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| 1 | Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation显示文摘The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver axis.The integrity of intestinal barrier is crucial for the maintenance of liver homeostasis.In this mutual relationship,the liver acts as a second firewall towards potentially harmful substances translocated from the gut,and is,in turn,is implicated in the regulation of the barrier.Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver damage.In particular,in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment,diet and gut dysbiosis as the primary pathogenic trigger.In advanced liver disease,intestinal permeability is enhanced by portal hypertension.The clinical consequence is an increased bacterial translocation that further worsens liver damage.Furthermore,this pathogenic mechanism is implicated in most of liver cirrhosis complications,such as spontaneous bacterial peritonitis,hepatorenal syndrome,portal vein thrombosis,hepatic encephalopathy,and hepatocellular carcinoma.After liver transplantation,the decrease in portal pressure should determine beneficial effects on the gut-liver axis,although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still lacking.How the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area,which deserves further attention. | Alberto Nicoletti Francesca Romana Ponziani Marco Biolato Venanzio Valenza Giuseppe Marrone Gabriele Sganga Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 2 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 3 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 4 | Strigolactone Analogs as Molecular Probes in Chasing the (SLs) Receptor/s: Design and Synthesis of Fluorescent Labeled Molecules显示文摘原来作为涉及 plantparasite 相互作用的 allelochemicals 识别了,更最近, Strigolactones (SL ) 被显示了在在植物和 mycorrhizal 真菌之间的根围通讯起多重关键作用。甚至更最近神经质的角色被归功于到拓宽这些相对简单的分子的生物影响的 SL。尽管有关键并且 multifaceted SL 的生物角色,绑如此的活跃分子的受体上没有数据,既不在生产植物也不在寄生杂草或 AM 真菌。SL 的通常认为的受体的信息能借助于结构、分子、基因的途径被聚集。我们这个话题上的贡献是设计和合成荧光灯在受体的 vivo 为察觉要用作探针的标记的 SL 类似物。通常认为的受体结构的知识将在为农业应用要求了的自然底层的类似物上增加研究。 | Cristina Prandi Helena Rosso Beatrice Lace Ernesto G. Occhiatot Alberto Oppedisano Silvia Tabasso Gabriele Alberto Marco Blangetti | 2013 | Molecular Plant2013，6，1： | 5 |
| 5 | Diabetic gastroenteropathy:An underdiagnosed complication显示文摘This article is an extensive review that provides an update on the pathophysiology,symptoms,diagnosis,and treatment of diabetic gastroenteropathy.There is no reported prevalence,but it has been described that patients with type 1 diabetes have a cumulative incidence at 10 years of 5.2%,and type 2 patients,1%.Also,in the group of type 1 diabetes,it has been observed that women are more likely to present this condition(5.8%vs 3.5%).Many factors are associate with its development(e.g.,hyperglycemia,vagal dysfunction,loss of expression of neural nitric oxide synthase in the myenteric plexus,alterations in the Cajal interstitial cell network,and oxidative stress).Gastrointestinal discomfort could be perceived 70% higher in diabetic patients,describing that 25%of diabetic patients experience gastrointestinal symptoms.Diabetic enteropathy could affect any portion of the gastrointestinal tract,but esophageal alterations were described in more than 60% of diabetic patients,also 60% of them present constipation,and 20%,diarrhea.Gastric emptying scintigraphy is useful to evaluate gastroparesis,therefore,gastric retention of more than 60%at 2 h has a sensitivity of 100% and specificity of 20% for diagnosis;however,other studies such as breath tests,with a sensitivity of 89% and a specificity of 80%,or the endoscopic capsule contribute to the diagnosis.There is no cure;however,management must be multidisciplinary,focused on slowing the progression of diabetic gastroenteropathy,reducing symptoms,and restoring function;that includes nutritional recommendation,maintain glucose levels kept below 180 mg/dL,use of prokinetics,anti-emetics;nowadays,it has been special interest in surgical treatment,such as pyloroplasty,also gastric electrical stimulation appears to be another alternative. | Marcio JoséConcepción Zavaleta Jhean Gabriel Gonzáles Yovera Diego Martín Moreno Marreros Luciana del Pilar Rafael Robles Kely Roxana Palomino Taype Karen Nohelly Soto Gálvez Luis Fernando Arriola Torres Julia Cristina Coronado Arroyo Luis Alberto Concepción Urteaga | 2021 | World Journal of Diabetes2021，12，6： | 4 |
| 6 | GDNF to the rescue:GDNF delivery effects on motor neurons and nerves,and muscle re-innervation after peripheral nerve injuries显示文摘Peripheral nerve injuries commonly occur due to trauma,like a traffic accident.Peripheral nerves get severed,causing motor neuron death and potential muscle atrophy.The current golden standard to treat peripheral nerve lesions,especially lesions with large(≥3 cm)nerve gaps,is the use of a nerve autograft or reimplantation in cases where nerve root avulsions occur.If not tended early,degeneration of motor neurons and loss of axon regeneration can occur,leading to loss of function.Although surgical procedures exist,patients often do not fully recover,and quality of life deteriorates.Peripheral nerves have limited regeneration,and it is usually mediated by Schwann cells and neurotrophic factors,like glial cell line-derived neurotrophic factor,as seen in Wallerian degeneration.Glial cell line-derived neurotrophic factor is a neurotrophic factor known to promote motor neuron survival and neurite outgrowth.Glial cell line-derived neurotrophic factor is upregulated in different forms of nerve injuries like axotomy,sciatic nerve crush,and compression,thus creating great interest to explore this protein as a potential treatment for peripheral nerve injuries.Exogenous glial cell line-derived neurotrophic factor has shown positive effects in regeneration and functional recovery when applied in experimental models of peripheral nerve injuries.In this review,we discuss the mechanism of repair provided by Schwann cells and upregulation of glial cell line-derived neurotrophic factor,the latest findings on the effects of glial cell line-derived neurotrophic factor in different types of peripheral nerve injuries,delivery systems,and complementary treatments(electrical muscle stimulation and exercise).Understanding and overcoming the challenges of proper timing and glial cell line-derived neurotrophic factor delivery is paramount to creating novel treatments to tend to peripheral nerve injuries to improve patients'quality of life. | Alberto F.Cintrón-Colón Gabriel Almeida-Alves Juliana M.VanGyseghem John M.Spitsbergen | 2022 | Neural Regeneration Research2022，17，4： | 4 |
| 7 | Comparing Land Degradation and Regeneration Trends in China Drylands显示文摘The aim of this paper is to offer a statistically sound method to make a precise account of the speed of land degradation and regeneration processes.Most common analyses of land degradation focus instead on the extent of degraded areas,rather than on the intensity of degradation processes.The study was implemented for the Potential Extent of Desertification in China(PEDC),composed by arid,semi-arid,and dry sub-humid regions and refers to the period 2002 to 2012.The metrics were standard partial regression coefficients from stepwise regressions,fitted using Net Primary Productivity as the dependent variable,and year number and aridity as predictors.The results indicate that:①the extension of degrading lands(292896 km 2 or 9.12%of PEDC)overcomes the area that is recovering(194560 km 2 or 6.06%of PEDC);and②the intensity of degrading trends is lower than that of increasing trends in three land cover types(grassland,desert,and crops)and in two aridity levels(semi-arid and dry sub-humid).Such an outcome might pinpoint restoration policies by the Chinese government,and document a possible case of hysteresis. | Gabriel Del BARRIO Zhihai GAO Jaime Martinez-VALDERRAMA Xiaosong LI Maria ESANJUAN Bin SUN Alberto RUIZ Bengyu WANG Juan PUIGDEFABREGAS | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 8 | A novel extra-glissonian approach for totally laparoscopic left hepatectomy显示文摘 | Fernando Rotellar Fernando Pardo Alberto Benito Pablo Martí-Cruchaga Gabriel Zozaya Nicolás Pedano | 2012 | Surgical Endoscopy2012，，9： | 2 |
| 9 | Pulmonary Vein Denervation Enhances Long-Term Benefit After Circumferential Ablation for Paroxysmal Atrial Fibrillation显示文摘 | Carlo Pappone Vincenzo Santinelli Francesco Manguso Gabriele Vicedomini Filippo Gugliotta Giuseppe Augello Patrizio Mazzone Valter Tortoriello Giovanni Landoni Alberto Zangrillo Christopher Lang Takeshi Tomita Cézar Mesas Elio Mastella Ottavio Alfieri | 2004 | Circulation: Journal of the American Heart Association2004，，3： | 2 |
| 10 | Microbial transformation of 10-deacetylbaccatin III (10-DAB) by Curvularia lunata and Trametes hirsuta显示文摘 | Alberto Arnone Adriana Bava Stefano Alemani Gianluca Nasini Ezio Bombardelli Gabriele Fontana | 2006 | Journal of Molecular Catalysis B Enzymatic2006，，3： | 1 |
| 11 | Docetaxel for treatment of solid tumours: a systematic review of clinical data 显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncot2005，6，7： | 1 |
| 12 | Obovamine, a new indole alkaloid from Stemmadenia obovat显示文摘 | Alberto Madinaveitia Matias Reina Gabriel de la Fuente | 2002 | Prod2002，65，： | 1 |
| 13 | Docetaxel for treatment of solid tumours:a systematic review of clinical data显示文摘 | Alberto M Frank F Gabriel H | 2005 | Lancet Oncol2005，6，4： | 1 |
| 14 | Impact of the History of Congestive Heart Failure on the Utility of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure: Results from the Breathing Not Properly Multinational Study显示文摘 | Adam Strunk Vikas Bhalla Paul Clopton Richard M. Nowak James McCord Judd E. Hollander Philippe Duc Alan B. Storrow William T. Abraham Alan H.B. Wu Gabriel Steg Alberto Perez Radmila Kazanegra Howard C. Herrmann Marie Claude Aumont Peter A. McCullough Alan | 2006 | The American Journal of Medicine2006，，1： | 1 |
| 15 | Prion-like Doppel gene (PRND) in the goat: genomic structure, cDNA, and polymorphisms显示文摘 | Cristina Uboldi Igor Vecchio Maria Gabriella Foti Alberto Azzalin Marianna Paulis Elena Raimondi Gabriele Vaccari Umberto Agrimi Giovanni Di Guardo Sergio Comincini Luca Ferretti | 2005 | Mammalian Genome2005，，12： | 1 |
| 16 | Isolation andstructure elucidation of new sesquiterpenes of protoilludane origin fromthe fungus Clavicorona divaricata显示文摘 | Alberto Arnone Gabriele Candiani Gianluca Nasini | 2003 | Tetrahedron2003，59，27： | 1 |
| 17 | A vision system for an underwater cable tracker 显示文摘 | Alberto Ortiz Miquel Simo Gabriel Olive | 2002 | Machine Vision Application2002，13，： | 1 |
| 18 | Visual Navigation for Mobile Robots: A Survey显示文摘 | Francisco Bonin-Font Alberto Ortiz Gabriel Oliver | 2008 | Journal of Intelligent and Robotic Systems2008，，3： | 1 |
| 19 | Visual navigation for mobile robots:A survey显示文摘 | BONIN-FONT Francisco ORTIZ Alberto OLIVER Gabriel | | 0，，03： | 1 |
| 20 | Radiometric calibration of vision cameras and intensity uncertainty estimation 显示文摘 | Alberto O Gabriel O | 2006 | hnage and Vision Computing2006，24，： | 1 |
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