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| 1 | Role of post-translational modification of the Y box binding protein 1 in human cancers显示文摘Y box binding protein-1(YBX1)belongs to a DNA-and RNA-binding family of transcription factors,containing the highly conserved cold shock domain(CSD).YBX1 is involved in a number of cellular functions including transcription,translation,DNA damage repair etc.,and it is upregulated during times of environmental stress.YBX1 is localized in both the cytoplasm and the nucleus.There,its nuclear translocation is observed in a number of cancers and is associated with poor prognosis and disease progression.Additionally,YBX1 expression is upregulated in a variety of cancers,pointing towards its role as a potential oncogene.Under certain circumstances,YBX1 also promotes the expression of multidrug resistance 1(MDR1)gene,which is involved in the development of drug resistance.Thus,it is critical to understand the mechanism of YBX1 regulation and its downstream effects on promoting cancer development.A number of recent studies have highlighted the mechanisms of YBX1 regulation.Mass spectrometric analyses have reported several post-translational modifications that possibly play an important role in modulating YBX1 function.Phosphorylation is the most widely occurring post-translational modification in YBX1.In vivo analyses of sites like S102 and more recently,S165 illustrate the relationship of post-translational regulation of YBX1 in promoting cell proliferation and tumor growth.This review provides a comprehensive and up-to-date account of post-translational modifications identified in YBX1.This knowledge is a key in allowing us to better understand the mechanism of YBX1 regulation,which will aid in development of novel therapeutic strategies to target YBX1 in many types of cancer in the future. | Lakshmi Prabhu Antja-Voy Hartley Matthew Martin Fadumo Warsame Emily Sun Tao Lu | 2015 | Genes & Diseases2015，2，3： | 3 |
| 2 | DNA Topoisomerase 1 Prevents R-loop Accumulation to Modulate Auxin-Regulated Root Development in Rice显示文摘R 环结构(RNA : DNA 混血儿) 在多样的有机体之中在许多生物进程,包括的 transcriptional 规定和染色体不稳定性有重要函数。DNA topoisomerase 1 (TOP1 ) , DNA 拓扑学的一个必要操纵者在 RNA 抄写和 DNA 复制期间处理,能由移开被 RNA 聚合酶在抄写期间做的积极、否定的 DNA supercoiling 阻止 R 环累积。TOP1 为植物开发被要求,但是很少在在植物在各种各样的生物进程阻止 co-transcriptional R 环累积对它的函数被知道。这里,我们显示出那击倒 OsTOP1 强烈影响米饭开发,在根建筑学和 gravitropism 引起缺点,它是植物生长素发信号和 transporter 基因的错误规定的后果。我们发现 R 环自然地在米饭被形成植物生长素相关的基因 loci,和 overaccumulate 当 OsTOP1 被击倒或 OsTOP1 蛋白质活动被禁止时。OsTOP1 因此将植物生长素相关的基因的精确表示层次放由阻止固有的 R 环的 overaccumulation。我们的数据表明在极的植物生长素的 R 环同样重要的因素搬运并且种 OsTOP1 作为一把钥匙工作与植物连接 transcriptional R 环的根开发,和热点荷尔蒙发信号,提供新卓见进荷尔蒙在植物发信号的 transcriptional 规定。 | Sarfraz Shafiq Chunli Chen Jing Yang Lingling Cheng Fei Ma Emilie Widemann Qianwen Sun | 2017 | Molecular Plant2017，10，6： | 2 |
| 3 | The phos-phoinositide 3-kinapendent activation of Btk is required for op-timal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cell显示文摘 | Hye Sun Kuehn Emily J Swindle Mi-Sun Kim | 2008 | J Immunol2008，181，11： | 1 |
| 4 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 5 | Influence of equiatomic Zr/Nb substitution on superelastic behavior of Ti–Nb–Zr alloy显示文摘 | Jinyong Zhang Fan Sun Yulin Hao Nicolas Gozdecki Emilie Lebrun Philippe Vermaut Richard Portier Thierry Gloriant Pascal Laheurte Frédéric Prima | 2013 | Materials Science & Engineering A2013，，： | 1 |
| 6 | Elevated hepatic iron: A confounding factor in chronic hepatitis C显示文摘 | Harriet C. Isom Emily I. McDevitt Mi Sun Moon | 2009 | BBA - General Subjects2009，，7： | 1 |
| 7 | Physical and toxicological profiles of human IAPP amyloids and plaques显示文摘Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence suggesting otherwise. To fill this knowledge gap, we examined the physical and biological characteristics of human islet amyloid polypeptide(IAPP) fibrils that were aged up to two months. Not only did aging decrease the toxicity of IAPP fibrils, but the fibrils also sequestered fresh IAPP and suppressed their toxicity in an embryonic zebrafish model. The mechanical properties of IAPP fibrils in different aging stages were probed by atomic force microscopy and sonication, which displayed comparable stiffness but age-dependent fragmentation, followed by self-assembly of such fragments into the largest lamellar amyloid structures reported to date. The dynamic structural and toxicity profiles of amyloid fibrils and plaques suggest that they play active, long-term roles in cell degeneration and may be a therapeutic target for amyloid diseases. | Aleksandr Kakinen Yunxiang Sun Ibrahim Javed Ava Faridi Emily H.Pilkington Pouya Faridi Anthony W.Purcell Ruhong Zhou Feng Ding Sijie Lin Pu Chun Ke Thomas P.Davis | 2019 | Science Bulletin2019，64，1： | 0 |
| 8 | 慢游泰国 恋恋三岛显示文摘潜水、SPA、海上晚宴、探索原住民的村落,雨季的泰国不仅能避开拥挤的人潮,还可获得更多亲身尝试的度假体验。9月,《旅游世界》惯隋呈现泰国岛屿度假新玩法,梳理苏梅岛、普吉岛和皮皮岛最有特色的体验项目,为你安排全新的长假度假提供新点子。 | Vita Sun 严磊 Emily Wang 袁晨雨 游森淼 六月 余仲乐 SHA | 2013 | 旅游世界2013，，9： | 0 |
| 9 | “宇宙之眼”艺术的纽带——中捷当代美术馆显示文摘中捷当代美术馆,是由捷克著名建筑师Zdeněk Fránek按国际美术馆的规范设计的、极具当代理念的地标性建筑,美术馆在捷克文化部与捷克驻华大使馆的支持下,由馆长覃琨瑛和水墨艺术家伊瑞出资创建。这座公益美术馆作为连接两国艺术与文化交流的纽带,为当代艺术家及艺术作品提供了面向世界的开放平台,成为了实现东西方艺术交流的桥梁与艺术殿堂。 | Emily Sun 无 | 2018 | 青年视觉2018，，2： | 0 |
| 10 | 拍卖行化身多元艺术空间——嘉德艺术中心显示文摘嘉德艺术中心紧邻紫禁城,作为一座全新的综合文化机构,将北京的古城韵味与现代大都会的蓬勃生机以及多元艺术融为一体.嘉德艺术中心是世界上第一个量身定制的拍卖行总部,在北京的中心创建了一个全新的多元艺术机构类型.建筑提供博物馆硬件质量的展示空间和最先进的艺术品保护设施,同时也是一个灵活丰富的文化空间,与餐馆、酒店、公共交通基础设施结合在一起. | Marcel Holmberg Sun Ke Emily Liang Cecilia Lei Yingda Ahrens Mark Biemans Kim Bjarke Catarina Canas Alicia Casals Michael Cavander Jeffrey Cheng Patrick Conway Dyno Du Nicolaz Frez Brian Fung Daniel Hawkins Xinran Ji Philipp Kramer Emeline Laurencon Yuyang Lin Mavis Liu Wymen Lo Max Ma Rafael Merino John Murphey Marcin Olszowski Kevin Ou Kevin Park Yanyadech Phornphong Aaron Powers Klementina Savickaite Jim Shi Chiara Storino Joseph Tang Yang Tao Elena Yang Quentin Yiu Francis Young Lei Yu Danny Zhang Bruno Zhao Weiwei Zhang Yi Zhu Catarina Canas Brian Fung Paloma Hernaiz Marcel Holmberg Tait Kaplan Jaime Oliver Joseph Tang | 2018 | 设计家2018，，1： | 0 |
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