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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Glucocorticoidmediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors 显示文摘 | Eberhardt W Schulze M Engels C | 2002 | Mol Endocrinol2002，16，8： | 1 |
| 3 | Prion protein is abnormally accumulated in inclusion-body myositis显示文摘 | ASKANAS V BILAK M ENGEL W K | 1993 | Neuroreport1993，5，1： | 1 |
| 4 | Effects of moulting and environmental factors on trace metal body-burdens and haemocyanin concentrations in the American lobster,Homarus americanus显示文摘 | Engel D W Brouwer M Mercaldo-Allen R | 2001 | Marine Environmental Research2001，52，： | 1 |
| 5 | The value of core decompression in treatment of femur head necrosis显示文摘 | Schneider W Breitenseher M Engel A | 2000 | Orthopade2000，29，5： | 1 |
| 6 | Metal regulation and molting in the blue crab, Callinectes sapidus: Metallothionein function in metal metabolism 显示文摘 | ENGEL D W BROUWER M | 1987 | Biological Bulletin1987，173，： | 1 |
| 7 | Effects of molting and environmental factors on trace metal body-burdens and hemocyanin concentrations in the American lobster, Homarus americanus 显示文摘 | Engel D W Brouwer M Allen M | 2001 | Mar Environ Res2001，52，： | 1 |
| 8 | Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats显示文摘 | Simonides Warner S Mulcahey Michelle A Redout Everaldo M Muller Alice Zuidwijk Marian J Visser Theo J Wassen Frank W J S Crescenzi Alessandra da-Silva Wagner S Harney John Engel Felix B Obregon Maria-Jesús Larsen P Reed Bianco Antonio C Huan | 2008 | Journal of Clinical Investigation2008，，3： | 1 |
| 9 | Diversity of L-leucine Catabolism in Various Microorganisms Involved in Dairy Fermentations,and Identification of the Rate-Controlling Step in the Formation of the Potent Flavour Component 3-Methylbutanal显示文摘 | SMIT B A ENGELS W J M WOUTERS J T M | 2004 | Appl Microbiol Biotechnol2004，64，： | 1 |
| 10 | Increased intraventricular pressure without ventriculomegaly in children with shunts: ' normal volume ''' hydrocephalus 显示文摘 | ENGEL M CARMEL P W CHUTORIAN A M | 1979 | Neurosurgery1979，5，5： | 1 |
| 11 | Partial Purification and Characterization of Two Aminotransferases from Lac- tococcus lactis subsp, cremoris B78 Involved in the Catabolism of Me- thionine and Branched-chain Amino Acids 显示文摘 | ENGELS W J M ALTING A C ARNTZ M M T G | 2000 | International Dairy Journal2000，10，7： | 1 |
| 12 | The value of core decompression in treatment of femur head necrosis 显示文摘 | Schneider W Breitenseher M Engel A | 2000 | Orthopade2000，29，5： | 1 |
| 13 | The value of core decompression intreatment of femur head necrosis显示文摘 | Schneider W Breitenseher M Engel A | 2000 | Orthopade2000，29，5： | 1 |
| 14 | Flavour formation by lactic acid bacteria and biochemical flavour profiling of cheese products显示文摘 | Smit G Smit B A Engels W M | 2005 | Federation of European Microbiological Societies2005，29，3： | 1 |
| 15 | Guidelines and recommendations for the safe operation of railings management facilities 显示文摘 | Dixon hardy D W Engels J M | 2007 | Environmental Engineering Science2007，24，5： | 1 |
| 16 | Bereitschaftspotential Preceding Speech after Holding Breath显示文摘 | Deecke L M Engel W Lang | 1986 | Experimental Brain Research1986，65，1： | 1 |
| 17 | The relativearrangement of chromosomes in mitosis interphase and and metaphase in Haplopappusgracilis显示文摘 | WERRY P A TH STOFFELSEN J K ENGELS F M LAAN F VAN DER SOANJERS A W | 1977 | Chromosoma(Brel)1977，36，： | 1 |
| 18 | Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells:involvement of nuclear factor-kappaB and Ets transcription factors 显示文摘 | Eberhardt W Schulze M Engels C | 2002 | Mol Endocrinol2002，16，8： | 1 |
| 19 | The value of core decompression in treatment of femur head necrosis显示文摘 | Schneider W Breitenseher M Engel A | 2000 | Orthopade2000，29，5： | 1 |
| 20 | Glucocorticoid-mediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor kappa-B and ets transcription factors显示文摘 | Eberhardt W Schulze M Engels C | 2002 | Endocrinol2002，16，8： | 1 |
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