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| 1 | 利用微波辅助萃取、电感耦合等离子体质谱和离子色谱联用方法测定生物和环境样品中的重金属以评价其对人体健康的潜在危害显示文摘[目的]测定生物和环境样品中的重金属及其化学形态,从而更准确地评价其对人体健康的潜在危害,并且监测重金属从环境基质到人体的迁移途径.[方法]利用微波辅助萃取进行样品预处理,离子色谱分离重金属不同化学形态,电感耦合等离子体质谱进行检测.[结果]微波辅助萃取能够将重金属的不同无机和有机形态从样品基质中有效分离,分离过程中金属形态不发生变化.将离子色谱和电感耦合等离子体质谱在线联用,辅以稳定性同位素标记,可以准确测定生物和环境样品中的金属(铅、铬和汞)形态.[结论]提高生物和环境样品中重金属检测的灵敏度,并且测定金属的化学形态,可以对评价重金属对人体健康的潜在危害提供重要信息. | Brian Buckley Willie Johnson Eric Fischer 涂强 Mark Heintz | 2003 | 环境与职业医学2003，20，6： | 4 |
| 2 | Bacteria may contribute to distant species recognition in ant-aphid mutualistic relationships显示文摘在蚂蚁和蚜虫种类之间的 Mutualistic 相互作用是可观的历史、当代的调查的题目,主要好处正在清洗并且为蚜虫的保护和为蚂蚁的充满糖类的蜜露。然而,问题至于影响这种关系的不稳定的 semiochemical 因素留下了。最近的研究加亮细菌的蜜露的角色在蚂蚁吸引力的不稳定的混合物。这里,远地区别 2 蚜虫种类的蚂蚁能力用双向 olfactometer 基于细菌的蜜露 semiochemicals 排出物被调查。两 mutualistic 蚜虫蚜虫属 fabae L。并且 nonmyrmecophilous 蚜虫 Acyrthosiphon pisum 哈里斯被发现为蚂蚁 Lasius 尼日尔漂亮 L。吸引力的水平在两试金是类似的(控制对蚜虫种类之一) 。不管多么当给在这之间的一种选择时 2 蚜虫种类,蚂蚁为蚜虫属 fabae 显示出重要偏爱。主要从细菌的起源,蜜露 volatiles 被知道是在蚂蚁吸引力的一个关键元素。用一样的 olfactometry 协议,蜜露射出的 volatiles 的相对优美从每蚜虫种收集了,由从各个孤立的细菌,蜜露被调查。再次,蚂蚁显著地比较喜欢蚜虫属 fabae 蜜露和细菌释放的 volatiles。这个信息建议微生物引起的蜜露 volatiles 使蚂蚁能远地区别蚜虫种类。这些结果加强在昆虫 symbioses 学习出现和微生物的潜在的影响的兴趣。 | Christophe Y. Fischer Claire Detrain Philippe Thonart Eric Haubruge Frederic Francis Francois J. Verheggen Georges C. Lognay | 2017 | Insect Science2017，24，2： | 3 |
| 3 | Golimumab in real-world practice in patients with ulcerative colitis:Twelve-month results显示文摘BACKGROUND The introduction of biologics has revolutionized the management of the chronic inflammatory bowel disease,ulcerative colitis(UC),with many patients experiencing significant improvements not only in their symptoms but in other outcomes relevant to individuals and society as a whole.In Germany,there are no prospective data>3 mo that assess the work productivity,daily activities and quality of life(QoL)of patients with moderate-to-severe UC treated with golimumab.AIM To assess change in work productivity,capacity for daily activities and QoL in UC patients treated with golimumab in Germany.METHODS The validated Work Productivity Activity Impairment(WPAI)Questionnaire was used to analyze the change in work productivity,the capacity for daily activities after three months(primary endpoint)and disease specific and health related QoL(HRQoL)up to 1 year(secondary endpoints).The changes in work productivity and activity impairment were evaluated every three months until month twelve compared to baseline.Disease-specific and health-related QoL were assessed with the inflammatory bowel disease questionnaire and with the short-form 12 health survey questionnaire(SF-12).RESULTS This prospective non-interventional study included 287 patients.The analysis population was comprised of 282 patients who had completed at least two visits.At baseline,61%of patients had moderate UC and 18%had severe UC.Furthermore,75%of patients worked full-time or part-time at baseline.A total of 212 patients who were employed at the start of the study(employed population)were evaluated for the primary endpoint.Golimumab significantly reduced all WPAI sub-scores compared to baseline after three,six,nine and twelve months after the start of treatment(P<0.0001).In addition,disease-specific QoL and HRQoL,as measured by the SF-12 questionnaire,improved significantly with golimumab at all evaluation times(P<0.0001 in each case vs baseline).CONCLUSION Treatment of moderate-to-severe UC with golimumab leads to significant improvements in patient´s work productivity,daily activity and QoL over twelve months. | Niels Teich Harald Grümmer Eric Jorgensen Thomas Liceni Frank Holtkamp-Endemann Tim Fischer Susanne Hohenberger | 2020 | World Journal of Gastroenterology2020，26，21： | 3 |
| 4 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 5 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 6 | Microbial fuel cell enables phosphate recovery from digested sewage sludge as struvite显示文摘 | Fabian Fischer Christèle Bastian Manuel Happe Eric Mabillard Nicolas Schmidt | 2011 | Bioresource Technology2011，，10： | 1 |
| 7 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 1 |
| 8 | Genotypic succession of mutations of the hepatitis B virus polymerase associated with lamivudine resistance显示文摘 | Klaus S Gutfreund Mark Williams Rajan George Vincent G Bain Mang M Ma Eric M Yoshida Jean-Pierre Villeneuve Karl P Fischer David L.J Tyrrell | 2000 | Journal of Hepatology2000，，3： | 1 |
| 9 | Anodic stripping voltammetry of lead and cadmium using a mercury film electrode and thiocyanate显示文摘 | Eric Fischer Constant M G Van den Berg | 1999 | Analytica Chimica Acta1999，385，13： | 1 |
| 10 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 1 |
| 11 | Vision-guided ocular growth in a mutant chicken model with diminished visual acuity显示文摘 | Eric R. Ritchey Christopher Zelinka Junhua Tang Jun Liu Kimberly A. Code Simon Petersen-Jones Andy J. Fischer | 2012 | Experimental Eye Research2012，，： | 1 |
| 12 | Comparison between visual assessment and quantitative angiography versus fractional flow reserve for native coronary narrowings of moderate severity显示文摘 | Joshua J Fischer Habib Samady John A McPherson Ian J Sarembock Eric R Powers Lawrence W Gimple Michael Ragosta | 2002 | The American Journal of Cardiology2002，，3： | 1 |
| 13 | Visual-Based Scheduling:4D Modeling on the San Mateo Country Health Center 显示文摘 | Eric Collier Martin Fischer | 1996 | Computing in Civil Engineering1996，，： | 1 |
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