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| 1 | Two-dimensional speckle tracking echocardiography for the assessment of atrial function显示文摘Echocardiography is the most common diagnostic method for assessing atrial function but the technique has some limitations. Traditionally, assessment of left atrial function has been performed by measuring volumes with 2D echocardiography. Additionally, it can be assessed with transmitral Doppler and pulmonary vein Doppler. Recently, an alternative method has been incorporated, namely, measurement of myocardial deformation with color tissue Doppler-derived strain. However, this method has several limitations, such as suboptimal reproducibility, angle-dependence, signal artifacts and the fact that it only measures regional strain and does not obtain information about the curved portion of the atrial roof. To overcome these limitations in the quantification of atrial function, the use of speckle tracking echocardiography (STE) strain has been proposed. This technique is not derived from Doppler but rather from 2D echocardiography; it is angle-independent and allows one to measure global as well as regional atrial strain. In this editorial, we describe the physical and pathophysiological concepts of STE and underline the clinical usefulness of this new technique. | Tomás Francisco Cianciulli María Cristina Saccheri Jorge Alberto Lax Alejandra Marina Bermann Daniel Ernesto Ferreiro | 2010 | World Journal of Cardiology2010，2，7： | 39 |
| 2 | Major osteoporotic fragility fractures: Risk factor updates and societal impact显示文摘Osteoporosis is a silent disease without any evidence of disease until a fracture occurs. Approximately 200 million people in the world are affected by osteoporosis and 8.9 million fractures occur each year worldwide. Fractures of the hip are a major public health burden, by means of both social cost and health condition of the elderly because these fractures are one of the main causes of morbidity, impairment, decreased quality of life and mortality in women and men. The aim of this review is to analyze the most important factors related to the enormous impact of osteoporotic fractures on population. Among the most common risk factors, low body mass index; history of fragility fracture, environmental risk, early menopause, smoking, lack of vitamin D, endocrine disorders(for example insulin-dependent diabetes mellitus), use of glucocorticoids, excessive alcohol intake, immobility and others represented the main clinical risk factors associated with augmented risk of fragility fracture. The increasing trend of osteoporosis is accompanied by an underutilization of the available preventive strategies and only a small number of patients at high fracture risk are recognized and successively referred for therapy. This report provides analytic evidences to assess the best practices in osteoporosis management and indications for the adoption of a correct healthcare strategy to significantly reduce the osteoporosis burden. Early diagnosis is the key to resize the impact of osteoporosis on healthcare system. In this context, attention must be focused on the identification of high fracture risk among osteoporotic patients. It is necessary to increase national awareness campaigns across countries in order to reduce the osteoporotic fractures incidence. | Paola Pisani Maria Daniela Renna Francesco Conversano Ernesto Casciaro Marco Di Paola Eugenio Quarta Maurizio Muratore Sergio Casciaro | 2016 | World Journal of Orthopedics2016，7，3： | 39 |
| 3 | Heart failure with preserved ejection fraction in the elderly: pathophysiology, diagnostic and therapeutic approach显示文摘Heart failure with preserved ejection fraction(HFpEF)is a clinical syndrome characterized by symptoms and sings of heart failure with elevated left ventricular filling pressures at rest or during exercise.It is the most common type of heart failure in the elderly and its prevalence increases with age and is higher in females at any given age.HFpEF is frequently accompanied of comorbid conditions such as diabetes mellitus,obesity,atrial fibrillation and renal dysfunction.The diagnosis relies in the integration of clinical information,laboratory data and interpretation of cardiac imaging and hemodynamic findings at rest and during exercise.Conditions that have a specific treatment such as coronary artery disease,valvular disease,cardiac amyloidosis and constrictive pericarditis should be considered and evaluated as appropriate.Aggressive management of comorbidities,optimization of blood pressure control and volume status using diuretics as needed are among the current treatment recommendations.There are no specific therapies that have shown to decrease mortality in HFpEF.In symptomatic patients with history of hospital admission for decompensated heart failure,the implantation of a wireless pulmonary artery pressure monitor should be considered.Finally,given the high mortality of this condition,goals of care discussion should be initiated early and involvement of palliative care medicine should be considered. | Ernesto Ruiz Duque Alexandros Briasoulis Paulino A Alvarez | 2019 | Journal of Geriatric Cardiology2019，16，5： | 13 |
| 4 | Sonographic markers for early diagnosis of fetal malformations显示文摘Fetal malformations are very frequent in industrialized countries.Although advanced maternal age may affect pregnancy outcome adversely,80%-90%of fetal malformations occur in the absence of a specific risk factor for parents.The only effective approach for prenatal screening is currently represented by an ultrasound scan.However,ultrasound methods present two important limitations:the substantial absence of quantitative parameters and the dependence on the sonographer experience.In recent years,together with the improvement in transducer technology,quantitative and objective sonographic markers highly predictive of fetal malformations have been developed.These markers can be detected at early gestation(11-14 wk)and generally are not pathological in themselves but have an increased incidence in abnormal fetuses.Thus,prenatal ultrasonography during the second trimester of gestation provides a'genetic sonogram',including,for instance,nuchal translucency,short humeral length,echogenic bowel,echogenic intracardiac focus and choroid plexus cyst,that is used to identify morphological features of fetal Down’s syndrome with a potential sensitivity of more than 90%.Other specific and sensitive markers can be seen in the case of cardiac defects and skeletal anomalies.In the future,sonographic markers could limit even more the use of invasive and dangerous techniques of prenatal diagnosis(amniocentesis,etc.). | Maria Daniela Renna Paola Pisani Francesco Conversano Emanuele Perrone Ernesto Casciaro Gian Carlo Di Renzo Marco Di Paola Antonio Perrone Sergio Casciaro | 2013 | World Journal of Radiology2013，5，10： | 12 |
| 5 | 耐多药结核病——预防和控制的关键步骤显示文摘耐多药结核病(multidrug-resistant tuberculosis,MDR-TB)被定义为,由至少对异烟肼(isoniazid)和利福平(rifampicirn)治疗耐药的结核分枝杆菌(Mycobacterium tuberculosis)引起的疾病。广泛耐药结核病(extensively drug-resistant,tuberculosis,XDR-TB)是指导疾病的多重耐药菌株还对使用任何氟喹诺酮治疗, | Eva Nathanson Paul Nunn Mukund Uplekar Katherine Floyd Ernesto Jaramillo Knut Lnnroth Diana Weil Mario Raviglione 王细文 | 2010 | 中华肺部疾病杂志(电子版)2010，3，6： | 10 |
| 6 | Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease显示文摘AIM: To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indices, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver (FL)and 41 with nonalcoholic steatohepatitis (NASH).METHODS: Circulating levels of Bcl-2 were detected in 84 patients with ultrasono graphic findings of 'bright liver' and/or hyper-transaminasemia of unknown origin and/or increase in γ-glutamyl-transpeptidase (γ-GT)strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups (43 with FL and 41 with NASH). Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS: Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein (CRP) concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index (BMI) values (P ≤ 0.0001) but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males (P = 0.0008).γ-GT activity was associated with homeostatic metabolic assessment (HOMA) (P = 0.0003) and with serum ferritin (P = 0.02). Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients presented a weak negative correlation between lobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metaboli-cally unhealthy overweight/obese patients (MUOs) was evidenced. HOMA, BMI and uric acid, in that sequence,best predicted serum Bcl-2 concentrations.CONCLUSION: MUOs could be detected by Bcl-2 levels.By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL. | Giovanni Tarantino Francesco Scopacasa Annamaria Colao Domenico Capone Marianna Tarantino Ernesto Grimaldi Silvia Savastano | 2011 | World Journal of Gastroenterology2011，17，48： | 10 |
| 7 | Endoscopic stenting for inoperable malignant biliary obstruction: A systematic review and meta-analysis显示文摘AIM: To analyze through meta-analyses the benefits of two types of stents in the inoperable malignant biliary obstruction.METHODS: A systematic review of randomized clinical trials(RCT) was conducted, with the last update on March 2015, using EMBASE, CINAHL(EBSCO), MEDLINE, LILACS/CENTRAL(BVS), SCOPUS, CAPES(Brazil), and gray literature. Information of the selected studies was extracted in sight of six outcomes: primarily regarding dysfunction, complication and reintervention rates; and secondarily costs, survival, and patency time. The data about characteristics of trial participants, inclusion and exclusion criteria and types of stents were also extracted. The bias was mainly assessed through the JADAD scale. This meta-analysis was registered in the PROSPERO database by the number CRD42014015078. The analysis of the absolute risk of the outcomes was performed using the software Rev Man, by computing risk differences(RD) of dichotomous variables and mean differences(MD) of continuous variables. Data on RD and MD for each primary outcome were calculated using the MantelHaenszel test and inconsistency was qualified and reported in χ2 and the Higgins method(I2). Sensitivity analysis was performed when heterogeneity was higher than 50%, a subsequent assay was done and other findings were compiled. Student's t-test was used for the comparison of weighted arithmetic means regarding secondary outcomes.RESULTS: Initial searching identified 3660 studies; 3539 were excluded through title, repetition, and/or abstract, while 121 studies were fully assessed and were excluded mainly because they did not compare self-expanding metal stents(SEMS) and plastic stents(PS), leading to thirteen RCT selected, with 13 articles and 1133 subjects meta-analyzed. The mean age was 69.5 years old, that were affected mostly by bile duct(proximal) and pancreatic tumors(distal). The preferred SEMS diameter used was the 10 mm(30 Fr) and the preferred PS diameter used was 10 Fr. In the metaanalysis, SEMS had lower overall stent dysfunction compared to PS(21.6% vs 46.8%, P < 0.00001) and fewer re-interventions(21.6% vs 56.6%, P < 0.00001), with no difference in complications(13.7% vs 15.9%, P = 0.16). In the secondary analysis, the mean survival rate was higher in the SEMS group(182 d vs 150 d, P < 0.0001), with a higher patency period(250 d vs 124 d, P < 0.0001) and a lower cost per patient(4193.98 vs 4728.65 Euros, P < 0.0985).CONCLUSION: SEMS are associated with lower stent dysfunction, lower re-intervention rates, better survival, and higher patency time. Complications and costs showed no difference. | Leonardo Zorrón Pu Eduardo Guimaraes Hourneaux de Moura Wanderley Marques Bernardo Felipe Iankelevich Baracat Ernesto Quaresma Mendonca AndréKondo Gustavo Oliveira Luz Carlos Kiyoshi Furuya Júnior Everson Luiz de Almeida Artifon | 2015 | World Journal of Gastroenterology2015，21，47： | 10 |
| 8 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 9 | Intestinal obstruction caused by torsed gangrenous Meckel's diverticulum encircling terminal ileum显示文摘Meckel's diverticulum(MD)is considered the most prevalent congenital anomaly of the gastrointestinal tract. It may result in a number of complications including hemorrhage,obstruction,and inflammation.Obstruction of various types is the most common presenting symptom in the adult population.Loop formations with the end of an MD and adjacent mesentery constricting the distal ileum is an uncommon cause of obstruction. Axial torsion and gangrene of MD is the rarest of the complications.The correct diagnosis of complicated MD before surgery is often difficult because this condition may mimic other acute abdominal pathologies.Delay in the diagnosis of a complicated MD can lead to signifi- cant morbidity and mortality.Here we describe the case of a patient with a very rare form of acute small bowel obstruction secondary to giant torsed gangrenous MD encircling the terminal ileum.To our knowledge, this co-occurrence of axial torsion and a loop-forming mechanism of obstruction has been reported only once in English medical literature. | Carmine Cartanese Tommaso Petitti Ernesto Marinelli Antonio Pignatelli Davide Martignetti Matteo Zuccarino Lucio Ferrozzi | 2011 | World Journal of Gastrointestinal Surgery2011，3，7： | 7 |
| 10 | Morphological and mineralogical characterizations of oolitic iron ore in the Exi region, China显示文摘The morphological and mineralogical characterizations of a Chinese oolitic iron ore (Exi deposit) were studied by scanning electron microscopy and energy-dispersive X-ray spectroscopy in this work. It is shown that the Exi ore is mainly composed of hematite, quartz, apatite, and chlorite. The hematite is present as the oolitic layers and in the spaces between the aggregated ooids; quartz exists as granular particles in the spaces and as nucleuses in ooids; the harmful mineral, apatite, is associated with hematite as the oolitic layers, fine dissemination, granular particles in the spaces, and nucleuses in ooids. From the viewpoint of mineral beneficiation, it is hard to separate apatite and chlorite but easy to separate quartz from hematite in the Exi iron ore in recovering the iron values. | Shao-xian Song Ernesto Fabian Campos-Toro Yi-min Zhang Alejandro Lopez-Valdivieso | 2013 | International Journal of Minerals,Metallurgy and Materials2013，20，2： | 7 |
| 11 | 中国南海软珊瑚Scleronephthya sp.化学成分的研究显示文摘对中国南海的软珊瑚Scleronephthyasp .的化学成分进行研究 ,从有免疫调节活性的乙醚可溶物中分离鉴定了 13个化合物 ,经1HNMR ,13 CNMR ,HMQC ,HMBC ,1H 1HCOSY和MS等光谱分析并结合文献数据 ,确证其结构分别为 :3 β 羟基 2 0 烯孕甾烷乙酸酯 ( 1) ,3 β 羟基 5 ,2 0 二烯孕甾烷乙酸酯 ( 2 ) ,3 酮 2 0 烯孕甾烷 ( 3 ) ,1 ,2 环氧 3 酮 2 0 烯孕甾烷( 4 ) ,1 ,2 0 二烯 3 酮孕甾烷 ( 5 ) ,1 烯 3 酮 2 0S 甲基 2 1 羟基孕甾烷乙酸酯 ( 6) ,1 烯 3 酮 2 0 β 羟基孕甾烷乙酸酯( 7) ,1 烯 3 ,2 2 二酮胆甾烷 ( 8) ,1 ,2 4 二烯 3 酮 2 2 ,2 3 二羟基胆甾烷 ( 9) ,O methylisogrifolin ( 1 0 ) ,( 1R ,3S,4S,7E ,1 1E) 3α,4α 环氧 7,1 1 ,1 5 三烯西松烷 ( 1 1 ) ,玉米黄素 1 2和 6 溴 3 羧酸吲哚 ( 1 3 ) ,其中化合物 4,6和 1 0是首次从自然界分离得到 .首次对化合物 6,7和 1 0的波谱数据进行了报道 ,而且利用 2DNMR对其进行了全归属 .对化合物 1~7可能的生源关系也进行了探讨 .化合物 6和 7对人宫颈癌细胞 (HELA)有抑制活性 ,IC50 分别为 3 .3和6.3mol/L ;化合物7对肝癌细胞 (BE740 2 )和人白血病细胞 (HL 60 )也显示抑制活性 ,IC50 分别为 3 .1和 0 .2 6mol/L ; | 严小红 郭跃伟 朱兴族 MOLLO Ernesto CIMINO Guido | 2004 | 有机化学2004，24，10： | 6 |
| 12 | 中国南海裸鳃目软体动物美丽拟皮片鳃(Dermatobranchus ornatus)及其可能的食源动物柳珊瑚Muricella sp.的化学成分研究显示文摘从中国南海的裸鳃目软体动物美丽拟皮片鳃(Dermatobranchusornatus)中分离得到4个eunicellane型二萜:Ophirin(1),calicophirinB(2),13-去乙酰氧基calicophirinB(3)及3-去乙酰基-13-去乙酰氧基calicophirinB(4);而由同时、同地采集到的柳珊瑚Muricellasp.中则分离得到calicophirinB(2),13-去乙酰氧基calicophirinB(3),astrogorgin(5)及类似物6.这些化合物的结构经波谱学实验并与文献报道的数据相对照得以确定,并首次对Ophirin(1)的NMR数据进行了全归属.Ophirin(1)的单晶X衍射实验不但进一步确证了化合物的结构,而且使这一类化合物的立体结构表述得到修正.本文是对Dermatobranchus属软体动物化学成分研究的首次报道;研究提示,美丽拟皮片鳃能通过选择适当的食物,并将食物中有用的次生代谢产物转移、富集到身体的特定部位,使之成为自身的化学防性物质.美丽拟皮片鳃与Muricella属柳珊瑚中共同出现的类似化合物支持二者间可能存在的捕食与被捕食的生态学关系. | 张文 GAVAGNIN Margherita 郭跃伟 MOLLO Ernesto CIMINO Guido | 2006 | 有机化学2006，26，12： | 6 |
| 13 | 中国南海豆荚软珊瑚(Lobophytum sp.)中倍半萜化学成分的研究显示文摘用硅胶柱层析和凝胶对柱层析对豆荚软珊瑚(Lobophytumsp.)的乙醚提取物进行分离纯化,得到6个倍半萜类似物;根据其化学性质,结合波谱技术(MS,NMR等),它们分别鉴定为:(+)alismol(1),alismoxide(2),entspathulenol(3),(+)10α,4βaromadendranediol(4),4α,10αaromadendranediol(5)及aromadendrane-10α,4βdiol(6)。这些化合物均系首次从该属珊瑚中分离得到。 | 张文 郭跃伟 Mollo Ernesto Cimino Guido | 2005 | 天然产物研究与开发2005，17，6： | 6 |
| 14 | Predictors of early and late hepatocellular carcinoma recurrence显示文摘Hepatocellular carcinoma(HCC)is the most frequent liver neoplasm,and its incidence rates are constantly increasing.Despite the availability of potentially curative treatments(liver transplantation,surgical resection,thermal ablation),long-term outcomes are affected by a high recurrence rate(up to 70%of cases 5 years after treatment).HCC recurrence within 2 years of treatment is defined as“early”and is generally caused by the occult intrahepatic spread of the primary neoplasm and related to the tumor burden.A recurrence that occurs after 2 years of treatment is defined as“late”and is related to de novo HCC,independent of the primary neoplasm.Early HCC recurrence has a significantly poorer prognosis and outcome than late recurrence.Different pathogenesis corresponds to different predictors of the risk of early or late recurrence.An adequate knowledge of predictive factors and recurrence risk stratification guides the therapeutic strategy and post-treatment surveillance.Patients at high risk of HCC recurrence should be referred to treatments with the lowest recurrence rate and when standardized to combined or adjuvant therapy regimens.This review aimed to expose the recurrence predictors and examine the differences between predictors of early and late recurrence. | Riccardo Nevola Rachele Ruocco Livio Criscuolo Angela Villani Maria Alfano Domenico Beccia Simona Imbriani Ernesto Claar Domenico Cozzolino Ferdinando Carlo Sasso Aldo Marrone Luigi Elio Adinolfi Luca Rinaldi | 2023 | World Journal of Gastroenterology2023，29，8： | 6 |
| 15 | Local recurrence of a parosteal osteosarcoma 21 years after incomplete resection显示文摘Parosteal osteosarcoma (POS) is the most common form of surface osteosarcoma. Its symptoms are insidious and its duration prior to diagnosis is considerably longer than that of other types of osteosarcoma. We report a case of POS with a growing mass but no evidence of metastasis. This tumor, which was diagnosed as calcified hematoma with benign characteristics, was incompletely resected in our hospital 21 years before the diagnosis of recurrence. The patient underwent a wide en bloc resection in our hospital and was free of symptoms, with no signs of tumor recurrence or metastasis during a 53-month follow-up. | Andrés Combalia Ernesto Muoz-Mahamud Antonio Palacín Jaume Pomés Vicente López | 2011 | Chinese Journal of Cancer2011，30，12： | 5 |
| 16 | Are acute exacerbations of chronic inflammatory appendicitis triggered by coprostasis and/or coproliths?显示文摘AIM: To examine the role of coprostasis and coproliths in recurrent appendicitis. METHODS: We evaluated four hundred and twenty seven consecutive pathology reports of all appende- ctomy specimens from January 2003 to December 2004. Findings were categorised as showing acute appen- dicitis, acute recurrent appendicitis, subacute recurrent appendicitis, chronic appendicitis, or appendices without inflammation. All patients had presented with acute right lower quadrant pain. In 94 instances, there was a history of recurrent similar episodes in the past. RESULTS: Of the 427 histology reports, 294 were inter- preted as showing acute appendicitis, 56 acute recurrent appendicitis, 34 subacute recurrent appen-dicitis, 28 chronic appendicitis, and 15 non-inflamed appendices. Coprostasis was observed in 58 patients (13.58%) and the presence of coprolith in 6 (1.4%). Coprostasis, and age, were among the predictors in the final model. CONCLUSION: Coprostasis but not coproliths seems to be a contributing factor to acute exacerbations of chronic inflammatory appendicitis. | George Sgourakis Georgios C Sotiropoulos Ernesto P Molmenti Charis Eibl Stylianous Bonticous Jurgen Moege Christoph Berchtold | 2008 | World Journal of Gastroenterology2008，14，20： | 5 |
| 17 | Ketamine anesthesia reduces intestinal ischemia/reperfusion injury in rats显示文摘AIM: To investigate the effects of ketamine anesthesia on the motility alterations and tissue injury caused by ischemia/reperfusion in rats. METHODS: Thirty male Wistar rats weighing 200-250 g were used. Ischemia was induced by ob-structing blood flow in 25% of the total small intesti-nal length (ileum) with a vascular clamp for 45 min, after which either 60 min or 24 h of reperfusion was allowed. Rats were either anesthetized with pento-barbital sodium (50 mg/kg) or ketamine (100 mg/kg). Control groups received sham surgery. After 60 min of reperfusion, the intestine was examined for mor-phological alterations, and after 24 h intestinal basic electrical rhythm (BER) frequency was calculated, and intestinal transit determined in all groups. RESULTS: The intestinal mucosa in rats that were anesthetized with ketamine showed moderate altera-tions such as epithelial lifting, while ulceration and hemorrhage was observed in rats that received pento-barbital sodium after 60 min of reperfusion. Quantita-tive analysis of structural damage using the Chiu scaleshowed significantly less injury in rats that received ketamine than in rats that did not (2.35 ± 1.14 vs 4.58 ± 0.50, P < 0.0001). The distance traveled by a mark-er, expressed as percentage of total intestinal length, in rats that received pentobarbital sodium was 20% ± 2% in comparison with 25.9% ± 1.64% in rats that re-ceived ketamine (P = 0.017). BER was not statistically different between groups. CONCLUSION: Our results show that ketamine anesthesia is associated with diminished intestinal injury and abolishes the intestinal transit delay induced by ischemia/reperfusion. | Carlos Rodrigo Cámara Francisco Javier Guzmán Ernesto Alexis Barrera Andrés Jesús Cabello Armando Garcia Nancy Esthela Fernández Eloy Caballero Jesus Ancer | 2008 | World Journal of Gastroenterology2008，14，33： | 5 |
| 18 | Strigolactone Analogs as Molecular Probes in Chasing the (SLs) Receptor/s: Design and Synthesis of Fluorescent Labeled Molecules显示文摘原来作为涉及 plantparasite 相互作用的 allelochemicals 识别了,更最近, Strigolactones (SL ) 被显示了在在植物和 mycorrhizal 真菌之间的根围通讯起多重关键作用。甚至更最近神经质的角色被归功于到拓宽这些相对简单的分子的生物影响的 SL。尽管有关键并且 multifaceted SL 的生物角色,绑如此的活跃分子的受体上没有数据,既不在生产植物也不在寄生杂草或 AM 真菌。SL 的通常认为的受体的信息能借助于结构、分子、基因的途径被聚集。我们这个话题上的贡献是设计和合成荧光灯在受体的 vivo 为察觉要用作探针的标记的 SL 类似物。通常认为的受体结构的知识将在为农业应用要求了的自然底层的类似物上增加研究。 | Cristina Prandi Helena Rosso Beatrice Lace Ernesto G. Occhiatot Alberto Oppedisano Silvia Tabasso Gabriele Alberto Marco Blangetti | 2013 | Molecular Plant2013，6，1： | 5 |
| 19 | 中国南海曲针绣球海绵Iotrochoto sinustyla化学成分的研究显示文摘从中国南海曲针绣球海绵Iotrochotosinustyla分离得到了 11个有机化合物。经1HNMR、13 CNMR、EIMS等波谱技术分析 ,结合文献对照 ,确定其结构分别为邻苯二甲酸正丁酯 (1) ,3 酮 4 烯豆甾烷 (2 ) ,3,6 二酮 4 烯豆甾烷 (3) ,胆固醇 (4) ,3 酮 4 烯 6 羟基豆甾烷 (5 ) ,鲨肝醇 (6 ) ,3R ,3′R 二羟基 β 胡萝卜素 (7) ,胸酰嘧啶 (8) ,胞嘧啶 (9) ,胸苷 (10 ) ,胞苷 (11) ,本文是对该生物化学成分的首次报道。 | 严小红 郭跃伟 宋国强 Mollo Ernesto Cimino Guido | 2003 | 天然产物研究与开发2003，15，4： | 5 |
| 20 | Childhood Functional Gastrointestinal Disorders: Child/Adolescent显示文摘 | Andrée Rasquin Carlo Di Lorenzo David Forbes Ernesto Guiraldes Jeffrey S. Hyams Annamaria Staiano Lynn S. Walker | 2006 | Gastroenterology2006，，5： | 5 |
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