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| 1 | Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis显示文摘AIM:To evaluate the natural history of human cytomegalovirus(HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive.METHODS:A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain,immunohistochemical assay and nested polymerase chain reaction on rectal biopsies.Among 85 screened patients(19 of whom were steroid resistant/dependant),28 were positive for HCMV;after remission the patients were followed up clinically and histologically.RESULTS:Among the 22 patients with complete followup,in 8(36%) patients HCMV-DNA persisted in the intestinal specimens.Among the HCMV positive patients,4(50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV.Among the 14 HCMV negative patients,3 with pouches developed pouchitis and 5 out of 11(45%) experienced a colitis flare-up.CONCLUSION:Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flareup despite remission;it seems that the virus is not responsible for the disease relapse. | Valeria Criscuoli Maria Rosa Rizzuto Luigi Montalbano Elena Gallo Mario Cottone | 2011 | World Journal of Gastroenterology2011，17，5： | 20 |
| 2 | Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of three randomised trials显示文摘 | Massimo Di Maio Cesare Gridelli Ciro Gallo Frances Shepherd Franco Vito Piantedosi Silvio Cigolari Luigi Manzione Alfonso Illiano Santi Barbera Sergio Federico Robbiati Luciano Frontini Elena Piazza Giovanni Pietro Ianniello Enzo Veltri Federico Castiglio | 2005 | Lancet Oncology2005，，9： | 2 |
| 3 | Direct effects of iodothyronines on excess fat storage in rat hepatocytes显示文摘 | Elena Grasselli Adriana Voci Laura Canesi Rita De Matteis Fernando Goglia Federica Cioffi Emilia Fugassa Gabriella Gallo Laura Vergani | 2010 | Journal of Hepatology2010，，6： | 2 |
| 4 | Direct effects of Bisphenol A on lipid homeostasis in rat hepatoma cells显示文摘 | Elena Grasselli Katia Cortese Adriana Voci Laura Vergani Rita Fabbri Cristina Barmo Gabriella Gallo Laura Canesi | 2013 | Chemosphere2013，，： | 1 |
| 5 | PAT protein mRNA expression in primary rat hepatocytes: effects of exposureto fatty acids显示文摘 | Elena Grasselli Adriana Voci Carlo Pesce Laura Canesi Emilia Fugassa Gabriella Gallo Laura Vergani | 2010 | International Journal of Molecular Medicine2010，，4： | 1 |
| 6 | Malarial pigment enhances heat shock protein-27 in THP-1 cells:new perspectives for in vitro studies on monocyte apoptosis prevention显示文摘Objective:To investigate the effect of malarial pigment(hemozoin,HZ) on expression of heat shock proteins(HSPs) and cell viability in human monocytes by using a stable cell line(THP-1 cells).Methods:THP-1 cells were fed with native HZ or treated with pro-apoptotic molecule gliotoxin for 9 h.Thereafter,the protein expression of HSP-27 and HSP-70 was evaluated by western blotting.Alternatively,HZ-fed cells were cultured up to 72 h and cell viability parameters(survival,apoptosis and necrosis rates) were measured by flow cytometric analysis. Results:HZ increased basal protein levels of HSP-27 without altering those of HSP-70 in THP-1 cells,and promoted long-term cell survival without inducing apoptosis.As expected,gliotoxin inhibited HSP-27 protein expression and promoted long-term cell apoptosis.Conclusions: Present data show that HZ prevents cell apoptosis and enhances the expression of anli-apoptotic HSP-27 in THP-1 cells,confirming the previous evidences obtained from HZ-fed immunopurified monocytes.Since the use of a stable cell line is pivotal to perform HSP-27 silencing experiments, monocytic THP-1 cells could be a good candidate line for such an approach,which is heavily required to clarify the role of HSP-27 in survival of impaired HZ-fed monocytes during falciparum malaria. | Mauro Prato Valentina Gallo Elena Valente Amina Khadjavi Giorgia Mandili Giuliana Giribaldi | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 1 |
| 7 | PAT protein mRNA expression in primary rat hepatocytes: effects of exposureto fatty acids显示文摘 | Elena Grasselli Adriana Voci Carlo Pesce Laura Canesi Emilia Fugassa Gabriella Gallo Laura Vergani | 2010 | International Journal of Molecular Medicine2010，，4： | 1 |
| 8 | Could JC virus provoke metastasis in colon cancer?显示文摘AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 test.RESULTS: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors. | Emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio Orlando Francesca Rossi Emanuele Orlando Marco Messina Giovanni Tomasello Attilio Ignazio Lo Monte Ennio La Rocca Aroldo Gabriele Rizzo | 2014 | World Journal of Gastroenterology2014，20，42： | 0 |
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