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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 4 | Detection of shifts in microbial community structure and diversity in soil caused by copper contamination using amplified ribosomal DNA restruction analysis显示文摘 | ERIC S PAULA L KAREL W | 1997 | FEMS Microbiology Ecology1997，23，： | 1 |
| 5 | Inter-organizational knowledge transfer:Current themes and future prospects 显示文摘 | Mark E S Marjorie A L Eric W K T | 2008 | Journal of Management Studies2008，45，4： | 1 |
| 6 | Learning patterns of activity using real-time tracking显示文摘 | STAUFFER C ERIC W CRIMSON L | | 0，，08： | 1 |
| 7 | Thermodynamic properties for the alternative refrigerants显示文摘 | Mark O M Eric W L Richard T J | 1998 | Int J Refrig1998，21，4： | 1 |
| 8 | The impact of virtu- al embedded ness on new venture survival:overcoming the Liabilities of Newness 显示文摘 | Eric A M Sally W F Thomas B L | 2007 | Entrepreneurship Theory and Practice2007，31，2： | 1 |
| 9 | Social lifecycle costs of cars with alternative fuels/engines显示文摘 | Joan M O Robert H W Eric D L | 2004 | Energy Policy2004，，32： | 1 |
| 10 | Learning Patterns of Activity Using Real- Time Tracking 显示文摘 | Stauffer C Eric W Grimson L | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，8： | 1 |
| 11 | Strength and stiffness of circular concrete-filled tubes 显示文摘 | CHARLES W R DAWN E L ERIC B | 2010 | Journal of Structural Engineering2010，136，： | 1 |
| 12 | Speculation in the housing marker显示文摘 | Eric J L Robert E W | 1997 | Urban Studies1997，34，9： | 1 |
| 13 | Computational experiments with a feature based stereo algorithm显示文摘 | Eric W Grimson L | 1985 | IEEE Transactions on Pattern Analysis and Machine Intelligence1985，7，1： | 1 |
| 14 | Effect of ozonation trihalomethane and haloacetic acid formation and speciation in a full-scale distribution system显示文摘 | Eric C W Fernando L R | 2011 | Ozone: Science & Engineering2011，33，1： | 1 |
| 15 | Nontuberculous Myeobacteria Infections and Anti-Tumor Necrosis Factor-α Ther- apy显示文摘 | KEVIN L W ERIC C SHELLIE Y | 2009 | Emerging Infectious Diseases2009，15，10： | 1 |
| 16 | Learning Patterns of Activity Using Real-time Tracking显示文摘 | Eric W Grimson L | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，22，8： | 1 |
| 17 | Surface soil moisture parameterization of the VIC-2L model : Evaluation and modification 显示文摘 | Xu L Eric F W Dennis P L | 1996 | Global Planet Change1996，13，： | 1 |
| 18 | Learning Patterns of Activity Using Real-Time Tracking显示文摘 | Chris Stauffer W Eric L Grimson | 2000 | IEEE Transaction On Pattern Analysis and Machine Intelligence2000，22，8： | 1 |
| 19 | Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism显示文摘 | Timothy A Kimbrell John T Little Robert T Dunn Mark A Frye Benjamin D Greenberg Eric M Wassermann Jennifer D Repella Aimee L Danielson Mark W Willis Brenda E Benson Andrew M Speer Elizabeth Osuch Mark S George Robert M Post | 1999 | Biological Psychiatry1999，，12： | 1 |
| 20 | IL-4-dependent CD86 expression requires JAK/STAT6 activation and is negatively regulated by PKCδ显示文摘 | Eric L D Danett K B Keith W K | 2004 | Cell Signal2004，16，2： | 1 |
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