2篇
您的检索式：作者名="Erfei Chen"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ZNF3 regulates proliferation,migration and invasion through MMP1 and TWIST in colorectal cancer显示文摘Colorectal cancer(CRC)is a malignant tumor with a high incidence and mortality worldwide.Currently,the underlying molecular mechanisms of CRC are still unclear.Zinc finger protein 3(ZNF3)is a zinc-finger transcription factor that has been reported as a candidate for breast cancer prognosis,suggesting its involvement in the regulation of tumorigenesis.However,the association between ZNF3 and CRC remains unknown.To investigate the role of ZNF3 in CRC,we first analyze the correlation between ZNF3 expression and CRC,and the results demonstrate that ZNF3 is highly expressed in CRC tissue and cells,which is associated with the age of CRC patients.In vitro studies show that ZNF3 overexpression promotes CRC cell migration.Compared to control cells,knockdown of ZNF3 markedly suppresses CRC cell proliferation,migration and invasion and promotes G0/G1 phase cell cycle arrest.The expressions of the EMT-related markers TWIST and MMP1 are significantly decreased when ZNF3 is silenced.Additionally,overexpression of MMP1 and TWIST exacerbates CRC cell proliferation,accelerates the S phase cell cycle in ZNF3-knockdown SW480 cells,and increases cell migration and invasion through Transwell chambers.These data suggest that ZNF3 is involved in cellular proliferation,migration and invasion by regulating MMP1 and TWIST in CRC cells. | Le Du Ning Liu Jianfeng Jin Meng Cao Yuantian Sun Xinzheng Gao Banzhan Ruan Shangfeng Yang Dongsheng Ge Yingzhuan Ye Yinxi Zhou Erfei Chen Jin Yang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 1 |
| 2 | Porous polymeric ligand promoted copper-catalyzed C-N coupling of(hetero)aryl chlorides under visible-light irradiation显示文摘A porous polymeric ligand(PPL)has been synthesized and complexed with copper to generate a heterogeneous catalyst(Cu@PPL)that has facilitated the efficient C-N coupling with various(hetero)aryl chlorides under mild conditions of visiblelight irradiation at 80°C(58 examples,up to 99%yields).This method could be applied to both aqueous ammonia and substituted amines,and is compatible to a variety of functional groups and heterocycles,as well as allows tandem C-N couplings with conjunctive dihalides.Furthermore,the heterogeneous characteristic of Cu@PPL has enabled a straightforward catalyst separation in multiple times of recycling with negligible catalytic efficiency loss by simple filtration,affording reaction mixtures containing less than 1 ppm of Cu residue. | Erfei Wang Kaixuan Chen Yinan Chen Jiawei Zhang Xinrong Lin Mao Chen | 2021 | Science China Chemistry2021，64，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员