|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cardiotrophin 1 stimulates beneficial myogenic and vascular remodeling of the heart显示文摘出生后的心通过 hypertrophic 生长适应应力和超载,可能病理学或有益的一个过程(生理的肥大) 。生理的肥大改进心脏的性能在健康并且 diseased 个人,然而,宣传这有利改编的机制仍然保持糟糕定义。我们识别 cytokine cardiotrophin (CT1 ) 1 作为能够包括导致的导出 cardiomyocyte 的 angiogenic 信号的心肌层,和刺激的短暂、可逆的肥大概括心的生理的生长的特色的一个因素增加了由脉管形成。CT1 的能力从 caspase 激活的调停 CK2 的制止发源导致生理的肥大,阻止到无限制的病理学的生长的转变。外长的 CT1 蛋白质交货稀释了病理并且在正确的心失败的一个严格的模型恢复了可收缩的功能,建议为这难处理的心脏病的一种新奇处理选择。 | Mohammad Abdul-Ghani Colin Suen Baohua Jiang Yupu Deng Jonathan J Weldrick Charis Putinski Steve Brunette Pasan Femando Tom T Lee Peter Flynn Frans H H Leenen Patrick G Burgon Duncan J Stewar Lynn A Megeney | 2017 | Cell Research2017，27，10： | 8 |
| 2 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 3 | Influence of diesel fuel on seed germina-tion显示文摘 | ADAM G DUNCAN H | 2002 | Environmental Pollution2002，120，2： | 1 |
| 4 | Finite element analyses of retaining wall behavior显示文摘 | CLOUGH G W DUNCAN J M | 1971 | Journal of Soil Mechanic and Foundation Division1971，97，12： | 1 |
| 5 | Lethal and sub-lethal effects of the salmon delousing agent dichlorvos on the larvae of the lobster (Homarus gammarus L) and herring (Clupea harengus L)显示文摘 | JOHN G M DEREK S DUNCAN D S | 1991 | Aquaculture1991，98，： | 1 |
| 6 | BCL10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube elosure显示文摘 | Ruland J Duncan G Elia A | 2001 | Cell2001，104，： | 1 |
| 7 | Constitutive behavior of geosynthetic interface显示文摘 | ESTERHUIZEN J J B FLIZ G M DUNCAN J M | 2001 | Journal of Geotechnical & Geoenvironmental Engineering2001，127，10： | 1 |
| 8 | The microbiology of butyrate formation in the human colon显示文摘 | PRYDE S E DUNCAN S H HOLD G L | 2002 | FEMS Microbiology Letters2002，217，2： | 1 |
| 9 | The microbiology of butyrate formation in the human colon显示文摘 | Pryde S E Duncan S H Hold G L | 2002 | FEMS Microbiology Letters2002，217，： | 1 |
| 10 | Regional receptor signaling components determine differential growth patterns in the human lens显示文摘 | Maidment JM Duncan G differences in tyrosine kinase Tamiya S | 2004 | Invest Ophthalmol Vis Sci2004，45，5： | 1 |
| 11 | Access to green space, physical activity and mental health: a twin study 显示文摘 | COHEN-CLINE H TURKHEIMER E DUNCAN G E | 2015 | Journal of epidemiology and community health2015，69，6： | 1 |
| 12 | Ion analysis of human cataractous lenses显示文摘 | Duncan G Bushell AR | 1975 | Exp Eye Res1975，20，3： | 1 |
| 13 | Finite element analysis of retaining wall behavior显示文摘 | CLOUGH G W DUNCAN J M | 1971 | Journal of the Soil Mechanics and Foundations Division ASCE1971，97，12： | 1 |
| 14 | Core stability and core strength显示文摘 | ANGELA E HIBBS KEVIN G THOMPSON DUNCAN FRENCH | 2008 | Sports Met2008，38，12： | 1 |
| 15 | MMP and TIMP expres-sion in quiescent,dividing,and differentiating human lens cells显示文摘 | Hodgkinson LM Duncan G Wang L | 2007 | Invest Ophthalmol Vis Sci2007，48，9： | 1 |
| 16 | Finite element analysis of retaining wall behavior 显示文摘 | CLOUGH G W DUNCAN J M | 1971 | Journal of the Soil Mechanics and Foundations Division1971，97，12： | 1 |
| 17 | Chronic Irreducible Posterolateral Knee Disloca- tion :Two- Stage Surgical Approach 显示文摘 | Hatem G Duncan J | 2007 | The Journal of Arthroscopic and Related Surge2007，5，23： | 1 |
| 18 | An investigation of the dynamic absorber effect in high speed machining 显示文摘 | Duncan G S Tummond M F Schmitz T L | 2005 | International Journal of Machine Tools & Manufacture2005，45，45： | 1 |
| 19 | Nanostructured materials for energy storage显示文摘 | NAZAR L F GOWARD G LEROUX F DUNCAN M HUANG H KERR T GAUBICHER J | 2001 | J Inorg Mater2001，3，3： | 1 |
| 20 | Saber: The develop- ment of information-based competence and execution of infor- mation-based competition显示文摘 | Duncan G C Richard O M James L M | 1995 | IEEE Annals of the History of Computing1995，17，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员