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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules显示文摘 | Eric J Robert W Mariska V | 1993 | Biochem Pharm1993，45，6： | 1 |
| 5 | Dy∶YAG phosphor coating using the solution precursor plasma spray process显示文摘 | DIAN Y C ERIC H J MICHAEL W R | 2009 | Journal of the American Ceramic Society2009，92，1： | 1 |
| 6 | Low pH,caprylate incubation as a second viral inactivation step in the manufacture of albumin:Parametric and validation studies显示文摘 | Anna J Eric U David J John W | | 0，，03： | 1 |
| 7 | Synthesis and electrochemical studies of LiMnO2 prepared at low temperature显示文摘 | Reimers J N Fuller Eric W | 1993 | Journal of Electrochemical Society1993，140，12： | 1 |
| 8 | Thermodynamic properties for the alternative refrigerants显示文摘 | Mark O M Eric W L Richard T J | 1998 | Int J Refrig1998，21，4： | 1 |
| 9 | Linking Citizen Satisfaction with E-Government and Trust in Government显示文摘 | ERIC W CHARLES H MOON J | 2005 | Journal of Public Administration Research and Theory2005，，3： | 1 |
| 10 | Dynamic time warping of spectroscopic batch data 显示文摘 | RAMAKER H J ERIC N M JOHAN A W | 2003 | Analytica Chimica Acta2003，498，12： | 1 |
| 11 | Past and Projected Rural Land Conversion in the US at State, Regional, and National Levels显示文摘 | ERIC M W ANITA T M RALPH J A | 2009 | Landscape and Urban Planning2009，89，1： | 1 |
| 12 | BAHG : Back- Bone- Assisted hop greedy routing for vanet's city environments显示文摘 | Pratap K S Eric H W Agruti J S | 2013 | IEEE Transactions on Intelligent Transportation Systems2013，14，1： | 1 |
| 13 | Speculation in the housing marker显示文摘 | Eric J L Robert E W | 1997 | Urban Studies1997，34，9： | 1 |
| 14 | On marketable air-pollution permits: The case for a system of pollution offsets显示文摘 | Krupnick A J Oates W E Eric V D V | 1983 | Journal of Environmental Economics and Management1983，10，3： | 1 |
| 15 | An algorithm for the optimization of Kubelka-Munk absorption and scattering coefficients 显示文摘 | ERIC W CORNELIUS J M ROY S B | 1987 | Color Research and Application1987，12，6： | 1 |
| 16 | Treatment of displaced pediat-ric supracondylar humerus fracture patterns requiring medial fixa-tion:A reliable and safer cross-pinning technique 显示文摘 | Eric W E Joanna H R Scott J M | 2012 | J PediatrOrthop2012，32，4： | 1 |
| 17 | Stab and puncture characterization of thermoplastic-impregnated aramid fabric显示文摘 | JESSIE B MAYO J ERIC D W | | 0，，09： | 1 |
| 18 | Gum chewing stimulates bowel motility in patients undergoing radical cystectomy with urinary diversion 显示文摘 | ERIK J K ERIC M W RAJ S P | 2007 | Urology2007，70，： | 1 |
| 19 | On the Depth and Dynamics of Online Search Behavior 显示文摘 | Johnson Eric J Wendy W Moe Peter S Fader | 2004 | Management Science2004，50，3： | 1 |
| 20 | Soil moisture esti- mates from TRMM Microwave lmager observations over the Southern United States 显示文摘 | Bindlish R Thomas J S Eric W | 2003 | Remote Sens Environ2003，85，： | 1 |
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