeiPing, LI ZhiHong, BAI XiXiang, WANG YouBao, GUO Bing, PENG ChaoHua, YANG Yi, SU Jun, CUI BaoQun, ZHOU ShuHua, ZHU ShengYun, XIA HaiHong, GUAN XiaLing, ZENG Sheng, ZHANG HuanQiao, CHEN YongShou, TANG HongQing, HUANG Li & FENG BeiYuan China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 8 |
| 8 | A new flavonoid with a benzoic acid substituent from Selaginella uncinata显示文摘6-(5-Carboxyl-2-methoxyphenyl )-apigenin (1 ) ,新 flavonoid,从 Selaginella uncinata (Desv ) 的 60% 乙醇摘录被孤立春天。它的结构被分光镜的方法建立。化合物 1 代表在 C-6 拥有一个安息香的酸取代者的 flavonoids 的第一个例子。 | Jun Xia Zheng Nai Li Wang Hao Gao Hong Wei Liu Hai Feng Chen Ming Fan Xin Sheng Yao | 2008 | Chinese Chemical Letters2008，19，9： | 8 |
| 9 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 10 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 11 | Geochemical Information Indicating the Water Recharge to Lakes and Immovable Megadunes in the Badain Jaran Desert显示文摘Calc-sinters distributed in the middle of lakes and rhizoconcretions scattered at the slopes of sand dunes were observed during three explorations to the Badain Jaran Desert in the past two years. Wet sands were also found underneath the dry surface sand layers of about 20–50 cm in thickness. The geochemical parameters were measured on minerals and water samples collected from the Badain Jaran Desert and neighboring areas. The results show that the water system in the desert may be recharged from the groundwater originating from the precipitation of the Qilian Mountains and/or the Tibetan Plateau rather than the local rainfalls. | CHEN Jiansheng ZHAO Xia SHENG Xuefeng WANG Jiyang GU Weizu CHEN Liang | 2005 | Acta Geologica Sinica(English Edition)2005，79，4： | 6 |
| 12 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 13 | Corticosteroid therapy in ulcerative colitis:Clinical response and predictors显示文摘AIM:To evaluate clinical response to initial corticosteroid(CS) treatment in Chinese ulcerative colitis patients(UC) and identify predictors of clinical response.METHODS:Four hundred and twenty-three UC patients who were initially treated with oral or intravenous CS from 2007 to 2011 were retrospectively reviewed at eight inflammatory bowel disease centers in China,and 101 consecutive cases with one-year follow-up were analyzed further for clinical response and predictors.Short-term outcomes within one month were classified as primary response and primary non-response.Longterm outcomes within one year were classified as prolonged CS response,CS dependence and secondary non-response.CS refractoriness included primary and secondary non-response.Multivariate analyses were performed to identify predictors associated with clinical response.RESULTS:Within one month,95.0%and 5.0%of the cases were classified into primary response andnon-response,respectively.Within one year,41.6%of cases were assessed as prolonged CS response,while49.5%as CS dependence and 4.0%as secondary nonresponse.The rate of CS refractoriness was 8.9%,while the cumulative rate of surgery was 6.9%within one year.After multivariate analysis of all the variables,tenesmus was found to be a negative predictor of CS dependence(OR=0.336;95%CI:0.147-0.768;P=0.013)and weight loss as a predictor of CS refractoriness(OR=5.662;95%CI:1.111-28.857;P=0.040).After one-month treatment,sustained high Sutherland score(≥6)also predicted CS dependence(OR=2.347;95%CI:0.935-5.890;P=0.014).CONCLUSION:Tenesmus was a negative predictor of CS dependence,while weight loss and sustained high Sutherland score were strongly associated with poor CS response. | Jin Li Fan Wang Hong-Jie Zhang Jian-Qiu Sheng Wen-Feng Yan Min-Xing Ma Ru-Ying Fan Fang Gu Chuan-Feng Li Da-Fan Chen Ping Zheng Yu-Pei Gu Qian Cao Hong Yang Jia-Ming Qian Pin-Jin Hu Bing Xia | 2015 | World Journal of Gastroenterology2015，21，10： | 5 |
| 14 | Construction of NH2-MIL-125(Ti)/Bi2WO6 composites with accelerated charge separation for degradation of organic contaminants under visible light irradiation显示文摘Photocatalysis is considered as an ideal strategy for water pollution treatment.However,it remains challenging to design a highly efficient photo-catalytic system through regulating the charge flow via a precise approach.In this work,a novel NH2-MIL-125(Ti)/Bi2WO6 composite was constructed via self-assembly growing Bi2WO6 nanosheets on NH2-MIL-125(Ti)material.The characterization results demonstrated that NH2-MIL-125(Ti)was successfully incorporated into Bi2WO6 and the photoexcited carriers could be efficiently separated and transferred between the two components.NH2-MIL-125(Ti)/Bi2WO6 composites displayed enhanced photocatalytic activity for the removal of rhodamine B(RhB)and tetracycline(TC)under visible light irradiation,and the optimal weight ratio of NH2-MIL-125(Ti)was determined to be 7 wt%.The introduction of NH2-MIL-125(Ti)into Bi2WO6 could raise the absorption of visible light,accelerate the separation and transfer of charge carriers,and boost photocatalytic activity.This research presents a wide range of possibilities for the further development of novel composites in the field of environment purification. | Sheng Yin Yong Chen Ming Li Qingsong Hu Yi Ding Yifan Shao Jun Di Jiexiang Xia Huaming Li | 2020 | Green Energy & Environment2020，5，2： | 5 |
| 15 | Neuroprotective effect of interleukin-6 regulation of voltage-gated Na^+ channels of cortical neurons is time-and dose-dependent显示文摘Interleukin-6 has been shown to be involved in nerve injury and nerve regeneration, but the effects of long-term administration of high concentrations of interleukin-6 on neurons in the central nervous system is poorly understood. This study investigated the effects of 24 hour exposure of interleukin-6 on cortical neurons at various concentrations(0.1, 1, 5 and 10 ng/m L) and the effects of 10 ng/m L interleukin-6 exposure to cortical neurons for various durations(2, 4, 8, 24 and 48 hours) by studying voltage-gated Na+ channels using a patch-clamp technique. Voltage-clamp recording results demonstrated that interleukin-6 suppressed Na+ currents through its receptor in a time- and dose-dependent manner, but did not alter voltage-dependent activation and inactivation. Current-clamp recording results were consistent with voltage-clamp recording results. Interleukin-6 reduced the action potential amplitude of cortical neurons, but did not change the action potential threshold. The regulation of voltage-gated Na+ channels in rat cortical neurons by interleukin-6 is time- and dose-dependent. | Wei Xia Guo-yi Peng Jiang-tao Sheng Fang-fang Zhu Jing-fang Guo Wei-qiang Chen | 2015 | Neural Regeneration Research2015，10，4： | 4 |
| 16 | The Synthesis of 7-[1-Aza-2-(dimethylamino)vinyl]-4-methylhydroquinolin-2-ones and their Isomerism in Different Solvents显示文摘The reaction of 7-amino-4-methyl-2(1H)-quinolone 1 and its 6-methyl derivative 2 with Vilsmeier reagent (DMF and POCl3) afforded 7-[1-aza-2-(dimethylamino)vinyl]-4-methyl- hydro- quinolin-2-one 3 and 7-[1-aza-2-(dimethylamino)vinyl]-4,6-dimethylhydroquinolin- 2-one 4, respec-tively. 1H-NMR analysis in different solvents indicated that isomerism occurred due to hindered rotation around the (CH3)2N-C:N σ-bond. The rotational energy barrier of 3 was calculated. | Qian ZHANG,1 Ying CHEN,1 Yun Hong ZHENG,1 Wan Yun SHENG,1 Peng XIA1* Yi XIA,2 Zheng Yu YANG,2 Kuo Hsiung LEE2 1Department of Organic Chemistry, The School of Pharmacy, Shanghai Medical University, 138 Yi Xue Yuan Road, Shanghai 200032 2Natural Products | 2001 | Chinese Chemical Letters2001，12，1： | 3 |
| 17 | 利伐沙班在非瓣膜病性房颤患者经导管射频消融术后抗凝中的代谢获益(英文)显示文摘目的:评估非瓣膜病性房颤患者应用利伐沙班抗凝治疗相较华法林的代谢获益,及利伐沙班应用的安全性和有效性。创新点:首次研究利伐沙班对房颤射频消融术后患者代谢水平影响,评估利伐沙班相较华法林抗凝治疗的代谢获益。方法:前瞻性入选2014年4月至7月共60例行经皮房颤导管射频消融术患者,随机分为利伐沙班治疗组和华法林治疗组。在术后15、30、60和90天检测代谢指标(包括血清总蛋白、白蛋白、球蛋白和高密度脂蛋白(HDL)等)变化,并随访出血、卒中和系统性栓塞事件等发生情况。结论:服用利伐沙班抗凝治疗患者在随访期间血清总蛋白、白蛋白、球蛋白和HDL水平较术前均显著升高,而华法林治疗组患者各项代谢指标呈先下降、后上升趋势。两组均没有发生死亡和栓塞事件,出血并发症发生率亦无明显差异。研究结果表明,非瓣膜病性房颤患者经导管射频消融术后接受利伐沙班抗凝具有代谢方面获益,与华法林相比两者在安全性和有效性方面无明显差异,研究结果可为临床选择合适抗凝方案提供参考。 | Jun ZHU Rong-jun GAO Qiang LIU Ru-hong JIANG Lu YU Ya-xun SUN Pei ZHANG Jian-wei LIN Yang YE Zu-wen ZHANG Shi-quan CHEN Hui CHENG Xia SHENG Chen-yang JIANG | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，11： | 3 |
| 18 | In vitro Screening of Ginkgolic Acids for Antiparasitic Activity against Cryptosporidium andersoni显示文摘Cryptosporidium is a protozoan parasite belonging to the phylum Apicomplexa that causes self-limiting diarrhea in immunocompetent individuals, and it may also cause chronic and life-threatening diarrhea in those that are immunocompromised[1]. The two main routes of Cryptosporidium transmission are via water and food. At least 30 Cryptosporidium species have been confirmed, including C. andersoni, with more than 70 genotypes of undefined species. | Chidiebere E.UGWU JIANG Yan Yan WU Liang XU Yu Xin YIN Jian Hai DUAN Li Ping CHEN Sheng Xia LIU Hua PAN Wei QUAN Hong SHEN Yu Juan CAO Jian Ping | 2019 | Biomedical and Environmental Sciences2019，32，4： | 3 |
| 19 | New formula for predicting standard liver volume in Chinese adults显示文摘AIM To obtain a reference range of morphological indices and establish a formula to accurately predict standard liver volume(SLV) in Chinese adults.METHODS Computed tomography(CT)-estimated total liver volume(CTLV) was determined in 369 Chinese adults. Age,sex,body weight,body height,body mass index,and body surface area(BSA) were recorded using CT. Total splenic volume,portal venous diameter(PVD),splenic venous diameter(SVD),and portal venous cross-sectional area(PVCSA) were also measured by CT. Stepwise multiple linear regression analysis was performed to evaluate the impact of each parameter on CTLV and to develop a new SLV formula. The accuracy of the new formula was compared with the existing formulas in a validation group.RESULTS The average CTLV was 1205.41 ± 257.53 cm3(range,593.80-2250.10 cm3). The average of PVD,SVD and PVCSA was 9.34 ± 1.51 mm,7.40 ± 1.31 mm and 173.22 ± 48.11 mm2,respectively. The CT-estimated splenic volume of healthy adults varied markedly(range,46.60-2892.30 cm3). Sex,age,body height,body weight,body mass index,and BSA were significantly correlated with CTLV. BSA showed the strongest correlation(r = 0.546,P < 0.001),and was used to establish a new model for calculating SLV: SLV(cm3) = 758.259 × BSA(m2)-124.272(R2 = 0.299,P < 0.001). This formula also predicted CTLV more accurately than the existing formulas,but overestimated CTLV in elderly subjects > 70 years of age,and underestimated liver volume when CTLV was > 1800 cm3.CONCLUSION Our new BSA-based formula is more accurate than other formulas in estimating SLV in Chinese adults. | Ling-Mei Feng Pei-Qin Wang Hong Yu Ru-Tan Chen Jian Wang Xia Sheng Zong-Li Yuan Pei-Mei Shi Wei-Fen Xie Xin Zeng | 2017 | World Journal of Gastroenterology2017，23，27： | 3 |
| 20 | Blue revolution for food security under carbon neutrality: A case from the water-saving and drought-resistance rice显示文摘The increasing concentration of greenhouse gases(GHGs)in Earth's atmosphere leads to global warming,which further causes a series of climate changes and does great harm to both human society and natural ecosystems.Agricultural GHG emissions,mainly in theform of methane(CH4)and nitrous oxide(N2O),areasignificantsourceofGHGs,accountingfor~14%total global GHGs(Zhang et al.,2022).One major source of agricultural GHGs is CH4 emissions from rice paddies,which is responsiblefor~10%-12%ofhuman-inducedCH4emissions(van Groenigen et al.,2013)and contributes~2.40%to the enhanced global warming effect(Zhang et al.,2022).The global warming potential of GHGs emissions from rice systems is roughly four times higher than either wheat or maize(Linquist et al.,2012). | Hui Xia Xianxian Zhang Yi Liu Junguo Bi Xiaosong Ma Anning Zhang Hongyan Liu Liang Chen Sheng Zhou Huan Gao Kai Xu Haibin Wei Guolan Liu Feiming Wang Hongyang Zhao Xingxing Luo Danping Hou Qiaojun Lou Fangjun Feng Liguo Zhou Shoujun Chen Ming Yan Tianfei Li Mingshou Li LeiWang Zaochang Liu Xinqiao Yu HanweiMei Lijun Luo | 2022 | Molecular Plant2022，15，9： | 3 |
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