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| 1 | Reelin induces EphB activation显示文摘进功能的 neuronal 网络的新生的神经原的集成在 neuronal 进程和与另外的神经原的 synaptic 接触的形成的发展中的大脑,生长和树枝状要求房间的移植到他们的最后的位置。在协调区别事件的这个复杂序列的信号之中的一个中央播放器是分泌 glycoprotein Reelin,它也调制 synaptic 粘性,学习并且在成年大脑的记忆形成。到 ApoER2 和 VLDL 受体的 Reelin 有约束力, LDL 受体家庭的二个成员,开始包含细胞内部的细胞质的适配器蛋白质 Disabled-1 的酷氨酸 phosphorylation 的发信号的串联,它指向 neuronal 细胞骨架并且最终控制在整个发展中的大脑放神经原。然而, Reelin 信号与另外的调停受体的发信号串联交往调整大脑开发和粘性的不同方面,是可能的。EphB 酷氨酸 kinases 经由通过 ephrin B transmembrane 蛋白质的双向发信号调整房间粘附和排斥依赖者过程。这里,我们证明 Reelin 绑在 EphB transmembrane 蛋白质的细胞外的领域,导致受体聚类和向前在神经原发信号的 EphB 的激活,独立于“古典”的 Reelin 受体, ApoER2 和 VLDLR。因此,鼠标缺乏 EphB1 和 EphB2 显示 CA3 海马趾的金字塔形的神经原的一个放的缺点,类似于那在 Reelin 缺乏的鼠标,和这房间迁居,缺点取决于 EphB 蛋白质的 kinase 活动。一起,我们的数据为在向前发信号的 Reelin 和 EphB 之间的信号集成提供生物化学、功能的证据。 | Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock | 2013 | Cell Research2013，23，4： | 5 |
| 2 | Copy number expansion of the STX17 duplication in melanoma tissue from Grey horses显示文摘 | Elisabeth S Freyja I Sofia M | 2012 | BMC Genomics2012，2，13： | 1 |
| 3 | A phase 1 study of SNS-032 (formerly BMS-387032), a potent inhibitor of cyclin-dependent kinases 2, 7 and 9 administered as a single oral dose and weekly infusion in patients with metastatic refractory solid tumors显示文摘 | Heath Elisabeth I Bible K Martell R E | 2008 | Invest New Drugs2008，26，1： | 1 |
| 4 | NICE guidance on cetuximab, bevacizumab, and panitumumab for treatment of metastatic colorectal cancer after first-line chemotherapy显示文摘 | Fiona Rinaldi Elisabeth George Amanda I Adler | 2012 | Lancet Oncology2012，，3： | 1 |
| 5 | Melem (2,5,8-triami- na-tri-s-triazine), an important intermediate during condensation of melamine rings to graphitic carbon ni- tride : synthesis, structure determination by X-ray pow- der diffractometry, solid-state NRM, and theoretical studies显示文摘 | Barbara J Elisabeth I Jurgen S | 2003 | Journal of American Chemical Society2003，125，10： | 1 |
| 6 | Diagnosis of Lung Cancer in Small Biopsies and Cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification显示文摘 | Travis William D Brambilla Elisabeth Noguchi Masayuki Nicholson Andrew G Geisinger Kim Yatabe Yasushi Ishikawa Yuichi Wistuba Ignacio Flieder Douglas B Franklin Wilbur Gazdar Adi Hasleton Philip S Henderson Douglas W Kerr Keith M Petersen I | 2013 | Archives of Pathology & Laboratory Medicine2013，，5： | 1 |
| 7 | 显示文摘 | Aburto J Alric I Elisabeth Borredon | 1999 | Starch1999，51，： | 1 |
| 8 | Polymorphisms in the IGF-1 and IGFBP3 promoter and the risk of breast canc- er显示文摘 | Kerstin W Kari H Elisabeth I | 2005 | Breast Cancer Research and Treatment2005，92，： | 1 |
| 9 | Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes显示文摘 | Peter Ammann Marco Maggiorini Osmund Bertel Edgar Haenseler Helen I Joller-Jemelka Erwin Oechslin Elisabeth I Minder Hans Rickli Thomas Fehr | 2003 | Journal of the American College of Cardiology2003，，： | 1 |
| 10 | Malnutrition determined by the patient-generated subjective global assessment is associated with poor outcomes in acute stroke patients显示文摘 | Judy M Judith D Elisabeth I | 2005 | Clinical Nutrition2005，，24： | 1 |
| 11 | On-chip Microelectrodes for Electrochemistry with Moveable PPy Bilayer Actuauors as Working Electrodes显示文摘 | Edwin W H J Elisabeth S Olle I | 1999 | Sensors and Actuators B1999，56，： | 1 |
| 12 | Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function显示文摘 | Elisabeth R Barton-Davis Daria I Shoturma H Lee Sweeney | 1998 | The National Academy of Sciences1998，95，15： | 1 |
| 13 | Energy-efficient elevators and escalators in Europe: An analysis of energy efficiency potentials and policy measures显示文摘 | An i bal De Almeida Simon I~irzel Carlos Patro Joo Fong Elisabeth D ti tschke | 2013 | Energy and Buildings2013，59，： | 1 |
| 14 | Semimechanistic Pharmacokinetic/Pharmacodynamic Model for Assessment of Activi-ty of Antibacterial Agents from Time-Kil Curve Experiments 显示文摘 | Elisabet I N Anders V Elisabeth L | 2007 | Antimicrob Agents Ch2007，，： | 1 |
| 15 | SJWD15012600001710显示文摘 | Ynto S Boer Carin M J Nieuwkerk Birgit I Witte Chris J J Mulder Gerd Bouma Elisabeth Bloemena | 2015 | Histopathology2015，，3： | 1 |
| 16 | Generation of 4-Hydroxy -2,5- Dimethyl- 3 ( 2 H ) - Furanone from Rhamnose as Affected by Reaction Parameters: Experimental Design Approach 显示文摘 | Silke I Tomas D Elisabeth G | 2009 | J Agric Food Chem2009，57，： | 1 |
| 17 | Colorectal cancer prognosis twenty years later显示文摘AIM:To evaluate changes in colorectal cancer(CRC) survival over the last 20 years.METHODS:We compared two groups of consecutive CRC patients that were prospectively recruited:Group Ⅰincluded 1990 patients diagnosed between 1980 and 1994.GroupⅡincluded 871 patients diagnosed in 2001.RESULTS:The average follow up time was 21 mo(1-229)for GroupⅠand 50 mo(1-73.4)for GroupⅡ.Overall median survival was significantly longer in Group Ⅱthan in GroupⅠ(73 mo vs 25 mo,P<0.001)and the difference was significant for all tumor stages.Post surgical mortality was 8% for GroupⅠand 2% for Group Ⅱ(P<0.001).Only 17% of GroupⅠpatients received chemotherapy compared with 50% of GroupⅡpatients(P<0.001).CONCLUSION:Survival in colorectal cancer patients has doubled over the past 20 years.This increase seems to be partly due to the generalization in the administration of chemotherapy and to the decrease of post surgical mortality. | Luis Bujanda Cristina Sarasqueta Elisabeth Hijona Lander Hijona Angel Cosme Ines Gil Jose Luis Elorza Jose I Asensio Santiago Larburu José M Enríquez-Navascués Rodrigo Jover Francesc Balaguer Xavier Llor Xavier Bessa Montserrat Andreu Artemio Paya Antoni Castells Gastrointestinal Oncology Group of the Spanish Gastroenterological Association | 2010 | World Journal of Gastroenterology2010，16，7： | 0 |
| 18 | Integrated adsorption and photocatalytic removal of methylene blue dye from aqueous solution by hierarchical Nb_(2)O_(5)@PAN/PVDF/ANO composite nanofibers显示文摘This work presents the development of hierarchical niobium pentoxide(Nb_(2)O_(5))-based composite nanofiber membranes for integrated adsorption and photocatalytic degradation of methylene blue(MB)pollutants from aqueous solutions.The Nb_(2)O_(5) nanorods were vertically grown using a hydrothermal process on a base electrospun nanofibrous membrane made of polyacrylonitrile/polyvinylidene fluoride/ammonium niobate(V)oxalate hydrate(Nb_(2)O_(5)@PAN/PVDF/ANO).They were characterized using field-emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD)analysis,and Fourier transform infrared(FTIR)spectroscopy.These composite nanofibers possessed a narrow optical bandgap energy of 3.31 eV and demonstrated an MB degradation efficiency of 96%after 480 min contact time.The pseudo-first-order kinetic study was also conducted,in which Nb_(2)O_(5)@PAN/PVDF/ANO nanofibers have kinetic constant values of 1.29×10^(-2) min^(-1) and 0.30×10^(-2) min^(-1) for adsorption and photocatalytic degradation of MB aqueous solutions,respectively.These values are 17.7 and 7.8 times greater than those of PAN/PVDF/ANO nanofibers without Nb_(2)O_(5) nanostructures.Besides their outstanding photocatalytic performance,the developed membrane materials exhibit advantageous characteristics in recycling,which subsequently widen their practical use in environmental remediation applications. | Aditya Rianjanu Kurniawan Deny Pratama Marpaung Elisabeth Kartini Arum Melati Rizky Aflaha Yudha Gusti Wibowo I Putu Mahendra Nursidik Yulianto Januar Widakdo Kuwat Triyana Hutomo Suryo Wasisto Tarmizi Taher | 2024 | Nano Materials Science2024，6，1： | 0 |
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