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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | Parvovirus B19 induced hepatic failure in an adult requiring liver transplantation显示文摘Parvovirus B19 induced acute hepatitis and hepatic failure have been previously reported, mainly in children. Very few cases of parvovirus induced hepatic failure have been reported in adults and fewer still have required liver transplantation. We report the case of a 55-year-old immunocompetent woman who developed fulminant hepatic failure after acute infection with Parvovirus B19 who subsequently underwent orthotopic liver transplantation. This is believed to be the first reported case in the literature in which an adult patient with fulminant hepatic failure associated with acute parvovirus B19 infection and without hematologic abnormalities has been identified prior to undergoing liver transplantation. This case suggests that Parvovirus B19 induced liver disease can affect adults, can occur in the absence of hematologic abnormalities and can be severe enough to require liver transplantation. | Darin S Krygier Urs P Steinbrecher Martin Petric Siegfried R Erb Stephen W Chung Charles H Scudamore Andrzej K Buczkowski Eric M Yoshida | 2009 | World Journal of Gastroenterology2009，15，32： | 3 |
| 4 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 5 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 6 | 100% Gelled LPG fracturing process: An alternative to conventional water- based fracturing techniques显示文摘 | Eric H Tudor Eng P Grant W | 2009 | SPE1244952009，，： | 1 |
| 7 | Structural Controls on Carlin - Type Gold Mineralization in the Gold Bar District, Eureka Coun- ty, Nevada显示文摘 | Ozcan Y Eric P N Murray W H | 2003 | Economic Geology2003，，98： | 1 |
| 8 | Value co-creation and purchase intention in social network sites: the role of electronic word-of- mouth and trust-a theoretical analysis 显示文摘 | Eric W K S-T Kevin K W H | 2014 | Computers in Human Behavior2014，31，： | 1 |
| 9 | Dy∶YAG phosphor coating using the solution precursor plasma spray process显示文摘 | DIAN Y C ERIC H J MICHAEL W R | 2009 | Journal of the American Ceramic Society2009，92，1： | 1 |
| 10 | Network phase in ABC triblock copolymers 显示文摘 | Thomes H E Eric W C Cordell M H | 2004 | Macromolecules2004，37，： | 1 |
| 11 | Linking Citizen Satisfaction with E-Government and Trust in Government显示文摘 | ERIC W CHARLES H MOON J | 2005 | Journal of Public Administration Research and Theory2005，，3： | 1 |
| 12 | Dynamic time warping of spectroscopic batch data 显示文摘 | RAMAKER H J ERIC N M JOHAN A W | 2003 | Analytica Chimica Acta2003，498，12： | 1 |
| 13 | Social lifecycle costs of cars with alternative fuels/engines显示文摘 | Joan M O Robert H W Eric D L | 2004 | Energy Policy2004，，32： | 1 |
| 14 | BAHG : Back- Bone- Assisted hop greedy routing for vanet's city environments显示文摘 | Pratap K S Eric H W Agruti J S | 2013 | IEEE Transactions on Intelligent Transportation Systems2013，14，1： | 1 |
| 15 | Chemical characterization of biobinder from swine ma- nure: Sustainable modifier for asphalt binder显示文摘 | Elham H Fini Eric W Kalberer Abolghasem Shahbazi | 2011 | J Mater Civil Eng2011，23，11： | 1 |
| 16 | Treatment of displaced pediat-ric supracondylar humerus fracture patterns requiring medial fixa-tion:A reliable and safer cross-pinning technique 显示文摘 | Eric W E Joanna H R Scott J M | 2012 | J PediatrOrthop2012，32，4： | 1 |
| 17 | Effect of maternal ethanol intake on fetal rabbit gastrointestinal development 显示文摘 | Guo W H Jeffrey P G Eric W F | 1994 | J Pediatr Surg1994，29，： | 1 |
| 18 | Dietary protein level andstage of development affect expression of an intestinal peptidetransporter ( ePepTl ) in chickens 显示文摘 | Chen H Pan Y X Eric A W | 2005 | J Nutr2005，135，2： | 1 |
| 19 | Corporate philanthropic practices 显示文摘 | Brown W O Eric H Janet K S | 2006 | Journal of CorporateFinance2006，12，5： | 1 |
| 20 | Antigen presentation:peptides and proteins scramble for the exit 显示文摘 | PAML J L ERIC W H KARIN R | 2000 | Current Biology2000，10，： | 1 |
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