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| 1 | Androgen receptor: structure, role in prostate cancer and drug discovery显示文摘Androgens and androgen receptors (AR) play a pivotal role in expression of the male phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate cancer, are associated with alterations in AR functions. Indeed, androgen blockade by drugs that prevent the production of androgens and/or block the action of the AR inhibits prostate cancer growth. However, resistance to these drugs often occurs after 2-3 years as the patients develop castration-resistant prostate cancer (CRPC). In CRPC, a functional AR remains a key regulator. Early studies focused on the functional domains of the AR and its crucial role in the pathology. The elucidation of the structures of the AR DNA binding domain (DBD) and ligand binding domain (LBD) provides a new framework for understanding the functions of this receptor and leads to the development of rational drug design for the treatment of prostate cancer. An overview of androgen receptor structure and activity, its actions in prostate cancer, and how structural information and high-throughput screening have been or can be used for drug discovery are provided herein. | MH Eileen TAN Jun LI H Eric XU Karsten MELCHER Eu-leong YONG | 2015 | Acta Pharmacologica Sinica2015，36，1： | 39 |
| 2 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 3 | collaborative evaluation of a fluorometric method for measuring alkaline phosphatase activity in Cow's,Sheep's,and Goat's milk显示文摘 | FRANK H EILEEN G | 2005 | Food Protection2005，68，5： | 1 |
| 4 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 5 | Novel fungitoxicity assays for inhibition of germination-associated adhesion of botrytis cinerea and Puccinia recondita spores 显示文摘 | Richard A Slawecki Eileen P Ryan David H Young | 2002 | Applied and Environmental Microbiology2002，68，2： | 1 |
| 6 | Relative contribution of outdoor particle sources to indoor concentrations显示文摘 | Eileen Abt Helen H Suh Paul Catalano | 2000 | Environment Science and Technology2000，34，： | 1 |
| 7 | Blockade, Hypotension and acute kidney injury in elective major orthopedic surgery 显示文摘 | Erik N Eileen H Erik L | 2014 | Journal of HospitalMedicine2014，9，5： | 1 |
| 8 | Effects of chlorine and ammonia from wastewater treatment facilities on biotic integrity 显示文摘 | James Karr R Roy Heidinger C Eileen Helmer H | 1985 | Journal WPCF1985，57，9： | 1 |
| 9 | Bone morphogenetic protein 2 4 in early fibromatous lesions of fibrodysplasia ossificans progressiva显示文摘 | Francis H Gannon Frederick S Kaplan Elizabeth Olmsted Gerald C Finkel Michael A Zasloff Eileen Shore | 1997 | Human Pathology1997，，3： | 1 |
| 10 | Mast cell involvement in fibrodysplasia ossificans progressiva显示文摘 | Francis H Gannon David Glaser Robert Caron Lester D.R Thompson Eileen M Shore Frederick S Kaplan | 2001 | Human Pathology2001，，8： | 1 |
| 11 | Motivational interviewing:a review显示文摘 | Eileen B Neville B Stephen H | | 0，，03： | 1 |
| 12 | Psychosocial intervention for a geriatric patient to address fears related to implantable cardioverter defibrillator discharges 显示文摘 | GUIDO U SAMUEL FS EILEEN H | 2004 | Psy- chosomatics2004，45，： | 1 |
| 13 | Late vs early clamping of the umbilical cord in full-term neonates-systematic review and meta-analysis of controlled trials显示文摘 | Eileen K H Eman S H | 2007 | JAMA2007，297，11： | 1 |
| 14 | Duloxetine 60mg once-daily in the treatment of painful physical symptoms in patients with major depressive disorder 显示文摘 | Stephen K Brannana Craig H Mallinckrodtb Eileen B Brown | 2005 | Journal of Psychiatric Research2005，39，39： | 1 |
| 15 | Curing behavior and thermal mechanical properties of cyanate ester blends显示文摘 | KOH H C Y DAI Jie TAN Eileen | | 0，，102： | 1 |
| 16 | Root biomass allocation in the world's upland forests显示文摘 | Michael A Eileen H | 1997 | Oeeologia1997，111，： | 1 |
| 17 | Nursing care quality and adverse events in US hospitals显示文摘 | Robert J Lucero Eileen T Lake Linda H Aiken | 2010 | Journal of Clinical Nursing2010，19，1516： | 1 |
| 18 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 19 | Apolipoprotein Ee4 is superior to apolipoprotein Ee2 in predicting cognitive scores over 30 months 显示文摘 | Paul R Balakrishnan N Eileen H | 2013 | Clinical Interventions in Aging2013，8，： | 1 |
| 20 | Human pharmaceuticals in US surface waters:a human health risk assessment显示文摘 | Bradley W S Eileen P H Janice M F | 2005 | Regulatory Toxicology and Pharmacology2005，42，3： | 1 |
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