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| 1 | Digital Earth 2020:towards the vision for the next decade显示文摘This position paper is the outcome of a brainstorming workshop organised by the International Society for Digital Earth(ISDE)in Beijing in March 2011.It argues that the vision of Digital Earth(DE)put forward by Vice-President Al Gore 13 years ago needs to be re-evaluated in the light of the many developments in the fields of information technology,data infrastructures and earth observation that have taken place since.The paper identifies the main policy,scientific and societal drivers for the development of DE and illustrates the multi-faceted nature of a new vision of DE grounding it with a few examples of potential applications.Because no single organisation can on its own develop all the aspects of DE,it is essential to develop a series of collaborations at the global level to turn the vision outlined in this paper into reality. | Max Craglia Kees de Bie Davina Jackson Martino Pesaresi Gabor Remetey-Fulopp Changlin Wang Alessandro Annoni Ling Bian Fred Campbell Manfred Ehlers John van Genderen Michael Goodchild Huadong Guo Anthony Lewis Richard Simpson Andrew Skidmore Peter Woodgate | 2012 | International Journal of Digital Earth2012，5，1： | 8 |
| 2 | Oral eplerenone for the management of chronic central serous chorioretinopathy显示文摘AIM: To examine eplerenone(Inspra, Pfizer), a mineralocorticoid receptor antagonist, as a treatment option for chronic central serous chorioretinopathy(CSCR).METHODS: A retrospective consecutive case series was conducted for patients receiving oral eplerenone for chronic CSCR. At baseline and each follow-up visit,spectral domain optical coherence tomography(SD-OCT)imaging was performed, including manual measurements of the height and diameter size of subretinal fluid. The primary outcome measure was the reduction in subretinal fluid following initiation of therapy.RESULTS: A total of 17 eyes of 13 patients treated with25 and 50 mg of oral eplerenone per day were identified.Subretinal fluid(SRF) decreased over time following eplerenone therapy(P = 0.007 and P =0.002, diameter and height respectively). Maximum SRF height decreased from a mean of 131.5 μm at baseline to 15.3 μm at day181+. SRF diameter decreased from an average of 2174.4μm at baseline to 46.9 μm at day 181 +. Log MAR visual acuity improved from 0.42(Snellen equivalent: 20/53) at baseline to 0.29(Snellen equivalent: 20/39) at day 181 +(P = 0.024). Central subfield thickness(CST) decreased from 339.5 μm at baseline to 270.3 μm at day 181+(P = 0.029).CONCLUSION: Eplerenone therapy resulted in significant anatomic and visual improvements in eyes with chronic CSCR. | Rishi P Singh Jonathan E Sears Rumneek Bedi Andrew P Schachat Justis P Ehlers Peter K Kaiser | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 6 |
| 3 | Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells显示文摘AIM To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells(PSCs).METHODS Quiescent PSCs were isolated from mouse pancreas and activated in vitro by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures(early-activated PSCs) and upon re-culturing(fullyactivated cells). Exhibition of vitamin A-containing lipid droplets was visualized by oil-red staining. Expression of α-smooth muscle actin(α-SMA), a marker of PSC activation, was monitored by immunofluorescence and immunoblot analysis. The rate of DNA synthesis was quantified by 5-bromo-2'-deoxyuridine(Brd U) incorporation assays. Real-time PCR was employed to monitor gene expression, and protein levels of interleukin-6(IL-6) were measured by ELISA. Uptake of proline was determined using 18 F-proline.RESULTS Sustained culture of originally quiescent PSCs inducedcell proliferation, loss of lipid droplets and exhibition of stress fibers, indicating cell activation. When added to PSCs in primary culture, all three D-vitamins diminished expression of α-SMA(to 32%-39% of the level of control cells; P < 0.05) and increased the storage of lipids(scores from 1.97-2.15 on a scale from 0-3; controls: 1.49; P < 0.05). No such effects were observed when D-vitamins were added to fully-activated cells, while incorporation of Brd U remained unaffected under both experimental conditions. Treatment of re-cultured PSCs with D-vitamins was associated with lower expression of IL-6(-42% to-49%; P < 0.05; also confirmed at the protein level) and increased expression of the vitamin D receptor gene(209%-321% vs controls; P < 0.05). There was no effect of D-vitamins on the expression of transforming growth factor-β1 and collagen type 1(chain α1). The lowest uptake of proline, a main component of collagen, was observed in calcipotriol-treated PSCs.CONCLUSION The three D-vitamins inhibit, with similar efficiencies, activation of PSCs in vitro, but cannot reverse the phenotype once the cells are fully activated. | Peter Wallbaum Sarah Rohde Luise Ehlers Falko Lange Alexander Hohn Carina Bergner Sarah Marie Schwarzenbock Bernd Joachim Krause Robert Jaster | 2018 | World Journal of Gastroenterology2018，24，2： | 3 |
| 4 | Propeller Torque Load and Propeller Shaft Torque Response Correlation During Ice-propeller Interaction显示文摘轮船使用推进机械系统创造方向性的戳。当轮船壳进展,航行在盖住冰的水里包含碎冰片和他们的 submergence。有时,沉没了冰片与推进器交往并且引起转矩负担的不规则的变化。作为结果,推进器和引擎动力学,变得的 imbalanced,和能量通过推进机械系统宣传直到平衡被到达。处于如此的 imbalanced 状况,测量推进器柄转矩反应不等于推进器转矩。在这个工作,因此,全面系统反应用契约图模型在冰相关的转矩负担下面被模仿。推进器和推进器柄之间的能量差别被估计并且与他们的相应机械能量有关。另外,机械能量在模式之中被散布。基于分发,运动并且势能为在推进器转矩和推进器柄反应之间的关联是重要的。 | Drazen Polic Soren Ehlers Vilmar AEsoy | 2017 | Journal of Marine Science and Application2017，16，1： | 3 |
| 5 | 遥感与GIS:朝着一体化空间信息处理的方向发展显示文摘近几年来,许多与地球有关的学科,包括城市和区域规划、自然资源管理、农业研究、地形测绘和地质勘探等,对最新、精确信息的需求日益迫切。为满足需求,热门话题是开发地理信息系统(GIS)。GIS能有效地存贮和检索数据,具有处理和显示功能,且为遥感数据综合利用奠定了基础。然而,使基于不同空间概念的遥感与GIS真正一体化,尚有一些障碍。本文分析了这些障碍,同时阐述了排除障碍的策略。迄今为止,遥感与GIS一体化应用的例子,包括地形测绘/DEM数据自动提取、制图特征提取、提高空间分辨率和城市与区域规划等。 | Manfred Ehlers 金逸民 | 1991 | 遥感信息1991，13，2： | 3 |
| 6 | Impact of mobile health and medical applications on clinical practice in gastroenterology显示文摘Mobile health apps (MHAs) and medical apps (MAs) are becoming increasinglypopular as digital interventions in a wide range of health-related applications inalmost all sectors of healthcare. The surge in demand for digital medical solutionshas been accelerated by the need for new diagnostic and therapeutic methods inthe current coronavirus disease 2019 pandemic. This also applies to clinicalpractice in gastroenterology, which has, in many respects, undergone a recentdigital transformation with numerous consequences that will impact patients andhealth care professionals in the near future. MHAs and MAs are considered tohave great potential, especially for chronic diseases, as they can support the selfmanagementof patients in many ways. Despite the great potential associated withthe application of MHAs and MAs in gastroenterology and health care in general,there are numerous challenges to be met in the future, including both the ethicaland legal aspects of applying this technology. The aim of this article is to providean overview of the current status of MHA and MA use in the field ofgastroenterology, describe the future perspectives in this field and point out someof the challenges that need to be addressed. | Sven Kernebeck Theresa S Busse Maximilian D Bottcher Jurgen Weitz Jan Ehlers Ulrich Bork Didactics Educational Research in Health | 2020 | World Journal of Gastroenterology2020，26，29： | 2 |
| 7 | Different characteristics of chronic dibutyltin dichloride-induced pancreatitis and cholangitis in mouse and rat显示文摘Background:Current animal models of chronic pancreatitis(CP)often provide only limited pathophysio-logical insights since they incompletely reflect the human disease.CP induced by injection of dibutyltin dichloride(DBTC-pancreatitis)shares with human CP the important feature of extended fibrosis and would be an even more attractive model if it could be transferred from rats to mice,as recently sug-gested in the context of combined ethanol and DBTC application.This study aimed to evaluate the effects of DBTC in pancreas and liver of C57BL/6 mice,a strain commonly used to engineer genetic mouse mod-els.Methods:C57BL/6 mice and Lewis rats were exposed to variable doses of DBTC.After an investigation period of up to 4 weeks,laboratory findings and histopathological changes of pancreas and liver were evaluated.Results:Chronic DBTC-pancreatitis in rats was characterized by acinar cell damage,ductal changes,fi-brosis,and inflammatory cell infiltrates.Mice treated with DBTC at 6–8 mg/kg body weight,the standard doses in rats,showed transient increases of lipase activities but no morphological signs of chronic DBTC-pancreatitis 4 weeks after injection of the drug.Increased doses of 10–12 mg/kg DBTC were intolerable due to their high toxicity.In contrast,mice and rats presented with a similar histopathology of the liver that can be characterized as a chronic-proliferative DBTC-cholangitis with predominating damage and proliferation of the small bile ducts as well as secondary portal inflammatory cell infiltrates and a begin-ning portal fibrosis.Conclusions:The DBTC-model cannot be transferred from rats to C57BL/6 mice with respect to chronic DBTC-pancreatitis,but might be of interest to study DBTC-cholangitis in both species. | Friederike Lütt Luise Ehlers Horst Nizze Robert Jaster | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 2 |
| 8 | The directly heating LaB6 cathodes显示文摘 | LUNG K N PINCOSY P A EHLERS K W | 1986 | Rev Sci Instrum1986，57，7： | 2 |
| 9 | Extent and chronology of Quaternary glaciation显示文摘 | Jurgen Ehlers Philip Gibbard | 2008 | Episodes2008，31，2： | 2 |
| 10 | Late Miocene exhumation and uplift of the Washington cascade range显示文摘 | Reiners P W Ehlers T A Garver J I | 2002 | Geology2002，30，9： | 1 |
| 11 | Psychological treatments for chronic post-traumatic stress disorder:Systematic review and Meta-analysis显示文摘 | Bisson JI Ehlers A Matthews R | 2007 | Br J Psychiatry2007，190，： | 1 |
| 12 | Inability of the polyphasic approach to systematics to determine the relatedness of the genera Xenorhabdus and Photorhabdus显示文摘 | Rainey F A Ehlers R U Stackebrandt E | 1995 | International journal of systematic bacteriology1995，45，： | 1 |
| 13 | Multi-sensor image fusion techniques in remote sensing显示文摘 | | 1991 | ISPRS Journal Photogrammetry and Remote Sensing1991，46，： | 1 |
| 14 | Mass production of entomopathogenic nematodes for plant protection 显示文摘 | Ehlers R U | 2001 | Applied Microbiology and Biotechnology2001，56，： | 1 |
| 15 | Potential and problems of multi-scale segmentation methods in remote sensing显示文摘 | SCHIEWE J TUFTE L EHLERS M | | 0，，01： | 1 |
| 16 | Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB,epidermal growth factor,transforming growth factor-alpha,acidic fibroblast growth factor,insulin-like growth factor-Ⅰ,and transforming growth factor-beta显示文摘 | Andresen JL Ehlers N | | 0，，1： | 1 |
| 17 | S3 Guideline: Sedation for gastrointestinal endoscopy 2008显示文摘 | A. Riphaus T. Wehrmann B. Weber J. Arnold U. Beilenhoff H. Bitter S. von Delius D. Domagk A. Ehlers S. Faiss D. Hartmann W. Heinrichs M.-L. Hermans C. Hofmann S. In der Smitten M. Jung G. K?hler M. Kraus J. Martin A. Meining J. Radke T. R?sch H. Seifert A | 2009 | Endoscopy2009，，09： | 1 |
| 18 | New perspectives on sea use management:Initial findings from European experience with marine spatial planning显示文摘 | DOUVERE F EHLER C N | 2008 | Journal of environmental management2008，90，： | 1 |
| 19 | Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-l, and transforming growth factor-beta显示文摘 | Andresen JL Ehlers N | 1998 | Curr Eye Res1998，17，1： | 1 |
| 20 | Effects of neonatal expo-sure to nicotine on electrophysiological parameters in adult rats显示文摘 | Ehlers CL Somes C Thomas J | 1997 | Pharmacol Biochem Behav1997，58，3： | 1 |
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