|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Recent Advances in Cys-loop Receptor Structure and Function 显示文摘 | SINE S M ENGEL A G | 2006 | Nature2006，440，： | 1 |
| 3 | Predictive value of serum SlOOp for monitoring patients with metastatic melanoma during chemotherapy adn/or immunotherapy 显示文摘 | Hauschild A Engel G Brenner W | 2003 | Br J Demratol2003，11，： | 1 |
| 4 | Pseudoaneu- rysm with an arteriovenous fistula tibial vessels after plantar fasciotomy : a case report 显示文摘 | Nierenberg G Hoffman A Engel A | 1997 | Foot Ankle lnt1997，18，5： | 1 |
| 5 | Flavour formation by lactic add bacteria and biochemical flavour profiling of cheese products 显示文摘 | SMIT G SMIT B A ENGELS WJ M | 2005 | FEMS Microbiology Reviews2005，29，3： | 1 |
| 6 | Isotopic composition of individual carbohydrates as indicators of early diagenesis of organic matter in peat显示文摘 | Macko S A Engel M H Hartley G | 1991 | Chemical Geology1991，93，： | 1 |
| 7 | Diagnostic value ofprocalcitonin serum levels in neutropenic patients with fever:comparison with interleukin-8显示文摘 | Engel A Steinbach G Kern P | 1999 | Scand J Infect Dis1999，31，2： | 1 |
| 8 | The effects of maxillary quad helix appliance expansion on cephalometric measurements in growing orthodontic patients显示文摘 | FRANK S W ENGEL G A | 1982 | Am J Orthod1982，81，5： | 1 |
| 9 | Predictive val- ue of S100B for monitoring patients with metastatic melanoma during chemotherapy and/or immunothetapy 显示文摘 | Hauschild A Engel G Brenner W | 1999 | Br J Dermatol1999，140，6： | 1 |
| 10 | Cbanges of cerebral biood flow during the secondary expansion of a cortical contusion assessed by 14C- iodoantiphrine in mice using a non-invaaive protocol显示文摘 | Engel D C Mies G Terpolilli N A | 2008 | Neurotrauma2008，25，7： | 1 |
| 11 | Adjuvant therapy for HER2 + breast cancer:practice,perception, and toxicity 显示文摘 | Rocque G Onitilo A Engel J | 2012 | Breast Cancer Res Treat2012，131，2： | 1 |
| 12 | The criterion validity of the Center for Epidemiologieal Studies Depression Scale (CES- D) in a sample of self-referred elders with depressive symptomatology 显示文摘 | Haringsma R Engels G I Beekman A T F | 2004 | International Journal of Geriatric Psychiatry2004，19，6： | 1 |
| 13 | Develop- ment and psychometric validation of an eating disorder- specific health-related quality of life instrument显示文摘 | Engel S G Wittrock D A Crosby R D | 2006 | Int J Eat Disord2006，39，1： | 1 |
| 14 | Duchenne dystrophy:electron microscopic findings pointing to a basic or early abnormality in the plasma membrane of the muscle fiber显示文摘 | Mokri B Engel A G | 1975 | Neurology1975，25，12： | 1 |
| 15 | Thephotogramme trie potential of low-cost UAVs inforestry and agriculture显示文摘 | Grenzdorffer G J Engel A Teichert B | 2008 | The International Archivesof the Photogrammetry Remote Sending and SpatialInformation Sciences2008，31，3： | 1 |
| 16 | Partial Purification and Characterization of Two Aminotransferases from Lac- tococcus lactis subsp, cremoris B78 Involved in the Catabolism of Me- thionine and Branched-chain Amino Acids 显示文摘 | ENGELS W J M ALTING A C ARNTZ M M T G | 2000 | International Dairy Journal2000，10，7： | 1 |
| 17 | Mice lacking canna- binoid CB1 - , CB2 - receptors or both receptors show increased susceptibility to trenitrobenzene sulfonic acid (TNBS) -induced co- litis 显示文摘 | Engel M A Kellermann C A Burnat G | 2010 | J Physiol Pharmaco12010，61，1： | 1 |
| 18 | Flavour formation by lactic acid bacteria and biochemical flavour profiling of cheese products显示文摘 | Smit G Smit B A Engels W M | 2005 | Federation of European Microbiological Societies2005，29，3： | 1 |
| 19 | Serum 25 (OH) vitamin D and risk of breast cancer: a nested case-control study from the French E3N cohort显示文摘 | Engel P Fagherazzi G Boutten A | 2010 | Cancer Epidemiol Biomarkers Prev2010，19，9： | 1 |
| 20 | Mutations in MyoTilin cause myofibrillar myopathy显示文摘 | SELCEN D ENGEL A G | 2004 | Neurology2004，62，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员