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| 1 | Alterations of seminal and hormonal parameters:An extrahepatic manifestation of HCV infection?显示文摘瞄准:在精液的参数和繁殖神经质的浆液层次上评估 HCV 感染和相对抗病毒的处理的可能的影响。方法:有 HCV 相关的长期的肝炎和 16 个健康男志愿者的十个男病人被学习。在所有使精液的参数遭到(nemaspermic 集中,进步活动性,形态学) 并且神经质的层次被决定。精液的参数和抑制素 B,刺激滤泡的荷尔蒙, luteinizing,总数和免费睾丸激素,雌二醇,在病人的 prolactine 在六和 12 个月以后被测量抗病毒联合(interferon+ribavirin ) 治疗。结果:在治疗前的病人比控制象更低的抑制素 B 和免费睾丸激素层次一样显示出显著地更低的 nemaspermic 活动性和形态学。在情况中的抑制素 B 层次被改进在五个应答者的六和 12 瞬间术后疗法(161.9+/-52.8 pg/mL 对 101.7+/-47.0 pg/mL 和 143.4+/-46.1 pg/mL 对 95.4+/-55.6 pg/mL,分别地) 。病人的神经质的模式显著地没改变术后疗法,与有起始的减小和全面随后的增长(19.7+/-6.4 pg/mL 对 13.6+/-5.0 pg/mL 对 17.3+/-5.7 pg/mL ) 的雌二醇层次的例外。然而,在 1 年的应答者,免费睾丸激素(14.2+/-2.54 pg/mL 对 17.1+/-2.58 pg/mL ) 的重要增长发生了。nemaspermic 形态学的一个缺陷发生了,当另外的精液的参数没在抗病毒的治疗期间显著地变化时。结论:有 HCV 感染的病人比控制显示出更坏的精子的参数,建议精子发生上的病毒的可能的否定影响,与在抗病毒的治疗期间的进一步温和的缺陷。然而,治疗能改进精子的功能,由增加的抑制素 B 层次建议了并且在应答者改进了神经质的模式。进一步的研究被需要证实这些初步的吸引人的结果。 | Marilena Durazzo Alberto Premoli Cataldo Di Bisceglie Angela Bertagna Emanuela Fagà Giampaolo Biroli Chiara Manieri Simona Bo Gianfranco Pagano | 2006 | World Journal of Gastroenterology2006，12，19： | 9 |
| 2 | Gender specific medicine in liver diseases:a point of view显示文摘Gender medicine focuses on the patho-physiological,clinical,prevention and treatment differences in diseases that are equally represented in men and women.The purpose of gender medicine is to ensure that each individual man and woman receives the best treatment possible based on scientific evidence.The concept of'gender'includes not only the sexual characteristics of individuals but also physiological and psychological attributes of men and women,including risk factors,protective/aggravating effects of sexual hormones and variances linked to genetics and corporal structures that explain biological and physiological differences between men and women.It is very important to consider all the biological,physiological,functional,psychological,social and cultural characteristics to provide patients with individualized disease management.Herein,we critically analyze the literature regarding gender differences for diseases and acquired conditions of the most representative hepatic pathologies:primary biliary cirrhosis,autoimmune hepatitis,primary sclerosing cholangitis,non alcoholic fatty liver disease and alcoholic liver disease,and viral chronic hepatitis B and C.The last section addresses hemochromatosis,which is a prevalent iron overload disorder in the Caucasian population.This review aims to describe data from the literature concerning viral chronic hepatitis during pregnancy,management during pregnancy and delivery,and new effective drugs for the prevention of maternal infection transmission without significant adverse effects or complications. | Marilena Durazzo Paola Belci Alessandro Collo Vanessa Prandi Erika Pistone Maria Martorana Roberto Gambino Simona Bo | 2014 | World Journal of Gastroenterology2014，20，9： | 3 |
| 3 | Type 2 diabetes mellitus and chronic hepatitis C: Which is worse? Results of a long-term retrospective cohort study显示文摘 | Chiara Giordanino Simone Ceretto Simona Bo Antonina Smedile Alessia Ciancio Elisabetta Bugianesi Rinaldo Pellicano Sharmila Fagoonee Elisabetta Versino Giuseppe Costa Daniele Arese Marco Sacco Mario Rizzetto Giorgio Saracco | 2011 | Digestive and Liver Disease2011，，5： | 3 |
| 4 | Associations between y-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: A possible implication for oxidative stress显示文摘AIM: To examine the relationships between γ -glutamyltransferase (GGT), alanine-aminotransferase (ALT),aspartate-aminotransferase (AST) and various metabolic parameters, C-reactive protein (CRP) and an oxidative stress marker (nitrotyrosine, NT) in subjects without any metabolic abnormalities from a population-based sample.METHODS: Two hundred and five subjects with normal body mass index (BMI), glucose tolerance, and without any metabolic abnormality were studied out of 1339subjects, without known liver diseases, alcohol abuse or use of hepatotoxic drugs, who are representative of the 45-64 aged population of Asti (north-western Italy).RESULTS: In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference,hs-CRP, triglyceride values, and GGT levels. In these subjects, male sex, higher hs-CRP and glucose levels are associated with GGT levels in a multiple regression model, after adjustments for multiple confounders.In the same model, median NT levels are significantly associated with the increasing GGT tertile (β = 1.06;95%CI 0.67-1.45), but not with the AST and ALT tertiles.In a multiple regression model, after adjusting for age,sex, BMI, waist, smoking, and alcohol consumption, both NT (β = 0.05; 95%CI 0.02-0.08) and hs-CRP levels (β =0.09; 95%CI 0.03-0.15) are significantly associated with fasting glycemia.CONCLUSION: GGT, an easy, universally standardized and available measurement, could represent an early marker of sub-clinical inflammation and oxidative stress in otherwise healthy individuals. Prospective studies are needed to establish if GGT could predict future diabetes in these subjects. | Simona Bo Roberto Gambino Marilena Durazzo Sabrina Guidi Elisa Tiozzo Federica Ghione Luigi Gentile Maurizio Cassader Gian Franco Pagano | 2005 | World Journal of Gastroenterology2005，11，45： | 2 |
| 5 | Effectiveness of a interven- tion on metabolic syndrome:A randomized cont roiled trial 显示文摘 | Simona Bo Giovannino C Carla B | 2007 | J Gen Intern Med2007，22，12： | 1 |
| 6 | The metabolic syndrome and high C-reactive protein: prevalence and differences by sex in a southern-European population-based cohort 显示文摘 | Simona Bo Luigi Gentile Giovannino Ciccone | 2005 | Diabetes Metab Res Rev2005，21，6： | 1 |
| 7 | Effectiveness of a Lifestyle Intervention on Metabolic Syndrome. A Randomized Controlled Trial显示文摘 | Simona Bo MD Giovannino Ciccone MD PhD Carla Baldi MD Lorenzo Benini MD Ferruccio Dusio MD Giuseppe Forastiere MD Claudio Lucia MD Claudio Nuti MD Marilena Durazzo MD Maurizio Cassader MD Luigi Gentile MD Gianfranco Pagano MD | 2007 | Journal of General Internal Medicine2007，，12： | 1 |
| 8 | Factors affecting hospitalization costs in Type 2 diabetic patients显示文摘 | Eva Pagano Simona Bo Michele Petrinco | 2009 | Joumalof Diabetes and its Complications2009，23，1： | 1 |
| 9 | Dietary magnesium and fiber intakes and inflammatory and metabolic indicators in middle-aged subjects from a populationbased cohort显示文摘 | Simona BO | 2006 | American Journal of Clinical Nutrition2006，84，5： | 1 |
| 10 | An integrated and cooperative architecture for multi-intersection traffic signal control显示文摘Traffic signal control(TSC)systems are one essential component in intelligent transport systems.However,relevant studies are usually independent of the urban traffic simulation environment,collaborative TSC algorithms and traffic signal communication.In this paper,we propose(1)an integrated and cooperative Internet-of-Things architecture,namely General City Traffic Computing System(GCTCS),which simultaneously leverages an urban traffic simulation environment,TSC algorithms,and traffic signal communication;and(2)a general multi-agent reinforcement learning algorithm,namely General-MARL,considering cooperation and communication between traffic lights for multi-intersection TSC.In experiments,we demonstrate that the integrated and cooperative architecture of GCTCS is much closer to the real-life traffic environment.The General-MARL increases the average movement speed of vehicles in traffic by 23.2%while decreases the network latency by 11.7%. | Qiang Wu Jianqing Wu Bojian Kang Bo Du Jun Shen Adriana Simona Mihăiţă | 2023 | Digital Transportation and Safety2023，2，2： | 0 |
| 11 | Can gender predict virological response to standard antiviral therapy for chronic hepatitis C? A retrospective study显示文摘Aim:The liver is a sexually dimorphic organ presenting gender differences in its metabolism,functions,enzyme activity,membrane lipid composition and immune response.This paper aimed to assess whether gender may predict virological response to standard antiviral therapy in subjects with chronic hepatitis C(CHC).Methods:The authors retrospectively analyzed 100 patients with genotype 1 CHC(55 men,45 women),who performed standard antiviral therapy(interferon and ribavirin for 12 months)in the period 2002-2012,evaluated with blood tests and abdominal ultrasound to compare different virological and biochemical response in both gender.Results:Rate of substained virological response(SVR)was higher,but not significant,in women than men(46.7%vs.34.5%,P=0.05);difference became significant after stratification by age(<50 and≥50 years).Specifically in the group aged under 50 years,rate of SVR was significantly higher in women than in men(66.7%vs.38.2%,P<0.05).Conclusion:Female gender may predict virological response to standard antiviral therapy in subjects with CHC aged below 50 years.Considering new potent and more expensive antiviral drugs actually available for HCV treatment,it could be useful to identify candidates firstly eligible to therapy. | Paola Belci Alessandro Collo Maria Martorana Andrea Evangelista Sara Giunti Roberto Gambino Maurizio Cassader Simona Bo Marilena Durazzo | 2016 | Hepatoma Research2016，2，1： | 0 |
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