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| 1 | Nitric oxide synthase and heme oxygenase expressions in human liver cirrhosis显示文摘瞄准:门静脉高血压是肝肝硬化的普通复杂并发症。肝内压力能以几个方法被提高。从内脏的内脏影响脉管系统, vasoconstrictors 的增加和增加的循环进门静脉系统的反常建筑学都可以作出贡献。因而内长的血管扩张药也许能减轻高血压。我们因此试图调查内长的血管扩张药的层次,氮的氧化物(没有) 并且通过氮的氧化物 synthase (NOS ) 的表示的一氧化碳(公司) 并且他我氧合酶(惊讶) 。方法:肝脏硬化症(n=20 ) 并且非肝脏硬化症(n=20 ) 肝从经历了外科的病人被获得。NOS 的各种各样的 isoforms 的 mRNA 和蛋白质表情并且惊讶用竞争 PCR,西方的污点和免疫组织化学被检验。结果:当内皮 NOS (eNOS ) 在硬变肝是起来调整的时,在可诱导的 NOS (i NOS ) 或神经元 NOS (nNOS ) 表情没有重要变化。附随地, caveolin-1, eNOS 的一个确定的下面管理者,是起来调整的。可诱导的 HO-1 和组成的 HO-2 被发现在不同本地化在硬变肝虽然显示出增加的表示。结论:NOS 表示力量的差别由于他们在在肝硬化的病理维持肝动态平衡或参与的不同角色。在高血压的肝以内的纯粹的应力可以导致 eNOS 的增加的表示。接着, caveolin-1 也被增加。这是否对进一步的肝硬化用作一个防御机理或是肝硬化的后果,是还未知的。HO-1 和 HO-2 的提高的表示建议公司可以微弱地作为血管扩张药虽然在它的角色补偿。它是可能的那个公司并且不在肝以内有平行或协调的功能并且可以在门静脉高血压的病理生理学反对地工作。 | Beatrice J Goh Bee Tee Tan Wei Min Hon Kang Hoe Lee Hoon Eng Khoo | 2006 | World Journal of Gastroenterology2006，12，4： | 19 |
| 2 | Anemia and iron deficiency in gastrointestinal and liver conditions显示文摘Iron deficiency anemia(IDA) is associated with a number of pathological gastrointestinal conditions other than inflammatory bowel disease, and also with liver disorders. Different factors such as chronic bleeding, malabsorption and inflammation may contribute to IDA. Although patients with symptoms of anemia are frequently referred to gastroenterologists, the approach to diagnosis and selection of treatment as well as follow-up measures is not standardized and suboptimal. Iron deficiency, even without anemia, can substantially impact physical and cognitive function and reduce quality of life. Therefore, regular iron status assessment and awareness of the clinical consequences of impaired iron status are critical. While the range of options for treatment of IDA is increasing due to the availability of effective and well-tolerated parenteral iron preparations, a comprehensive overview of IDA and its therapy in patients with gastrointestinal conditions is currently lacking. Furthermore, definitions and assessment of iron status lack harmonization and there is a paucity of expert guidelines on this topic. This review summarizes current thinking concerning IDA as a common co-morbidity in specific gastrointestinal and liver disorders, and thus encourages a more unified treatment approach to anemia and iron deficiency, while offering gastroenterologists guidance on treatment options for IDA in everyday clinical practice. | Jürgen Stein Susan Connor Garth Virgin David Eng Hui Ong Lisandro Pereyra | 2016 | World Journal of Gastroenterology2016，22，35： | 5 |
| 3 | The effects of exercise on cognition in Parkinson’s disease: a systematic review显示文摘Cognitive impairments are highly prevalent in Parkinson’s disease(PD)and can substantially affect a patient’s quality of life.These impairments remain difficult to manage with current clinical therapies,but exercise has been identified as a possible treatment.The objective of this systematic review was to accumulate and analyze evidence for the effects of exercise on cognition in both animal models of PD and human disease.This systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)statement.Fourteen original reports were identified,including six pre-clinical animal studies and eight human clinical studies.These studies used various exercise interventions and evaluated many different outcome measures;therefore,only a qualitative synthesis was performed.The evidence from animal studies supports the role of exercise to improve cognition in humans through the promotion of neuronal proliferation,neuroprotection and neurogenesis.These findings warrant more research to determine what roles these neural mechanisms play in clinical populations.The reports on cognitive changes in clinical studies demonstrate that a range of exercise programs can improve cognition in humans.While each clinical study demonstrated improvements in a marker of cognition,there were limitations in each study,including non-randomized designs and risk of bias.The Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was used and the quality of the evidence for human studies were rated from“low”to“moderate”and the strength of the recommendations were rated from“weak”to“strong”.Studies that assessed executive function,compared to general cognitive abilities,received a higher GRADE rating.Overall,this systematic review found that in animal models exercise results in behavioral and corresponding neurobiological changes in the basal ganglia related to cognition.The clinical studies showed that various types of exercise,including aerobic,resistance and dance can improve cognitive function,although the optimal type,amount,mechanisms,and duration of exercise are unclear.With growing support for exercise to improve not only motor symptoms,but also cognitive impairments in PD,health care providers and policy makers should recommend exercise as part of routine management and neurorehabilitation for this disorder. | Danielle K Murray Matthew A Sacheli Janice J Eng A Jon Stoessl | 2014 | Translational Neurodegeneration2014，3，1： | 3 |
| 4 | 新技术新装置提高炼能——石脑油催化裂解(ACO)生产低碳烯烃显示文摘源自蒸汽裂解和炼油厂的丙烯将无法满足未来对丙烯的需求,所以新技术的盛行也并非偶然。ACO工艺采用直馏石蜡基馏份作为原料,可以生产比传统热裂解工艺更多的烯烃,丙烯/乙烯比(P/E)之比高达1:1。如今,SK能源公司已建造了世界上第一个ACO装置,并在2010年最后一个季度投入生产。接下来,商业催化剂的性能会进一步被验证。 | Michael J Tallman Curtis Eng Sun Choi Deuk Soo Park | 2011 | 科技信息(石油与装备)2011，，1： | 2 |
| 5 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 6 | Spectrum of magnetic resonance imaging findings in congenital lumbar spinal stenosis显示文摘AIM: To investigate whether congenital lumbar spinal stenosis(CLSS) is associated with a specific degenerative changes of the lumbar spine. METHODS: The lumbar spine magnetic resonance imaging studies of 52 subjects with CLSS and 48 control subjects were retrospectively evaluated. In each examination, the five lumbar levels were assessed for the presence or absence of circumferential or shallow annular bulges, annular tears, anterior or posterior disc herniations, epidural lipomatosis, Schmorl's nodes,spondylolisthesis, pars defects, and stress reactions of the posterior vertebral elements. RESULTS: Compared to control individuals, subjects with CLSS exhibited increased incidence of circumferential and shallow annular bulges, annular tears, discherniations and spondylolisthesis(P < 0.05). CONCLUSION: CLSS is associated with increased incidence of degenerative changes in specific osseous and soft-tissue elements of the lumbar spine. | Theodoros Soldatos Majid Chalian Shrey Thawait Alan J Belzberg John Eng John A Carrino Avneesh Chhabra | 2014 | World Journal of Clinical Cases2014，2，12： | 2 |
| 7 | Hidradenocarcinoma:a histological andimmunohistochemical study显示文摘 | KO C J COCHRAN A J ENG W | 2006 | J Cutan Pathol2006，33，11： | 1 |
| 8 | Direct analysis of protein complexes using mass spectrometry显示文摘 | Link AJ Eng J Schieltz DM | 1999 | Nat Biotechnol1999，17，： | 1 |
| 9 | Germline Epigenetic Regulation of KILLIN in Cowden and Cowden-like Syndrome 显示文摘 | Bennett K L Mester J Eng C | 2010 | J AMA-J Am Med Assoc2010，304，24： | 1 |
| 10 | Kinetic analysis of the lower limbsduring walking:What information can be gained from athree-dimensional model显示文摘 | Eng J J Winter D A | 1995 | Biomech1995，28，6： | 1 |
| 11 | Isolation and characterization of exendin-4, an exendin-analogue, from Heloderma suspectum venom: further evidence for an exendin receptor on dispersed acini from guinea pig pancreas 显示文摘 | ENG J KLEINMAN W A SINGH L | 1992 | J Biol Chem1992，267，11： | 1 |
| 12 | CT angiography with volume rendering for quantifying vascular stenoses: in vitro validation of accuracy 显示文摘 | Kuszyk BS Heath DG Johnson PT Eng J Fishman EK | 1999 | MR Am J Roentgenol1999，173，2： | 1 |
| 13 | CT of primary cystic pancreatic neoplasms: can CT be used for patient triage and treatment 显示文摘 | Curry CA Eng J Horton KM st al | 2000 | AJR Am J Roentgenol2000，175，1： | 1 |
| 14 | Drug-Induced esophagitis显示文摘 | Eng J Sabanathan S | 1991 | Am J Gastroenterol1991，86，9： | 1 |
| 15 | Primmy malignanl mehmonm of the esophagus 显示文摘 | Sabanathan S Eng J Pradhan GN | 1989 | Am J Gastroenterol1989，84，12： | 1 |
| 16 | Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension显示文摘 | GORZELNIAK K ENGELI S JANKE J | 2002 | J Hypertens2002，20，： | 1 |
| 17 | Accuracy of CT in the diagnosis of pulmonary embolism:a systematic literature review显示文摘 | Krishnan JA Segal JB | 2004 | AJR2004，183，6： | 1 |
| 18 | Factors involved in the regulation of mesangial cell proliferation in vitro and in vivo显示文摘 | Floege J Eng E Young BA | 1993 | Kidney Int1993，43，39： | 1 |
| 19 | Pleomorphic xanthoastroeyto- ma:a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis, a study of 12 cases显示文摘 | Kepes J J Rubinstein L J Eng L F | 1979 | Cancer1979，44，5： | 1 |
| 20 | IL-7 enhances periph- eral T cell reconstitution after allogeneic hematopoietic stem cell transplantation显示文摘 | Alpdogan O Murilan S J Eng J M | 2003 | J Clin Invest2003，112，7： | 1 |
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