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| 1 | Hot Working Characteristic of Superaustenitic Stainless Steel 254SMO显示文摘Hot deformation characteristic of superaustenitic stainless steel 254SMO has been studied by isothermal compression testing in the temperature range of 950–1,200 °C and strain rate range of 0.01–10 s-1.The activation energy of 496 kJ/mol was calculated by a hyperbolic-sine type equation over the entire range of strain rates and temperatures.In order to obtain optimum hot working conditions,processing maps consisting of power dissipation map and instability map were constructed at different strains.The power dissipation map exhibits two domains with relatively high efficiencies of power dissipation.The first domain occurs in the temperature range of 990–1,070 °C and the strain rate range of0.01–0.1 s-1.Microstructure observation in this domain indicates the partial dynamic recrystallization(DRX) accompanied with precipitation of tetragonal sigma phase.The second domain occurs in the temperature range of 1,140–1,200 °C and the strain rate range of 0.01–1 s-1with a peak efficiency of power dissipation of 39%,and in this domain,the microstructure observation reveals the full DRX.The instability map shows that flow instability occurs at the temperatures below 1,140 °C and the strain rates above 0.1 s-1. | Enxiang Pu Wenjie Zheng Jinzhong Xiang Zhigang Song Han Feng Yuliang Zhu | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，2： | 6 |
| 2 | Effects of Feiwei granules in the treatment of idiopathic pulmonary fibrosis:a randomized and placebo-controlled trial显示文摘OBJECTIVE:To document the therapeutic effect of Feiwei granules(FGs) for idiopathic pulmonary fi brosis(IPF).METHODS:One hundred cases with IPF were randomized into the treatment group(80) and control group(20).Both groups were given basic treatment with prednisone.The treatment group was given FGs,and the control group was given Jinshuibao capsules(JCs).Treatment lasted for 6 months.The Medical Research Council Dyspnea Scale(MRCDS),the Saint George's Hospital Respiratory Questionnaire(SGHRQ),pulmonary function,the Traditional Chinese Medicine Syndrome Score(TCMSS),6-min walking test(6MWT) and blood gas analyses were recorded before the study as well as3 months and 6 months after treatment.RESULTS:FGs showed greater efficacy than the control in certain parameters between before the study and 6 months,and between 3 months and 6months,in the MRCDS,some indicators in the SGHRQ,and the TCMSS.There were no significant differences between the treatment group and control group in the remainder of the indices evaluated.In the treatment group,there were significant differences in before and after treatment in the MRCDS,SGHRQ,TCMSS and 6MWT.CONCLUSION:FGs were similar to JCs for IPF treatment. | Yu Yang Sun Zengtao Shi Liqing Zhang Yanping Zhou Zhaoshan Zhang Shunan Chao Enxiang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 5 |
| 3 | Effect of rifampicin pre-and post-treatment on rotenone-induced dopaminergic neuronal apoptosis and alpha-synuclein expression显示文摘BACKGROUND: Rifampicin inhibits the formation of α-synuclein multimer and protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyritine (MPTP)-induced PC12 cell apoptosis.OBJECTIVE: To compare the effect of rifampicin pre-and post-treatment on tyrosine hydroxylase and α-synuclein expression in substantia nigra pars compacta in a rat model of Parkinson’s disease.DESIGN,TIME AND SETTING: A randomized,controlled experiment was performed at the Experimental Animal Center of Sun Yat-sen University North Campus (China) from November 2006 to October 2008.MATERIALS: Rifampicin was purchased from MD,USA;rotenone was purchased from Sigma,USA;mouse anti-rat α-synuclein monoclonal antibody was purchased from B&D,USA;and rabbit anti-rat tyrosine hydroxylase monoclonal antibody was purchased from Chemicon,USA.METHODS: A total of 72 male,Sprague Dawley rats,aged 8 weeks,were randomly assigned to 5 groups: blank control (n = 12),rifampicin (n = 12),rotenone (n = 16),rifampicin pre-treatment (n = 16),and rifampicin post-treatment (n = 16).Parkinson’s disease model rats were established via a subcutaneous injection of rotenone (1.5 mg/kg per day) in the three treatment groups,once a day for 3 successive weeks.Rifampicin (30 mg/kg per day) was intragastrically administered in the rifampicin pre-treatment group 3 days prior to rotenone induction and in the rifampicin post-treatment group 7 days after rotenone induction.Rats were treated with a subcutaneous injection of 1 mL/kg per day sunflower oil in the blank control group and an intragastric injection of 30 mg/kg per day rifampicin in the rifampicin group,once a day for 3 successive weeks in total.MAIN OUTCOME MEASURES: Prior to treatment and in the end of the 3rd week after treatment,the rats were evaluated using the modified neurological severity score.The substantia nigra from the rats was extracted for hematoxylin-eosin staining.Western blot analysis was performed to determine tyrosine hydroxylase and α-synuclein expression.RESULTS: Hematoxylin-eosin staining revealed a significant reduction in the number of substantia nigral neurons in the rotenone group,in addition to neurodegradation,hypopigmentation,and pyknosis.In the rifampicin pre-treatment and post-treatment groups,the number of dopaminergic neurons was significantly increased compared with the rotenone group (P < 0.01),with slight neuronal damage.Compared with the rotenone group,substantia nigral tyrosine hydroxylase expres-sion was significantly increased in the rifampicin pre-treatment and post-treatment groups (P < 0.01),but α-synuclein expression and modified neurological severity scores were significantly decreased (P < 0.01).In addition,the effect of rifampicin in the pre-treatment group was superior to the post-treatment group.There was no significant difference in tyrosine hydroxylase and α-synuclein expression,or in the modified neurological severity scores,between the blank control and rifampicin groups (P > 0.05).CONCLUSION: Rifampicin significantly attenuated neuropathological and behavioral motor deficits induced by rotenone.Moreover,rifampicin enhanced tyrosine hydroxylase expression,but inhibited α-synuclein expression.The effect of rifampicin pre-treatment was superior to rifampicin post-treatment. | Yuanlin Sun Guohua Zhang Jie Xu Shiwen Chen Enxiang Tao Changqing Xu M. Catherine Bennett | 2010 | Neural Regeneration Research2010，5，2： | 4 |
| 4 | Rifampicin inhibits apoptosis in rotenone-induced differentiated PC12 cells by ameliorating mitochondrial oxidative stress显示文摘BACKGROUND:Previous studies have shown that rifampicin exhibits neuroprotective effects,but the precise mechanisms remain unclear.Rifampicin is thought to exert the neuroprotective effect as a hydroxyl free radical scavenger.OBJECTIVE:To investigate the protective effects of rifampicin pretreatment on rotenone-induced mitochondrial oxidative stress in differentiated PC12 cells.DESIGN,TIME AND SETTING:A repeated measure,cell-based study was performed at the Department of Neurology,Second Affiliated Hospital,Sun Yat-sen University,China between December 2007 and November 2008.MATERIALS:PC12 cells were a kind gift from the Physiology Laboratory of Zhongshan Medical School,Sun Yat-sen University,China.Rotenone and rifampicin were purchased from Sigma,USA.METHODS:PC12 cells were differentiated by culturing with 100 ng/mL 7S nerve growth factor for 9 days in Dulbecco's modified Eagle's medium/Nutrient Mix F12(DMEM/F12) supplemented with 10% fetal bovine serum.The cells were assigned to six groups according to various treatment conditions:control,cultured with normal media;rifampicin group,treated with 300 μmol/L rotenone for 26 hours;rotenone group,treated with 2.5 μmol/L rotenone for 24 hours;rifampicin pretreatment groups,pretreated with 100,200,and 300 μmol/L rifampicin for 2 hours,respectively,followed by 2.5 μmol/L rotenone for 24 hours.MAIN OUTCOME MEASURES:Mitochondrial membrane potential was measured by fluorescence microscopy and flow cytometry,respectively,using rhodamine123 staining.Intracellular reactive oxygen species formation was analyzed by flow cytometry using 2',7'-dichlorofluorescin-diacetate staining,and intracellular reduced glutathione was measured with a microplate reader.Cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Cell apoptosis was detected by Hoechst 33342 staining and flow cytometry.RESULTS:Increased apoptosis in rotenone-induced,differentiated,PC12 cells was accompanied by the loss of mitochondrial transmembrane potential,the formation of reactive oxygen species,and reduced glutathione depletion(P<0.01).Rotenone-induced mitochondrial dysfunction was blocked in a dose-dependent manner by rifampicin(P<0.05 or P<0.01).CONCLUSION:Pretreatment of differentiated PC12 cells with rifampicin blocked rotenone-induced apoptosis by ameliorating mitochondrial dysfunction and oxidative stress. | Shiwen Chen Yuanlin Sun Zhifeng Zeng Enxiang Tao | 2010 | Neural Regeneration Research2010，5，4： | 2 |
| 5 | Paroxetine engenders analgesic effects through inhibition of p38 phosphorylation in a rat migraine model显示文摘In this study,a model of migraine was established by electrical stimulation of the superior sagittal sinus in rats.These rats were then treated orally with paroxetine at doses of 2.5,5,or 10 mg/kg per day for 14 days.Following treatment,mechanical withdrawal thresholds were significantly higher,extracellular concentrations of 5-hydroxytryptamine in the periaqueductal grey matter and nucleus reticularis gigantocellularis were higher,and the expression of phosphorylated p38 in the trigeminal nucleus caudalis was lower.Our experimental findings suggest that paroxetine has analgesic effects in a rat migraine model,which are mediated by inhibition of p38 phosphorylation. | Chuanming Wang Wei Bi Yanran Liang Xiuna Jing Songhua Xiao Yannan Fang Qiaoyun Shi Enxiang Tao | 2012 | Neural Regeneration Research2012，7，13： | 2 |
| 6 | Mechanical Properties of Silica Aerogels Prepared from a Mixture of TEOS and Organo-alkoxysilanes of Type R_1SiX_3显示文摘Silica aerogels were prepared from a mixture of tetraethylorthosilicate and organoalkoxysilanes. The effects of organo-alkoxysilanes on the mechanical properties of the silica aerogels were studied. The flexibility of silica aerogels was significantly improved by incorporation of organo-alkoxysilanes. When MTES and TEOS were combined as precursors of silica areogels, with the increased amount of MTES, the apparent elastic modulus and apparent compressive strength monotonously rose. At the same organoalkoxysilanes to TEOS ratio, the size of alkyl groups of the organo-alkoxysilanes had little effect on the mechanical properties. In series of MTES and TEOS, the lowest elastic modulus of silica skeleton and the highest compressive strength of silica skeleton were observed at MTES to TEOS ratio of around 50:50. At a certain organo-alkoxysilanes to TEOS ratio, the elastic modulus of silica skeleton increased and the compressive strength of silica skeleton decreased with the size increase of the alkyl groups. | 杨海龙 孔祥明 ZHANG Yanrong WU Chunchao CAO Enxiang | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，1： | 1 |
| 7 | Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration显示文摘 | Yanran Liang Zhonglin Liu Xintao Shuai Weiwei Wang Jun Liu Wei Bi Chuanming Wang Xiuna Jing Yunyun Liu Enxiang Tao | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 8 | Neuron-specific enolase expression in a rat model of radiation-induced brain injury following vascular endothelial growth factor-modified neural stem cell transplantation显示文摘<正>BACKGROUND:Previous studies have shown that transplantation of vascular endothelial growth factor(VEGF)-modified neural stem cells(NSC) provides better outcomes,compared with neural stem cells,in the treatment of brain damage. OBJECTIVE:To compare the effects of VEGF-modified NSC transplantation and NSC transplantation on radiation-induced brain injury,and to determine neuron-specific enolase(NSE) expression in the brain. DESIGN,TIME,AND SETTING:The randomized,controlled study was performed at the Linbaixin Experimental Center,Second Affiliated Hospital,Sun Yat-sen University,China from November 2007 to October 2008. MATERIALS:VEGF-modified C17.2 NSCs were supplied by Harvard Medical School,USA. Streptavidin-biotin-peroxidase-complex kit(Boster,China) and 5,6-carboxyfluorescein diacetate succinimidyl ester(Fluka,USA) were used in this study. METHODS:A total of 84 Sprague Dawley rats were randomly assigned to a blank control group(n = 20),model group(n = 20),NSC group(n = 20),and a VEGF-modified NSC group(n = 24).Rat models of radiation-induced brain injury were established in the model,NSC,and VEGF-modified NSC groups.At 1 week following model induction,10μL(5×10~4 cells/μL) VEGF-modified NSCs or NSCs were respectively infused into the striatum and cerebral cortex of rats from the VEGF-modified NSC and NSC groups.A total of 10μL saline was injected into rats from the blank control and model groups. MAIN OUTCOME MEASURES:NSE expression in the brain was detected by immunohistochemistry following VEGF-modified NSC transplantation. RESULTS:NSE expression was significantly decreased in the brains of radiation-induced brain injury rats(P<0.05).The number of NSE-positive neurons significantly increased in the NSC and VEGF-modified NSC groups,compared with the model group(P<0.05).NSE expression significantly increased in the VEGF-modified NSC group,compared with the NSC group,at 6 weeks following transplantation(P<0.05). CONCLUSION:VEGF-modified NSC transplantation increased NSE expression in rats with radiation-induced brain injury,and the outcomes were superior to NSC transplantation. | Songhua Xiao Chaohui Duan Qingyu Shen Yigang Xing Ying Peng Enxiang Tao Jun Liu | 2009 | Neural Regeneration Research2009，4，10： | 1 |
| 9 | What have we known so far for fluorescence staining and quantification of microplastics:A tutorial review显示文摘Understanding the fate and toxicity of microplastics(MPs,<5 mm plastic particles)is limited by quantification methods.This paper summarizes the methods in use and presents new ones.First,sampling and pretreatment processes ofMPs,including sample collection,digestion,density separation,and quality control are reviewed.Then the promising and convenient staining procedures and quantification methods for MPs using fluorescence dyes are reviewed.The factors that influence the staining of MPs,including their physicochemical properties,are summarized to provide an optimal operation procedure.In general,the digestion step is crucial to eliminate natural organic matter(NOM)to avoid interference in quantification.Chloroform was reported to be the most appropriate solvent,and 10–20μg/mL are recommended as optimal dye concentrations.In addition,a heating and cooling procedure is recommended to maintain the fluorescence intensity of MPs for two months.After staining,a fluorescence microscope is usually used to characterize the morphology,mass,or number of MPs,but compositional analysis cannot be determined with it.These fluorescence staining methods have been implemented to study MP abundance,transport,and toxicity and have been combined with other chemical characterization techniques,such as Fourier transform infrared spectroscopy and Raman spectroscopy.More studies are needed to focus on the synthesis of novel dyes to avoid NOM’s interference.They need to be combined with other spectroscopic techniques to characterize plastic composition and to develop image-analysis methods.The stability of stained MPs needs to be improved. | Shengdong Liu Enxiang Shang Jingnan Liu Yining Wang Nanthi Bolan MBKirkham Yang Li | 2022 | Frontiers of Environmental Science & Engineering2022，16，1： | 1 |
| 10 | Hot deformation characteristic and processing map of superaustenitic stainless steel S32654显示文摘 | Enxiang Pu Wenjie Zheng Jinzhong Xiang Zhigang Song Ji Li | 2014 | Materials Science & Engineering A2014，，： | 1 |
| 11 | Analysis of the diagnosis and treatment of 78 gastric cancer cases in young people显示文摘Objective: To summarize the causes of difficulty in gastric cancer diagnosis in young people and explore potential methods of improving diagnostic accuracy. Methods: We retrospectively analyzed 78 cases of gastric cancer in young people (14–35 years). Results: The clinical manifestations of gastric carcinoma in young people show no specificity, and the initial symptoms were diverse, with discomfort in the upper abdomen as the main symptom. There are four causes of difficulty in early detection: (1) The previous physician relied on antacids and did not use or analyze the results of gastroscopic examination and barium meal examination of the upper digestive tract; (2) The physician performing the endoscopic examination did not strictly follow the standards in the biopsy of fine pathological changes in suspected early cancer; (3) The physician lacked a good understanding of the clinical progress of ulcerating-healing-ulcerating in the ulcerating type of early gastric cancer; (4) Lacked a good understanding of precancerous lesions in the gastric mucosa. Conclusion: Early gastroscopy and pathological examina- tion must be conducted for people who above 20 years of age with one or more of the following symptoms: dull pain in the upper abdomen, anorexia, fatigue, tarry stool and vomiting of unknown origin. The results of gastroscopic examination should be taken into consideration for patients with recurrent ulcer, and biopsy should be standardized. Biopsy specimens should be taken from several loci in the suspected lesions, and should be repeated if necessary. Precancerous lesions of gastric mucosa should be closely followed up using gastroscopy. | Enxiang Zhou Mingxing Wen Yunshan Li Duxin Qing | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，6： | 0 |
| 12 | A j,υ model for the analysis and prediction of tides显示文摘In this paper, the j, υ corrected formulae of the amplitudes and the phases of 58 astronomical constituents are given, and the models for the analysis and prediction of 169 constituents are presented. The new Cartwright’s calculated results of the tidal potential are used, and the quadratic analysis is made. It has been proved by a number of trials that the harmonic constants of constituents are more stable and the accuracy of the predicted result reliable. | Chen Zongyong, Huang Zuke, Zhou Tianhua, Tang Enxiang and Wang Yuzhou Ocean University of Qingdao,Qingdao,China No, 57653 Unit of Chinese People’s Liberation Army,China | 1990 | Acta Oceanologica Sinica1990，9，4： | 0 |
| 13 | Generation and classification of transcriptomes in two Croomia species and molecular evolution of CYC/TB1 genes in Stemonaceae显示文摘The genus Croomia(Stemonaceae) is an excellent model for studying the evolution of the Eastern Asia(EA)-Eastern North America(ENA) floristic disjunction and the genetic mechanisms of floral zygomorphy formation. In addition to the presence of both actinomorphic and zygomorphic flowers within the genus, species are disjunctively distributed between EA and ENA. However, due to the limited availability of genomic resources, few studies of Croomia have examined these questions. In this study,we sequenced the floral and leaf transcriptomes of the zygomorphic flowered Croomia heterosepala and the actinomorphic flowered Croomia japonica, and used comparative genomic approaches to investigate the transcriptome evolution of the two closely related species. The sequencing and de novo assembly of transcriptomes from flowers of C. heterosepala(ChFlower), flowers of C. japonica(CjFlower), and leaves of C. japonica(CjLeaf) yielded 57,193, 62,131 and 64,448 unigenes, respectively. In addition, estimation of Ka/Ks ratios for 11,566 potential orthologous groups between ChFlower and CjFlower revealed that only six pairs had Ka/Ks ratios significantly greater than 1 and are likely under positive selection. A total of 429 single copy nuclear genes(SCNGs) and 21,460 expression sequence tags-simple sequence repeats(ESTSSRs) were identified in this study. Specifically, we identified seven CYC/TB1-like genes from Stemonaceae. Phylogenetic and molecular evolution analyses indicated that these CYC/TB1-like genes formed a monophyletic clade(SteTBL1) and were subject to strong purifying selection. The shifts of floral symmetry in Stemonaceae do not appear to be correlated with TBL copy number. | Ruisen Lu Wuqin Xu Qixiang Lu Pan Li Jocelyn Losh Faiza Hina Enxiang Li Yingxiong Qiu | 2018 | Plant Diversity2018，40，6： | 0 |
| 14 | Aggregation of graphene oxide and its environmental implications in the aquatic environment显示文摘Graphene oxide(GO) with unique characteristics grasps striking potentials in both academic and industrial applications. After being released into natural waters, the dispersity and stability of GO might be altered by the chemical conditions in the receiving water bodies. In this review, we summarized that the aggregation of GO in aquatic environments is mostly dependent on properties of nanoparticles(size,structure, and functional groups) and complex water chemistry(p H, temperature, light, ionic strength,and dissolved organic matter). The knowledge about the aggregation/stability of GO is still insufficient due to the variations in GO properties and complex system of natural waters. Although studies about environmental transformation of graphene-related materials can be accessed but a systematic study taking into consideration the various factors of GO and aquatic systems responsible for aggregation of GO is still lacking. Therefore, we summarized that GO homoaggregation or heteroaggregation with other solid particles can affect the distribution in different depths of rivers and toxicity toward plankton or benthic organisms. More studies are needed to investigate the stability of GO in the long term, the effect of other nanomaterial on GO aggregation, the alteration of water constituents at different regions/time and its effect on GO aggregation, to understand the transportation and impact of GO in the environment. | Jawad Ali Yang Li Enxiang Shang Xinjie Wang Jian Zhao Muhammad Mohiuddin Xinghui Xia | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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