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| 1 | Intrahepatic cholestasis of pregnancy:When should you look further?显示文摘Pruritis with abnormal liver function tests is the classical presentation of intrahepatic cholestasis of pregnancy(ICP),a condition associated with significant fetal complications.Although the etiology of ICP is unclear in many cases,certain features of the clinical presentation should alert the practitioner to the possibility of an underlying metabolic defect, which may not only affect subsequent pregnancies, but may be an indicator of more serious subsequent liver disease.We report a kindred of Anglo-Celtic descent,among whom many members present with ICP,gallstones or cholestasis related to use of oral contraception.Genetic studies revealed a novel mutation in the ABCB4 gene,which codes for a phospholipid transport protein.The clinical significance of this mutation and the importance of identifying such patients are discussed. | Winita Hardikar Shivani Kansal Ronald P J Oude Elferink Peter Angus | 2009 | World Journal of Gastroenterology2009，15，9： | 22 |
| 2 | Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study显示文摘AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal cancer.METHODS TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards model.RESULTS Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases. | René Scheer Alexi Baidoshvili Shorena Zoidze Marloes AG Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest | 2017 | World Journal of Gastrointestinal Oncology2017，9，12： | 3 |
| 3 | Prognostic Factors for Locoregional Recurrences in Colon Cancer显示文摘 | M. Elferink O. Visser T. Wiggers R. Otter R. Tollenaar J. Langendijk S. Siesling | 2012 | Annals of Surgical Oncology2012，，7： | 2 |
| 4 | The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood显示文摘 | Emmanuel Jacquemin J. Marleen L. De Vree Danièle Cresteil Etienne M. Sokal Ekkehard Sturm Micheline Dumont George L. Scheffer Marianne Paul Martin Burdelski Piter J. Bosma Olivier Bernard Michelle Hadchouel Ronald P.J. Oude Elferink | 2001 | Gastroenterology2001，，6： | 2 |
| 5 | The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man显示文摘 | Paulusma CC Oude Elferink RP | 1997 | J Mol Med1997，75，23： | 1 |
| 6 | Targeting the ABCB4 gene to control cholesterol homeostasis显示文摘 | Oude Elferink RP Beuers U | | 0，，10： | 1 |
| 7 | Function and pathophysiological importance of ABCB4 ( MDR3 P - glycoprotein) 显示文摘 | Oude Elferink RP Paulusma CC | 2007 | Pflugers Arch2007，453，5： | 1 |
| 8 | AN2 of oral bioavail- ability: transporters as gatekeepers in the gut 显示文摘 | Dietrich CG Geier A Oude Elferink RP | 2003 | Gut2003，52，12： | 1 |
| 9 | Clinical evaluation of eight differentD-dimer tests for the exclusion of deep venous thrombosis in primary care patients显示文摘 | Oude Elferink RF Loot AE Van De KlashorstCG | 2015 | Scand JClin Lab Investn2015，75，3： | 1 |
| 10 | Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to acomplete absence of phospholipid from bile and to liver disease 显示文摘 | Smit JJ Schinkel AH Oude Elferink RP | 1993 | Ce111993，75，3： | 1 |
| 11 | Sulfate reduction in methanogenic bioreactors显示文摘 | STEFANE J H OUDE ELFERINK | 2004 | Microbiology Reviews2004，15，： | 1 |
| 12 | The diag nostie value of CRP,IL-8,PCT and Strem 1 in the detec tion of bacterial infections in pediatric oncolggy patients with febrile neutropenia显示文摘 | Miedema K G de Bont E S Elferink R F | 2011 | Support Care Cancer2011，19，10： | 1 |
| 13 | Anaerobic lactic acid degradation during ensilage of whole crop maize inoculated with Lactobacillus buchneri inhibits yeast growth and improves aerobic stability 显示文摘 | DRIEHUIS F OUDE ELFERINK S J W H SPOELSTRA S F | 1999 | Journal of Applied Microbiology1999，87，4： | 1 |
| 14 | Blue-light cystoscopy in the evaluation of non-muscle-invasive bladder cancer显示文摘 | Oude Elferink P Witjes JA | 2014 | Ther Adv Urol2014，6，1： | 1 |
| 15 | Function and pathophysiological importance of ABCB4(MDR3 P-glycoprotein)显示文摘 | Oude Elferink RP Paulusma CC | | 0，，05： | 1 |
| 16 | The diagnostic value of CRP, IL-8,PCT,and TREM-1 in the detection of bacterial infections in pediatric oneology patients with febrile neutropenia 显示文摘 | Miedema KG de Bont ES Elferink RF | 2011 | Suppert Care Cancer2011，19，10： | 1 |
| 17 | The diagnostic value of CRP,IL-8 ,PCT,and sTREM-1 in the detection of bacterial in- fections in pediatric oncology patients with febrile neutropenia 显示文摘 | Miedema KG de Bont ES Elferink RF | 2011 | Support Care Cancer2011，19，10： | 1 |
| 18 | Anaerobic conversion of lactic acid to acetic acid and 1,2-propanediol by Lactobacillus buchneri 显示文摘 | OUDE ELFERINK S J W H KROONEMAN J GOTYSCHAL J C | 2001 | Appl Environ Microbiol2001，67，1： | 1 |
| 19 | Receptor-tyrosine-kinase-targeted thera- pies for head and neck cancer显示文摘 | Elferink L A Resto V A | 2011 | J Signal Transduct2011，2011，98： | 1 |
| 20 | Anaerobic conversion of lactic acid to acetic acid and 1,2-pro- panediol by Lactobacillus buchneri显示文摘 | Oude Elferink S J W H Krooneman J Gottschal J C | 2001 | Applied and Environment Microbiology2001，67，： | 1 |
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