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| 1 | Alterations of seminal and hormonal parameters:An extrahepatic manifestation of HCV infection?显示文摘瞄准:在精液的参数和繁殖神经质的浆液层次上评估 HCV 感染和相对抗病毒的处理的可能的影响。方法:有 HCV 相关的长期的肝炎和 16 个健康男志愿者的十个男病人被学习。在所有使精液的参数遭到(nemaspermic 集中,进步活动性,形态学) 并且神经质的层次被决定。精液的参数和抑制素 B,刺激滤泡的荷尔蒙, luteinizing,总数和免费睾丸激素,雌二醇,在病人的 prolactine 在六和 12 个月以后被测量抗病毒联合(interferon+ribavirin ) 治疗。结果:在治疗前的病人比控制象更低的抑制素 B 和免费睾丸激素层次一样显示出显著地更低的 nemaspermic 活动性和形态学。在情况中的抑制素 B 层次被改进在五个应答者的六和 12 瞬间术后疗法(161.9+/-52.8 pg/mL 对 101.7+/-47.0 pg/mL 和 143.4+/-46.1 pg/mL 对 95.4+/-55.6 pg/mL,分别地) 。病人的神经质的模式显著地没改变术后疗法,与有起始的减小和全面随后的增长(19.7+/-6.4 pg/mL 对 13.6+/-5.0 pg/mL 对 17.3+/-5.7 pg/mL ) 的雌二醇层次的例外。然而,在 1 年的应答者,免费睾丸激素(14.2+/-2.54 pg/mL 对 17.1+/-2.58 pg/mL ) 的重要增长发生了。nemaspermic 形态学的一个缺陷发生了,当另外的精液的参数没在抗病毒的治疗期间显著地变化时。结论:有 HCV 感染的病人比控制显示出更坏的精子的参数,建议精子发生上的病毒的可能的否定影响,与在抗病毒的治疗期间的进一步温和的缺陷。然而,治疗能改进精子的功能,由增加的抑制素 B 层次建议了并且在应答者改进了神经质的模式。进一步的研究被需要证实这些初步的吸引人的结果。 | Marilena Durazzo Alberto Premoli Cataldo Di Bisceglie Angela Bertagna Emanuela Fagà Giampaolo Biroli Chiara Manieri Simona Bo Gianfranco Pagano | 2006 | World Journal of Gastroenterology2006，12，19： | 9 |
| 2 | Lack of association between seroprevalence of Helicobacterpylori infection and primary biliary cirrhosis显示文摘AIM: To determine the association between seroprevalence of Helicobacter pylori(Hpylon) infection and primary biliary cirrhosis (PBC).METHODS: In this case-control study, 149 consecutive patients (10 males, 139 females, mean age 58.2+11 years, range 26-82 years) suffering from PBC and 619 consecutive healthy volunteer blood donors (523 males, 96 females, mean age 47±5.3 years, range 18-65 years) attending the Hospital Blood Bank and residing in the same area were recruited. A commercial enzyme linked immunosorbent assay was used to detect anti-Hpylori(IgG) antibodies in serum.RESULTS: Antibodies to Hpyloriwere present in 78 (52.3%) out of 149 PBC-patients and in 291 (47%) out of 619 volunteers (P= 0.24, OR 1.24, 95% CI 0.85-1.80). In the subjects less than 60 years old, the prevalence of Hpylori infection among PBC-patients (40/79) was slightly higher than in controls (50.6% vs46.2%) P= 0.46, OR = 1.19, 95% CI: 0.72-1.95). In those over 60 years, the prevalence of H pyloriinfection was similar between PBC-patients and controls (54.2% vs57.8%, P= 0.7, OR 0.86, 95% CI 0.36-2.07). CONCLUSION: There is no association between seroprevalence of Hpyloriinfection and primary biliary cirrhosis. | Marilena Durazzo Floriano Rosina Alberto Premoli Enrico Morello Sharmila Fagoonee Rosaria Innarella Enrico Solerio Rinaldo Pellicano Mario Rizzetto | 2004 | World Journal of Gastroenterology2004，10，21： | 4 |
| 3 | Long‐term outcome of hepatitis B virus‐related C hronic H epatitis under protracted nucleos(t)ide analogues显示文摘 | G. A. Niro A. M. Ippolito R. Fontana M. R. Valvano D. Gioffreda A. Iacobellis A. Merla M. Durazzo G. Lotti L. Di Mauro A. Andriulli | 2013 | J Viral Hepat2013，，7： | 3 |
| 4 | Gender specific medicine in liver diseases:a point of view显示文摘Gender medicine focuses on the patho-physiological,clinical,prevention and treatment differences in diseases that are equally represented in men and women.The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence.The concept of'gender'includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women,including risk factors,protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women.It is very important to consider all the biological,physiological,functional,psychological,social and cultural characteristics to provide patients with individualized disease management.Herein,we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies:primary biliary cirrhosis,autoimmune hepatitis,primary sclerosing cholangitis,non alcoholic fatty liver disease and alcoholic liver disease,and viral chronic hepatitis B and C.The last section addresses hemochromatosis,which is a prevalent iron overload disorder in the Caucasian population.This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy,management during pregnancy and delivery,and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications. | Marilena Durazzo Paola Belci Alessandro Collo Vanessa Prandi Erika Pistone Maria Martorana Roberto Gambino Simona Bo | 2014 | World Journal of Gastroenterology2014，20，9： | 3 |
| 5 | Hepatitis delta virus: From infection to new therapeutic strategies显示文摘The hepatitis delta virus(HDV)is a small RNA virus that encodes a single protein and which requires the hepatitis B virus(HBV)-encoded hepatitis B surface antigen(HBsAg)for its assembly and transmission.HBV/HDV co-infections exist worldwide and show a higher prevalence among selected groups of HBV-infected populations,specifically intravenous drug users,practitioners of high-risk sexual behaviours,and patients with cirrhosis and hepatocellular carcinoma.The chronic form of HDV-related hepatitis is usually severe and rapidly progressive.Patterns of the viral infection itself,including the status of co-infection or super-infection,virus genotypes(both for HBV and HDV),and persistence of the virus’replication,influence the outcome of the accompanying and manifested liver disease.Unfortunately,disease severity is burdened by the lack of an effective cure for either virus type.For decades,the main treatment option has been interferon,administered as mono-therapy or in combination with nucleos(t)ide analogues.While its efficacy has been reported for different doses,durations and courses,only a minority of patients achieve a sustained response,which is the foundation of eventual improvement in related liver fibrosis.The need for an efficient therapeutic alternative remains.Research efforts towards this end have led to new treatment options that target specific steps in the HDV life cycle;the most promising among these are myrcludex B,which inhibits virus entry into hepatocytes,lonafarnib,which inhibits farnesylation of the viral-encoded LHDAg large hepatitis D antigen,and REP-2139,which interferes with HBsAg release and assembly. | Grazia A Niro Arianna Ferro Francesca Cicerchia Isabella Brascugli Marilena Durazzo | 2021 | World Journal of Gastroenterology2021，27，24： | 2 |
| 6 | Associations between y-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: A possible implication for oxidative stress显示文摘AIM: To examine the relationships between γ -glutamyltransferase (GGT), alanine-aminotransferase (ALT),aspartate-aminotransferase (AST) and various metabolic parameters, C-reactive protein (CRP) and an oxidative stress marker (nitrotyrosine, NT) in subjects without any metabolic abnormalities from a population-based sample.METHODS: Two hundred and five subjects with normal body mass index (BMI), glucose tolerance, and without any metabolic abnormality were studied out of 1339subjects, without known liver diseases, alcohol abuse or use of hepatotoxic drugs, who are representative of the 45-64 aged population of Asti (north-western Italy).RESULTS: In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference,hs-CRP, triglyceride values, and GGT levels. In these subjects, male sex, higher hs-CRP and glucose levels are associated with GGT levels in a multiple regression model, after adjustments for multiple confounders.In the same model, median NT levels are significantly associated with the increasing GGT tertile (β = 1.06;95%CI 0.67-1.45), but not with the AST and ALT tertiles.In a multiple regression model, after adjusting for age,sex, BMI, waist, smoking, and alcohol consumption, both NT (β = 0.05; 95%CI 0.02-0.08) and hs-CRP levels (β =0.09; 95%CI 0.03-0.15) are significantly associated with fasting glycemia.CONCLUSION: GGT, an easy, universally standardized and available measurement, could represent an early marker of sub-clinical inflammation and oxidative stress in otherwise healthy individuals. Prospective studies are needed to establish if GGT could predict future diabetes in these subjects. | Simona Bo Roberto Gambino Marilena Durazzo Sabrina Guidi Elisa Tiozzo Federica Ghione Luigi Gentile Maurizio Cassader Gian Franco Pagano | 2005 | World Journal of Gastroenterology2005，11，45： | 2 |
| 7 | Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis显示文摘 | Giovanni Musso Roberto Gambino Franco De Michieli Maurizio Cassader Mario Rizzetto Marilena Durazzo Emanuela Fagà Barbara Silli Gianfranco Pagano | 2003 | Hepatology2003，，4： | 2 |
| 8 | Clinical suspicion and parathyroid carcinoma management显示文摘 | MONTENEGRO FL TAVARES MR DURAZZO MD | 2006 | Sao Paulo Med J2006，124，1： | 1 |
| 9 | Associations between serum uric acid and adipokines,markers of inflammation,and endothelial dysfunction显示文摘 | Bo S Gambino R Durazzo M | 2008 | J Endocrinol Invest2008，31，6： | 1 |
| 10 | Clinical suspicion and parathyroid carcinoma management显示文摘 | Montenegro FL Tavares MR Durazzo MD | 2006 | Sao Panlo Med J2006，124，1： | 1 |
| 11 | Adipokines inNASH : postprandial lipid metabolism as a link between ad-iponectin and liver disease 显示文摘 | Musso G Gambino R Durazzo M | 2005 | Hepatology2005，42，5： | 1 |
| 12 | Absorption of strawberry phytochemicals and antioxidant status changes in humans显示文摘 | E. Azzini F. Intorre P. Vitaglione A. Napolitano M.S. Foddai A. Durazzo A. Fumagalli G. Catasta L. Rossi E. Venneria M.F. Testa A. Raguzzini L. Palomba V. Fogliano G. Maiani | 2010 | Journal of Berry Research2010，，2： | 1 |
| 13 | Adipnkines in NASH: postprandial lipid metabolism as a link between adiponectin and lives disease 显示文摘 | Musso R Gambino Durazzo M | 2005 | Hepatology2005，42，： | 1 |
| 14 | Meta-analysis of infrapopliteal angioplasty for chronic critical ischemia显示文摘 | Romiti M Albers M Brochardo-Neto FC Durazzo AES Pereira CAB De Luccia N | | 0，，： | 1 |
| 15 | Thyroid nodules: Evaluation with power Doppler and duplex Doppler ultrasound显示文摘 | Maria Cristina Chammas Renê Gerhard Ilka Regina Souza De Oliveira Azzo Widman Nestor De Barros Marcelo Durazzo Alberto Ferraz Giovanni Guido Cerri | 2005 | Otolaryngology - Head and Neck Surgery2005，，6： | 1 |
| 16 | Exsolution in the mss-pentlandite system: Textural and genetic implications for Ni-sulfide ores显示文摘 | A. Durazzo L. A. Taylor | 1982 | Mineralium Deposita1982，，3： | 1 |
| 17 | Associations between serum uric acid and adipokines,markers of inflammation,and endothelial dysfunction显示文摘 | Bo S Gambino R Durazzo M | 2008 | J Endocrinol Invest2008，31，6： | 1 |
| 18 | Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression? 显示文摘 | Durazzo M Niro G Premoli A | 2009 | J Gastroenterol2009，44，5： | 1 |
| 19 | Overl- ap syndromes of autoimmune hepantis : what is known so far 显示文摘 | DURAZZO M PREMOLI A FAGOONEE S | 2003 | Dig Dis sci2003，48，3： | 1 |
| 20 | The effects of chronic cigarette smoking on cognitive recovery during early absti- nence from alcohol显示文摘 | Pennington DL Durazzo TC Schmidt TP | 2013 | Alcohol Clin Exp Res2013，37，7： | 1 |
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