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| 1 | Natural history of cytomegalovirus infection in a series of patients diagnosed with moderate-severe ulcerative colitis显示文摘AIM:To evaluate the natural history of human cytomegalovirus(HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive.METHODS:A series of 85 patients with moderate-severe ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain,immunohistochemical assay and nested polymerase chain reaction on rectal biopsies.Among 85 screened patients(19 of whom were steroid resistant/dependant),28 were positive for HCMV;after remission the patients were followed up clinically and histologically.RESULTS:Among the 22 patients with complete followup,in 8(36%) patients HCMV-DNA persisted in the intestinal specimens.Among the HCMV positive patients,4(50%) experienced at least one moderate-severe flare-up of colitis without evidence of peripheral HCMV.Among the 14 HCMV negative patients,3 with pouches developed pouchitis and 5 out of 11(45%) experienced a colitis flare-up.CONCLUSION:Our preliminary results suggest that HCMV may remain in the colon after an acute colitis flareup despite remission;it seems that the virus is not responsible for the disease relapse. | Valeria Criscuoli Maria Rosa Rizzuto Luigi Montalbano Elena Gallo Mario Cottone | 2011 | World Journal of Gastroenterology2011，17，5： | 20 |
| 2 | Cytomegalovirus and inflammatory bowel disease: Is there a link?显示文摘这份报告的目的是在煽动性的肠疾病(IBD ) 给 Cytomegalovirus (CMV ) 感染的流行病学、临床、诊断、治疗学的特征的一个全面看法。这个话题上的出版报告的评论被执行,与对在研究和采用的诊断方法包括的病人的选择给予的特别注意。CMV 经常与 IBD 被联系。在一些情况中, CMV 感染与差的结果被联系,但是哪个病人是更可能的被假装,不是清楚的并且在哪个疾病的舞台。在 IBD 的抗病毒的治疗的使用是争论的,有控制的实验研究被需要。与 IBD 的发展和治疗有关的 CMV 感染的自然科学没被澄清,但是因为病毒的坚持的可能性,在免疫在考虑拿它是重要的有免疫系统的损害主人和病毒的相互作用。 | Valeria Criscuoli Maria Rosa Rizzuto Mario Cottone | 2006 | World Journal of Gastroenterology2006，12，30： | 7 |
| 3 | Methodology for high-quality studies on course and prognosis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are characterized by a chronic course with an alternation of relapses and remissions.Questions about prognosis are important for the patient who wants to know how the disease will affect his/her life and also for clinicians to make management decisions.Correct selection of the patients is the basis for good methodological studies on the course of IBD.A great proportion of data on the course of IBD is derived from a limited number of cohort studies.Studies help to define the endpoints for clinical trials and to identify subsets of patients in whom the prognosis of the disease can be stratified according to clinical features.Specific scientific requirements for high-quality studies on prognosis are the following:use of inception cohort,description of referral patterns,completeness of follow-up,objective outcome criteria,blind outcome assessment,adjustment for extraneous prognostic factors and statistical issues.We analyzed each of these requirements in studies on IBDs.To date,prospective and populationbased cohort studies are the standard for an unbiased assessment of prognosis.A better knowledge of the course of disease of chronic disorders ideally requires:(1) data from population-based studies,to avoid selection bias from referral centers in which patients with a more severe disease are usually treated;(2) inclusion of patients seen at the onset of the disease excluding misdiagnosed cases;and(3) follow-up from the onset of the disease to the end without dropouts. | Irene Modesto Giovanni Perricone Ambrogio Orlando Mario Cottone | 2012 | World Journal of Gastroenterology2012，18，29： | 7 |
| 4 | Gastrointestinal lesions associated with spondyloarthropathies显示文摘Subclinical gut inflammation has been described in up to twothirds of patients with spondyloarthropathies(SpA).Arthritis represents an extraintestinal manifestation of several gastrointestinal diseases, including inflammatory bowel disease(IBD), Whipple's disease, Behcet's disease, celiac disease, intestinal bypass surgery, parasitic infections of the gut and pseudomembranous colitis.Moreover about two thirds of nonsteroidal antiinflammatory drug users demonstrate intestinal inflammation.Arthritis may manifest as a peripheral or axial arthritis.The spondyloarthropathy family consists of the following entities:ankylosing spondylitis, undifferentiated spondyloarthritis, reactive arthritis, psoriatic arthritis, spondyloarthritis associated with IBD, juvenile onset spondyloarthritis.This topic reviews the major gastrointestinal manifestations that can occur in patients with SpA and in nonsteroidal anti inflammatory drugs users. | Ambrogio Orlando Sara Renna Giovanni Perricone Mario Cottone | 2009 | World Journal of Gastroenterology2009，15，20： | 3 |
| 5 | Is 5-ASA Still the Treatment of Choice for Ulcerative Colitis?显示文摘 | Mario Cottone Sara Renna Irene Modesto Ambrogio Orlando | 2011 | Current Drug Targets2011，，10： | 2 |
| 6 | 艺术的扩张旧金山现代博物馆扩建项目显示文摘自成立的25年以来,Sn(o)hetta建筑事务所一直致力于大型公共文化空间的设计开发,它们坚持跨学科的设计实践理念,将建筑和周围景观进行融合式设计.2016年5月14日开馆的旧金山当代艺术博物馆(SFMOMA)扩建项目是他们最新的设计力作. | violet(编译) Craig Dykers Aaron Dorf Lara Kauiman Jon McNeal Simon Ewings Alan Gordon Marianne Lau Elaine Molinar Kjetil Traedal Thorsen Nick Anderson Behrang Behin Sam Brisette Chad Carpenter Michael Cotton Aroussiak Gabrielian Kyle Johnson Nick Koster Mario Mohan Neda Mostafavi Anne-Rachel Schiffmann Carrie Tsang Giancarlo Valle Henrik Kam(摄影) Iwan Baan(摄影) 无 | 2016 | 室内设计与装修2016，0，7： | 2 |
| 7 | Mortality and Causes of Death in Celiac Disease in a Mediterranean Area显示文摘 | Mario Cottone Anna Termini Lorenzo Oliva Antonino Magliocco Ciro Marrone Ambrogio Orlando Filippo Pinzone Roberto Di Mitri Matteo Rosselli Aroldo Rizzo Luigi Pagliaro | 1999 | Digestive Diseases and Sciences1999，，12： | 1 |
| 8 | Mortality in patients with coeliac disease and their relatives: a cohort study显示文摘 | Giovanni Corrao Gino Roberto Corazza Vincenzo Bagnardi Giovanna Brusco Carolina Ciacci Mario Cottone Carla Sategna Guidetti Paolo Usai Pietro Cesari Maria Antonietta Pelli Silvano Loperfido Umberto Volta Antonino Calabró Maria Certo | 2001 | The Lancet . 2001 (9279)2001，，9279： | 1 |
| 9 | Unusual perforation after balloon dilation in a Crohn’s disease patient: Report of a case显示文摘 | Filippo Mocciaro Sara Renna Gaspare Solina Marco Giunta Mario Cottone Ambrogio Orlando | 2011 | Journal of Crohn’s and Colitis2011，，3： | 1 |
| 10 | Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome显示文摘 | Emanuele Sinagra Claudia Romano Mario Cottone Giovanni Barbara | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 11 | Treatment of small hepatocellular carcinoma with percutaneous ethanol injection: a validated prognostic model显示文摘 | Ambrogio Orlando Adele D’Antoni Calogero Cammà Maddalena Albanese Tito Livraghi Guido Torzill Roberto Virdone Elio Sciarrino Rosa Giovanna Simonetti Alberto Maringhini Luigi Pagliaro Mario Cottone | 2000 | The American Journal of Gastroenterology2000，，10： | 1 |
| 12 | Ultrasonography and alpha-fetoprotein in diagnosis of hepatocellular carcinoma in cirrhosis显示文摘 | Alberto Maringhini Mario Cottone Elio Sciarrino Maria Pia Marcenò Francesco Seta Giorgio Fusco Fortunato Rinaldi Luigi Pagliaro | 1988 | Digestive Diseases and Sciences1988，，1： | 1 |
| 13 | Regional variations in the use of complementary and alternative medicines (CAM) for inflammatory bowel disease patients in Italy: An IG-IBD study显示文摘 | Perla Bertomoro Sara Renna Mario Cottone Gabriele Riegler Fabrizio Bossa Licio Giglio Luca Pastorelli Claudio Papi Fabiana Castiglione Erika Angelucci Roberta Pica Maria Carla Di Paolo Renata D’Incà | 2009 | Journal of Crohn’s and Colitis2009，，3： | 1 |
| 14 | The Role of Portal Vein Thrombosis in the Clinical Course of Inflammatory Bowel Diseases: Report on Three Cases and Review of the Literature显示文摘 | Emanuele Sinagra Emma Aragona Claudia Romano Simonetta Maisano Ambrogio Orlando Roberto Virdone Lorenzo Tesè Irene Modesto Valeria Criscuoli Mario Cottone Paolo Gionchetti | 2012 | <journal-title>Gastroenterology Research and Practice2012，，： | 1 |
| 15 | Oral lichen planus after certolizumab pegol treatment in a patient with Crohn’s disease显示文摘 | Filippo Mocciaro Ambrogio Orlando Sara Renna Maria Rosa Rizzuto Mario Cottone | 2011 | Journal of Crohn’s and Colitis2011，，2： | 1 |
| 16 | Clinical implications of mucosal healing in the management of patients with inflammatory bowel disease显示文摘 | Ambrogio Orlando Francesco William Guglielmi Mario Cottone Emanuele Orlando Claudia Romano Emanuele Sinagra | 2013 | Digestive and Liver Disease2013，，12： | 1 |
| 17 | Psychopharmacological Treatment and Psychological Interventions in Irritable Bowel Syndrome显示文摘 | Emanuele Sinagra Claudia Romano Mario Cottone Giovanni Barbara | 2012 | Gastroenterology Research and Practice2012，，： | 1 |
| 18 | Mesalazine for the treatment of inflammatory bowel disease显示文摘 | Valeria Criscuoli Irene Modesto Ambrogio Orlando Mario Cottone | 2013 | Expert Opinion on Pharmacotherapy2013，，12： | 1 |
| 19 | Efficacy and safety of endoscopic balloon dilation of symptomatic intestinal Crohn’s disease strictures显示文摘 | Daniela Scimeca Filippo Mocciaro Mario Cottone Luigi Maria Montalbano Gennaro D’Amico Mirko Olivo Rosalba Orlando Ambrogio Orlando | 2010 | Digestive and Liver Disease2010，，2： | 1 |
| 20 | Could JC virus provoke metastasis in colon cancer?显示文摘AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 test.RESULTS: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors. | Emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio Orlando Francesca Rossi Emanuele Orlando Marco Messina Giovanni Tomasello Attilio Ignazio Lo Monte Ennio La Rocca Aroldo Gabriele Rizzo | 2014 | World Journal of Gastroenterology2014，20，42： | 0 |
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