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| 1 | A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response显示文摘病毒的 RNA 的识别由 cytosolic 传感器 retinoic 组织酸可诱导的基因 --(RIG-I ) 我导致表明与类型的产生达到顶点的串联的激活我干扰素(IFN ) 抗病毒的反应。对病毒的病原体的抗病毒、煽动性的回答的发作要求表明改编者, kinases 和 transcriptional 蛋白质到 mitochondrial 的调整空间与时间的招募抗病毒的发信号蛋白质(MAVS ) 。我们以前示威了 serine/threonine kinase IKKε被招募到 MAVS 后面的仙台或小囊的口炎病毒(VSV ) 感染的 C 终端区域,在 Lys500 由 MAVS 的连接 Lys63 的 polyubiquitination 调停了,导致下游的 IFN 发信号的抑制(Paz 等,摩尔房间 Biol, 2009 ) 。在这研究,我们证明 MAVS 的 C 终点在 MAVS 的 aa450-468 区域怀有一个新奇 TRAF3 有约束力的地点。一个一致交往 TRAF 主题(提姆) , 455-PEENEY-460,在这以内,地点为 TRAF3 绑定和 IFN 抗病毒的反应基因的激活被要求,而 TIM 的变化消除 TRAF3 绑定和下游的 IFN 反应。有表示 MAVS 的一个变异提姆的版本的构造的 MAVS −/− 老鼠胚胎成纤维细胞的宪法没能恢复抗病毒的反应或块 VSV 复制,而野类型的 MAVS 重新组成 VSV 复制的抗病毒的抑制。而且, IKKε 的招募;到在经由 Lys500 的 MAVS 的一个邻近的 C 终端地点(aa 468-540 ) , ubiquitination 减少了 TRAF3 绑定和蛋白质稳定性,因此贡献 IKKε调停 IFN 反应关机。这研究证明 MAVS 怀有功能的 C 终端参予 IFN 抗病毒的反应的积极、否定的规定的 TRAF3 有约束力的地点。 | Suzanne Paz Myriam Vilasco Steven J Werden Meztli Arguello Deshanthe Joseph-Pillai Tiejun Zhao Thi Lien-Anh Nguyen Qiang Sun Eliane F Meurs Rongtuan Lin John Hiscott | 2011 | Cell Research2011，21，6： | 12 |
| 2 | 考虑应变补偿的Al2024合金本构方程研究显示文摘采用昂热力学实验室高温拉伸实验机对Al2024合金进行高温拉伸实验,实验温度为350、400和450℃,应变速率为1×10^(-3)、5×10^(-4)和1×10^(-4)s^(-1),获得应力-应变曲线。借助Arrhenius方程对实验数据进行拟合,考虑到应变量对流变应力的影响,建立各材料参数与应变量的关系,并通过三次方程表示,从而对本构方程进行修正。结果表明:Al2024合金在高温拉伸过程中会发生再结晶,出现软化现象;合金在实验温度下表现出较好的塑性,在450℃下伸长率达到80%以上;拟合得到的本构方程具有较高的精确性,误差小于5%,可以用于仿真模拟。 | 冯建铭 ELIANE Giraud 曹旭东 李淑慧 PHILIPPE Dal Santo | 2017 | 塑性工程学报2017，24，6： | 9 |
| 3 | The interferon inducing pathways and the hepatitis C virus显示文摘The innate immune response is triggered by a variety of pathogens, including viruses, and requires rapid induction of typeⅠ?interferons (IFN), such as IFNβ and IFNα. IFN induction occurs when specific pathogen motifs bind to specific cellular receptors. In non-professional immune, virally-infected cells, IFN induction is essentially initiated after the binding of dsRNA structures to TLR3 receptors or to intracytosolic RNA helicases, such as RIG-Ⅰ/MDA5. This leads to the recruitment of specific adaptors, such as TRIF for TLR3 and the mitochondrial-associated IPS-1/VISA/MAVS/CARDIF adapter protein for the RNA helicases, and the ultimate recruitment of kinases, such as MAPKs, the canonical IKK complex and the TBK1/IKKε kinases, which activate the transcription factors ATF-2/ c-jun, NF-κB and IRF3, respectively. The coordinated action of these transcription factors leads to induction of IFN and of pro-inflammatory cytokines and to the establishment of the innate immune response. HCV can cleave both the adapters TRIF and IPS-1/VISA/MAVS/ CARDIF through the action of its NS3/4A protease. This provokes abrogation of the induction of the IFN and cytokine pathways and favours viral propagation and presumably HCV chronic infection. | Eliane F Meurs Adrien Breiman | 2007 | World Journal of Gastroenterology2007，13，17： | 8 |
| 4 | What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases显示文摘Helicobacter pylori(H. pylori) infection is present in more than half the world's population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric adenocarcinoma.The clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cag A and vac A genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cag A-negative. Several other virulence genes have been searched for, but these genes remain less well known that cag A and vac A. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and ice A based on the relevance shown in several studies in the literature. | Débora Menezes da Costa Eliane dos Santos Pereira Silvia Helena Barem Rabenhorst | 2015 | World Journal of Gastroenterology2015，21，37： | 6 |
| 5 | Dietary supplementation with free methionine or methionine dipeptide mitigates intestinal oxidative stress induced by Eimeria spp. challenge in broiler chickens显示文摘Background: This study evaluated the effects of Eimeria spp. challenge and dietary supplementation with free methionine or methionine dipeptide on animal performance;expression of genes associated with the immune system, antioxidant system, and amino acid transport in the jejunum;and redox status of the jejunum of broiler chickens.Methods: A randomized, 2 × 3 factorial design was used, in which Eimeria spp. challenge was the first factor(Eimeria-challenged, EC, or unchallenged, UC, broilers) and methionine supplementation was the second factor(non-supplemented, NS;free DL-methionine, DL-Met;and methionine dipeptide, DL-methionyl-DL-methionine, DLMMet). At 14 days of age, chickens were inoculated orally with sporulated oocysts of Eimeria acervulina, Eimeria praecox, Eimeria maxima, and Eimeria mitis. Birds were killed by cervical dislocation 144 h post-inoculation(PI), and the jejunum was collected for biochemical and molecular analyses.Results: EC broilers had a 13% lower feed intake(FI), 37% lower body weight gain(BWG), and 39% higher feed conversion ratio(FCR) than UC broilers. Chickens fed the DL-Met diet had higher BWG(about 12% higher) and better FCR(about 12% lower) than chickens fed the NS diet. EC chickens had lower relative weight of the bursa of Fabricius(51.8%) and higher relative weights of the spleen and whole intestine(53.6% and 26.3%, respectively) than UC chickens. Eimeria spp. challenge led to an increase in the levels of oxidative substances, such as nitrite and thiobarbituric acid reactive substances(TBARS), in the jejunum of chickens 144 h PI. Among UC chickens, those fed the DL-Met diet had higher total antioxidant capacity(TAC) and lower catalase(CAT) and superoxide dismutase(SOD) activities. EC chickens that received the NS diet had higher carbonylated protein content(CP). This result was associated with their lower TAC and catalase activity. The lower TAC in EC chickens might have been due to reduced expression of catalase(CAT) and superoxide dismutase 1(SOD1) genes. Chickens fed the DL-Met and DLMMet diets had lower nitrite content. Eimeria spp. challenge suppressed neutral amino acid transporter 1(B0 AT1),peptide transporter 1(PEPT1), toll-like receptor 5(TLR5), interleukin 2(IL2), and occludin(OCLN) gene expression and enhanced cationic amino acid transporter 1(CAT-1) and interferon gamma(IFNG) gene expression. The highest PEPT1 expression level was observed in broilers fed the DL-MMet diet, and the lowest TLR5 expression level was found in broilers fed the NS diet.Conclusion: Our results show for the first time that supplementation with methionine as free amino acid or dipeptide helps protect the intestinal cells of broilers under Eimeria spp. challenge from the oxidative damage induced by free radicals, mainly through modulation of the antioxidant system. | Angélica de Souza Khatlab Ana Paula Del Vesco Adhemar Rodrigues de Oliveira Neto Roberta Pereira Miranda Fernandes Eliane Gasparino | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 6 |
| 6 | Biomarkers in precision therapy in colorectal cancer显示文摘Colorectal cancer(CRC)is the most commonly diagnosed cancer in Europe.Because CRC is also a major cause of cancerrelated deaths worldwide,a lot of research has been focused on the discovery and development of biomarkers to improve the diagnostic process and to predict treatment outcomes.Up till now only a few biomarkers are recommended by expert panels.Current TNM criteria,however,cause substantial under-and overtreatment of CRC patients.Consequently,there is a growing need for new and efficient biomarkers to ensure optimal treatment allocation.An ideal biomarker should be easily translated into clinical practice,to identify patients who can be spared from treatment or benefit from therapy,ultimately resulting in precision medicine in the future.In this review we aim to provide an overview of a number of frequently studied biomarkers in CRC and,at the same time,we will emphasize the challenges and controversies that withhold the clinical introduction of these biomarkers.We will discuss both prognostic and predictive markers of chemotherapy,aspirin therapy as well as overall therapy toxicity.Currently,only mutant KRAS,mutant BRAF,MSI and the Oncotype DXColon Cancer Assay are used in clinical practice.Other biomarker studies showed insufficient evidence to be introduced into clinical practice.Divergent patient selection criteria,absence of validation studies and a large number of single biomarker studies are possibly responsible.We therefore recommend that future studies focus on combining key markers,rather than analysing single markers,standardizing study protocols,and validate the results in independent study cohorts,followed by prospective clinical trials. | Marlies S.Reimers Eliane C.M.Zeestraten Peter J.K.Kuppen Gerrit Jan Liefers Cornelis J.H.van de Velde | 2013 | Gastroenterology Report2013，1，3： | 3 |
| 7 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 8 | Studies on the interactions of Haemophilus parasuis with porcine epithelial tracheal cells: Limited role of LOS in apoptosis and pro-inflammatory cytokine release显示文摘 | Bénédicte Bouchet Ghyslaine Vanier Mario Jacques Eliane Auger Marcelo Gottschalk | 2008 | Microbial Pathogenesis2008，，2： | 2 |
| 9 | Architecting Fault Tolerance with Exception Handling: Verification and Validation显示文摘When building dependable systems by integrating untrusted software components that were not originally designed to interact with each other, it is likely the occurrence of architectural mismatches related to assumptions in their failure behaviour. These mismatches, if not prevented during system design, have to be tolerated during runtime. This paper presents an architectural abstraction based on exception handling for structuring fault-tolerant software systems. This abstraction comprises several components and connectors that promote an existing untrusted software element into an idealised fault-tolerant architectural element. Moreover, it is considered in the context of a rigorous software development approach based on formal methods for representing the structure and behaviour of the software architecture. The proposed approach relies on a formal specification and verification for analysing exception propagation, and verifying important dependability properties, such as deadlock freedom, and scenarios of architectural reconfiguration. The formal models are automatically generated using model transformation from UML diagrams: component diagram representing the system structure, and sequence diagrams representing the system behaviour. Finally, the formal models are also used for generating unit and integration test cases that are used for assessing the correctness of the source code. The feasibility of the proposed architectural approach was evaluated on an embedded critical case study. | Patrick H. S. Brito Rogério de Lemos Cecília M. F. Rubira Eliane Martins | 2009 | Journal of Computer Science & Technology2009，24，2： | 2 |
| 10 | The Influence of Public Policies on Urban Mobility: A Comparative Study between Porto Alegre (Brazil) and Washington D.C. (United States)显示文摘 | Mauricio Kunz Alcindo Neckel Henrique Aniceto Kujawa Angela Chiamentti Eliane Thaines Bodah | 2017 | Journal of Civil Engineering and Architecture2017，11，3： | 2 |
| 11 | Biliary tract reconstruction using jejunal tube:an experimental study in dogs显示文摘BACKGROUND:To physiologically reconstruct the biliary tract,Crema et al suggested the application of the Monti principle to the biliary tract,already used in humans for the urinary tract.With this technique,a jejunal segment is transversely retubularized.This study aimed to evaluate the efficacy of jejunal tube interposition between the common bile duct and duodenum in dogs.METHODS:Thirteen dogs underwent a laparoscopic common bile duct ligature,followed by a biliodigestive connection by jejunal tube interposition after one week.The levels of glutamic-pyruvic and glutamic-oxalacetic transaminases,total bilirubins,alkaline phosphatase and gamma-glutamyltransferase were assessed before surgery and thereafter weekly until euthanasia,which was performed 6 weeks after biliodigestive connection.RESULTS:Data on 9 dogs were analyzed statistically.The dogs presented with obstructive jaundice after common bile duct ligature,as confirmed by biochemical examination.They showed a statistically significant reduction in cholestasis after biliodigestive connection by jejunal tube interposition and were healthy until the end of the experiment.CONCLUSION:A statistically significant reduction was seen in total bilirubin and canalicular enzymes(alkaline phosphatase and gamma-glutamyltransferase)in the 9 dogs 6 weeks after biliodigestive connetion by jejunal tube interposition. | Eliane Anrain Trentini Eduardo Crema Juan Carlos Llanos Mauro Masson Lerco Luiz Alberto Magna Luiz Sergio Leonardi | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，2： | 2 |
| 12 | Microfibrillated Cellulose from Sugarcane Bagasse as a Biorefinery Product for Ethanol Production显示文摘Research involving the preparation of microfibrillated cellulose(MFC)from sugarcane bagasse is a relevant topic to the production of new nanomaterials and more accessible cellulose substrates for the production of second generation ethanol.Regarding the transformation of cellulose into glucose,the precursor of second generation ethanol,this nanosized cellulosic substrate represents a more appropriate material for the chemical hydrolysis process.The high aspect ratio of MFC improves hydrolysis,requiring mild conditions and decreasing the generation of by-products.Here,MFC was prepared from sugarcane bagasse by ultrasound defibrillation.This material was oxidized with 2,2,6,6-tetramethylpiperidine-N-oxyl(TEMPO)to produce negatively charged high defibrillated MFC.The MFC was characterized by Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD),scanning electron microscopy(SEM)and viscosity measurements. | Rafael Grande Eliane Trovatti Maria Tereza B.Pimenta Antonio J.F.Carvalho | 2018 | Journal of Renewable Materials2018，6，2： | 2 |
| 13 | Sal‐like protein 4 (SALL4), a stem cell biomarker in liver cancers显示文摘 | Tsunekazu Oikawa Akihide Kamiya Mikio Zeniya Hiromi Chikada Ahn Dong Hyuck Yuji Yamazaki Eliane Wauthier Hisao Tajiri Lance D. Miller Xin Wei Wang Lola M. Reid Hiromitsu Nakauchi | 2013 | Hepatology2013，，4： | 2 |
| 14 | Prevalence of malocclusion and the impact on quality of life 18--year--old 显示文摘 | Eliane SA | 2005 | Oral Health Prey Dent2005，3，4： | 1 |
| 15 | Inhibitory action of aqueous coffee ground extracts on the corrosion of carbon steel in HCl solution显示文摘 | Vanessa Vasconcelos Torres Roberto Salgado Amado Camila Faia de Sá Tatiana Lopez Fernandez Carlos Alberto da Silva Riehl Alexandre Guedes Torres Eliane D’Elia | 2011 | Corrosion Science2011，，7： | 1 |
| 16 | ConData: a tool for automating specification-based test case? generation for communication systems 显示文摘 | Eliane Martins Selma B Sabiao Aha Maria Ambrosio | 2000 | IEEE Proceedings of the2000，33，： | 1 |
| 17 | Recent advances in soybean transformation显示文摘 | Harold NT Randy DD Eliane RS | 1997 | Plant Tissue Culture Biotechnol1997，3，： | 1 |
| 18 | Molecular characterization of Pisolithus spp. isolates by rDNA PCR-RFLP显示文摘 | Eliane A. Gomes Everaldo G. de Barros Maria Catarina M. Kasuya Elza F. Araújo | 1999 | Mycorrhiza1999，，4： | 1 |
| 19 | Distribution of the maxillary artery as it relates to sinus floor augmentation 显示文摘 | ELIAN N WALLACE S CHO S C | 2005 | Int J Oral Maxillofac Implants2005，20，5： | 1 |
| 20 | Mechanical thermal synthesis of chro-mium carbides显示文摘 | Osvaldo Mitsuyuki Cintho Eliane Aparecida Peixoto Favilla José Deodoro Trani Capocchi | 2007 | Journal of Alloys and Compounds2007，439，： | 1 |
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