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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | A Sustained Virologic Response Is Durable in Patients With Chronic Hepatitis C Treated With Peginterferon Alfa-2a and Ribavirin显示文摘 | Mark G. Swain Ming–Yang Lai Mitchell L. Shiffman W. Graham E. Cooksley Stefan Zeuzem Douglas T. Dieterich Armand Abergel Mário G. Pess?a Amy Lin Andreas Tietz Edward V. Connell Moisés Diago | 2010 | Gastroenterology2010，，5： | 3 |
| 3 | Gastric intestinal metaplasia is associated with gastric dysplasia but is inversely correlated with esophageal dysplasia显示文摘AIM To determine which clinical factors might be associated with gastric intestinal metaplasia(IM) in a North American population.METHODS Pathology and endoscopy databases at an academicmedical center were reviewed to identify patients with and without gastric IM on biopsies for a retrospective cohort study. Patient demographics, insurance status, and other clinical factors were reviewed.RESULTS Four hundred and sixty-eight patients with gastric IM(mean age: 61.0 years ± 14.4 years, 55.5% female) and 171 without gastric IM(mean age: 48.8 years ± 20.8 years, 55.0% female) were compared. The endoscopic appearance of atrophic gastritis correlated with finding gastric IM on histopathology(OR = 2.05, P = 0.051). Gastric IM was associated with histologic findings of chronic gastritis(OR = 2.56, P < 0.001), gastric ulcer(OR = 6.97, P = 0.015), gastric dysplasia(OR = 6.11, P = 0.038), and gastric cancer(OR = 6.53, P = 0.027). Histologic findings of Barrett's esophagus(OR = 0.28, P = 0.003) and esophageal dysplasia(OR = 0.11, P = 0.014) were inversely associated with gastric IM. Tobacco use(OR = 1.73, P = 0.005) was associated with gastric IM.CONCLUSION Patients who smoke or have the endoscopic finding of atrophic gastritis are more likely to have gastric IM and should have screening gastric biopsies during esophagogastroduodenoscopy(EGD). Patients with gastric IM are at increased risk for having gastric dysplasia and cancer, and surveillance EGD with gastric biopsies in these patients might be reasonable. | Justin M Gomez James T Patrie Wissam Bleibel Jeanetta W Frye Bryan G Sauer Vanessa M Shami Edward B Stelow Christopher A Moskaluk Andrew Y Wang | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 3 |
| 4 | 生活方式和饮食因素:预防致死性前列腺癌显示文摘预防致死性前列腺癌是一个重要的公共卫生难题。解决该难题可以改善人们的健康状况,减少罹患该疾病的痛苦。本综述围绕某些与致命性前列腺癌预防有关的生活方式和饮食因素研究进行讨论。我们还对以下行为风险因素的研究进行总结:肥胖和体重变化、体育活动、吸烟状况、抗氧化剂摄入量、维生素D和钙、以及咖啡摄入量。 | Kathryn M Wilson Edward L Giovannucci Lorelei A Mucci | 2012 | Asian Journal of Andrology2012，14，3： | 3 |
| 5 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 6 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 7 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 8 | Analysis of stained objects in histological sections by spectral imaging and differential absorption显示文摘 | Woemer B M Edwards D A | 1999 | Journal of Histochemistry & Cytochemistry1999，47，10： | 1 |
| 9 | Toxicity comparison of biosurfactants and synthetic surfactants used in oil spill remediation to two estuarine species显示文摘 | Edwards K R Lepo J E Lewis M A | 2003 | Marine Pollution Bulletin2003，46，10： | 1 |
| 10 | A role forSalmonella fimbriae in intraperitoneal infections 显示文摘 | Edward tk A Schifferli D M Maloy S R | 2000 | Proc Natl Acad Sci USA2000，97，3： | 1 |
| 11 | Effect of feeding tuna oil or soybean oil as supplements to sows in late pregnancy on piglet tissue composition and piglet Viability显示文摘 | Rooke J A Bland I M Edwards S A | 1998 | British Journal of Nutrition1998，80，： | 1 |
| 12 | The management of traumatic spondylolisthesis of the axis 显示文摘 | Levine A M Edwards C C | 1985 | J Bone joint Surg (Am)1985，67，： | 1 |
| 13 | Studies to determine whether an interaction exists among boron,calcium and cholecalciferol on the skeletal development of broiler chicks显示文摘 | Eliot M A Edwards H M | 1992 | Poultry Science1992，71，4： | 1 |
| 14 | Fault diagnosis of rotating machinery 显示文摘 | EDWARDS S LEES A W FRISWELL M I | 1998 | Shock and Vibration Digest1998，30，1： | 1 |
| 15 | Simple sequence repeat(SSR)marker survey of the cassava(Manihot esculenta Crantz)genome:toward a SSR-based molecular genetic map of cassava显示文摘 | Mba R E C Stephenson P Edwards K Mezer S Nkumbira J Gulberg U Apel K Gale M Tohme J Fregene M A | | 0，，： | 1 |
| 16 | Weld ability and hot ductility of chromium- modified Ni3A1 alloys 显示文摘 | Maguire M C Edwards G R David S A | 1992 | Weldin: Iournal1992，71，7： | 1 |
| 17 | The role played by depres- sion associated with somatic symptomatology in accounting for the gen- der difference in the prevalence of depression 显示文摘 | Silverstein B Edwards T Gamma A et M | 2013 | Soc Psychiatry Psy- chiatr Epidemiol2013，48，2： | 1 |
| 18 | Toll-like receptor expression in murine DCsubsets:lack of TLR7 expression by CD8-DC correlates with unresponsiveness to imidazoquinolinrs显示文摘 | Edwards A D Diebold S S Slack E M | 2003 | Eur J Immunol2003，33，： | 1 |
| 19 | Optinization modeling of water quality in an uncertain environment显示文摘 | Donald H B Edward A M | 1985 | Water Resource Research1985，21，7： | 1 |
| 20 | A data mining approach for signal detection and analysis显示文摘 | Bate A Lindquist M Edward IR | 2002 | Drug saf2002，25，6： | 1 |
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