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| 1 | Qualitative and quantitative analyses of the bifidobacterial microbiota in the colonic mucosa of patients with colorectal cancer, diverticulitis and inflammatory bowel disease显示文摘AIM: To characterize the bifidobacterial microbiota of the colonic mucosa in patients with colon cancer, inflammatory bowel disease or diverticulitis. METHODS: A sample of the distal colonic mucosa was taken during surgery from a total of 34 patients, twenty-one with diagnosed colorectal cancer, nine with diverticulitis and four with inflammatory bowel disease, requiring surgery for their condition. Bacterial DNA was extracted from the resected mucosal samples and bifidobacterial mucosa-associated microbiota was qualitatively and quantitatively determined by means of qualitative and quantitative PCR. RESULTS: Bifidobacteria were found in 100% of the samples from patients with diverticulitis or IBD and a 76% of those suffering colon cancer. The species B. longum and B. bifidum were the most widely found, followed by B. animalis, B. catenulatum and B. adolescentis. B. breve, B. dentium and B. angulatum were not detected in any sample. A significantly higher occurrence of B. longum was observed in patients with diverticulitis than in those with colon cancer or IBD (100%, 62% and 75%, respectively, P < 0.05). Similar results were obtained for B. animalis (56%, 0% and 25%, P < 0.05), while B. adolescentis was only found in the mucosa from patients with colon cancer (5 out of 21, 24%). At the quantitative level, patients with colon cancer or IBD showed lower counts of total Bifidobacterium (4.94 and 5.91 vs 6.96 log Cells/sample, respectively, P < 0.05) and of the species B. longum (4.05 and 4.79 vs 6.76, P < 0.05) than those with diverticulitis. CONCLUSION: Aberrancies in mucosa associated microbiota are present in different intestinal diseases. This may indicate a role of the microbiota in the pathogenesis of these diseases. | Miguel Gueimonde Arthur Ouwehand Heikki Huhtinen Eeva Salminen Seppo Salminen | 2007 | World Journal of Gastroenterology2007，13，29： | 25 |
| 2 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 3 | Cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease显示文摘AIM:To investigate cognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease(IBD).METHODS:A neuropsychological test battery,including subtests of the Wechsler Adult Intelligence ScaleRevised and Ⅲ,Wechsler Memory Scale-Revised,California Verbal Learning Test(CVLT),Stroop Color-Word Test,and Trail Making Test,which assessed verbal and visual short-and long-term memory,processing speed,logical reasoning,verbal intelligence,attention,and executive functioning,was administered to 13-to 19-year-old patients with IBD(n = 34;active disease n = 20).Depressive symptoms were measured with the Beck Depression Inventory.The findings were compared with peers with non-acute juvenile idiopathic arthritis(JIA;n = 23).Patients with coexisting psychiatric disorders were excluded.RESULTS:The IBD group,especially patients in the acute phase,made more perseverative errors in the CVLT test that assessed verbal memory than the JIA group(6.0 ± 4.3 vs 3.3 ± 2.9,P < 0.01),but no other differences between the IBD and JIA groups were observed in the neuropsychological tests.The difference was close to statistical significance,even when glucocorticoid medication was controlled for(P < 0.052).The IBD group had more depressive symptoms than the JIA group(7.9 ± 7.6 vs 4.0 ± 4.0,P < 0.05).Approximately one third of the IBD group had at least mild depressive symptoms,and those with acute illness had the highest scores.However,depressive symptoms were not related to the difference in the verbal memory test(perseverative errors in the CVLT) between the IBD and JIA groups.CONCLUSION:Adolescents with acute IBD may have mild verbal memory problems but no major cognitive deficits compared to peers with JIA. | Anu E Castaneda Annamari Tuulio-Henriksson Eeva T Aronen Mauri Marttunen Kaija-Leena Kolho | 2013 | World Journal of Gastroenterology2013，19，10： | 5 |
| 4 | Relationship between COX-2 and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma显示文摘AIM: To investigate the correlation between cyclooxygenase-2 (COX-2) and cell cycle-regulatory proteins in patients with esophageal squamous cell carcinoma (ESCC). METHODS: One hundred and two surgically obtained specimens of ESCC were randomly collected. All specimens were obtained from patients who had not received chemoor radiotherapy prior to surgical resection.Twenty-eight specimens of normal squamous epithelium served as controls. The expression of COX-2, Ki-67, cyclin A and p27 was examined by immunohistochemistry. The Pearson test was used to analyze the relationship between groups. RESULTS: The protein level of COX-2, Ki-67 and cyclin A was significantly higher in ESCC than in normal squamous epithelium (74.7±61.2 vs 30.2 ± 43.4, 64.0 ± 51.6 vs 11.6 ± 2.3, 44.2 ± 32.2 vs 11.7 ± 5.0, respectively, all P<0.01). In contrast, the protein level of p27 was signifi cantly lower in ESCC than in normal squamous epithelium (182.0 ±69.0 vs 266.4±28.0, P<0.01). In ESCC, COX-2 expression was correlated with T stage, the score of T1-T2 stage was lower than that of T3-T4 stage (55.0±42.3 vs 83.0 ± 66.5, P<0.05), and Ki-67, cyclin A and p27 expressions were correlated with the tumor differentiation (43.8±31.7 vs 98.4± 84.8, 32.0 ± 19.0 vs 54.1 ±53.7,206.2±61.5 vs 123.5±68.3, respectively, all P<0.01). COX-2 expression was positively correlated to Ki-67, cyclin A and negatively correlated to p27 expression in ESCC (r=0.270, 0.233 and-0.311, respectively, all P<0.05).CONCLUSION: The expression of COX-2 is correlated with tumor cell invasion and is closely related to the cell proliferation in patients with ESCC. | Jun-Xing Huang Mao-Song Lin Yun-Lei Zhang Feng-Yue Li Rong-Yu Qian Wei-Chang Chen Zheng-Xiang Song Ping Chen Eeva Salminen | 2010 | World Journal of Gastroenterology2010，16，47： | 3 |
| 5 | Expression of thymidylate synthase and glutathione-stransferase π in patients with esophageal squamous cell carcinoma显示文摘AIM:To investigate the expression of thymidylate synthase(TS)and glutathione-s-transferaseπ(GST-π) in esophageal squamous cell carcinoma and their association with the clinicopathologic characteristics. METHODS:Immunohistochemical methods were used to detect the expression of TS and GST-πin surgically resected formalin-fixed,paraffin-embedded esophageal squamous cell carcinoma(ESCC)tissue sections from 102 patients(median age,58 years)and in 28 normal esophageal mucosa(NEM)samples.The relationship between TS and GST-πexpression and clinicopathologic factors was examined. RESULTS:The expression of TS and GST-πwas not statistically significantly associated with age of the patients,tumor size,lymph node metastasis,depth of invasion or tumor stage.TS staining was positive in 17.86%of normal esophageal mucosa and in 42.16% of ESCC samples(P<0.05).The expression level of TSwas not only significantly lower in well-differentiated (21.88%)than in poorly-differentiated carcinomas (51.43%,P<0.05),but was also significantly higher in samples from male patients(46.51%)than from female patients(18.75%,P<0.05).GST-πwas positively stained in 78.57%of normal esophageal mucosa and in 53.92%of ESCC samples(P<0.05).The expression level of GST-πwas also significantly higher in welldifferentiated carcinomas(65.63%)than in poorlydifferentiated carcinomas(35.00%,P<0.05). CONCLUSION:The expression of TS and of GST-πmay be used as molecular markers for the characterization of ESCC.Poorly-differentiated cells showed increased expression of TS and reduced expression of GST-π. | Jun-Xing Huang Feng-Yue Li Wei Xiao Zheng-Xiang Song Rong-Yu Qian Ping Chen, Eeva Salminen | 2009 | World Journal of Gastroenterology2009，15，34： | 3 |
| 6 | Association of Early Repolarization and Sudden Cardiac Death During an Acute Coronary Event显示文摘 | Jani T. Tikkanen Viktor Wichmann M. Juhani Junttila Meri Rainio Eeva Hookana Olli-Pekka Lappi Marja-Leena Kortelainen Olli Anttonen Heikki V. Huikuri | 2012 | Circulation: Arrhythmia and Electrophysiology2012，，4： | 2 |
| 7 | Insulin resistance and adiposity correlate with acute-phase reaction and soluble cell adhesion molecules in type 2 diabetes显示文摘 | Eeva Leinonen Eva Hurt-Camejo Olov Wiklund Lillemor Mattson Hultén Anne Hiukka Marja-Riitta Taskinen | 2002 | Atherosclerosis2002，，： | 2 |
| 8 | SEM observations on stress corrosion cracking of commercially pure titanium in a topical fluoride solution显示文摘 | Mauno H O Kononen Eeva T Lavonius Jorma K Kivilahti | 1995 | Dent Mater1995，11，： | 1 |
| 9 | 8q24amplification intransitional cell carcinoma of bladder显示文摘 | Visapaa H Swligson D Eeva M | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 10 | Invasive Group A Streptococcal Infections in Children: A Nationwide Survey in Finland显示文摘 | Terhi Tapiainen Saana Launonen Marjo Renko Harri Saxen Eeva Salo Matti Korppi Leena Kainulainen Tarja Heiskanen-Kosma Laura Lindholm Jaana Vuopio Tiina Huotari Jarmo Rusanen Matti Uhari | 2016 | The Pediatric Infectious Disease Journal2016，，： | 1 |
| 11 | Assessing heavy metal pollution using Great Tits ( Parus major ): feathers and excrements from nestlings and adults显示文摘 | R. A. Costa T. Eeva C. Eira J. Vaqueiro J. V. Vingada | 2013 | Environmental Monitoring and Assessment2013，，6： | 1 |
| 12 | Characterization of biomass-based flash pyrolysis oils显示文摘 | Kai Sioila Eeva Kcoppala Leena Fagerna s | 1998 | BiomassandBioenergy1998，14，2： | 1 |
| 13 | Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme显示文摘 | ZHOU H MIKI R EEVA M | | 0，，08： | 1 |
| 14 | Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats显示文摘 | Palojoki Eeva Saraste Antti Eriksson Anders | 2001 | Am J Physiol Heart Cire Physiol2001，280，： | 1 |
| 15 | SEM observations on stress corrosion cracking of commercially pure titanium in a topical fluoride solution 显示文摘 | MAUNO H KIINIINEN 0 LAVONIUS EEVA T KIVILAHTI JORMA K | 1995 | Dental Materials1995，11，4： | 1 |
| 16 | Pollution related effects on immune function and stress in a free living population of pied flycatcher Ficedula hypole- uca显示文摘 | Eeva T Hasselquist D Langefors A | 2005 | Journal of Avian Biology2005，36，5： | 1 |
| 17 | Trace elements in faeces of great tit nestlings in relation to breeding performance in coastal areas in central Portugal显示文摘 | Costa RA Eeva T Eira C | 2012 | Arch Environ Contain Toxicol2012，63，4： | 1 |
| 18 | Feedback regulation of mitochondria by caspase-9 in the B cell receptormediated apoptosis显示文摘 | Eeva J Nuutinen U Ropponen A | 2009 | Scand J Immunol2009，70，6： | 1 |
| 19 | 8q24 amplification intransi- tional cell carcinoma ofbladder 显示文摘 | Visapaa H Swligson D Eeva M | 2003 | Appl lmmunohistochem Mol Morpho2003，11，1： | 1 |
| 20 | Release of bioactive peptides by enzymatic proteolysis of Lactobacillus GC fermented UHT milk显示文摘 | ROKKA T EEVA L | 1997 | Milchwis- senschaft1997，52，12： | 1 |
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