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| 1 | Non-alcoholic fatty liver disease and thyroid dysfunction:A systematic review显示文摘Thyroid hormones are totally involved in the regulation of body weight, lipid metabolism, and insulin resistance. Therefore it is anticipated that thyroid hormones may have a role in the pathogenesis of non alcoholic fatty liver disease(NAFLD) and non alcoholic steatohepatitis(NASH). In this study, we reviewed the current literature on the association between thyroid dysfunction and NAFLD/NASH. A search for English language medical literature reporting an association between thyroid dysfunction and NAFLD/NASH in humans was conducted across PubMed, ISI Web of Science, and Scopus in August, 2013. Out of 140 studies initially identified through the search, 11 relevant articles were included in the final review. Thyroid dysfunctions in the form of overt or subclinical hypothyroidism are prevalent among patients with NAFLD/NASH. Hypothyroidism appears to be an independent risk factor for NAFLD/NASH in some studies; however, other newly published studies failed to find such anassociation. The results of the studies on the role of thyroid abnormalities in NAFLD/NASH are inconsistent, and further research is recommended to determine the relationship between hypothyroidism and NAFLD/NASH and the underlying mechanisms. | Ahad Eshraghian Alireza Hamidian Jahromi | 2014 | World Journal of Gastroenterology2014，20，25： | 15 |
| 2 | Current and emerging pharmacological therapy for nonalcoholic fatty liver disease显示文摘The main treatment of patients with non-alcoholic fatty liver disease(NAFLD) is life style modification including weight reduction and dietary regimen.Majority of patients are safely treated with this management and pharmacologic interventions are not recommended. However, a subgroup of NAFLD patients with non-alcoholic steatohepatitis(NASH) who cannot achieve goals of life style modification may need pharmacological therapy. One major obstacle is measurement of histological outcome by liver biopsy which is an invasive method and is not recommended routinely in these patients. Several medications, mainly targeting baseline mechanism of NAFLD, have been investigated in clinical trials for treatment of NASH with promising results. At present, only pioglitazone acting as insulin sensitizing agent and vitamin E as an antioxidant have been recommended for treatment of NASH by international guidelines. Lipid lowering agents including statins and fibrates, pentoxifylline, angiotensin receptor blockers, ursodeoxycholic acid, probiotics and synbiotics are current agents with beneficial effects for treatment of NASH but have not been approved yet. Several emerging medications are in development for treatment of NASH. Obeticholic acid, liraglutide, elafibranor, cenicriviroc and aramchol have been tested in clinical trials or are completing trials. Here in, current and upcoming medications with promising results in clinical trial for treatment of NAFLD were reviewed. | Ahad Eshraghian | 2017 | World Journal of Gastroenterology2017，23，42： | 11 |
| 3 | Epidemiology of Helicobacter pylori infection among the healthy population in Iran and countries of the Eastern Mediterranean Region:A systematic review of prevalence and risk factors显示文摘AIM:To investigate the epidemiology of Helicobacter pylori(H.pylori)infection among the healthy asymptomatic population in Iran and countries of the Eastern Mediterranean Region.METHODS:A computerized English language literature search of Pub Med,ISI Web of Science,Scopus,and Google Scholar was performed in September 2013.The terms,'Eastern Mediterranean Regional Office(EMRO)'and'Helicobacter pylori','H.pylori'and'prevalence'were used as key words in titles and/or abstracts.A complementary literature search was also performed in the following countries:Afghanistan,Bahrain,Djibouti,Egypt,Iran,Iraq,Jordan,Kuwait,Lebanon,Libya,Morocco,Oman,Pakistan,Palestine,Qatar,Saudi Arabia,Somalia,Sudan,Syria,Tunisia,The United Arab Emirates,and Yemen.RESULTS:In the electronic search,a total of 308 articles were initially identified.Of these articles,26 relevant articles were identified and included in the study.There were 10 studies from Iran,5 studies from the Kingdom of Saudi Arabia,4 studies from Egypt,2 from the United Arab Emirates,and one study from Libya,Oman,Tunisia,and Lebanon,respectively.The overall prevalence of H.pylori infection in Iran,irrespective of time and age group,ranged from 30.6%to 82%.The overall prevalence of H.pylori infection,irrespective of time and age group,in other EMRO countries ranged from 22%to 87.6%.CONCLUSION:The prevalence of H.pylori in EMRO countries is still high in the healthy asymptomatic population.Strategies to improve sanitary facilities,educational status,and socioeconomic status should be implemented to minimize H.pylori infection. | Ahad Eshraghian | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 4 | Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level显示文摘AIM To investigate incidence and survival of post-transplant lymphoproliferative disorder(PTLD) patients after liver transplantation. METHODS A cross-sectional survey was conducted among patients who underwent liver transplantation at Shiraz Transplant Center(Shiraz, Iran) between August 2004 and March 2015. Clinical and laboratory data of patients were collected using a data gathering form. RESULTS There were 40 cases of PTLD in the pediatric age group and 13 cases in the adult group. The incidence of PTLD was 6.25% in pediatric patients and 1.18% in adult liver transplant recipients. The post-PTLD survival of patients at 6 mo was 75.1% ± 6%, at 1 year was 68.9% ± 6.5% and at 5 years was 39.2% ± 14.2%. Higher serum tacrolimus level was associated with lower post-PTLD survival in pediatric patients(OR = 1.07, 95%CI: 1.006-1.15, P = 0.032). A serum tacrolimus level over 11.1 ng/mL was predictive of post PTLD survival(sensitivity = 90%, specificity = 52%, area under the curve = 0.738, P = 0.035). CONCLUSION Incidence of PTLD in our liver transplant patients is comparable to other centers. Transplant physicians may consider adjustment of tacrolimus dose to maintain its serum level below this cutoff point. | Ahad Eshraghian Mohammad Hadi Imanieh Seyed Mohsen Dehghani Saman Nikeghbalian Alireza Shamsaeefar Frouzan Barshans Kourosh Kazemi Bita Geramizadeh Seyed Ali Malek-Hosseini | 2017 | World Journal of Gastroenterology2017，23，7： | 7 |
| 5 | Interstitial cells of Cajal: a novel hypothesis for the pathophysiology of irritable bowel syndrome 显示文摘 | Eshraghian A Eshraghian H | 2011 | Can J Gastroenterol2011，25，5： | 1 |
| 6 | Interstitial cells of Cajal , a novel hypothesis for the pathophysiology of irritable bowel syndrome显示文摘 | Eshraghian A Eshraghian H | 2011 | CanJ Gastroenterol2011，25，5： | 1 |
| 7 | Compari- son of chromoendoscopy and conventional endoscopy in the detection of premalignant gastric lesions显示文摘 | Taghavi SA Membari ME Eshraghian A | 2009 | Can J Gastroenterol2009，23，2： | 1 |
| 8 | First detection of enterovirus 71 from an acute flaccid paralysis case with residual paralysisin Iran显示文摘 | Shahmahmoodi S Mehrabi Z Eshraghian MR | 2008 | J Clin Virol2008，42，4： | 1 |
| 9 | First de-tection of enterovirus 71 from an acute flaccid paralysis casewith residual paralysis in Iran 显示文摘 | Shahmahmoodi S Mehrabi Z Eshraghian MR | 2008 | J Clin Virol2008，42，4： | 1 |
| 10 | Multilevel zero-inflated negative binomial regres- sion modeling for over-dispersed count data with ex- tra zeros显示文摘 | Moghimbeigi A Eshraghian M R Mohammad K | 2008 | Journal of Applied Statistics2008，35，10： | 1 |
| 11 | Effect of iron repletion and correction of iron deficiency on thyroid function in iron-deficient Iranian adolescent girls 显示文摘 | Eftekhari MH Eshraghian MR Mozaffari- Khosravi H | 2007 | Pak J Biol Sci2007，10，2： | 1 |
| 12 | Metabolic abnormalities in patients with nephrolithiasis:comparison of first-episode with recurrent cases in southern iran显示文摘 | Hosseini MM Eshraghian A Dehghanian I | 2010 | Int Urol Nephrol2010，42，1： | 1 |
| 13 | Morphometric differentiation between camel and sheep strains of Echinococcus granulosus using computer image analysis system(CIAS)显示文摘Objective:To find importance of morphometrie criterion of larval rostellar hook of Echinococcus granulosus(E.granulosus) and the easy and reliable method for distinguish sheep and camel strains in epidemiologic studies.Methods:Larval rostellar hooks(n=1860) of 31 camel and sheep isolates in Iran,which aheady had been characterized by PCR.were carefully processed by computerized imagime analysis system(CIAS) and acquired data about rostellar books were analyzed using software SPSS.Results:Measurement analysis of rostellar hooks[mean Iength (24.23±3.12lμm]indicated that length of the large hook was a remarkable parameter for strain differentiation.Data analysis demonstrated that CIAS could be used as a reliable tool to distinguish camel from sheep strains with high sensitivity(95.2%) and specificity(91.5%). Conclusions:CIAS as a specific,sensitive,economic,fast,and reliable means might be used for differentiation of E.granulosus strains.Although perimeter and area were measured by digital technology,they were not shown as discriminative criterion as total hook length did. | Gholamreza Mowlavi Mitra Salehi Mohammadreza Eshraghian Mohammad Bagher Rokni Majid Fasihi-Harandi Ehsan Mohajeran Abdoreza Salahi-Moghaddam | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，1： | 1 |
| 14 | Helicobacter pylori Infection as a Risk Factor for Insulin Resistance显示文摘 | Ahad Eshraghian Seyed Ali Hashemi Alireza Hamidian Jahromi Hamed Eshraghian Seyed Masoum Masoompour Mohamad Ali Davarpanah Kavus Eshraghian Seyed Alireza Taghavi | 2009 | Digestive Diseases and Sciences2009，，9： | 1 |
| 15 | Homocysteine level and coronary artery disease显示文摘 | Kazemi MB Eshraghian K Omrani GR | 2006 | Angiology2006，57，1： | 1 |
| 16 | The continuous story of Helicobacter pylori infection and insulin resistancerthis time in Japan显示文摘 | Eshraghian A | 2010 | Helicobacter2010，15，2： | 1 |
| 17 | Hyperlipidemia in Iranian liver transplant recipients:prevalence and risk factors显示文摘 | Dehghani SM Taghavi SA Eshraghian A | 2007 | J Gastroenterol2007，42，9： | 1 |
| 18 | Homocysteine level and coronary artery disease显示文摘 | Sharif-Kazemi M B Eshraghian K Omrani G R | 2006 | Angiology2006，57，1： | 1 |
| 19 | Helicobacter pylori infection as a risk factor for insulin re-sistance显示文摘 | Eshraghian A Hashemi SA Hamidian Jahromi A | 2009 | Dig Dis Sci2009，，9： | 1 |
| 20 | Effect of iron repletion and correction of iron deficiency on thyroid function in iron deficient Iranian adeloscent girls显示文摘 | Iftekhari MH Eshraghian MR Khosravi HM | 2007 | Pak J Biol Sci2007，10，2： | 1 |
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